Iowa City Research Articles

Sarcopenia is Associated With Decreased Brain Volume in the General Population: A Longitudinal Cohort Study

Background: Substantial evidence supports an association between physical activity and cognitive function. However, the role of muscle mass and function in brain structural changes is not well known. This study investigated whether sarcopenia, defined as low muscle mass and strength, affects brain atrophy in the general middle-to-later aged population. Methods: A total of 1284 participants with sarcopenic measurements and baseline and 4-year follow-up brain magnetic resonance images were recruited from the Korean Genome and Epidemiology Study. Muscle mass was represented as appendicular skeletal muscle mass divided by the body mass index. Muscle function was measured by handgrip strength. The low mass and strength groups were defined as being in the lowest quintile of each variable for one’s sex. Sarcopenia was defined as being in the lowest quintile for both muscle mass and strength. Findings: Of the 1284 subjects, 12·6%, 10·8%, and 5·4% were classified as the low mass, low strength, and sarcopenia groups, respectively. All three groups presented greater loss in gray matter (GM) volume than the control group. The adjusted mean changes of GM volume during 4-year follow-up period were -9·6 mL in the control group, whereas -11·6 mL in the other three groups (P < 0·001). For lobar brain volumes, the low mass group presented greater atrophy in frontal and occipital GM. The significantly faster atrophy in parietal GM was observed in the sarcopenia group compared with the control group, mostly driven by atrophy in the left inferior parietal lobule. In a joint regression model, low muscle mass, but not muscle strength, was an independent factor associated with rapid GM atrophy. Interpretation: Sarcopenia is associated with rapid declines in GM volume, especially parietal GM volume, in the general population. Maintaining good levels of muscle mass could be important for brain health in later adulthood. Funding Statement: This research was supported by funds (2009-E71002-00, 2010-E71001-00, 2011-E71004-00, 2012-E71005-00, 2013-E71005-00, 2014-E71003-00, 2015-P71001-00, 2016-E71003-00, 2017-E71001-00, 2018-E7101-00) from the Korean Centers for Disease Control and Prevention, the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MSIT) (NRF-2019M3E5D3073102,2019R1H1A2039682, 2020R1F1A1074265), a Korea University Grant (K1824431), Ansan-Si hidden champion fostering and supporting project funded by Ansan city, and computational resources provided by the University of Iowa, Iowa City, Iowa. . Declaration of Interests: No potential conflicts of interest relevant to this article are reported. Ethics Approval Statement: Each participant signed an informed consent form. This study was performed according to the principles of the Declaration of Helsinki of the World Medical Association and was approved by the Institutional Review Board of Korea University Ansan Hospital.

The Evolution of Pediatric Pulmonology as I Have Seen It.

Pediatric Allergy, Immunology, and PulmonologyVol. 33, No. 4 My Corner: Allergy and Pulmonary Highlights from Around the WorldThe Evolution of Pediatric Pulmonology as I Have Seen ItMiles WeinbergerMiles WeinbergerAddress correspondence to: Miles Weinberger, MD, 450 Sandalwood Court, Encinitas, CA 92024, USA E-mail Address: miles-weinberger@uiowa.eduwww.milesweinberger.comDivision of Pediatric Respiratory Medicine, Rady Children's Hospital, Department of Pediatrics, University of California San Diego, San Diego, California, USA.University of Iowa, Iowa City, Iowa, USA.Search for more papers by this authorPublished Online:16 Dec 2020https://doi.org/10.1089/ped.2020.1308AboutSectionsView articleView Full TextPDF/EPUB Permissions & CitationsPermissionsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail View article"The Evolution of Pediatric Pulmonology as I Have Seen It." Pediatric Allergy, Immunology, and Pulmonology, 33(4), pp. 191–192FiguresReferencesRelatedDetails Volume 33Issue 4Dec 2020 InformationCopyright 2020, Mary Ann Liebert, Inc., publishersTo cite this article:Miles Weinberger.The Evolution of Pediatric Pulmonology as I Have Seen It.Pediatric Allergy, Immunology, and Pulmonology.Dec 2020.191-192.http://doi.org/10.1089/ped.2020.1308Published in Volume: 33 Issue 4: December 16, 2020PDF download

Celebrating Jim Morgan: A Brilliant Teacher and Caring Mentor.

RETURN TO ARTICLES ASAPPREVPerspectiveCelebrating Jim Morgan: A Brilliant Teacher and Caring MentorJames J. Morgan, 1932−2020Jerald L. SchnoorJerald L. SchnoorDepartment of Civil and Environmental Engineering University of Iowa, Iowa City, Iowa 52242, United StatesMore by Jerald L. SchnoorCite this: Environ. Sci. Technol. 2020, XXXX, XXX, XXX-XXXPublication Date (Web):November 30, 2020Publication History Received30 October 2020Published online30 November 2020https://doi.org/10.1021/acs.est.0c07340© 2021 American Chemical SocietyRIGHTS & PERMISSIONSACS AuthorChoiceCC: Creative CommonsBY: Credit must be given to the creatorNC: Only noncommercial uses of the work are permittedND: No derivatives or adaptations of the work are permittedArticle Views705Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-AlertsSUBJECTS:Oxides,Students,Transition metals,Environmental science,Water treatment Get e-Alerts

This Month in Adult Urology

This Month in Adult Urology

Irish on the Move: Performing Mobility in American Variety Theatre. Michelle Granshaw. Iowa City: University of Iowa Press, 2019, 285 p.

Irish on the Move: Performing Mobility in American Variety Theatre. Michelle Granshaw. Iowa City: University of Iowa Press, 2019, 285 p.

Nanomaterials-Based Membranes Increase Flux and Selectivity to Enable Chemical Separations

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTNanomaterials-Based Membranes Increase Flux and Selectivity to Enable Chemical SeparationsNed B. Bowden*Ned B. BowdenDepartment of Chemistry, University of Iowa, Iowa City, Iowa 52242, United States*Email: [email protected]More by Ned B. Bowdenhttp://orcid.org/0000-0003-1628-8515Cite this: ACS Appl. Nano Mater. 2020, 3, 10, 9538–9541Publication Date (Web):October 14, 2020Publication History Published online14 October 2020Published inissue 23 October 2020https://doi.org/10.1021/acsanm.0c02471Copyright © 2020 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views1509Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (629 KB) Get e-AlertsSUBJECTS:Fluxes,Membranes,Nanomaterials,Selectivity,Two dimensional materials Get e-Alerts

Implementing virtual OSCE using an open-source online interactive 3D library.

Journal of Dental EducationVolume 85, Issue S1 p. 1037-1039 ADVANCING THROUGH INNOVATION Implementing virtual OSCE using an open-source online interactive 3D library Ahmed Mahrous DDS, MS, Corresponding Author Ahmed Mahrous DDS, MS [email protected] orcid.org/0000-0001-5436-8247 Department of Prosthodontics, University of Iowa College of Dentistry, Iowa City, Iowa, USA Correspondence Ahmed Mahrous, DDS, MS, Clinical Assistant Professor, Department of Prosthodontics, University of Iowa, College of Dentistry, 801 Newton Rd DSB, Iowa City, IA 52242, USA. Email: [email protected]Search for more papers by this authorRawa Alammari DDS, MHI, MS, Rawa Alammari DDS, MHI, MS Department of Operative Dentistry, A.T Still University, Mesa, Arizona, USASearch for more papers by this authorAmira Elgreatly DDS, MS, Amira Elgreatly DDS, MS Department of Operative Dentistry, University of Iowa College of Dentistry, Iowa City, Iowa, USASearch for more papers by this author Ahmed Mahrous DDS, MS, Corresponding Author Ahmed Mahrous DDS, MS [email protected] orcid.org/0000-0001-5436-8247 Department of Prosthodontics, University of Iowa College of Dentistry, Iowa City, Iowa, USA Correspondence Ahmed Mahrous, DDS, MS, Clinical Assistant Professor, Department of Prosthodontics, University of Iowa, College of Dentistry, 801 Newton Rd DSB, Iowa City, IA 52242, USA. Email: [email protected]Search for more papers by this authorRawa Alammari DDS, MHI, MS, Rawa Alammari DDS, MHI, MS Department of Operative Dentistry, A.T Still University, Mesa, Arizona, USASearch for more papers by this authorAmira Elgreatly DDS, MS, Amira Elgreatly DDS, MS Department of Operative Dentistry, University of Iowa College of Dentistry, Iowa City, Iowa, USASearch for more papers by this author First published: 02 October 2020 https://doi.org/10.1002/jdd.12449Citations: 1Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article.Citing Literature Volume85, IssueS1Supplement: Advancing Through Innovation in a Challenging TimeJune 2021Pages 1037-1039 This article also appears in:Advancing Through Innovation in a Challenging Time RelatedInformation

Development and implementation of a Telenephrology dashboard for active surveillance of kidney disease: a quality improvement project

BackgroundKidney disease accounts for more than 49 billion dollars in healthcare expenditures annually. Early detection and intervention may reduce the burden of disease. We describe a quality improvement project to develop a telenephrology dashboard that proactively monitors kidney disease.MethodsOne hundred eighty-four thousands Veterans within the Iowa City Veterans Affairs Health Care System were eligible for telenephrology consultation. The dashboard accessed the charts of 53,085 Veterans at risk for kidney disease. We utilized Lean-Six Sigma tools and principles and the Define-Measure-Analyze-Improve-Control Framework to develop and deploy a telenephrology dashboard in 4 community-based outpatient clinics (CBOCs). The primary measure was the number of days to complete consultation. Secondary measures included number of electronic consultations per month, distance and cost of Veteran travel saved, and number of steps for completion of consult.ResultsThe data of 1384 Veterans at the 4 CBOCs were analyzed by the telenephrology dashboard, of which 459 generated telenephrology consults. The number of days to complete any type of consultation was unchanged (48.9 days in 2019, compared to 41.6 days in 2017). The average Veteran saved between $21.60 to $63.90 per trip to Iowa City. Between March 2019 and August 2019, there were 27.3 telenephrology consults per month. The number of steps needed to complete the consult request was decreased from 13 to 9.ConclusionsUtilization of the telenephrology dashboard system contributed to an increase in consultations completed through electronic means without decreasing face-to-face consults. Electronic consults now outnumber traditional face-to-face consultations at our institution. Telenephrology consultation improved early detection and identification of kidney disease and saved time and costs for Veterans in travel, but did not decrease the average number of days to complete consultation requests.

Point of View.

Ignacio V. Ponseti Chair and Professor of Orthopaedic Surgery and Pediatrics. Address correspondence and reprint requests to Stuart L. Weinstein, MD, Department of Orthopaedic Surgery, University of Iowa Hospitals, Iowa City, IA 52242; E-mail: [email protected] The manuscript submitted does not contain information about medical device(s)/drug(s). No funds were received in support of this work. No relevant financial activities outside the submitted work.

In celebration of American Pharmacists Month, a look at lives dedicated to pharmacy

In celebration of American Pharmacists Month, a look at lives dedicated to pharmacy

Joe Spradlin: JABA thanks you for your contributions

Journal of Applied Behavior AnalysisVolume 53, Issue 4 p. 1960-1960 Comment Joe Spradlin: JABA thanks you for your contributions David P. Wacker PhD, Corresponding Author David P. Wacker PhD david-wacker@uiowa.edu Department of Pediatrics, The University of Iowa Address correspondence to: David P. Wacker, 140 Center for Disabilities and Development, The University of Iowa, Iowa City, Iowa, 52242. Email: david-wacker@uiowa.eduSearch for more papers by this author David P. Wacker PhD, Corresponding Author David P. Wacker PhD david-wacker@uiowa.edu Department of Pediatrics, The University of Iowa Address correspondence to: David P. Wacker, 140 Center for Disabilities and Development, The University of Iowa, Iowa City, Iowa, 52242. Email: david-wacker@uiowa.eduSearch for more papers by this author First published: 09 September 2020 https://doi.org/10.1002/jaba.764Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume53, Issue4Autumn (Fall) 2020Pages 1960-1960 RelatedInformation

Disney's Star Wars: Forces of Production, Promotion, and ReceptionWilliamProctor, RichardMcCulloch, editors. Iowa City: University of Iowa Press, 2019.

Disney's Star Wars: Forces of Production, Promotion, and ReceptionWilliamProctor, RichardMcCulloch, editors. Iowa City: University of Iowa Press, 2019.

Editorial introductions

Editorial introductions

Vessela Warner and Diana Manole Staging Postcommunism: Alternative Theatre in Eastern and Central Europe after 1989 Iowa City: University of Iowa Press, 2020. 263 p. $90.00. ISBN: 978-1-60938-677-1.

Vessela Warner and Diana Manole Staging Postcommunism: Alternative Theatre in Eastern and Central Europe after 1989 Iowa City: University of Iowa Press, 2020. 263 p. $90.00. ISBN: 978-1-60938-677-1.

Remote literature review with emphasis on critical appraisal and clinical applicability.

Journal of Dental EducationVolume 85, Issue S1 p. 912-914 ADVANCING THROUGH INNOVATION Remote literature review with emphasis on critical appraisal and clinical applicability Satheesh Elangovan BDS, DSc, DMSc, Corresponding Author Satheesh Elangovan BDS, DSc, DMSc [email protected] orcid.org/0000-0001-5740-6026 Department of Periodontics, The University of Iowa College of Dentistry and Dental Clinics, Iowa, Iowa City, USA Correspondence Dr. Satheesh Elangovan, BDS, DSc, DMSc, Professor, Department of Periodontics, The University of Iowa College of Dentistry, Iowa City, IA-52242, USA. Email: [email protected]Search for more papers by this authorMegumi Williamson DDS, MS, PhD, Megumi Williamson DDS, MS, PhD Department of Periodontics, The University of Iowa College of Dentistry and Dental Clinics, Iowa, Iowa City, USASearch for more papers by this authorGustavo Avila-Ortiz DDS, MS, PhD, Gustavo Avila-Ortiz DDS, MS, PhD Department of Periodontics, The University of Iowa College of Dentistry and Dental Clinics, Iowa, Iowa City, USASearch for more papers by this author Satheesh Elangovan BDS, DSc, DMSc, Corresponding Author Satheesh Elangovan BDS, DSc, DMSc [email protected] orcid.org/0000-0001-5740-6026 Department of Periodontics, The University of Iowa College of Dentistry and Dental Clinics, Iowa, Iowa City, USA Correspondence Dr. Satheesh Elangovan, BDS, DSc, DMSc, Professor, Department of Periodontics, The University of Iowa College of Dentistry, Iowa City, IA-52242, USA. Email: [email protected]Search for more papers by this authorMegumi Williamson DDS, MS, PhD, Megumi Williamson DDS, MS, PhD Department of Periodontics, The University of Iowa College of Dentistry and Dental Clinics, Iowa, Iowa City, USASearch for more papers by this authorGustavo Avila-Ortiz DDS, MS, PhD, Gustavo Avila-Ortiz DDS, MS, PhD Department of Periodontics, The University of Iowa College of Dentistry and Dental Clinics, Iowa, Iowa City, USASearch for more papers by this author First published: 19 July 2020 https://doi.org/10.1002/jdd.12342Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume85, IssueS1Supplement: Advancing Through Innovation in a Challenging TimeJune 2021Pages 912-914 This article also appears in:Advancing Through Innovation in a Challenging Time RelatedInformation

Associations Of Sleep, Physical Activity, And Sedentary Behavior Across Pregnancy Trimesters

PURPOSE: Sleep and physical activity are altered in pregnancy and may affect pregnancy health; however, whether these behaviors influence each other is not well understood. In this study, we describe self-reported sleep parameters across pregnancy trimesters and examine associations with objectively measured moderate-to-vigorous physical activity (MVPA) and sedentary behavior (SB). METHODS: Women were recruited from Iowa City, IA and Pittsburgh, PA to assess sleep, MVPA, and SB in each trimester of pregnancy. Sleep was measured using the Pittsburgh Sleep Quality Index. MVPA and SB were estimated using a waist-worn ActiGraph GT3X and thigh-worn activPAL3 micro, respectively; data were considered valid with ≥4 days of ≥10 hours of wear. Mixed effects models were used to examine changes in sleep parameters (global sleep score, poor sleep quality, sleep efficiency, sleep duration) across trimesters. Associations of MVPA and SB trajectories with sleep parameters were also examined using mixed effects models. RESULTS: Women (n=120) averaged 31.1 ± 4.7 years of age with a pre-pregnancy BMI of 26.8 ± 6.7 kg/m2. As seen in the Table, differences were found for all sleep parameters across pregnancy trimesters, with adverse changes occurring in the third trimester compared to the first and second trimesters. MVPA trajectory was not associated with any of the sleep parameters. Women in the high SB trajectory had greater sleep efficiency (β=4.78%, 95% CI: 0.07, 9.49) and women in the moderate and high SB trajectories also had longer sleep duration (β=0.79 hours, 95% CI: 0.23, 1.35; β=0.80 hours, 95% CI: 0.26, 1.33, respectively), compared to those in the low SB trajectory. CONCLUSIONS: Few studies have examined self-reported sleep measures across pregnancy trimesters. Findings indicate that sleep quality, efficiency, and duration are adversely affected in the third trimester. Contrary to our hypotheses, high SB but not MVPA was favorably associated with sleep parameters.

Interim Guidance for Basic and Advanced Life Support in Adults, Children, and Neonates With Suspected or Confirmed COVID-19: From the Emergency Cardiovascular Care Committee and Get With The Guidelines-Resuscitation Adult and Pediatric Task Forces of the American Heart Association.

Interim Guidance for Basic and Advanced Life Support in Adults, Children, and Neonates With Suspected or Confirmed COVID-19: From the Emergency Cardiovascular Care Committee and Get With The Guidelines-Resuscitation Adult and Pediatric Task Forces of the American Heart Association.

Transcatheter Aortic Valve Replacement in the Coronavirus Disease 2019 (COVID-19) Era.

Transcatheter Aortic Valve Replacement in the Coronavirus Disease 2019 (COVID-19) Era.

"Hot Zones" for Otolaryngologists: Assessing the geographic distribution of aerosol-generating procedures amidst the COVID-19 pandemic.

ObjectiveGiven high COVID-19 viral load and aerosolization in the head and neck, otolaryngologists are subject to uniquely elevated viral exposure in most of their inpatient and outpatient procedures and interventions. While elective activity has halted across the board nationally, the slow plateau of COVID-19 case rates prompts the question of timing of resumption of clinical activity. We sought to prospectively predict geographical “hot zones” for otolaryngological exposure to COVID-19 based on procedural volumes data from 2013 to 2017.MethodsOtolaryngologic CPT codes were stratified based on risk-level, according to recently published specialty-specific guidelines. Using the Medicare POSPUF database, aerosol-generating procedures (AGPs) were mapped based on hospital referral regions, against up-to-date COVID-19 case distribution data, as of April 24, 2020.ResultsThe most common AGPs were diagnostic flexible laryngoscopy, diagnostic nasal endoscopy, and flexible laryngoscopy with stroboscopy. The regions with the most AGPs per otolaryngologist were Iowa City, IA, Detroit, MI, and Burlington, VT, while the states with the most COVID-19 cases as of April 24th are New York, New Jersey, and Massachusetts.ConclusionsOur study provides a model for predicting possible “hot zones” for otolaryngologic exposure based on both COVID-19 case density and AGP-density. As the focus shifts to resuming elective procedures, these potential “hot zones” need to be evaluated for appropriate risk-based decision-making, such as “reopening strategies” and allocation of resources.

Survival After In-Hospital Cardiac Arrest in Critically Ill Patients: Implications for COVID-19 Outbreak?

The coronavirus disease 2019 (COVID-19) outbreak is placing a considerable strain on U.S. healthcare systems by requiring both significant acute resources and endangering healthcare team members th...