The aim of this study was to develop a mobile application for patients with Type 2 diabetes initiating insulin therapy for the first time and to evaluate its effects on insulin knowledge, insulin injection skills, self-management of insulin therapy and attitudes towards insulin use. This randomized controlled study included 88 participants assigned by block randomization to intervention (mobile application, n = 44) and control (standard care, n = 44) groups. The intervention group received insulin training via the mobile app, whereas the control group received standard care. Data were collected at baseline (T1), on the 14th day (T2) and on the 28th day (T3) using the Patient Information Form, Insulin Knowledge Form, Insulin Treatment Assessment Scale, Insulin Treatment Self-Management Scale and Insulin Injection Skill Observation Form. In the intervention group using the mobile application, a statistically significant increase over time was observed in the levels of insulin-related knowledge, self-management of insulin treatment and insulin injection skills, whereas negative attitudes and perceptions regarding insulin treatment decreased (p < 0.05). No statistically significant change was observed in the control group (p > 0.05). The results obtained in the present study indicated that the mobile application developed for patients with Type 2 diabetes using insulin for the first time is effective in disease self-management, fosters positive behavioural changes and serves as a viable educational tool for individuals with Type 2 diabetes. The application can be integrated into routine nursing-led diabetes education programmes to enhance continuity of care and support patients during insulin initiation. ClinicalTrials.gov identifier: NCT06060743.

Effects of catechin-enriched green tea combined with exercise on physical performance and muscle mass in community-dwelling older adults: A cluster-randomized, placebo-controlled trial.

Role of social capital in improving diet of pregnant women in Southern Ethiopia: A non-randomized cluster controlled study.

The effect of finger feeding on stress and comfort behaviors in preterm infants.

Efficacy of telephone-based health counseling with wearable device-Smartphone monitoring in older adults with metabolic syndrome: A randomized controlled trial.

Fragmentation within the healthcare system is a challenge to continuous care provision internationally. Patients with age-associated and chronic diseases with complex care requirements often face barriers to managing their care. Patient navigation interventions aim to support patients with their individual care coordination needs. Here, we investigate the feasibility and efficacy of a patient-oriented navigation program for stroke and lung cancer patients. Results of two randomized controlled trials that were part of a mixed methods study, are reported. 170 stroke patients and 64 lung cancer patients were randomized. The intervention group received the personal navigation for one year. The control group received a brochure with regional support offers. Two primary feasibility criteria were analyzed: uptake of initial navigation meetings (>70%) and drop-out of intervention (<40%). Further, we investigated the program's efficacy regarding satisfaction and trust with medical care. Both primary feasibility criteria were met as 96.9% (95%CI: 90.8%-100.0%) of lung cancer patients and 86.9% (95%CI: 79.9%-94.1%) of stroke patients of the intervention group received a first navigation meeting and only 10.5% (95%CI: 0%-24.3%) of lung cancer patients and 8.6% (7 of 81 patients, 95%CI: 2.5%-14.8%) of stroke patients dropped out of the study. Overall, no significantly higher satisfaction levels with medical care were detected for the intervention group with control group as reference (lung cancer: OR (95%CI): 1.40 (0.44-4.46); stroke: OR (95%CI): 1.16 (0.64-2.11), values > 1 indicate higher satisfaction in intervention group). In exploratory subgroup analyses, stroke patients without partner in the intervention group reported higher levels of trust with medical care compared to controls (OR (95%CI): 3.53 (1.14-10.09)). Our findings suggest feasibility of a patient-oriented navigation program focused on care coordination and support with social care questions regarding its uptake. Identifying patient subgroups with higher navigational need should be focussed on for efficient program implementation.

Effects of Kolcaba's comfort theory-based breathing awareness intervention initiated in the second trimester on third-trimester comfort in primiparous women: a randomised controlled trial.

Sharing patient-reported goals via an app is associated with more fundamental goal communication in neurosurgical consultations for patients with a brain tumor.

Effect of end-of-life care video simulation versus written unfolding case study on nursing students' knowledge, communication attitude, and clinical judgment: A quasi-experimental study.

Ventilator-associated pneumonia (VAP) caused by carbapenem-resistant Acinetobacter baumannii (CRAB) poses a significant therapeutic challenge with high mortality rates. This study evaluated the clinical efficacy of high-dose ampicillin-sulbactam combined with colistin compared to standard colistin-based regimens. This retrospective study was conducted on 83 patients with CRAB-VAP at Hanoi Medical University Hospital, Vietnam, from May 2024 to May 2025. Patients were divided into an intervention group (n = 33) treated with high-dose ampicillin-sulbactam combined with colistin and a control group (n = 50) receiving other antibiotic regimens combined with colistin. Primary outcomes included 28-day mortality and total ventilation duration. The intervention group achieved significantly lower 28-day mortality (6.1% vs. 38.0%; p < 0.001) and higher microbiological clearance rates by day 14 (93.9% vs. 30.0%; p < 0.001). While early acute kidney injury was more frequent in the intervention group (66.7% vs. 24.0%), renal function outcomes were comparable by day 14. Multivariable analysis identified day-14 microbiological clearance as the strongest independent predictor of survival (hazard ratio [HR] = 13.03; p < 0.001). High-dose ampicillin-sulbactam combined with colistin significantly improves microbiological clearance and survival in patients with CRAB-VAP. Despite a higher incidence of transient nephrotoxicity, the regimen provides a substantial survival benefit.

Network intervention analysis of ACT processes in cocaine use disorder.

The impact of Open Dialogue on health care costs: A nationwide register-based cohort study among young Danes in acute psychiatric crises.

App-based healthy lifestyle education during pregnancy: Longitudinal effects on mental health in a quasi-experimental study.

Impact of limited N2O intraperitoneal convection, pulmonary recruitment with patient repositioning, and CO2 deflation alone on laparoscopic cholecystectomy outcomes.

Your team is counting on you: Digital gamification and team motivation in alcohol aftercare.

The benefits of revascularization in patients with chronic total occlusion (CTO) and reduced left ventricular ejection fraction (LVEF) remain controversial. This study aimed to investigate the clinical impact of CTO revascularization in patients with reduced LVEF compared with those receiving medical treatment (MT). In total, 369 consecutive patients diagnosed with CTO by coronary angiography were allocated to either the MT group ( n = 204) or the percutaneous coronary intervention (PCI, n = 165) group according to the treatment strategy. The 5-year clinical outcomes were compared between the two groups using a Cox proportional hazards model. After inverse probability treatment weighting analysis, the pseudo-sample sizes in the MT and PCI groups were 364 and 370, respectively. After a median 6-year follow-up period (interquartile range, 5.0-8.1 years), the incidence of cardiac death was higher in the MT and PCI groups, at 9.0 and 4.5%, respectively ( P = 0.019). Cardiac death following heart failure hospitalization occurred in 3.8 and 1.0%, respectively ( P = 0.017). In contrast, target vessel revascularization for CTO lesions was more frequent in the PCI group than in the MT group (11.5 and 22.7%, respectively, P < 0.001). In the inverse probability treatment weighting population, patients undergoing CTO revascularization had survival benefits for cardiac death [hazard ratio: 0.48 (95% CI, 0.26-0.88)] and cardiac death after heart failure hospitalization [hazard ratio: 0.27 (95% CI, 0.08-0.84)]. In patients with LV systolic dysfunction, particularly those with EF less than or equal to 40%, successful CTO revascularization is associated with long-term survival benefits. These results suggest that successful CTO revascularization is associated with reduced rates of cardiac death and death after hospitalization for heart failure.

Investigating the effect of probiotics on seizure-related symptoms in children with medication-resistant epilepsy: a randomized clinical trial.

Effects of pickleball on pre-frailty, physical fitness, 24-hour movement behaviors, and quality of life in older adults: A randomized controlled trial.

Association between timely initial supportive management and short-term outcomes in pediatric febrile seizures: A retrospective inpatient cohort study.

Comparison of nonsurgical treatment approaches for partial rotator cuff tears: a systematic review and meta-analysis.