Intrinsic Link Research Articles

An Integrated Immune-Related Bioinformatics Analysis in Lung Squamous Cell Carcinoma Patients

Through combined bioinformatics analysis, the goal of untrrec research was to develop and confirm the immune-related prognostic signature in LUSC (lung squamous cell carcinoma). We constructed an optimized prognostic risk model consisting of five PIR-lncRNAs (AC107884.1, LCMT1-AS1, AL163051.1, AC005730.3 and LINC02635). To evaluate and verify the prognostic value of the model, we subsequently conducted independent prognostic and mortality analysis on the prognostic risk model. Additionally, we conducted a distinct study of immune cell infiltration in the model among high- and low individuals. By using co-expression network analysis, we were able to identify 654 immune-related lncRNAs (IR-lncRNAs) and 18 prognostic IR-lncRNAs (PIR-lncRNAs) and derive 546 differently expressed genes and 21 immune-related genes. We proved that the impact of immunotherapy in individuals in the high-risk category may be lessened through the study of immune escape and immunotherapy. Our findings elucidate the intrinsic molecular biological link between the pathogenic genes of LUSC and immune cells, which has important exploration and reference significance for the precise and potential immunotherapy of LUSC patients, especially for high-risk patients.

Structural covariation between cerebellum and neocortex intrinsic structural covariation links cerebellum subregions to the cerebral cortex.

The human cerebellum is increasingly recognized to be involved in nonmotor and higher-order cognitive functions. Yet, its ties with the entire cerebral cortex have not been holistically studied in a whole brain exploration with a unified analytical framework. Here, we characterized dissociable cortical-cerebellar structural covariation patterns based on regional gray matter volume (GMV) across the brain in n = 38,527 UK Biobank participants. Our results invigorate previous observations in that important shares of cortical-cerebellar structural covariation are described as 1) a dissociation between the higher-level cognitive system and lower-level sensorimotor system and 2) an anticorrelation between the visual-attention system and advanced associative networks within the cerebellum. We also discovered a novel pattern of ipsilateral, rather than contralateral, cerebral-cerebellar associations. Furthermore, phenome-wide association assays revealed key phenotypes, including cognitive phenotypes, lifestyle, physical properties, and blood assays, associated with each decomposed covariation pattern, helping to understand their real-world implications. This systems neuroscience view paves the way for future studies to explore the implications of these structural covariations, potentially illuminating new pathways in our understanding of neurological and cognitive disorders.NEW & NOTEWORTHY Cerebellum's association with the entire cerebral cortex has not been holistically studied in a unified way. Here, we conjointly characterize the population-level cortical-cerebellar structural covariation patterns leveraging ∼40,000 UK Biobank participants whole brain structural scans and ∼1,000 phenotypes. We revitalize the previous hypothesis of an anticorrelation between the visual-attention system and advanced associative networks within the cerebellum. We also discovered a novel ipsilateral cerebral-cerebellar associations. Phenome-wide association (PheWAS) revealed real-world implications of the structural covariation patterns.

Impact of Climate Risk on Stock Market

This study provides an in-depth look at the intricate interplay between climate risk and its repercussions on the stock market, analyzing in detail the differences across markets and time intervals. The study reveals a notable correlation between climate risk and the stock market and that there are some variations in this relationship. Specifically, the U.S. market is more sensitive to climate risk, while the European market is relatively less so. In addition, the COVID-19 has a short-term impact. This study summarizes and generalizes the literature of the last three years and employs a variety of descriptive methods in order to reveal the intrinsic link between the two. The findings provide a crucial reference for investors and policy makers to gain a more nuanced comprehension of the ramifications of climate risk on equity markets. Subsequent investigations could go deeper into the relationship between climate risk on other financial markets (e.g., bond markets) and the differences in response to climate risk across different climate sectors.

Introduction to the Special Issue on the Role of Place in Sustainability: Key Trends and Agenda for Future Research

This editorial reviews key themes, trends, and assumptions of organizational research on place and sustainability and introduces the special issue on the “Role of Place in Sustainability.” While recent theorizing has often emphasized global issues such as grand challenges, planetary boundaries, and climate change, this special issue revisits the local by focusing on the role of place in sustainability. We discuss trends and subdomains of research on place and sustainability and identify key assumptions at the interplay between global and local perspectives. Instead of advocating for universal solutions or exclusively context-specific approaches, we highlight the concept of “senses of place,” emphasizing the connections among diverse notions of place and intrinsic links to these locations. We demonstrate how the four insightful articles featured in this special issue provide a broader dialogue on place and sustainability. Finally, we outline a research agenda that identifies underexplored themes in place-based sustainability studies.

Gut microbiota: A key role for human milk oligosaccharides in regulating host health early in life.

Human milk oligosaccharides (HMOs) are an evolutionarily significant advantage bestowed by mothers for facilitating the development of the infant's gut microbiota. They can avoid absorption in the stomach and small intestine, reaching the colon successfully, where they engage in close interactions with gut microbes. This process also enables HMOs to exert additional prebiotic effects, including regulating the mucus layer, promoting physical growth and brain development, as well as preventing and mitigating conditions such as NEC, allergies, and diarrhea. Here, we comprehensively review the primary ways by which gut microbiota, including Bifidobacteria and other genera, utilize HMOs, and we classify them into five central pathways. Furthermore, we emphasize the metabolic benefits of bacteria consuming HMOs, particularly the recently identified intrinsic link between HMOs and the metabolic conversion of tryptophan to indole and its derivatives. We also examine the extensive probiotic roles of HMOs and their recent research advancements, specifically concentrating on the unsummarized role of HMOs in regulating the mucus layer, where their interaction with the gut microbiota becomes crucial. Additionally, we delve into the principal tools used for functional mining of new HMOs. In conclusion, our study presents a thorough analysis of the interaction mechanism between HMOs and gut microbiota, emphasizing the cooperative utilization of HMOs by gut microbiota, and provides an overview of the subsequent probiotic effects of this interaction. This review provides new insights into the interaction of HMOs with the gut microbiota, which will inform the mechanisms by which HMOs function.

Unearthing the Potential Therapeutic Effects of Oxyresveratrol Based on Intrinsic Links between Pharmacological Effects: Implications for the Gut-Liver-Brain Axis.

Oxyresveratrol is a stilbene compound with a simple chemical structure and various therapeutic potentials. This study summarized and analyzed the multiple pharmacological effects and mechanisms of oxyresveratrol, identifying its prominent performance in neuroprotection, hepatoprotection, and anti-inflammatory activities in the intestines. By integrating the pharmacological effects of oxyresveratrol with insights from the network pharmacology and molecular docking of its interactions with targets linked to gut-liver-brain axis disorders, it has been shown that oxyresveratrol may hold promise for the treatment of gut-liver-brain axis-related disorders. The synergistic effect between various mechanisms has inspired further research and the development of oxyresveratrol's application value.

Endothelial Cell Dysfunction Due to Molecules Secreted by Macrophages in Sepsis.

Sepsis is recognized as a syndrome of systemic inflammatory reaction induced by dysregulation of the body's immunity against infection. The multiple organ dysfunction associated with sepsis is a serious threat to the patient's life. Endothelial cell dysfunction has been extensively studied in sepsis. However, the role of macrophages in sepsis is not well understood and the intrinsic link between the two cells has not been elucidated. Macrophages are first-line cells of the immune response, whereas endothelial cells are a class of cells that are highly altered in function and morphology. In sepsis, various cytokines secreted by macrophages and endothelial cell dysfunction are inextricably linked. Therefore, investigating how macrophages affect endothelial cells could offer a theoretical foundation for the treatment of sepsis. This review links molecules (TNF-α, CCL2, ROS, VEGF, MMP-9, and NO) secreted by macrophages under inflammatory conditions to endothelial cell dysfunction (adhesion, permeability, and coagulability), refining the pathophysiologic mechanisms of sepsis. At the same time, multiple approaches (a variety of miRNA and medicines) regulating macrophage polarization are also summarized, providing new insights into reversing endothelial cell dysfunction and improving the outcome of sepsis treatment.

The Radio Galaxy Environment Reference Survey (RAGERS): a submillimetre study of the environments of massive radio-quiet galaxies at z = 1–3

ABSTRACT Measuring the environments of massive galaxies at high redshift is crucial to understanding galaxy evolution and the conditions that gave rise to the distribution of matter we see in the Universe today. While high-z radio galaxies (HzRGs) and quasars tend to reside in protocluster-like systems, the environments of their radio-quiet counterparts are relatively unexplored, particularly in the submillimetre, which traces dust-obscured star formation. In this study, we search for 850 μm-selected submillimetre galaxies (SMGs) in the environments of massive ($M_{\star }$$\gt 10^{11}$${\rm M}_{\odot }$), radio-quiet ($L_{500 {\rm MHz}}$$\lesssim 10^{25}$ WHz$^{-1}$) galaxies at $z \sim 1\!-\!3$ using data from the SCUBA-2 COSMOS (S2COSMOS) survey. By constructing number counts in circular regions of radius 1–6 arcmin and comparing with blank-field measurements, we find no significant overdensities of SMGs around massive radio-quiet galaxies at any of these scales, despite being sensitive down to overdensities of $\delta \sim 0.4$. To probe deeper than the catalogue we also examine the distribution of peaks in the SCUBA-2 signal-to-noise (SNR) map, which reveals only tentative signs of any difference in the SMG densities of the radio-quiet galaxy environments compared to the blank field, and only on smaller scales (1 arcmin radii, corresponding to $\sim 0.5$ Mpc) and higher SNR thresholds. We conclude that massive, radio-quiet galaxies at cosmic noon are typically in environments with $\delta \lesssim 0.4$, which are either consistent with the blank field or contain only weak overdensities spanning sub-Mpc scales. The contrast between our results and studies of HzRGs with similar stellar masses and redshifts implies an intrinsic link between the wide-field environment and the radio luminosity of the active galactic nucleus at high redshift.

Intrinsic link between PGRN and Gba1 D409V mutation dosage in potentiating Gaucher disease.

Gaucher disease (GD) is caused by biallelic GBA1/Gba1 mutations that encode defective glucocerebrosidase (GCase). Progranulin (PGRN, encoded by GRN/Grn) is a modifier of GCase, but the interplay between PGRN and GCase, specifically GBA1/Gba1 mutations, contributing to GD severity is unclear. Mouse models were developed with various dosages of Gba1 D409V mutation against the PGRN deficiency (Grn-/-) [Grn-/-;Gba1D409V/WT (PG9Vwt), Grn-/-;Gba1D409V/D409V (PG9V), Grn-/-;Gba1D409V/Null (PG9VN)]. Disease progression in those mouse models was characterized by biochemical, pathological, transcriptomic, and neurobehavioral analyses. Compared to PG9Vwt, Grn-/-;Gba1WT/Null and Grn-/- mice that had a higher level of GCase activity and undetectable pathologies, homozygous or hemizygous D409V in PG9V or PG9VN, respectively, resulted in profound inflammation and neurodegeneration. PG9VN mice exhibited much earlier onset, shorter life span, tissue fibrosis, and more severe phenotypes than PG9V mice. Glycosphingolipid accumulation, inflammatory responses, lysosomal-autophagy dysfunction, microgliosis, retinal gliosis, as well as α-Synuclein increases were much more pronounced in PG9VN mice. Neurodegeneration in PG9VN was characterized by activated microglial phagocytosis of impaired neurons and programmed cell death due to necrosis and, possibly, pyroptosis. Brain transcriptomic analyses revealed the intrinsic relationship between D409V dosage, and the degree of altered gene expression related to lysosome dysfunction, microgliosis, and neurodegeneration in GD, suggesting the disease severity is dependent on a GCase activity threshold related to Gba1 D409V dosage and loss of PGRN. These findings contribute to a deeper understanding of GD pathogenesis by elucidating additional underlying mechanisms of interplay between PGRN and Gba1 mutation dosage in modulating GCase function and disease severity in GD and GBA1-associated neurodegenerative diseases.

Time-Dependent Effects of Altered Prebedtime Light Exposure in Enclosed Spaces on Sleep Performance Associated with Human States.

Exposure to artificial light influences human performance, which is essential for maintaining healthy work and sleep. However, existing research has not explored the intrinsic links between sleep performance and human states over time under prebedtime light exposure interventions (LEIs). To investigate the time-dependent effects of altered prebedtime light exposure, four LEI groupings (#L1 - #L4) and a Time factor (D8, D9, and D10) were chosen for sleep experiments in enclosed spaces. Forty-eight young adults recruited were available for data analysis. Subjective alertness (SA), negative affect (NA), subjective sleep, and objective sleep were measured via the Karolinska Sleepiness Scale, Positive and Negative Affect Schedule, Next-day Self-assessment Sleep Quality, and joint assessment of wrist actigraphy and sleep diaries, respectively. Statistical analysis was used for the effects of light exposure on the human states (corresponding to the SA and NA) and sleep performance, while the process model helped construct the associations between the two. The statistical effects revealed that the Time had a significant main effect on subjective sleep and changes in prebedtime alertness; the LEI had a significant main effect only on sleep onset latency (SOL). After undergoing altered prebedtime light exposure, the mean SA increased at prebedtime of D9 (p = 0.022) and D10 (p = 0.044); No significant effect on the NA was observed; Mean subjective sleep had a significant increase from D8 to D10. Moreover, five actigraphy-estimated sleep parameters were interrelated. In light of this, a chained pathway relationship was identified. The SOL played a mediating predictor between prebedtime state and objective sleep, which was linked to the awakening state through subjective sleep. Our study suggests that time-dependent effects of altered prebedtime light exposure on sleep performance are associated with human states at prebedtime and awakening, with implications for its prediction of sleep health.

Excess goodwill and enterprise litigation risk

Corporate mergers and acquisitions (M&A) are now a common strategic choice for enterprises. As such, goodwill, which is a core asset of M&A activities, is pivotal for financial valuation and accounting. However, the phenomenon of ‘excess goodwill’, resulting from overvaluation due to management overconfidence and performance promises, poses significant risks, including potential financial statement distortions and increased litigation. This study investigates the intrinsic link between excess goodwill and corporate litigation risk by utilising theoretical analyses and empirical tests. By analysing data from A-share listed companies in Shanghai and Shenzhen from 2007 to 2022, we employed the regression residual method to measure excess goodwill and determine its impact on litigation risk through mediating factors such as financing constraints, risk-taking and agency costs. The findings indicate that excess goodwill significantly increases litigation risk, with a more pronounced effect on manufacturing firms and those with low internal control quality. This research provides valuable insights into optimising goodwill accounting treatment and enhancing enterprise risk management practices. The study's implications suggest that stricter internal controls and cautious goodwill valuation practices are essential to mitigate risks, ultimately contributing to the stability of the capital market and the protection of investor interests.

Virtues as protective factors for adolescent mental health.

This paper explores the decline in adolescent mental health and the weakening of traditional moral frameworks, positing education in the virtues as protective of mental health due to the intrinsic link between moral/existential wellbeing and psychological health. By integrating character education into school curricula, a continuous "dosage" of moral guidance may be an optimal way to ensure a gradual and ever-clearer articulation of a life worth living and how to live well. The paper critiques popular clinical and positive psychological approaches to promoting wellbeing, which often miss the existential and moral dimensions of adolescent growth. The conclusion emphasizes the need for integrating moral education into mental health interventions to address the comprehensive existential and moral dimensions of adolescent development. This paper advocates for a proactive character developmental model that nurtures moral and existential growth, recognizing challenges with virtue and meta-virtue development as integral to personal and moral evolution, and enhancing the moral and psychological fortitude of adolescents.

Study on Expansion Rate of Steel Slag Cement-Stabilized Macadam Based on BP Neural Network.

The physicochemical properties of steel slag were investigated using SEM and IR, and it was found that free calcium oxide and free magnesium oxide in steel slag produce calcium hydroxide when in contact with water, leading to volume expansion. Thus, the expansion rate of steel slag itself was first investigated, and it was found that the volume expansion of steel slag was more obvious in seven days after water immersion. Then, the cement dosages of 5% and 6% of the steel slag expansion rate and cement-stabilized gravel volume changes between the intrinsic link were further explored after the study found that the cement bonding effect can be partially inhibited due to the volume of expansion caused by the steel slag, so it can be seen that increasing the dosage of cement can reduce the volume expansion of steel slag cement-stabilized gravel with the same dosage of steel slag. Finally, a prediction model of the expansion rate of steel slag cement-stabilized gravel based on the BP (back propagation) neural network was established, which was verified to be a reliable basis for predicting the expansion rate of steel slag cement-stabilized aggregates and improving the accuracy of the proportioning design.

Enhancing Place Emotion Analysis with Multi-View Emotion Recognition from Geo-Tagged Photos: A Global Tourist Attraction Perspective

User−generated geo−tagged photos (UGPs) have emerged as a valuable tool for analyzing large−scale tourist place emotions with unprecedented detail. This process involves extracting and analyzing human emotions associated with specific locations. However, previous studies have been limited to analyzing individual faces in the UGPs. This approach falls short of representing the contextual scene characteristics, such as environmental elements and overall scene context, which may contain implicit emotional knowledge. To address this issue, we propose an innovative computational framework for global tourist place emotion analysis leveraging UGPs. Specifically, we first introduce a Multi−view Graph Fusion Network (M−GFN) to effectively recognize multi−view emotions from UGPs, considering crowd emotions and scene implicit sentiment. After that, we designed an attraction−specific emotion index (AEI) to quantitatively measure place emotions based on the identified multi−view emotions at various tourist attractions with place types. Complementing the AEI, we employ the emotion intensity index (EII) and Pearson correlation coefficient (PCC) to deepen the exploration of the association between attraction types and place emotions. The synergy of AEI, EII, and PCC allows comprehensive attraction−specific place emotion extraction, enhancing the overall quality of tourist place emotion analysis. Extensive experiments demonstrate that our framework enhances existing place emotion analysis methods, and the M−GFN outperforms state−of−the−art emotion recognition methods. Our framework can be adapted for various geo−emotion analysis tasks, like recognizing and regulating workplace emotions, underscoring the intrinsic link between emotions and geographic contexts.

Exploring emotional experiences and dataset construction in the era of short videos based on physiological signals

ObjectiveThis study aims to uncover the intrinsic links between emotional experiences and physiological responses as users watch short videos on social media platforms, with a particular focus on using changes in physiological signals to identify and understand different emotional states. MethodsTo achieve this objective, a simulated experiment was designed to browse short videos and induce and record physiological signals under seven typical emotional states. The recorded signals included electroencephalogram, galvanic skin response, skin temperature, and heart rate, resulting in the creation of a dataset. Machine learning algorithms were employed to classify emotions and evaluate the dataset’s effectiveness. Statistical testing methods were used to analyze signal feature changes and distributions across different emotional states, exploring trends and their statistical significance. ResultsThe study successfully constructed an emotion-physiological signal dataset. Statistical tests revealed significant changes in physiological signal characteristics across different emotional states, providing extensive data support for understanding how emotions specifically affect physiological responses. ConclusionThe research not only confirmed the practicality of the constructed dataset in emotion recognition tasks but also provided empirical evidence of how emotions influence physiological responses through detailed analysis of physiological signals. SignificanceThe findings of this study hold significant value for emotional science, psychological research, and the entertainment industry. They not only facilitate a deeper exploration of individual emotional physiological mechanisms but also provide a scientific basis for optimizing content recommendation systems, intelligent entertainment technologies, and affective-aware applications.

THE HALF MOTHER: AN INQUIRY INTO THE POETICS OF RESISTANCE LITERATURE

“The Half Mother: An Inquiry into the Poetics of Resistance Literature” investigates the dynamic interplay between literary representation and political resistance in the context of the Kashmir conflict. This paper delves into how Shahnaz Bashir's novel, The Half Mother, exemplifies the genre of resistance literature by exploring the intersection of personal and collective trauma amidst a protracted conflict. The Kashmir Valley, historically a cradle of poetic and artistic expression, has faced profound devastation since the late 1980s due to a surge in violence and insurgency. This period, marked by intense militarization and human rights abuses, has given rise to a distinct body of English-language literature that seeks to authentically portray the lived experiences of its people.The study situates The Half Mother within the broader framework of resistance literature, drawing on Ghassan Kanafani's theoretical construct of resistance as both a cultural and political act. This study demonstrates how these literary efforts transcend mere chronicles of victimhood to engage in a profound examination of human resilience and the quest for self-determination. Bashir’s novel thus emerges as a pivotal text that not only contributes to the international literary discourse but also amplifies the voices of a marginalized and silenced population. The Half Mother encapsulates the transformation of individual suffering into a collective resistance, shedding light on the intrinsic link between literary creation and political struggle, and offering a poignant commentary on the enduring human spirit amidst adversity.

Research on Consumption Characteristics and Marketing Strategy of Micro-short Drama from the Perspective of Self-Determination Theory

Purpose - With the integration of science, technology, and culture, micro-dramas have emerged as a new driving force in advancing China’s short video industry. The purpose of this study is to deeply understand and analyze the characteristics of consumer consumption behavior to provide a theoretical perspective for the marketing strategy of microdrama. Design/Methodology/Approach - Based on the internal motivation of consumers and the characteristics of the micro-drama industry, a comprehensive analysis framework is constructed based on the three core dimensions of “autonomy, ability and belonging” in the self-determination theory (SDT). Through literature review, case analysis, and other methods, the consumption characteristics of micro-dramas are systematically examined. Subsequently, targeted marketing strategies are proposed accordingly. Findings - The study shows that consumers show diversified motives and demands in the consumption of short dramas, among which the pursuit of autonomy, the sense of ability and the construction of belonging become the key factors affecting consumers’ decision-making. Based on these findings, this study further refines the consumption characteristics of microdramas and reveals the intrinsic link between them and marketing strategies. Research Implications - This study enriches the theoretical research in the field of drama marketing. Through indepth understanding of the consumption characteristics of consumers, enterprises can more accurately locate the target market and formulate more effective marketing strategies, so as to promote the sustainable and healthy development of the drama industry.

Home in the Poetry of Saudi Distinguished Poets: Abdullah Al-Faisal a Case in Point (2)

It can be posited that an individual's attachment to their homeland evolves and matures in tandem with their personal development, ultimately becoming an intrinsic aspect of their consciousness. The resonant call of the poet, though profound, is inevitably eclipsed by the enduring and primordial nature of one's homeland; it remains a perpetually innate affection. This paper, the second instalment in a tripartite series, seeks to elucidate the expertise, familiarity, and proficiency of Abdullah Al-Faisal as expressed through his poetic oeuvre, while concurrently illuminating his profound loyalty to the extensive and illustrious territory to which he is indelibly connected. This research commences with a brief overview of poetry and its cultural significance, before delving into the context of the Kingdom of Saudi Arabia, particularly focusing on the relationship between poetry and the concept of homeland. Subsequently, the study examines the literary contributions of the poet Abdullah Al-Faisal, with a primary emphasis on his poem "The Redemption." Utilising a critical-analytical-descriptive methodology, the investigation highlighted key thematic elements within the poem. Through a detailed analysis of selected lines from "The Redemption," the research elucidates the nuanced and multifaceted nature of the idea of homeland as expressed in Al-Faisal's work. The study posits that Al-Faisal's poetry serves as a conduit for expressing profound nationalistic sentiments. Additionally, it illustrates his unwavering dedication to his homeland, as evidenced by the intimate portrayal of his connection to the land throughout his oeuvre. The concluding section synthesises these findings, affirming the intrinsic link between Al-Faisal's poetic expressions and the themes of national identity and belonging.

Clay minerals control silicon isotope variations of fine-grained river sediments: Implication for the trade-off between physical erosion and chemical weathering

Stable silicon (Si) isotopes in fluvial sediments can provide insights into understanding silicate weathering processes on the Earth's surface. However, a lack of comprehensive studies has hindered full understanding of the factors influencing Si isotope fractionation during continental weathering. In this study, through the analysis of Si isotopes in fine-grained sediments from 13 rivers surrounding the South China Sea, significant variation of Si isotopes in bulk detrital sediments (<63 μm) was observed, with δ30Si values ranging from −0.17‰ to −1.09‰. At basin scale, the δ30Si values are influenced by multiple controlling factors such as climatic conditions, lithology, and tectonic settings, which have a close relationship with the content of clay minerals. The characteristics of weathering types and intensities are ultimately reflected in the weathering products, specifically clay minerals. Compiling data across multiple grain sizes from major rivers globally, robust correlations based on clay mineral classification between δ30Si and Al/Si ratio have been observed, which are unaffected by regional and grain-size variations. As the dominant clay mineral group transitions from illite/chlorite to smectite and kaolinite, the degree of Si isotope fractionation increases progressively. This sequence indicates a shift from stronger physical erosion to more intensive chemical weathering, suggesting a transition in the weathering regime from weathering-limited to transport-limited. This study reveals the intrinsic link between Si isotopic compositions and clay mineral assemblages, providing implications for similar stable isotope research and offering a potential indicator for understanding continental weathering processes and their contributions to the global carbon cycle.

Resilience and successful aging: A systematic review and meta-analysis

BackgroundThis systematic review and meta-analysis investigates the relationship between successful aging (SA) and resilience in older adults, focusing on individuals aged 60 and above, to address a significant gap in understanding how resilience contributes to SA. MethodsFollowing the Cochrane review guidelines, we conducted searches in databases such as Web of Science, PsycNet, and PubMed up to December 2021 and used PRISMA as a tool for reporting the results. Our inclusion criteria were studies on psychological resilience and SA in older adults aged 60 and above. Exclusion criteria included studies on physical resilience, medical outcomes of SA, other indicators not used in screened studies (e.g., prevalence, means), populations with suicidal ideation or chronic/palliative illnesses, studies considering resilience as an indicator of SA, and qualitative studies on the association between resilience and SA. ResultsA total of 21 studies were included and assessed for risk of bias using funnel plot and trim-and-fill methods. The meta-analysis revealed a medium effect size indicating a positive relationship between resilience and SA. However, high heterogeneity warrants a cautious interpretation of these results. No significant differences were found between older adults in the general population and those in retirement communities, nor were geographical variations (Asia, Europe, America) found to moderate this relationship. DiscussionThe findings highlight the intrinsic link between older adults' attitudes towards aging, their subjective evaluations, and their level of psychological resilience. Resilience acts as a protective factor against psychological and physical adversities, underscoring the importance of resilience-enhancing strategies in interventions aimed at promoting SA. The conclusions drawn from this analysis should be approached with caution due to the heterogeneity of the included studies.