Iodine-catalyzed Three-component Reaction Research Articles

Metal-free one-pot synthesis of quinoline-2,4-carboxylates via a molecular iodine-catalyzed three-component reaction of arylamines, ethyl glyoxylate, and α-ketoesters

Abstract A simple and metal-free method has been developed for the construction of quinoline-2,4-carboxylates under mild conditions via a molecular iodine-catalyzed three-component tandem reaction of arylamines, ethyl glyoxylate, and α -ketoesters. The present protocol provides a convenient and attractive approach to various quinoline-2,4-carboxylates in moderate to good yields with excellent functional group tolerance.

Iodine-catalyzed three-component reaction of quinazoline-2,5-diones with aldehydes and styrenes for the synthesis of allylamine derivatives

Iodine-catalyzed three component reaction of quinazoline-2,5-diones, aldehydes, and styrenes provides allylamine derivatives was described. Both paraformaldehyde and ethyl glyoxalate can be applied in this reaction with simple styrenes with high regioselectivity.

Iodine-Catalyzed Three-Component Reaction: A Rapid Synthesis of α-Alkoxy Azides and Homoallyl Ethers

Iodine is found to be an efficient catalyst for the three-component coupling of aldehydes, alcohols, and TMSN 3 under mild and neutral conditions to provide α-alkoxy azides in good yields and with high selectivity. Allyltrimethylsilane also reacts rapidly with aldehydes in the presence of alcohols to produce homoallyl ethers under similar conditions. The use of iodine makes this procedure simple, convenient and cost-effective.