Internal Frame Research Articles

Sufficiency of ITD for (biased) human auditory azimuthal perception.

Experiments on human auditory perception have shown that interaural time difference (ITD) is sufficient to generate spatial percepts, even though stimuli containing only the ITD cue are perceived as being emitted from inside the head instead of from external locations at specific azimuths. These experiments are thus interpreted as "lateralization" instead of "localization" tasks. In fact, lateralized spatial perception has been quantified using tasks in which participants have to report their estimates by selecting a putative location inside the head, or matching the perceived position to sounds with a given interaural level difference. Therefore, these estimates are made with respect to internal frames of reference, but it is unclear whether these percepts have any significance for the more ecological problem of locating an external sound source. In order to investigate the link between internalized spatial percepts and sound localization, we designed a new task in which subjects are instructed to report externalized azimuthal location for sounds containing only ITD cues. Despite the mismatch between an internalized percept having to be reported as emanating from an external location, subjects were able to estimate azimuths consistently. Furthermore, normalized estimates were indistinguishable from those obtained using traditional lateralization tasks. Our results revealed a direct relationship between perceived azimuths and ITD, which deviates from that obtained from acoustical analysis of binaural recordings, revealing estimation biases. Intriguingly, these results indicate that externalized percepts are not required for the generation of azimuthal percepts.

Hiking Backpack Design Development with Integrated Splint Feature for Fracture Injuries

The background of this design is the risk of fracture injury to climbers when mountaineering. According to the International Alpine Trauma Registry (IATR), there were 306 mountaineering accidents resulting in fractures in 2019. First aid for fractures requires standardized equipment and methods to assist the rescue process. The problem studied is the difficulty of climbers in utilizing climbing equipment as splints when treating fracture victims on the mountain. The purpose of this design is to develop climbing equipment so that it can be converted into a means of bandaging to perform first aid for fracture injuries. The design method used is Quality Function Deployment (QFD), to determine the priority aspects related to the specifications of the means of massaging that users want. The result of the design is a backpack product with an internal frame that applies a collapsible mechanism so that it can be quickly accessed in an emergency and can be adjusted according to the dimensions of the body part that has a fracture injury. The developed splint design successfully meets the criteria for dimensional customization to the user's body and can immobilize the fracture according to standard first aid procedures.

Why the standard definition of creativity fails to capture the creative act

The “standard definition” of creativity holds that a creative idea is one that is novel and useful. This judgement is customarily based on an external frame of reference as it is passed by people who are receiving the idea (the recipient). The internal frame of reference of the person who has generated the idea (the creator) is usually ignored. I make two cases in this paper. First, that employing external frames of reference in assessing creative products has been erroneously applied to understand the creative mind. Second, that any definition of creativity needs to be one that can be reasonably applied whether following an internal frame of reference of the creative experience or an external frame of reference of the creative product. With these aims in mind, I propose the following amendment to the definition of creativity: a creative idea is one that is both novel and satisfying.

An Analysis of Discourse and Its Constitutive Elements within the Framework of Cognitive Linguistics

This article examines discourse itself, along with its internal elements, namely concept and frame. Initially, the notion of cognitivity and its primary features are discussed, followed by a presentation of various ideas and considerations found in the scientific literature related to discourse, accompanied by expressed attitudes toward these perspectives. Subsequently, the emergence of discourse and its internal elements are studied and analyzed. A concept is characterized as a series of frames that convey the same or similar ideas and imaginations, comprising a nucleus, a perinuclear zone, and a periphery. The nucleus of a concept is typically expressed in language through the initial lexical meanings of root words. A frame is defined as a set of concepts that contribute to the creation of the general meaning of a specific concept along with its nuanced interpretations. The frames forming the perinuclear zone serve as carriers of certain shades of the main idea and are generally expressed in language through grammatical forms and other auxiliary linguistic units. The frames that constitute the periphery of a concept possess the potential to express particular nuances of the main idea at specific moments and are typically represented in language by various linguistic units that manifest in distinct syntactic situations.

Alternative transcripts recode human genes to express overlapping, frameshifted microproteins.

Overlapping genes were thought to be essentially absent from the human genome until the discovery of abundant, frameshifted internal open reading frames (iORFs) nested within annotated protein coding sequences. However, it is currently unclear how many functional human iORFs exist and how they are expressed. We demonstrate that, in hundreds of cases, alternative transcript variants that bypass the start codon of annotated coding sequences (CDSs) can recode a human gene to express the iORF-encoded microprotein. While many human genes generate such non- coding alternative transcripts, they are poorly annotated. Here we develope a new analysis pipeline enabling the assignment of translated human iORFs to alternative transcripts, and provide long- read sequencing and molecular validation of their expression in dozens of cases. Finally, we demonstrate that a conserved DEDD2 iORF switches the function of this gene from pro- to anti- apoptotic. This work thus demonstrates that alternative transcript variants can broadly reprogram human genes to express frameshifted iORFs, revealing new levels of complexity in the human transcriptome and proteome.

Pitfalls in measurements of R1 relaxation rates of protein backbone 15N nuclei.

The dynamics of the backbone and side-chains of protein are routinely studied by interpreting experimentally determined 15N spin relaxation rates. R1(15N), the longitudinal relaxation rate, reports on fast motions and encodes, together with the transverse relaxation R2, structural information about the shape of the molecule and the orientation of the amide bond vectors in the internal diffusion frame. Determining error-free 15N longitudinal relaxation rates remains a challenge for small, disordered, and medium-sized proteins. Here, we show that mono-exponential fitting is sufficient, with no statistical preference for bi-exponential fitting up to 800MHz. A detailed comparison of the TROSY and HSQC techniques at medium and high fields showed no statistically significant differences. The least error-prone DD/CSA interference removal technique is the selective inversion of amide signals while avoiding water resonance. The exchange of amide with solvent deuterons appears to affect the rate R1 of solvent-exposed amides in all fields tested and in each DD/CSA interference removal technique in a statistically significant manner. In summary, the most accurate R1(15N) rates in proteins are achieved by selective amide inversion, without the addition of D2O. Importantly, at high magnetic fields stronger than 800MHz, when non-mono-exponential decay is involved, it is advisable to consider elimination of the shortest delays (typically up to 0.32s) or bi-exponential fitting.

Biaxial seismic response of base-column connections in sub-standard steel buildings: dataset.

Existing steel frames not complying with modern seismic codes are often vulnerable to earthquakes due to inadequate seismic detailing. These types of framed structures typically feature semi-rigid and partial strength column-base connections; the behaviour of such connections may significantly affect their seismic performance. However, current code provisions offer limited guidance for the assessment and retrofit of column-base connections To fill the knowledge gap, the H2020 EU-funded Earthquake Assessment of Base-Column Connections in Existing Steel Frames (HITBASE) project experimentally investigated, the response of exposed column-base plate connections. Bi-directional Pseudo-Dynamic tests were carried out at the Structures Laboratory (STRULAB) of the University of Patras within the framework of Engineering Research Infrastructures for European Synergies (ERIES). The case-study steel frame featured two types of column-base plate connections, i.e., stiffened and unstiffened, representing respectively the base connections of an external moment-resisting frame and an internal gravity frame. The experimental programme comprised free vibration tests to identify the modal properties of the sample steel frame. A set of quasi-static cyclic tests and Pseudo-Dynamic tests were then carried out to investigate the performance of the steel frame under bi-directional earthquake sequences. The response of each component constituting the column-base plate connections was monitored during the tests to fully capture the behaviour of the connections. Such experimental results allow model calibration and further parametric investigation on column base plate connections.

Teleanalysis Does Not Have to be "Muted": On the Crucial Role of the Analyst's Internal Frame in any Setting.

Given that practicing teleanalytically is relatively new and more widespread than ever, questions about how to practice and teach it effectively have increased and are more pressing than ever. To contribute answers to these questions, this paper addresses long-standing and persisting negative views of teleanalysis as an inherently muted, remote, and pale experience with reduced therapeutic effectiveness. I propose that this view of teleanalysis as inherently inferior to in-office analysis limits or even precludes its therapeutic usefulness because it allows analysts to avoid making analytic use of the disturbing feelings hiding within the experience of practicing teleanalysis. Through case examples, I suggest that when analysts do not take our negative views of teleanalysis at face value but instead consider them as symbolic expressions of our and our patients' anxieties, we can improve our understanding of our analytic functioning within the tele-setting and enhance our capacity to think and engage analytically effectively in any setting. I maintain that these considerations have important implications, not only for how experienced analysts practice, but also for how we treat and teach future analysts.

Experimental studies of the impact of fluid sloshing in the tank on the dynamic characteristics of the “wing model – fuel tank” system

Flexible response of the airframe structural elements under operational loads are one of the main sources of fatigue damage accumulation. It is known that fuel sloshing in tanks can change the dynamic (frequencies and shapes of natural oscillations) and dissipative properties (oscillation damping decrements) of an elastic system, including partially or completely fuelfilled tanks. It is specified that fuel sloshing in tanks due to the additional oscillation energy dissipation of the elastic system can have a significant impact on both the fatigue and aeroelastic characteristics of aircraft structural elements. Theoretical and experimental studies, applicably to the majority of currently operating transport aircraft, have shown that when modeling dynamic phenomena and solving aeroelasticity problems, fuel can be considered conditionally solidified, which actually does not affect the resultant effect. The advent of modern heavy transport aircraft with a high aspect ratio wing and four engines on pylons under the wing has led to a considerable change in the dynamic picture of the aircraft interaction with the environment. The main feature is that, under this arrangement, the first horizontal bending mode of the wing is embedded in the main flexible modes that determine the dynamic response to external effects. In this case, the model of solidified fuel can have a significant impact on the accuracy of predicting dynamic loads and, as a consequence, on the quantitative characteristics of durability and aeroelasticity. The article presents the results of experimental studies of the impact of fluid sloshing in the tank on the dynamic characteristics (frequencies of natural oscillations and amplitudes of forced oscillations) of the “wing model – fuel tank” system. The design of the experimental installation and the methodology of conducting experiments are described. During the experiment, the tank was partially filled with liquid or full, and horizontal bending modes of the wing model, for which considering liquid sloshing in the tank is the most relevant, were studied. The tank refueling levels are determined at which the maximum effect of the system oscillation damping is achieved due to energy dissipation under liquid sloshing. The effect of various factors (presence of a top cover, internal structural frame, perforation in the structural frame) on the amplitudes and frequencies of forced oscillations is analyzed.

On the question of the internal frame

ABSTRACT This paper attempts to expand José Bleger's classic, metapsychological descriptions of the psychoanalytic frame to formulate and emphasize the role of the analyst's internal frame in establishing a psychoanalytic observational perspective in the analytic situation. The rationale for doing so follows from clinical necessity, especially when working with patients and psychic organizations that are ‘beyond neurosis' and in non-traditional settings such as distance and telemetric analyses. Clinically speaking, in its most effective state, the analyst’s internal frame can inform the possibility of an observational vertex aimed at the intuitive grasp of psychic reality rather than a sense-based, empirical observation of parameters denoted by the elements of a consensually validatable social reality.

Superposed transpressional tectonics of an intraterrane shear zone resulted in Shillong plateau evolution, NE India

The analysis of shear zone kinematics plays a crucial role in understanding the tectonics at micro-, meso-, and regional scales within a given terrane. This study focuses on investigating the kinematics of prominent asymmetric structural features preserved within the Barapani Shear Zone (BSZ). These features are utilized to establish vorticity numbers in relation to the reference frames of the BSZ. Typically, shear zones provide finite values for kinematics and vorticity numbers. The BSZ is identified as an intraterrane, multiply deformed shear zone within the Shillong Plateau, which exhibits varying kinematics and vorticity numbers measured across different deformation zones.The research reveals that the BSZ underwent successive D1, D2, D3, and D4 events, resulting in preserved S1, S2, and S3 planar fabrics, with D4 evidenced by brittle deformation features. However, determining shear zone kinematics purely based on the orientation of these planar fabrics and mineral lineation with respect to the external reference frame is insufficient. Consequently, this study calculates vorticity numbers and kinematics by considering both the external and internal reference frames of the BSZ. The study suggests that superposed transpressional tectonics prevailed during D2 and D3 events.

Salford Twist Mill: Uncovering an Iconic Textile Factory

ABSTRACT The Salford Twist Mill of 1799–1801 has attracted much attention as a pioneering example of an iron-framed building, the first textile mill in England to have benefited from steam heating and one of the earliest buildings in the world to have been permanently lit by gas. Aspects of the mill’s development have been debated since its destruction in the mid-20th century, although several points of contention were clarified during an archaeological excavation and associated research conducted by the University of Salford in 2016–17. In particular, fragments of structural ironwork recovered from demolition layers yielded fresh evidence for the building’s internal cast-iron frame, and excavation of the engine room enabled details of the power-transmission system to be elucidated. Whilst this article necessarily recites earlier work, it combines the key findings from the recent investigation with a review of previous studies to provide a definitive account of one of the first iron-framed mills.

The HLA-II immunopeptidome of SARS-CoV-2

Targeted synthetic vaccines have the potential to transform our response to viral outbreaks, yet the design of these vaccines requires a comprehensive knowledge of viral immunogens. Here, we report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) peptides that are naturally processed and loaded onto human leukocyte antigen-II (HLA-II) complexes in infected cells. We identify over 500 unique viral peptides from canonical proteins as well as from overlapping internal open reading frames. Most HLA-II peptides colocalize with known CD4+ Tcell epitopes in coronavirus disease 2019 patients, including 2 reported immunodominant regions in the SARS-CoV-2 membrane protein. Overall, our analyses show that HLA-I and HLA-II pathways target distinct viral proteins, with the structural proteins accounting for most of the HLA-II peptidome and nonstructural and noncanonical proteins accounting for the majority of the HLA-I peptidome. These findings highlight the need for a vaccine design that incorporates multiple viral elements harboring CD4+ and CD8+ Tcell epitopes to maximize vaccine effectiveness.

TRACL: Temporal reconstruction and adaptive consistency loss for semi‐supervised video semantic segmentation

AbstractWhile existing supervised semantic segmentation methods have shown significant performance improvements, they heavily rely on large‐scale pixel‐level annotated data. To reduce this dependence, recent research has proposed semi‐supervised learning‐based methods that have achieved great success. However, almost all these works are mainly dedicated to image semantic segmentation, while semi‐supervised video semantic segmentation (SVSS) has been barely explored. Due to the significant difference between video data and image, simply adapting semi‐supervised image semantic segmentation approaches to SVSS may neglect the inherent temporal correlations in video frames. This paper presents a novel method (named TRACL) with temporal reconstruction (TR) and adaptive consistency loss (ACL) for SVSS, aiming to fully utilize the temporal relations of internal frames in video clip. The authors’ TR method implements the reconstruction from the feature and output levels to narrow the distribution gap between internal video frames. Specifically, considering the underlying data distribution, the authors construct Gaussian models for each category, and use probability density function to obtain the similarity between different feature maps for temporal feature reconstruction. The authors’ ACL can adaptively select two pixel‐wise consistency loss including Flow Consistency Loss and Reconstruction Consistency Loss, providing stronger supervision signals for unlabelled frames during model training. Additionally, the authors extend their method to unlabelled video for more training data by employing mean‐teacher structure. Extensive experiments on three datasets including Cityscapes, Camvid and VSPW demonstrate that the authors’ proposed method outperforms previous state‐of‐the‐art methods.

Transference: The Matrix of the Frame

I use the clinical example of a traumatized adolescent to talk about how a transference experience creates the frame where the analytic work occurs. Out of the external boundaries of the relationships with an object, the internal frame, the womb of transformation processes, is created. The analyst’s capacity to wait is essential for the transformation that creates and shapes the transference experience, which, like playing, becomes the matrix of the frame where it happens as it happens. As the traumatic experiences find their place in the transference and begin to be integrated, the adolescent becomes more present and real in the session.

Mathematics education faculty members' perceptions of barriers to distance education: Q-method analysis

As a result of the great earthquake disaster in Turkey, mathematics education in universities was reorganized as distance education after the pandemic period. This article aims to identify the barriers to distance education practices in higher education. In line with the aim of this study; Q methodology was used to help determine the perceptions and perspectives of faculty members regarding the barriers to distance education in the process of teaching mathematics in higher education. Q methodology aims to reveal the internal frame of reference of individuals through their preferences. According to the findings of the study, participants identified barriers under 3 factors. These 3 factors, in order of weight, represent student, curriculum and technology barriers. In general, it was seen that the 4 factors revealed by the methodology in the study yielded results compatible with the literature. However, it was determined that the barriers arising from the teacher did not carry a factor load in the study. Another unique result was the identification of barriers arising from the nature of mathematics. It was understood that there are unique obstacles specific to the field of mathematics due to pedagogy and curriculum. In this respect, investigating the barriers to field-specific extended education will provide more accurate findings. In this study, which was conducted with Q methodology and supported by qualitative data, the identified barriers to distance education were consistent with the general literature. Q methodology reveals that it is a compatible tool for various research in similar situations.

Temporal and spatial reference frames in visual working memory are defined by ordinal and relational properties.

Natural environments provide a rich spatiotemporal context that allows for visual objects to be differentiated based on different types of information: their absolute or relative spatial or temporal coordinates, or their ordinal positions in a spatial or temporal sequence. Here, we investigated which spatial and temporal properties are incidentally encoded along with to-be-remembered features to provide reference frames in visual working memory (VWM). We tested the different possibilities in a spatiotemporal color change-detection task by transforming spatial and/or temporal structures of item presentation at retrieval relative to encoding. More precisely, spatial and/or temporal coordinates were (a) switched, changing the order of items in a spatial or temporal sequence (ordinal transformation); (b) multiplied by different factors, changing interitem distances (relational transformation); or (c) multiplied by a constant factor, expanding or shrinking the entire configuration (global transformation). Such transformations of the external reference frame at retrieval should only interfere with VWM if the internal reference frame relies on the spatial or temporal properties affected by the respective transformation. We found that ordinal and relational transformations of either the spatial or temporal structure impaired performance, whereas global transformations did not. Thus, reference frames appear to be primarily defined by interitem relations-including relative distances between items as well as their order-rather than absolute positions in space or time. These results corroborate and extend previous findings for the spatial domain, and highlight functional similarities of the spatial and temporal dimensions in VWM by revealing the same metrical properties for temporal reference frames. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Object representation in a gravitational reference frame.

When your head tilts laterally, as in sports, reaching, and resting, your eyes counterrotate less than 20%, and thus eye images rotate, over a total range of about 180°. Yet, the world appears stable and vision remains normal. We discovered a neural strategy for rotational stability in anterior inferotemporal cortex (IT), the final stage of object vision in primates. We measured object orientation tuning of IT neurons in macaque monkeys tilted +25 and -25° laterally, producing ~40° difference in retinal image orientation. Among IT neurons with consistent object orientation tuning, 63% remained stable with respect to gravity across tilts. Gravitational tuning depended on vestibular/somatosensory but also visual cues, consistent with previous evidence that IT processes scene cues for gravity's orientation. In addition to stability across image rotations, an internal gravitational reference frame is important for physical understanding of a world where object position, posture, structure, shape, movement, and behavior interact critically with gravity.

Rotational Dynamics of a Protein under Shear Flow Studied by the Eckart Frame Formalism.

Proteins are natural polymers that play an essential role in both living organisms and biotechnological applications. During certain bioprocessing steps, they can be exposed to significant mechanical stress induced by, for example, shear flow or sonication, resulting in reduced therapeutic efficacy, aggregation, or even a loss of activity. For this reason, there is a need to understand and determine the susceptibility of the protein activity to the experienced mechanical stress. To acquire this knowledge, it is necessary to study the rotational dynamics of the protein. Commonly, the rotational dynamics of soft molecules is interpreted based on a theoretical analysis performed in an inertial laboratory frame. However, the obtained angular velocity mixes pure rotations and vibrations with angular momentum, consequently lacking a clear dynamical interpretation. On the other hand, the use of the noninertial internal Eckart frame allows the determination of pure angular velocity as it minimizes the coupling between the rotational and vibrational degrees of freedom. In the present work, by conducting open-boundary molecular dynamics simulations and exploiting the Eckart frame formalism, we study the rotational dynamics of a small protein under the shear flow of various strengths. Our results show that the angular velocity increases nonlinearly with increasing shear rate. Furthermore, the protein gains vibrational angular momentum at higher shear rates, which is reflected in the higher angular velocity computed by employing the Eckart frame formalism and confirmed by analysis of the contributions to the total kinetic energy of the biomolecule.

Dynamic Response Analysis of Submarines Based on FEM-ALE Coupling Method in Floating Ice Conditions

To address global challenges, research on the safety of polar navigation is indispensable. However, most of studies focus on traditional surface vessels, with few research studies on submarine. The dynamic response of submarine during surface navigation in floating ice channels under special conditions is studied in this work. Firstly, a model of the submarine incorporating an intact internal frame was established. Subsequently, the FEM-ALE coupled method was employed to simulate the structure-ice interaction, and the obtained results was verified by the Colbourne method. Then, the parametric study (navigation speed, ice thickness, and floating ice size) were analyzed from the perspectives of ice resistance, stress and plastic strain. Finally, an empirical equation suitable for the interaction between submarine and floating ice during surface navigation is improved based on the Colbourne method.