Osteonecrosis of the femoral head is a pathologic process with multifactorial origins, characterised by pain, alteration of the anatomy and biomechanics of the hip and increasing patient disability. The treatment method depends on the stage of the disease, the size and location of the lesions, whether the involvement is uni- or bilateral, the age of the patient, how active the patient is, their general health conditions and life expectancy. The unsatisfactory results obtained in saving the femoral head using the available methods have lead in recent years to renewed interest in this disease and seeking new methods and treatments aimed at arresting its development or even preventing its onset. We present a clinical case study of a new method involving core decompression combined with the introduction of mesenchymal cells through a specific titanium screw called “SOIB”.