Integration Process Research Articles

Increased Caregiver Interaction with the NICU Environment during Medication Administration May Contribute to Higher Infection Rates: A Pilot Observational Study.

After nearly 3 years without a single central line-associated bloodstream infection (CLABSI), our neonatal intensive care unit (NICU) experienced a significant rise in CLABSI rates beginning in 2019. The increase coincided with changes made to the intravenous (IV) medication pump integration process, which added more safety checks and procedural steps. This study aimed to investigate the potential association between these process changes and increased CLABSI and non-CLABSI (bloodstream infection, BSI) rates prior to inclusion in a future QI project Key Driver Diagram.This observational pilot study used a mixed-methods approach, including statistical process control analysis to confirm a special-cause increase in CLABSI rate, human factors observations, and environmental microbiome sampling focusing on the equipment involved in the IV pump integration. We compared these findings to the CLABSI and BSI rates to identify temporal and geographic associations.Following the 2019 implementation of IV pump integration, statistically significant increases in CLABSI and BSI rates were observed. The enhanced safety checks added steps to IV medication administrations, with timestamp observation indicating up to 14 location changes around the bed spaces and a mean of 5.5 minutes for any IV medication administration. Environmental microbial sampling showed a 27% positivity rate. The highest microbial burden was found on patient-specific mobile equipment (30%) used during IV medication administration, including isolettes, IV hubs, and glove boxes, compared with other equipment (26%) like nursing computers or ventilators (p = 0.093). A strong overlap was observed between the microorganisms found in the NICU environment and those responsible for positive patient blood cultures, particularly coagulase-negative Staphylococcus (CONS).Though not statistically significant, the findings suggest that the added complexity and extended duration of the modified IV pump integration process may have increased the frequency of caregiver interactions with the NICU environment, exposing immune-vulnerable NICU patients to a higher risk of infection. Further human factors analysis and quality improvement efforts are necessary to simplify the IV medication administration process, reduce environmental microbial loads, and decrease infection rates. · Increased CLABSI/BSI rates post-IV pump integration.. · High microbial load on equipment related to the IV medication administration process.. · Process changes with IV pump integration to enhance patient safety may have unintended consequences, like increasing caregiver-environment interaction and patient infection rates..

Assessment of Socio-Economic Transformations in The Border ‎Regions of Ukraine and Poland

The purpose of this article is to examine the socio-economic transformations of the border regions of Ukraine and Poland in the context of ‎European integration processes, labor migration, and the impact of the war in Ukraine, as well as to assess the effectiveness of cross-border ‎cooperation and the use of EU financial instruments for regional development. The study analyzes the characteristics of these transformations, shaped by the interplay of economic policy, European integration, and migration trends. It shows that these regions act as important ‎hubs of economic and social interaction, reflecting differences in institutional capacity, labor markets, and investment potential. The research ‎demonstrates that Poland’s EU membership has ensured access to substantial financial resources, which have positively influenced the ‎development of its border voivodeships. In contrast, Ukrainian regions remain in a phase of economic convergence and have limited access to ‎similar support mechanisms. Labor migration is identified as a major factor driving transformation, affecting demographics, employment, ‎and social dynamics. The analysis confirms that Poland remains the primary destination for Ukrainian labor migration, generating both op-‎opportunities for economic growth and challenges related to workforce imbalances and adaptation in the labor market. Moreover, the war in ‎Ukraine has intensified these processes, putting additional pressure on Poland’s social systems and labor market. The study emphasizes that ‎cross-border cooperation is a key tool for the development of border regions; however, its implementation is uneven due to administrative ‎barriers and differences in strategic priorities between the countries. Despite the expansion of Ukrainian regions’ participation in European ‎programs, their ability to attract funding remains limited compared to their Polish counterparts. The research substantiates the need to develop effective regional development strategies aimed at reducing economic asymmetry and ensuring sustainable development within the ‎framework of Ukraine’s European integration‎.

The Usability and Experience of Artificial Intelligence‐Based Conversational Agents in Health Education for Cancer Patients: A Scoping Review

ABSTRACTBackgroundArtificial intelligence‐based conversational agents (CAs) have shown transformative potential in healthcare, yet their application in cancer health education has remained underexplored, particularly regarding usability and patients' experiences. Existing reviews lack a dedicated focus on user perspectives, limiting insights into how CAs can be optimised for patient needs.AimTo explore the usability and experience of artificial intelligence‐based conversational agents in health education for cancer from the user perspective.DesignA scoping review was conducted with the Joanna Briggs Institute Scoping Reviews conduct guidance and reported according to the preferred reporting items for systematic reviews and meta‐analyses extension for scoping reviews checklist.MethodsA search was performed in PubMed, Embase, CINAHL, Web of Science, PsycINFO, IEEE Xplore Digital Library and ACM Digital Library from their inception to March 6, 2024. The references to the articles included were also searched. The Pillar Integration Process was employed to chart data.ResultsA total of 12 studies were included in this scoping review, which revealed that CAs supported diverse educational contexts, including cancer‐related knowledge (41.7%), pretest genetics (33.3%), self‐management (16.7%) and psychological skills (8.3%). Three studies reported that patients preferred interactions with multiple options or ‘read more’ functions. Patients were generally optimistic about the CAs and reported that CAs provided informational, physical, and psychological support for them. However, limitations such as insufficient customisation, lack of empathy, and defects in understanding free‐input questions were noted.ConclusionThis review demonstrated that CAs are promising complementary tools in cancer education, alleviating healthcare burdens while enhancing patient engagement, which was particularly critical in resource‐limited settings. However, clinical implementation requires more rigorous validation of safety protocols and high‐quality original studies.Relevance to Clinical PracticeNurses and policymakers should consider CAs valuable tools to enhance cancer health education, provided that they align with patient needs and institutional safety standards.

Roots and Wings of The Children Silent Odyssey: The Integration of Child and Youth Migrants in the Attica, Greece

Although the integration processes of migrants as such are often discussed, aspects of migration and integration of children and youth have not received much attention. This study examines the multifaceted process of integration of refugee and migrant children and youth in the Attica region of Greece. The main aim of the study is to analyze the current difficulties within the migration of children, and the means of their integration. To achieve the objective, qualitative research was conducted. The paper explains how different factors of a social, educational, and psychological nature converge in their experiences of integration. The results of the study highlight the crucial role of NGOs in facilitating non-formal education that supports children’s integration, however, the government funding of NGOs’ programs for immigrants is problematic. Because the majority of migrant respondents stated that they do not feel integrated at all in Greek society, the Greek government should support the integration process of migrant and refugee children and youth by providing them with better access to language learning, schooling, psychological support, and social services. We have found that other aspects, such as education, finances, or family reunification currently represent more significant factors for migrants’ decision to stay or leave Greece.

Implementing Large Language Models in Health Care: Clinician-Focused Review With Interactive Guideline.

Large language models (LLMs) can generate outputs understandable by humans, such as answers to medical questions and radiology reports. With the rapid development of LLMs, clinicians face a growing challenge in determining the most suitable algorithms to support their work. We aimed to provide clinicians and other health care practitioners with systematic guidance in selecting an LLM that is relevant and appropriate to their needs and facilitate the integration process of LLMs in health care. We conducted a literature search of full-text publications in English on clinical applications of LLMs published between January 1, 2022, and March 31, 2025, on PubMed, ScienceDirect, Scopus, and IEEE Xplore. We excluded papers from journals below a set citation threshold, as well as papers that did not focus on LLMs, were not research based, or did not involve clinical applications. We also conducted a literature search on arXiv within the same investigated period and included papers on the clinical applications of innovative multimodal LLMs. This led to a total of 270 studies. We collected 330 LLMs and recorded their application frequency in clinical tasks and frequency of best performance in their context. On the basis of a 5-stage clinical workflow, we found that stages 2, 3, and 4 are key stages in the clinical workflow, involving numerous clinical subtasks and LLMs. However, the diversity of LLMs that may perform optimally in each context remains limited. GPT-3.5 and GPT-4 were the most versatile models in the 5-stage clinical workflow, applied to 52% (29/56) and 71% (40/56) of the clinical subtasks, respectively, and they performed best in 29% (16/56) and 54% (30/56) of the clinical subtasks, respectively. General-purpose LLMs may not perform well in specialized areas as they often require lightweight prompt engineering methods or fine-tuning techniques based on specific datasets to improve model performance. Most LLMs with multimodal abilities are closed-source models and, therefore, lack of transparency, model customization, and fine-tuning for specific clinical tasks and may also pose challenges regarding data protection and privacy, which are common requirements in clinical settings. In this review, we found that LLMs may help clinicians in a variety of clinical tasks. However, we did not find evidence of generalist clinical LLMs successfully applicable to a wide range of clinical tasks. Therefore, their clinical deployment remains challenging. On the basis of this review, we propose an interactive online guideline for clinicians to select suitable LLMs by clinical task. With a clinical perspective and free of unnecessary technical jargon, this guideline may be used as a reference to successfully apply LLMs in clinical settings.

The coloniality of civic integration requirements in Britain. Learning as a civilising force

ABSTRACT Research on naturalisation and civic integration has mostly focused on how the state policies reproduce colonial social and cultural hierarchies by acting as a homogenizing force that promote nationalistic views. Such views, in turn, act as exclusionary measures with migrants in a diversity of status. This paper offers a novel account of affective citizenship with a focus on trading learning for belonging in migrants’ experiences with civic integration processes. In particular, I draw on the link between learning and deservingness to reveal the contours of the coloniality in citizenship tests. For this purpose, I analyse semi-structured interviews with EU citizens naturalising as British after Brexit. Through this analysis I illustrate how civic integration requirements such as learning for the Life in the UK test constructed a hierarchy of belonging, where European citizens were at the top and Europe’s others were placed at the bottom. The article shows how EU citizens internalised (colonial) nationalistic and exclusionary views in their narratives about the Life in the UK test. Paying attention to emotional responses to naturalisation processes helps to reveal how individuals can simultaneously resist and reinforce nationalistic views, thus perpetuating inequalities and contributing to colonial discourses around culture, belonging and citizenship.

The Missing Window of Opportunity and Quasi-Experimental Effects of Institutional Integration: Evidence from Ukraine

Abstract We examine the contribution of institutional integration to a country’s institutional capacity. To this end, we examine the effects of remaining outside of the European integration process for 28 Ukrainian provinces in the period 1996–2020. We construct novel, machine-learning supported subnational estimates of institutional capacity and quality for Ukraine and for central and eastern European countries that have completed institutional integration. Based on the latent residual component extraction of institutional quality from the existing governance indicators, we use Bayesian posterior analysis under non-informative objective prior function to construct institutional quality indicators from more than 1.8 million randomly sequenced samples across Markov chain Monte Carlo simulations. By comparing the residualized institutional quality trajectories of Ukrainian provinces with their central and eastern European peers that were admitted to the European Union in 2004 and after, we assess the institutional quality cost of failing to institutionally integrate with the EU. Based on the large-scale synthetic control and difference-in-differences analysis, we find evidence of large-scale negative institutional quality and capacity effects of missing the European integration path such as heightened political instability and rampant deterioration of the rule of law and control of corruption. The statistical significance of the estimated effects is evaluated across a comprehensive placebo simulation with more than 34 billion placebo averages for each institutional quality outcome.

Media and migration: challenging negative perceptions and misinformation

ABSTRACT Migration is a complex global phenomenon that affects societies economically, socially and culturally. The media play a pivotal role in constructing public opinion on migration, shaping policy and influencing depictions of immigrants in society. This article examines the presentation and interpretation of evidence on media coverage of migration in three contexts: the United Kingdom (UK), Australia and South Africa. These nations offer diverse perspectives on migration, shaped by unique histories, immigration policies and media cultures. By analysing how data are used to frame migration in each nation, we can better understand the media’s role in developing public discourse and shaping societal integration processes. Just as letters once shaped private views of migrants, today’s social media platforms, such as WhatsApp, perform similar functions, forming communities that extend beyond the reach of mass media.

MODERN TYPES OF BUSINESS PROCESS DIVERSIFICATION STRATEGIES IN THE CONTEXT OF EUROPEAN INTEGRATION

THE AIM OF THE STUDY was to highlight the existing strategies for diversifying business processes in the context of Ukraine's European integration. RESEARCH METHODS. The following research methods were used in the article: general scientific methods, methods of studying economic phenomena and processes: method of comparison, method of synthesis, graph and tabular method, method of structuring and grouping. RESULTS. The article proves that topical issues of ensuring the effectiveness of diversification of business processes in the context of European integration are of fundamental importance, since the competitiveness of enterprises and their sustainability in foreign markets depend on the successful implementation of diversification strategies. This is especially important in the context of constant changes in the global market and the need to adapt to new business conditions determined by integration processes and the need to comply with international standards. The article systematises and summarises the main diversification strategies, such as vertical, horizontal, conglomerate and international. The essence of each strategy is described, their features are noted, and the main differences, advantages and risks are highlighted. The study also summarises the possible consequences and identifies the need to adapt to the new business environment in line with European standards. It is proved that vertical diversification involves expansion along the production or supply chain to optimise costs, while horizontal diversification involves expansion of activities at the same level of production or services to expand the range or improve quality. The process of entering the European market by opening branches in Poland by Nova Poshta LLC is studied, the adaptation of the business model by forming an international team and the strategy of cooperation with the local partner InPost is analysed. The financial costs of opening branches were estimated and the changes in the company's corporate identity in the context of European integration were recorded KEYWORDS: risks; expansion of activities; vertical and horizontal diversification; international markets; martial law; supply chains; innovative development.

Mechanical Modelling of Integration and Debonding Process of Ultra-Thin Inorganic Chips

The research on ultra-thin inorganic chips is an important field in the development of inorganic flexible electronics. By thinning the inorganic (mainly silicon-based) chip to less than 50 μm, it will gain a certain degree of flexibility. After the ultra-thin chip is integrated into the flexible substrate, it is bent repeatedly during the operation of the system. When the bending angle is excessively large, the chip and substrate will debond, or the chip will break. In this process, whether the chip can be stably adhered to the substrate depends on many factors, and debonding can only be reduced by continuously adjusting the process parameters. From an energy method perspective, this study divides the bending process of flexible silicon-based chips and flexible films into two states: debonding and non-debonding. A debonding mechanical model of flexible chips is established, and the regulatory relationship between the adhesion coefficient between the chip and film, chip geometric size, and material parameters was established. Experiments were also conducted to verify the relevant theoretical results. The theoretical results show that the risk of chip debonding decreases with a reduction in chip thickness, an increase in interface adhesion, and an increase in bending radius. Improving the interface adhesion during the bending process can effectively stabilize the adhesion of flexible chips. This paper provides a theoretical basis for the integration and bending of ultra-thin flexible chips and flexible substrates, promoting the practical assembly and application of ultra-thin chips.

Evaluation of Beijing-Tianjin-Hebei Logistics Development Level and Suggestions for Improvement

In view of the accelerated pace of regional integration, the issue of city clusters has increasingly emphasized its importance in economic development. The Beijing-Tianjin-Hebei City Cluster, as the core of the Capital Economic Circle and the hub of logistics in the north, has seen a remarkable integration process, but the imbalance of logistics development among the cities within the cluster and its challenges should not be ignored. Therefore, based on this background, this paper constructs a set of logistics development level assessment system, and analyzes the logistics development status of each city in the Beijing-Tianjin-Hebei city cluster by using principal component analysis. By calculating the composite score, we rank the logistics development level of each city, aiming to accurately identify the problems faced by each city in the field of logistics, and accordingly put forward targeted improvement strategies and enhancement suggestions.

A Two-Dimensional NiS/MoS2 Metal-Semiconductor Vertical Heterojunction for a Sub-100 nm Transistor.

The reliable contact between two-dimensional (2D) semiconducting transition-metal dichalcogenides (TMDCs) and electrodes is the prerequisite for constructing next-generation electronic devices. Despite considerable efforts having been devoted, realizing such a desirable target remains a great challenge due to the complexity of selective doping on 2D semiconducting TMDCs and the physical damage during the metal electrode integration process. Here, we propose a two-step chemical vapor deposition strategy to synthesize 2D metallic NiS with excellent electronic conductivity and robust environmental stability on monolayer MoS2. The in situ fabricated 2D NiS/MoS2 vertical heterojunctions possess perfect contacts and intrinsic interfaces, which deliver distinguished device performances featured with a high average carrier mobility (59.8 cm2 V-1 s-1) and large on/off current ratio. Particularly, due to the improved interface contact, monolayer MoS2 short-channel transistors exhibit an approximate current saturation under a low drain-source bias (0.9 V) with the on-state current density of 1.20 mA μm-1, which outperforms the equivalent silicon complementary metal-oxide semiconductor and satisfies the target of the International Roadmap for Devices and Systems. This work contributes to the growth of van der Waals metal-semiconductor heterojunctions and the integration of future 2D electronics.

A data-intelligence-intensive bioinformatics copilot system for large-scale omics research and scientific insights

Advancements in high-throughput sequencing technologies and artificial intelligence (AI) offer unprecedented opportunities for groundbreaking discoveries in bioinformatics research. However, the challenges of exponential growth of omics data and the rapid development of AI technologies require automated big biological data analysis capability and interdisciplinary knowledge-driven scientific insight. Here, we propose a data-intelligence-intensive bioinformatics copilot (Bio-Copilot) system that synergizes AI capabilities with human researchers to facilitate hypothesis-free exploratory research and inspire novel scientific insights in large-scale omics studies. Bio-Copilot forms high-quality intensive intelligence through close collaboration between multiple agents, driven by large language models (LLMs), and human researchers. To augment the capabilities of Bio-Copilot, this study devises an agent group management strategy, an effective human–agent interaction mechanism, a shared interdisciplinary knowledge database, and continuous learning strategies for the agents. We comprehensively compare Bio-Copilot against GPT-4o and several leading AI agents across diverse bioinformatics tasks, using a broad range of evaluation metrics. Bio-Copilot achieves overall state-of-the-art performance across all tasks, while showcasing exceptional task completeness. Furthermore, on application to constructing a large-scale human lung cell atlas, Bio-Copilot not only reproduces the intricate data integration process detailed in a seminal study but also introduces a recursive, multilevel annotation strategy to capture the continuous nature of cellular states and uncovers the characteristics of rare cell types, highlighting its potential to unravel hidden complexities in biological systems. Beyond the technical achievements, this study also underscores the profound implications of integrating AI capabilities with expert knowledge in accelerating impactful biological discoveries and exploring uncharted territories.

Mechanism and simulation analysis of cross-regional vegetable production and marketing docking in big cities based on evolutionary game

Non-local vegetables have become a crucial source of vegetable supply for major cities, establishing stable production-marketing linkage mechanisms between large cities and external vegetable-producing regions is now imperative. Existing research has primarily examined, from a static perspective, the mechanisms by which government interventions influence the cross-regional alignment of agricultural production and marketing, yet it has not explored the dynamic characteristics and evolutionary patterns that emerge in the cross-regional integration of vegetable supply chains. This paper aims to establish a stable and healthy cross-regional vegetable production and sales docking mechanism. Based on evolutionary game theory, it constructs a tripartite evolutionary game model involving “government guidance—farmer participation—wholesaler operation” to explore the behavioral strategies and mutual influence mechanisms of the three parties. Through simulation analysis, the study investigates the impact of these three parties on the efficient and stable operation of the cross-regional production, and sales docking chain. The research results show that the level of government support and subsidies for wholesalers and farmers influence the strategic behavior of wholesalers and farmers. Appropriate supervision and penalties are conducive to the consistency of decision-making behavior between the government and wholesalers, while excessive supervision and penalties can lead to increased costs that wholesalers cannot bear, resulting in non-responsive behavior from wholesalers and causing a vicious cycle in the operation of the production and sales docking chain. A key contribution of this paper lies in its application of an evolutionary game model to describe the decision-making processes and adaptive learning behaviors of the three principal actors—government, wholesalers, and farmers—throughout the cross-regional production—marketing integration process, and to trace their dynamic evolution over time. By framing these interactions under conditions of bounded rationality, the model both analyzes and predicts the collective strategies that emerge among stakeholders, thereby furnishing essential theoretical insights for strengthening integration and securing vegetable supply. In doing so, it extends existing agricultural supply theory and offers actionable guidance for orderly production planning in major vegetable—producing regions and for accurately aligning output with primary consumption markets.

FEATURES OF TRANSNATIONALIZATION IN THE CONDITIONS OF GLOBALIZATION

The article is devoted to the analysis of the main trends of modern processes of trans-nationalization in the conditions of globalization starting from the 19th century to the present. It is emphasized that starting from the 19th century. Trans-nationalization acts as one of the main global trends in the development of the world economy and a tool for the economic growth of national economies and business entities and management. These trends lead to the deployment of trans-nationalization and the intensification of international investment activity, international trade, scientific and technical exchange and integration processes. The complexity of the above phenomenon leads to the strengthening of theoretical research, the formation of separate scientific directions and various approaches to the concept and content of trans-nationalization. It is proved that trans-nationalization is an integral part of the processes of globalization, and acts as an economic mechanism that establishes qualitatively new social priorities, goals of international policy of states, the nature and dynamics of the life of society and the state. It is the processes of trans-nationalization that have absorbed practically all the signs, characteristics, advantages and disadvantages of globalization processes. It is established that the main driving force of trans-nationalization has become transnational corporations, which are actively strengthening and expanding their spheres of activity and influence. The features of the entry of transnational companies into the world level for investment and expansion of sales markets for their products are analyzed. It is outlined that globalization significantly affects trans-nationalization, contributing to the expansion of TNC operations, the spread of production networks, the diversification of markets and localization. TNCs play an important role in the global economy, stimulating development, innovation and redistribution of resources. At the same time, trans-nationalization also poses risks for local markets and requires adaptation to new conditions of competition and regulation.

The evolution and impact of popular culture in contemporary Vietnam

Popular culture is a dynamic expression of collective identity in modern society, reflecting the interplay between tradition and modern influences. This research analyzes the development of popular culture in Vietnam within the context of globalization, digital transformation, and socioeconomic development. Through systematic analysis of cultural industries and international integration processes, the study shows how popular culture has shifted from a peripheral position to become a central driving force in national development, especially after the Doi Moi reforms in 1986. Results indicate that Vietnam’s cultural policies need to balance preserving authenticity while adopting positive international influences, contributing to understanding cultural evolution in transitional economies.

Enhancing multiple object tracking accuracy via quantum annealing

Multiple object tracking (MOT), a key task in image recognition, poses a persistent challenge in balancing processing speed and tracking accuracy. This study presents a novel approach that leverages quantum annealing (QA) to expedite computation speed, while improving tracking accuracy through the ensemble processing of object tracking methods. A method to improve the matching integration process is also proposed. By utilizing the sequential nature of MOT, this study further augments the tracking method via reverse annealing. Experimental validation confirms the maintenance of high accuracy with an annealing time of a mere 3 s per tracking process. Notably, the time-to-solution achieved reductions of over 99% compared to conventional QA implementations. The proposed method holds significant potential for real-time MOT applications, including traffic flow measurement for urban traffic light control, collision prediction for autonomous robots and vehicles, and management of products mass-produced in factories.

The Influence of The Vidovdan Myth on Serbia’s Security Strategy and Foreign Policy Towards Kosovo

The Vidovdan myth holds a central place in Serbian political mythology and has evolved into a strategic instrument in shaping Serbia’s foreign and security policy, particularly in relation to Kosovo. This study examines how the myth is employed to legitimize Serbia’s revisionist discourse, justify interference in Kosovo’s internal affairs, and construct a permanent threat doctrine. Relying on the constructivist approach in international relations and political discourse analysis, the article argues that Vidovdan functions as an ideological mechanism with significant impact on regional security, Euro-Atlantic integration processes, and Kosovo’s international standing.

Educación intercultural en la Universidad Jesuita de Paraguay

One of the societies that has suffered the most and continues to demand the recognition of their rights is that of Indigenous peoples in Latin America. Areas related to health, the economy, and education are among these requirements. This article describes a case study of members of different Indigenous peoples in Paraguay pursuing a university degree at the Jesuit University (UJP) in that country. The successful recruitment process, the application of current perspectives, the building of trust, and adaptation to new environments allowed for high levels of inclusion among the different actors in the academic community. This research uses a qualitative approach, descriptive level, and documentary techniques. The initial data obtained indicate a balanced and ongoing alignment with respect to scholarships, residencies, Ignatian pedagogy, ecumenism, and academic development, all of which contribute to strengthening interculturality. It is concluded that despite the various difficulties at the national level, as well as in the academic integration process within the UJP, it is possible to identify positive aspects that allow for improvements in order to provide an appropriate and more humane education for members of Aboriginal communities.

Cell Therapy for Periodontal, Soft-Tissue, and Craniofacial Regeneration.

Periodontal and craniofacial regeneration presents significant challenges owing to the complex tissue architecture, inadequate vascularization, and diminished stem cell populations within damaged tissues. Traditionally, autologous bone grafts or alternative bone substitute materials have been employed to address these conditions; however, these approaches are constrained by donor site morbidity, limited availability, and suboptimal regenerative efficacy. The advancement of mesenchymal stem/stromal cell (MSC) biology has accelerated the development of cell-based therapies in modern dentistry, which now focuses on biologically driven approaches to regenerate tissues. MSC-based therapies currently under investigation, both preclinically and clinically, show promise for improving tissue integration and healing processes of both soft and hard tissues, attributable to their multipotent nature, immunomodulatory properties, and paracrine signaling capabilities. Nevertheless, obstacles persist, including inconsistent standardization, limited scalability, regulatory hurdles, a paucity of controlled studies, and restricted biomaterial options. This review evaluates MSC-based treatments for periodontal and craniofacial reconstruction by discussing recent research findings and existing obstacles. This review also examines future prospects, such as advanced biofabrication methods, including 3D printing and bioprinting, which have the potential to improve personalized cell therapy for periodontal and craniofacial regeneration.