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Integrated Program Research Articles (Page 1)

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4221 Articles

Published in last 50 years

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  • Integration Of Technologies
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Articles published on Integrated Program

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  • New
  • Research Article
  • 10.21511/ppm.23(4).2025.17
Socio-economic integration of military veterans in Ukraine: Public perceptions and policy challenges
  • Nov 6, 2025
  • Problems and Perspectives in Management
  • Natalia Samoliuk + 3 more

Type of the article: Research ArticleAbstractMilitary veterans constitute a distinct social group whose socio-economic integration is becoming increasingly urgent due to the growing number of veterans, which today approaches one million individuals. The aim of this study is to assess the problems related to the socio-economic integration of military veterans and to explore potential solutions, taking into account public perceptions and the population’s readiness to support veterans. In 2024 a sociological survey targeted 516 veterans and 850 members of the general population in Ukraine. Data were processed using IBM SPSS Statistics (version 20). The findings indicate that, despite certain societal stereotypes, the relationship between these groups is predominantly positive. The mean population assessment of conflict in relations does not exceed 2.35 points (on a five-point scale), while veterans’ assessments do not exceed 2.75 points. Veterans’ relations with state authorities responsible for social guarantees are less favorable, with evaluations ranging from 2.46 to 3.24 points. The most prevalent form of support for veterans is the willingness to provide financial or material assistance (20.6% and 24.4% of respondents, respectively). There are promising conditions for encouraging support for veteran-led businesses: 7.8% of respondents indicated a preference for purchasing goods from such enterprises. Furthermore, 9.1% of respondents expressed support for the development of economic incentives for companies established by veterans or employing veterans. The results provide a basis for improving state programs for veteran integration, suggesting that traditional support measures may be significantly strengthened by policies aimed at increasing veterans’ active participation in economic life.AcknowledgmentsSupported by the National Research Foundation of Ukraine under project No.2021.01/0343 “Ensuring social protection of ATO / JFO participants and social integration of IDP under the condition of increasing threats to social security”.

  • New
  • Research Article
  • 10.3389/fpsyg.2025.1662636
The impact of social support on the quality of sports participation among individuals with disabilities: the chain mediating effects of psychological capital and self-esteem
  • Nov 5, 2025
  • Frontiers in Psychology
  • Jiahui Peng + 3 more

Background Individuals with disabilities possess the right to equally participate in cultural, recreational, and sporting activities. Enhancing the quality of sports participation among this population is therefore of significant importance for promoting social equity. Grounded in Conservation of Resources Theory and the Social Cognitive Framework, this study focuses on the sequential transmission pathway involving psychological capital and self-esteem. It aims to elucidate the chain mediation mechanism through which social support influences the quality of sports participation among individuals with disabilities, thereby providing a theoretical foundation and practical targets for optimizing sports policies for this group. Methods Employing a stratified random sampling method, a cross-sectional questionnaire survey was conducted with 632 individuals with disabilities across 12 cities in 6 provinces spanning Eastern, Central, and Western China. Data collected were analyzed using SPSS for descriptive statistics, correlation analysis, and regression analysis. The bias-corrected bootstrap method (5,000 resamples) was utilized to test the chain mediating effects. Results (1) Social support significantly and positively predicted the quality of sports participation among individuals with disabilities (Total effect = 0.786, 95% CI [0.680, 0.891]), with the direct effect accounting for 49.87%. (2) Both psychological capital ( β = 0.478) and self-esteem ( β = 0.154) independently and positively predicted the quality of sports participation. (3) The total mediating effect of psychological capital and self-esteem was significant (Effect = 0.394, 95% CI [0.313, 0.484]), accounting for 50.13% of the total effect. Among the specific paths, “Social Support → Psychological Capital → Quality of Sports Participation” contributed the most (Effect = 0.294, Proportion = 37.41%). The chain path “Social Support → Psychological Capital → Self-Esteem → Quality of Sports Participation” was also significant (Effect = 0.025, Proportion = 3.18%). Conclusion Social support not only directly enhances the quality of sports participation among individuals with disabilities but also facilitates a transformation from external empowerment to internal drive through the chain psychological mechanism of “Psychological Capital → Self-Esteem.” Theoretically, this study verifies the hierarchical progressive effect of positive psychological resources within the “Environment-Cognition-Behavior” pathway, deepening the psychological dynamic model of sports participation for individuals with disabilities. Practically, it suggests that improving participation quality requires the simultaneous construction of a multi-level social support network and the development of targeted integrated intervention programs focusing on psychological capital and self-esteem, to achieve a synergistic leap from participation “quantity” to experiential “quality.”

  • New
  • Research Article
  • 10.1016/s0140-6736(25)01246-2
Challenges and opportunities in developing integrated sexual and reproductive health programmes.
  • Nov 1, 2025
  • Lancet (London, England)
  • Kenneth H Mayer + 13 more

Challenges and opportunities in developing integrated sexual and reproductive health programmes.

  • New
  • Research Article
  • 10.1016/j.psychres.2025.116757
Protecting children in crisis: An integrated approach to mass trauma response - clinical innovations, systems coordination, and evidence-based interventions.
  • Nov 1, 2025
  • Psychiatry research
  • Tomer Mevorach + 5 more

Protecting children in crisis: An integrated approach to mass trauma response - clinical innovations, systems coordination, and evidence-based interventions.

  • New
  • Research Article
On The Threshold between Birth and Release: an Integrative Obstetrics Intervention
  • Nov 1, 2025
  • Harefuah
  • Eran Ben-Arye + 5 more

Over the past decade, complementary medicine services have been increasingly integrated into departments of obstetrics (i.e., Integrative Obstetrics) throughout Israel. This case report is presented with the goal to learn about a collaborative treatment setting involving a team of obstetric and integrative medicine practitioners. The narrative-qualitative case report analyzed the response of a woman who had been referred to an Integrative Obstetrics service after giving birth. The patient was hospitalized in the postnatal obstetric department, where she was referred by the chief department nurse to an Integrative Obstetrics service treatment with the indication of post-lumbar puncture headache pain, two days following birth. The narratives analyzed for the case study included those from the patient, the referring nurse, the patient, the integrative medicine practitioner, and the patient's obstetrician. This case study was analyzed within the broader context of integrative obstetric programs in Israel. In conclusion, communication between the obstetric and integrative medicine teams is a key factor in providing an informed referral to integrative obstetric care, based on a focused clinical indication (e.g., pain), and in creating a unified and multi-disciplinary therapeutic approach which is then documented in the patient's medical record.

  • New
  • Research Article
  • 10.1016/j.jpain.2025.105533
Making underrepresented pain visible: Chronic pain disparities among immigrant adolescents in 30 European countries.
  • Nov 1, 2025
  • The journal of pain
  • Josep Roman-Juan + 6 more

Making underrepresented pain visible: Chronic pain disparities among immigrant adolescents in 30 European countries.

  • New
  • Research Article
  • 10.1016/j.yebeh.2025.110557
Examining psychiatric and cognitive adverse effects of brivaracetam, clobazam, lacosamide, eslicarbazepine, and perampanel in a veteran population.
  • Nov 1, 2025
  • Epilepsy & behavior : E&B
  • Poojith Nuthalapati + 6 more

Examining psychiatric and cognitive adverse effects of brivaracetam, clobazam, lacosamide, eslicarbazepine, and perampanel in a veteran population.

  • New
  • Research Article
  • 10.1111/imig.70109
Cities, Asylum Reception and Legal Uncertainty: National Integration Framework and the Limits of Local Authorities
  • Nov 1, 2025
  • International Migration
  • Senyo Dotsey

ABSTRACT While some (progressive) cities have been proactive in forced migrants' reception and integration policy formulation, the central state is ultimately the chief architect of migration policy and the legal framework. Legal status considerably shapes all facets of forced migrants' lifeworlds and thus has significant implications for policy and integration. The Italian government has recently made significant changes to its migration system, affecting asylum‐seekers and refugees' legal status and subsequent city‐level integration efforts. This article thus investigates the interplay between asylum‐seekers' legal status, national migration policy framework and local integration programme. Employing the concept of legal uncertainty and qualitative exploration of a local integration project in Bergamo, it problematises the state's institutional production of uncertain and precarious migration status and how this shapes the prospects of asylum‐seekers' integration processes. It is shown that the city's efforts to integrate asylum‐seekers, starting from their arrival, are stifled by the national migration legal framework.

  • New
  • Research Article
  • 10.23856/7133
CULTURAL IDENTITY AND CROSS-CULTURAL ADAPTATION OF UKRAINIAN WOMEN IN FORCED AND VOLUNTARY MIGRATION: A CASE STUDY
  • Oct 30, 2025
  • Scientific Journal of Polonia University
  • Iryna Soroka

This article examines the strategies for preserving cultural identity and the peculiarities of cross-cultural adaptation among the Ukrainian women who participated in a case study.The study is based on the analysis of culture shock stages by Oberg and acculturation strategies outlined in Berry’s model. Five Ukrainian women in forced migration (in Poland, Sweden, Switzerland, and the UK) and five females in voluntary migration (in India, Poland, Italy, and Germany) participated in this research. Data collection methods of the study include a survey in Google Forms, direct observation, and phenomenological interviews. A software program MAXQDA was used for qualitative data analysis. The results show that the Ukrainian women in both forced and voluntary migration encounter challenges such as language barriers, social exclusion, differences in social norms, and difficulties in medical services. They experience crisis, recovery, and adjustment stages of culture shock, with common emotions including anxiety, homesickness, confusion, frustration, curiosity, and excitement. Key adaptation resources involve social support, experiential learning, and digital media. Regardless of migration type or future plans, women maintain cultural identity through native language use, traditional celebrations, Ukrainian cuisine, and cultural events. These insights can assist NGOs, psychologists, and social workers in creating more effective programs for integration and mental health support of migrants.

  • New
  • Research Article
  • 10.1371/journal.pone.0335442.r007
Predicting hypertension and identifying most important factors among married women in Bangladesh using machine learning approach
  • Oct 30, 2025
  • PLOS One
  • Novel Chandra Das + 7 more

IntroductionHypertension is a leading contributor to maternal and cardiometabolic morbidity in Bangladesh. We developed and interpreted machine-learning (ML) models to predict hypertension and rank associated factors among married women with the goal of informing targeted screening and policy in low-resource settings.MethodsWe analyzed 4,253 married women from the nationally representative BDHS 2017–18 survey (hypertension prevalence: 23.1%). Twelve ML algorithms were trained under six class-balancing strategies with hyperparameters tuned via random search. Validation used a hold-out test set (80/20) and repeated stratified k-fold cross-validation; bootstrap confidence intervals were estimated for the selected model. Model performance was compared with parametric and non-parametric tests. To interpret results, SHAP was used to rank the top 20 predictors and visualize feature effects. Models quantify associations rather than causation.ResultsThe Extra Trees classifier with SMOTE+ENN achieved the best discrimination (F1 = 0.94; AUC-PR = 0.95; ROC-AUC = 0.95). Compared with the original imbalanced training, minority-class detection improved substantially (Extra Trees F1 increased from 0.08 to 0.94; recall from 0.04 to 0.95) while accuracy and ROC-AUC remained relatively stable across samplers. Statistical testing favored SMOTE+ENN for recall, F1, G-mean and AUC-PR. SHAP identified age, parity, recent births, contraceptive use, spousal education and BMI as key predictors. Younger age (<35 years) and normal/underweight status were protective, while parity ≥2–3, husbands’ age ≥ 40 years and overweight/obesity increased risk.ConclusionsAn interpretable ensemble model built primarily on sociodemographic and behavioral variables supplemented by limited biometric markers (BMI, glucose) can accurately flag hypertensive risk among married women in Bangladesh. Findings support programmatic integration of risk scores into eRegistries, routine blood pressure checks in family planning and postpartum visits, husband-focused education/SMS interventions and prioritization of high-parity households in high-risk regions. External validation on BDHS-2022 is planned to assess generalizability.

  • New
  • Research Article
  • 10.1176/appi.ps.20250020
Changes in Police Contact After Admission to the Assertive Community Treatment With Police Integration Program.
  • Oct 30, 2025
  • Psychiatric services (Washington, D.C.)
  • Sean D Morgan + 3 more

The assertive community treatment (ACT) model has been shown to successfully reduce hospitalizations and increase quality of life for individuals living with severe mental illness (e.g., psychotic disorders or schizophrenia). Participation in ACT alone, however, does not decrease clients' contact with the criminal justice system. ACT with police integration (ACT-PI), a novel model that entails integrating police officers into existing ACT teams, is viewed by clients and staff as an acceptable method to reduce criminal encounters with unknown police officers. The aim of the study was to examine changes in multiple types of police encounters before and after admission to the program. The authors collected data from 448 unique ACT-PI clients who had at least one police contact between 2008 and 2019. The number of overall police encounters significantly decreased, in particular for non-mental health-related occurrences. The number of mental health-related police encounters increased. These changes were especially evident among clients whom police identified by their race, suggesting that the ACT-PI program may have nuanced effects on outcomes for this group. These findings provide further support for the ACT-PI program as an effective method to reduce the criminalization of persons with severe mental illness and to shift remaining police responses toward mental health-related interventions.

  • New
  • Research Article
  • 10.58246/7jnqj540
PECULIARITIES OF SOCIAL DEVELOPMENT OF OLDERPRESCHOOL CHILDREN WITH SPEECH DISORDERS: SPECIFICSOF SOCIAL FORMATION OF OLDER PRESCHOOL CHILDRENWITH SPEECH IMPAIRMENTS
  • Oct 26, 2025
  • Scientific Journals of the International Academy of Applied Sciences in Lomza
  • Yana Rybchenko + 1 more

The relevance of studying the social development of older preschool children with speech impairments (SI) is determined by the increasing prevalence of this problem among pupils and the need for their social adaptation. Successful development of such children in society depends on early diagnosis and correction of SI. Understanding the peculiarities of theirsocial development will help in forming effective methods of inclusion in group activities and developing friendly relationships. The purpose of this article is to study and systematize these peculiarities to develop individualized approaches to teaching and social integration of thesechildren. This article aims to analyze the peculiarities of social development of older preschool children with SI to identify factors influencing their social adaptation and integration into society. The results of contemporary scientific research by both Ukrainian and foreignresearchers are considered, indicating the need for further improvement of approaches to correctional speech therapy and development of social skills in this category of children. Based on the analysis of the provided data, a conclusion is made about the importance of improving diagnostic mechanisms and support to ensure the full social formation of children with SI. Such an approach will contribute to the creation of a more inclusive society, where every child has the opportunity to reach their potential, regardless of existing difficulties. Moreover, the article points out the need for the development and implementation of individualized approaches to the education and development of these children, which will facilitate their successful inclusion in society and achievement of their full potential. The study of this problem has an important practical dimension aimed at improving the quality of life of children with SI and their socialadaptation. The results of the article can be used as a basis for further research in this area and for the development of programs and methods to support the social formation of older preschool children with speech impairments. Such a comprehensive approach will not only improve thequality of life of children with SI but also support their families and educational institutions in providing effective support and opportunities for development. Further research in this direction can help to improve intervention programs and provide optimal conditions for thesocial development of older preschool children with SI. This approach will contribute to building a more inclusive society, where every child has the opportunity to reach their potential and realize themselves in all spheres of life. The application of the results of this article in practice can also contribute to the creation of a more educated environment that promotesunderstanding and acceptance of diversity. Addressing the problems of social development of children with speech impairments is important for building a fair and inclusive society, where every individual has the right to a full life and development. Thus, research in this area is of great importance not only for the academic world but also for the formation of a more tolerant and open society in general. In addition, studying the social formation of children with speech impairments can contribute to the development of more effective support and integration programs ineducational and social environments. Raising awareness of these issues among pedagogical and medical staff can improve the quality of service delivery to these children and their families. Further research can also help identify the individual needs of each child and develop personalized approaches to their upbringing and education. Moreover, it is important toconsider these issues in the context of the broader socio-cultural and economic situation to ensure adapted and effective support strategies. It is also necessary to ensure access to necessary resources and services for all children with speech impairments, regardless of their social statusor place of residence. Such a deep and comprehensive approach can help take a step towards creating a more just and inclusive society.In summary, this article offers an important contribution to the understanding of the social development of older preschool children with speech impairments. Its results can be used to shape policies and programs aimed at improving the quality of life and social adaptation of this vulnerable category of children. Paying attention to these issues will not only enrich our scientific knowledge but also contribute to the creation of a more just and favorable environment for all. It is likely that further research in this area will bring new ideas and approaches that will help solve the complex problems associated with the social developmentof children with speech impairments. Such an in-depth analysis and understanding of the problem can serve as a basis for practical measures aimed at ensuring a better future for these children and their families.

  • New
  • Research Article
  • 10.36349/easjpbs.2025.v07i04.005
Reconceptualization of Sufi Psychotherapy for Post-Traumatic Stress Disorder from Al-Ghazali's Perspective
  • Oct 22, 2025
  • EAS Journal of Psychology and Behavioural Sciences
  • Muhammad Nuruttamam Al Amin + 9 more

Post-traumatic stress disorder for short, is a disorder involving the mind, soul, and spirit that creates a gap in social relationships. Patients sufferingm must receive attention, especially from Muslim individuals, as a social responsibility. The completeness of Islam is very important in terms of the mind and soul, placing both on the list of al-sarodiya al-khams, namely the demands of care and maintenance of al-'Aql and al-Nafs. This study, Al-Ghazali's perspective is a theory of the soul that is also included in the area of Sufism. Gaining an understanding of the indications and treatment of post-traumatic stress disorder in the soul, so that the reconceptualization of Sufi psychotherapy from Al-Ghazali's perspective Based on the results of the above research, Al-Ghazali's concept of the soul and Islamic education related to the concept of Sufi psychotherapy would be ideal if implemented in an integral educational program. This concept will produce a balance between mental education (spirituality and morality) and intellectuality, because basically Al-Ghazali's concepts.

  • Research Article
  • 10.36676/irt.v11.i4.1682
The processes of transition and adoption for children in orphanages
  • Oct 13, 2025
  • Innovative Research Thoughts
  • Anchit + 1 more

The processes of transition and adaptation for children residing in orphanages encompass a myriad of intricate emotional, social, and institutional elements that must be carefully considered and addressed. This comprehensive study delves into the intricate process through which children navigate the challenging transition from residing in institutional care settings to being embraced by their new adoptive families. It sheds light on the pivotal role that caregivers, social workers, and adoptive parents play in supporting and nurturing these children as they embark on this transformative journey towards a brighter future. It emphasizes the psychological adjustments that children undergo, such as the formation of attachments, the development of identity, and the process of coping with previous traumatic experiences. The study also delves into the examination of institutional practices that are designed to facilitate smoother transitions for individuals, such as pre-adoption counseling services, gradual integration programs, and comprehensive post-adoption follow-up initiatives. By thoroughly analyzing and examining these processes, the study aims to provide valuable and in-depth insights into the most effective and efficient best practices for ensuring that adoption not only meets all necessary legal requirements but also actively and positively contributes to promoting and fostering the child’s long-term emotional, psychological, and social well-being and development.

  • Research Article
  • 10.54097/dbmv6x95
A Study on the Multi-Dimensional Equilibrium in Sustainable Tourism Based on an Integrated AHP-Entropy and Dynamic Programming Model
  • Oct 11, 2025
  • Journal of Education, Humanities and Social Sciences
  • Yongxing Ge

Coastal destinations globally are confronting unprecedented cruise tourism expansion, driven by rising disposable incomes and middle-class growth, which generates substantial economic revenue (exceeding $150 billion annually for port economies) while simultaneously straining local infrastructure, compromising resident well-being, and degrading fragile marine ecosystems; compounded by climate change impacts such as sea-level rise and extreme weather events accelerating natural landmark deterioration, iconic regions like Venice and Caribbean islands face critical sustainability trade-offs between short-term profits and irreversible socio-ecological costs. To address this, our study proposes an integrated multi-objective optimization framework dynamically balancing economic benefits, social equity, and environmental conservation through synthesized Analytic Hierarchy Process (AHP)-entropy weighting that quantifies stakeholder priorities (residents &gt; tourists &gt; operators) and cross-dimensional feedback mechanisms; employing dynamic programming with IoT/satellite data inputs (e.g., tourist density, coral bleaching alerts), it continuously adjusts visitor capacity caps, environmental expenditure allocation, and attraction diversification strategies via sensitivity-validated algorithms tested under 12 climate-tourism scenarios. Quantitatively validated across eight global hotspots (including Santorini and Phuket), this model demonstrably reduces ecological damage by 22%, increases resident satisfaction by 35%, and optimizes disaster funding allocation, offering a transferable methodology for sustainable tourism governance in overtourism-affected regions worldwide.

  • Research Article
  • 10.7554/elife.106075.3
Reassessing the link between adiposity and head and neck cancer: a Mendelian randomization study
  • Oct 9, 2025
  • eLife
  • Fernanda Morales Berstein + 12 more

Background:Adiposity has been associated with an increased risk of head and neck cancer (HNC). Although body mass index (BMI) has been inversely associated with HNC risk among smokers, this is likely due to confounding. Previous Mendelian randomization (MR) studies could not fully discount causality between adiposity and HNC. Hence, we aimed to revisit this using the largest genome-wide association study (GWAS) of HNC available, which has more granular data on HNC subsites.Methods:We assessed the genetically predicted effects of BMI (N=806,834), waist-to-hip ratio (WHR; N=697,734) and waist circumference (N=462,166) on the risk of HNC (N=12,264 cases) and its subsites using a two-sample MR framework. We used inverse variance weighted (IVW) MR and multiple sensitivity analyses, including multivariable MR (MVMR), to explore the direct effects of the adiposity measures on HNC, while accounting for smoking behaviour (a well-known HNC risk factor).Results:In univariable MR, higher genetically predicted BMI increased the risk of overall HNC (IVW OR = 1.17 per 1-SD higher BMI, 95% CI 1.02–1.34). However, the IVW effect was attenuated when smoking was included in the MVMR model (OR accounting for comprehensive smoking index = 0.96 per 1-SD higher BMI, 95% CI 0.80–1.15). Furthermore, we did not find a link between genetically predicted WHR (IVW OR = 1.05 per 1-SD higher WHR, 95% CI 0.89–1.24) or waist circumference and HNC risk (IVW OR = 1.01 per 1-SD higher waist circumference, 95% CI 0.85–1.21).Conclusions:Our findings suggest that adiposity does not play a major role in HNC risk.Funding:FMB was supported by a Wellcome Trust PhD studentship in Molecular, Genetic and Lifecourse Epidemiology (224982/Z/22/Z). RCR was supported by a Cancer Research UK grant (C18281/A29019). MCB is supported by a University of Bristol Vice Chancellor’s Fellowship, the British Heart Foundation (AA/18/1/34219) and the UK Medical Research Council (MC_UU_00032/5). GDS works within the MRC Integrative Epidemiology Unit at the University of Bristol, which is supported by the Medical Research Council (MC_UU_00032/1). CLR was supported by the Medical Research Council (MC_UU_00011/5) and by a Cancer Research UK (C18281/A29019) programme grant (the Integrative Cancer Epidemiology Programme). SV was funded by an EU Horizon 2020 grant (agreement number 825771) and NIDCR National Institutes of Dental and Craniofacial Health (R03DE030257). JK works in a unit that receives support from the University of Bristol, a Cancer Research UK grant (C18281/A29019) and the UK Medical Research Council (grant number: MC_UU_00032/7).

  • Research Article
  • 10.7554/elife.106075
Reassessing the link between adiposity and head and neck cancer: a Mendelian randomization study.
  • Oct 9, 2025
  • eLife
  • Fernanda Morales-Berstein + 12 more

Adiposity has been associated with an increased risk of head and neck cancer (HNC). Although body mass index (BMI) has been inversely associated with HNC risk among smokers, this is likely due to confounding. Previous Mendelian randomization (MR) studies could not fully discount causality between adiposity and HNC. Hence, we aimed to revisit this using the largest genome-wide association study (GWAS) of HNC available, which has more granular data on HNC subsites. We assessed the genetically predicted effects of BMI (N=806,834), waist-to-hip ratio (WHR; N=697,734) and waist circumference (N=462,166) on the risk of HNC (N=12,264 cases) and its subsites using a two-sample MR framework. We used inverse variance weighted (IVW) MR and multiple sensitivity analyses, including multivariable MR (MVMR), to explore the direct effects of the adiposity measures on HNC, while accounting for smoking behaviour (a well-known HNC risk factor). In univariable MR, higher genetically predicted BMI increased the risk of overall HNC (IVW OR = 1.17 per 1-SD higher BMI, 95% CI 1.02-1.34). However, the IVW effect was attenuated when smoking was included in the MVMR model (OR accounting for comprehensive smoking index = 0.96 per 1-SD higher BMI, 95% CI 0.80-1.15). Furthermore, we did not find a link between genetically predicted WHR (IVW OR = 1.05 per 1-SD higher WHR, 95% CI 0.89-1.24) or waist circumference and HNC risk (IVW OR = 1.01 per 1-SD higher waist circumference, 95% CI 0.85-1.21). Our findings suggest that adiposity does not play a major role in HNC risk. FMB was supported by a Wellcome Trust PhD studentship in Molecular, Genetic and Lifecourse Epidemiology (224982/Z/22/Z). RCR was supported by a Cancer Research UK grant (C18281/A29019). MCB is supported by a University of Bristol Vice Chancellor's Fellowship, the British Heart Foundation (AA/18/1/34219) and the UK Medical Research Council (MC_UU_00032/5). GDS works within the MRC Integrative Epidemiology Unit at the University of Bristol, which is supported by the Medical Research Council (MC_UU_00032/1). CLR was supported by the Medical Research Council (MC_UU_00011/5) and by a Cancer Research UK (C18281/A29019) programme grant (the Integrative Cancer Epidemiology Programme). SV was funded by an EU Horizon 2020 grant (agreement number 825771) and NIDCR National Institutes of Dental and Craniofacial Health (R03DE030257). JK works in a unit that receives support from the University of Bristol, a Cancer Research UK grant (C18281/A29019) and the UK Medical Research Council (grant number: MC_UU_00032/7).

  • Research Article
  • 10.7554/elife.106075.3.sa2
Reassessing the link between adiposity and head and neck cancer: a Mendelian randomization study
  • Oct 9, 2025
  • eLife
  • Fernanda Morales Berstein + 12 more

Background:Adiposity has been associated with an increased risk of head and neck cancer (HNC). Although body mass index (BMI) has been inversely associated with HNC risk among smokers, this is likely due to confounding. Previous Mendelian randomization (MR) studies could not fully discount causality between adiposity and HNC. Hence, we aimed to revisit this using the largest genome-wide association study (GWAS) of HNC available, which has more granular data on HNC subsites.Methods:We assessed the genetically predicted effects of BMI (N=806,834), waist-to-hip ratio (WHR; N=697,734) and waist circumference (N=462,166) on the risk of HNC (N=12,264 cases) and its subsites using a two-sample MR framework. We used inverse variance weighted (IVW) MR and multiple sensitivity analyses, including multivariable MR (MVMR), to explore the direct effects of the adiposity measures on HNC, while accounting for smoking behaviour (a well-known HNC risk factor).Results:In univariable MR, higher genetically predicted BMI increased the risk of overall HNC (IVW OR = 1.17 per 1-SD higher BMI, 95% CI 1.02–1.34). However, the IVW effect was attenuated when smoking was included in the MVMR model (OR accounting for comprehensive smoking index = 0.96 per 1-SD higher BMI, 95% CI 0.80–1.15). Furthermore, we did not find a link between genetically predicted WHR (IVW OR = 1.05 per 1-SD higher WHR, 95% CI 0.89–1.24) or waist circumference and HNC risk (IVW OR = 1.01 per 1-SD higher waist circumference, 95% CI 0.85–1.21).Conclusions:Our findings suggest that adiposity does not play a major role in HNC risk.Funding:FMB was supported by a Wellcome Trust PhD studentship in Molecular, Genetic and Lifecourse Epidemiology (224982/Z/22/Z). RCR was supported by a Cancer Research UK grant (C18281/A29019). MCB is supported by a University of Bristol Vice Chancellor’s Fellowship, the British Heart Foundation (AA/18/1/34219) and the UK Medical Research Council (MC_UU_00032/5). GDS works within the MRC Integrative Epidemiology Unit at the University of Bristol, which is supported by the Medical Research Council (MC_UU_00032/1). CLR was supported by the Medical Research Council (MC_UU_00011/5) and by a Cancer Research UK (C18281/A29019) programme grant (the Integrative Cancer Epidemiology Programme). SV was funded by an EU Horizon 2020 grant (agreement number 825771) and NIDCR National Institutes of Dental and Craniofacial Health (R03DE030257). JK works in a unit that receives support from the University of Bristol, a Cancer Research UK grant (C18281/A29019) and the UK Medical Research Council (grant number: MC_UU_00032/7).

  • Research Article
  • 10.3390/curroncol32100564
Supporting Employment After Cancer: A Mixed-Methods Evaluation of a Vocational Integration Programme for Childhood, Adolescent, and Young Adult Cancer Survivors
  • Oct 8, 2025
  • Current Oncology
  • Margherita Dionisi-Vici + 9 more

Simple SummaryChildhood, adolescent, and young adult cancer (CAYAC) survivors often face difficulties entering the workforce, and this transition is frequently complicated by the long-term effects of illness and treatment. Although guidelines emphasise the importance of vocational support, few structured interventions have been developed and systematically evaluated for this population. This study explored a vocational integration programme specifically designed for CAYAC survivors in a tertiary cancer centre in Italy. The programme combined individualised career guidance, soft skills training, and a paid internship, delivered by a multidisciplinary team. A mixed-method approach was used to examine both feasibility and impact, providing a comprehensive understanding of how such interventions may respond to the complex needs of young cancer survivors. The study highlights the significance of tailored, socially supportive vocational programmes and offers insights that may inform future research, clinical practice, and policy development in the field of survivorship care.Childhood, adolescent, and young adult cancer (CAYAC) survivors often face challenges entering the workforce due to long-term physical, cognitive, and psychological late effects, defined as chronic health conditions resulting from cancer and its treatments. This study evaluated a vocational integration programme that addresses these barriers and promotes psychosocial well-being. The multidisciplinary intervention combined career guidance, soft-skills training, and a paid internship. Using a mixed-method design with questionnaires and semi-structured interviews, we assessed feasibility, satisfaction, and psychosocial outcomes. Thirteen participants (mean-age-at-diagnosis: 12.9 years, SD 5.2; mean-age-at-interview: 27.2 years, SD 5.3) reported over 40 late effects, mostly of moderate severity. Health-Related Quality of Life (HRQoL), measured by the SF-12, showed a Physical Component Score mean of 45.2 (SD 9.1) and a Mental Component Score mean of 43.5 (SD 11.2), indicating greater psychological impact. The programme received high satisfaction ratings (mean 8.3/10) and was described as motivating and valuable, enhancing self-confidence and career prospects. Social support emerged as a key facilitator, while participants noted the need for flexibility and individualised pacing. Despite a limited sample size and potential recruitment bias, this study provides preliminary insights into the feasibility and perceived value of tailored vocational programmes, emphasising the importance of adaptable, socially supportive interventions for CAYAC survivors.

  • Research Article
  • 10.59075/0rnpb157
Parent-Teacher Collaboration and Student Learning Outcomes: Exploring Mechanisms, Strategies, and the Role of Technology at the Secondary Level
  • Oct 5, 2025
  • The Critical Review of Social Sciences Studies
  • Aqeela Noor + 2 more

This research explores the influence of parent–teacher collaboration on student learning outcomes at the secondary school level. Parent–teacher collaboration, defined as a cooperative relationship grounded in open communication, shared decision-making, and mutual accountability, is widely recognized as a factor that promotes student achievement. A descriptive quantitative design was employed, drawing data from 260 secondary school teachers in District Rajanpur, Pakistan, selected through simple random sampling. Two validated, researcher-developed questionnaires measured aspects of collaboration (mechanisms and strategies) and learning outcomes (social-emotional growth and technology use). Reliability analysis confirmed satisfactory internal consistency (α = .85 and .84). Data were analyzed using descriptive statistics, correlation, regression, t-tests, and ANOVA through SPSS v27. Findings indicated a strong positive correlation (r = .896) between parent–teacher collaboration and student outcomes. Regression results further showed that higher collaboration significantly predicted improved outcomes (β = .934). Differences based on teacher demographics were also noted, while technology emerged as a central enabler of effective collaboration. The study recommends adopting structured communication systems, digital integration, and capacity-building programs for teachers and parents to enhance academic performance and socio-emotional development among students.

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