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  • New
  • Research Article
  • 10.25259/ach_39_2024
Impact of SARS-CoV-2 Pandemic on the Severity and Outcome of Guillain–Barré Syndrome in Children
  • Mar 11, 2026
  • Annals of Child Health
  • Ganesan Mahadevan Ramakrishnan + 3 more

Objectives: Following the COVID-19 pandemic, various studies and case reports in adults have proposed an association between COVID-19 and Guillain–Barré syndrome (GBS). We aimed to investigate whether the SARSCOV-2 pandemic had produced an impact on the severity and outcome of GBS in children. Material and Methods: Guillain Barré syndrome (GBS) cases admitted during the COVID-19 pandemic from March 2020 to July 2021 were recruited prospectively, and the case records of children with GBS admitted from July 2018 to February 2020 (before the SARS-COV-2 pandemic) were included in the study for comparison. The Hughes disability score, Medical Research Council (MRC) Score, duration of hospital stay, need for ventilation, need for tracheostomy, death, Erasmus score, need for repeat dose of intravenous immunoglobulin, autonomic symptoms, and cranial nerve involvement were used to assess the severity and outcome of GBS in the 2 groups and also among the different electrophysiological variants of GBS. The data were recorded in an EXCEL sheet and analyzed with the Statistical Package for the Social Sciences software. Ethical committee approval was given by our institutional ethical committee. Results: A total of 31 GBS cases admitted in the 3- 20 months duration before the pandemic (Group A), and 27 cases during the 17 months period during the pandemic (Group B) were enrolled in the study. The mean MRC score at admission among the children in Group A and Group B was 33.74 and 34 ( P = 0.89), respectively. The mean MRC score at discharge was 42 for Group A and 45 for Group B ( P = 0.156). Twenty two percent of the children with GBS in Group A and 16% in Group B required mechanical ventilation ( P = 0.662). Three children in Group A and 2 children in Group B required tracheostomy ( P = 0.759), and 1 child died in each group. The mean Erasmus score was 4 in Group A and 5 in Group B ( P = 0.003), which was statistically significant. The electrophysiological variants revealed acute motor axonal neuropathy accounting for 51% and 48%, and the demyelinating variant (Acute Inflammatory Demyelinating Polyneuropathy) for 26% and 44% of GBS cases before and during the pandemic, respectively ( P = 0.168). Conclusion: SARS-COV-2 pandemic appears to have no impact on GBS presentation, severity, and outcomes in children.

  • New
  • Research Article
  • 10.3390/life16030456
Baseline DISE Anatomy Predicts Jaw-Thrust Responsiveness in Obstructive Sleep Apnea
  • Mar 11, 2026
  • Life
  • Wei-Hung Chang + 3 more

Background: Drug-induced sleep endoscopy (DISE) with a jaw-thrust maneuver is used to simulate mandibular advancement in obstructive sleep apnea (OSA), yet determinants of functional airway improvement remain incompletely defined. Objective: To identify clinical, polysomnographic, and baseline DISE anatomic factors associated with jaw-thrust responsiveness. Methods: We conducted a single-center retrospective observational study of adults with polysomnography-confirmed OSA who underwent DISE with paired baseline and jaw-thrust VOTE assessments between 1 January 2015 and 31 December 2025 (n = 355). Jaw-thrust responsiveness was defined a priori as a within-subject reduction in the number of obstructed VOTE sites (grade ≥ 1). Multivariable logistic regression was used to identify independent correlates within a prespecified explanatory modeling framework. The study was approved by the Institutional Review Board of Taipei Tzu Chi Hospital (protocol 14-IRB079), with the need for informed consent being waived. Results: Jaw thrust reduced overall obstruction burden from two (two to three) to one (one to two) sites (Wilcoxon p < 0.001). Hypopharyngeal levels demonstrated the greatest improvement, particularly at the tongue base (39.2% to 7.6%) and epiglottis (23.9% to 5.4%) (both p < 0.001). Overall, 62.8% met responder criteria and 18.9% achieved complete normalization. In multivariable analysis (n = 272), baseline tongue-base collapse (adjusted odds ratio [aOR] 2.46, 95% CI 1.20–5.04) and greater baseline multilevel obstruction burden (aOR 1.85 per SD, 95% CI 1.19–2.85) were independently associated with responsiveness, whereas conventional PSG severity metrics were not. Conclusions: In adults with OSA, jaw-thrust responsiveness during DISE is more strongly associated with baseline anatomic phenotype than with global PSG severity. Standardized DISE functional assessment may provide complementary information to support phenotype-informed selection of non-CPAP therapies, pending prospective validation.

  • New
  • Research Article
  • 10.1186/s44158-026-00374-y
Anesthetic strategies for manual removal of retained placenta: an observational cohort study at a university referral center.
  • Mar 11, 2026
  • Journal of anesthesia, analgesia and critical care
  • Mohamad Yousef + 6 more

Retained placenta is a significant cause of postpartum hemorrhage (PPH) and maternal morbidity. Despite its clinical importance, limited data exists on the safety and effectiveness of different anesthetic techniques for manual removal of placenta (MROP). This study aimed to assess anesthesia-related outcomes and complications in a large tertiary care center with 20,000 to 22,000 annual deliveries. A retrospective cohort study was conducted on women who underwent MROP in the operating room between January 2018 and September 2024. Institutional Review Board approval was obtained prior to data collection. Patient demographics, risk factors, anesthetic techniques, and clinical outcomes were collected and analyzed. During the study period, there were 130,338 vaginal deliveries at our institution. Among 1,366 women (1.05%) undergoing MROP, 860 required placental revision and 506 underwent manual placental removal. Vacuum-assisted delivery was performed in 99 cases (22%). Neuraxial anesthesia was the predominant modality (81.9%), with spinal anesthesia most frequently used (73.7%) and 25.7% subsequently converted to epidural anesthesia. General anesthesia (GA) (16.6%) and sedation (1.5%) were less commonly employed. Women receiving GA had significantly higher risks of blood transfusion (RR 6.0 for RBC, RR 19.5 for FFP, p < 0.0001), longer hospitalization (4.1 ± 2.3 vs. 3.5 ± 3.4 days, p < 0.002), and increased need for ICU/PACU monitoring (RR 20.9, p < 0.0001). Difficult intubation occurred in three cases, with one reported case of aspiration. No hysterectomies were required. Neuraxial anesthesia was the preferred method for MROP, demonstrating a low failure rate. In contrast, GA was associated with increased morbidity, including higher transfusion requirements, prolonged hospitalization, and greater need for intensive monitoring. The occurrence of airway complications in GA cases underscores the importance of optimizing anesthetic management. Minimizing the use of GA, when feasible, may contribute to improved patient outcomes in MROP procedures.

  • New
  • Research Article
  • 10.1136/bmjopen-2025-101276
Home-based physical activity intelligent programme for patients with lower extremity Ilizarov: a study protocol for a randomised controlled trial.
  • Mar 11, 2026
  • BMJ open
  • Fei Lu + 4 more

Lower extremity Ilizarov surgery, a common procedure for correcting bone deformities, is often associated with reduced physical activity (PA) and functional decline. The home-based PA intelligent programme (HB-PAIP) has shown promise in improving postoperative outcomes. However, standardised, intelligent programmes specifically designed for patients undergoing lower extremity Ilizarov surgery are lacking. This study aims to evaluate the effects of a 6-month home-based intelligent interaction programme on PA levels and to assess its impact on mental health, self-efficacy and quality of life among patients with lower extremity Ilizarov. A total of 166 participants aged ≥18 years who have undergone lower extremity Ilizarov surgery will be randomly allocated to either the HB-PAIP group or control group (CG) at a 1:1 ratio. The HB-PAIP group will receive a 6-month, structured and algorithm-guided home rehabilitation programme via an intelligent motion rehabilitation management system, whereas CG will receive traditional care. The assessments will be conducted at baseline, 3 months (mid-intervention) and 6 months (post-intervention). The primary outcome is functional mobility assessed by the Timed Up-and-Go test. Secondary outcomes include the 10-metre walking test, the passive ankle range of motion, the Activity of Daily Living score, the Visual Analogue Scale score, the mental status measured using the Hamilton Anxiety and Hamilton Depression Scales and serum levels of haemoglobin and albumin. This study was initially approved by the Human Ethics Review Board of the Second Affiliated Hospital of Zhejiang University School of Medicine on 26 January 2024 (approval number: 20240139). The protocol amendment was approved on 28 January 2026 (approval number: 20260134). Results will be disseminated through peer-reviewed publications and presentations at relevant scientific conferences. ChiCTR2400093880.

  • New
  • Research Article
  • 10.1136/bmjopen-2025-112266
Protocol for the development of the Asian consensus recommendations on the standardised diagnosis and imaging of intracranial atherosclerotic stenosis applying a modified Delphi approach.
  • Mar 10, 2026
  • BMJ open
  • Jose C Navarro + 3 more

Intracranial atherosclerotic stenosis (ICAS) is a leading cause of ischaemic stroke, particularly among Asian populations, and continues to impose a significant burden across the region. Despite this, evidence from Asia remains fragmented. Findings from our previously conducted scoping review revealed an absence of standardised diagnostic criteria and imaging protocols. This resulted in marked methodological inconsistencies in regional ICAS research, thereby limiting the validity and interpretability of existing data. To address this, we have initiated a consensus process that aims to establish standardised definitions, develop harmonised diagnostic protocols and outline research standards and priorities for ICAS across Asia. A modified Delphi approach will be employed to formulate consensus-based recommendations through a structured, iterative, multistage process. Draft Delphi statements will be informed by targeted literature reviews and formatted into five-point Likert scale questionnaires with fields allowing for qualitative feedback. An expert core group was selected based on their established clinical and research expertise in intracranial atherosclerosis, cerebrovascular imaging and stroke, with deliberate consideration for geographic and disciplinary diversity. This group will serve as the formal voting panel. The process will comprise three to four anonymous online rounds, with a predefined consensus threshold of ≥80% agreement. Statements that do not reach consensus will be revised based on aggregated feedback and re-evaluated in subsequent rounds. A non-voting hybrid conference, open to the public, will follow the second round to facilitate broader engagement and discussion; relevant points will be incorporated into the subsequent round. Consensus on research standards and priorities will follow the finalisation of recommendations on standardised definitions and harmonised diagnostic protocols to ensure alignment with preceding outcomes. This consensus was granted exemption by the Jose R. Reyes Memorial Medical Center Institutional Review Board (No. 2025-221). Resulting recommendations will be disseminated through peer-reviewed publication and presentation at scientific fora. https://doi.org/10.17605/OSF.IO/MB6GP.

  • New
  • Research Article
  • 10.1371/journal.pmen.0000573
Metabolic syndrome among patients with severe mental illness attending a tertiary hospital in northwestern, Tanzania: A cross sectional study
  • Mar 10, 2026
  • PLOS Mental Health
  • Didas Raymond Msele + 6 more

Patients with severe mental illness exhibit a significantly higher prevalence of metabolic syndrome, with a risk approximately two times greater than that of the general population. This elevated risk may be attributed to factors such as the mental illness itself, the use of psychotropic medications, obesity, high-fat diets, low levels of physical activity, and smoking. The study aimed to determine the prevalence of metabolic syndrome and its associated factors among patients with severe mental illness attending Bugando Medical Centre [BMC] in Mwanza, Tanzania. This cross-sectional study included adults aged 18 years and above who attended the psychiatric clinic at BMC. Systematic random sampling was used. Data were collected using a structured questionnaire. Data analysis was performed using STATA version 17. Ethical approval was granted by the Institutional Review Board of MUHAS. In addition, permission to conduct the study was granted by the Director General of BMC, and written informed consent was obtained from all participating patients. A total of 305 patients participated in the study, with a mean age of 38.5 ± 14.2 years (range: 18–90 years). More than half of the participants [58.7%] were male. Metabolic syndrome (MetS) was identified in 33.1% of the participants. Increasing age was significantly associated with metabolic syndrome (MetS); participants aged ≥45 years had fivefold higher odds of having metabolic syndrome (MetS) compared with those aged 18–24 years [AOR 5.15, 95%CI: 1.55 – 17.16; P ≤ 0.008]. Three out of ten participants with severe mental illness were found to have metabolic syndrome, indicating a relatively high prevalence in this population. Increasing age was significantly associated with the precence of metabolic syndrome. Routine and frequent screening measures should be emphasized for the aging population with severe mental illness. A multi-disciplinary approach is essential to ensure comprehensive and holistic management.

  • New
  • Research Article
  • 10.1177/09697330261424350
Navigating institutional cracks: Ethical dilemmas and resilience in narrative nursing practice.
  • Mar 8, 2026
  • Nursing ethics
  • Xusheng Chen + 1 more

BackgroundNarrative nursing is recognized as a vital relational ethical practice for upholding patient dignity and counteracting the dehumanizing effects of the biomedical model. However, its implementation in China's high-pressure, task-oriented hospital environments creates profound ethical tensions. The clash between the ideal of humanistic care and the reality of efficiency logic often precipitates moral distress among nurses, yet their lived ethical experiences within these systemic constraints remain under-explored.AimTo explore the ethical challenges, moral distress, and resilience strategies encountered by Chinese clinical nurses when implementing narrative nursing in resource-constrained settings.Research designA qualitative descriptive phenomenological design was adopted to capture the essence of nurses' lived experiences.Participants26 registered nurses were recruited via purposive sampling from six clinical departments (including Oncology, Obstetrics, and Hepatobiliary Surgery) within a tertiary Grade-A hospital in China. Data were collected through six focus group discussions.Ethical considerationsThe study was approved by the Institutional Review Board of The Eighth Affiliated Hospital of Southern Medical University. Written informed consent was obtained from all participants, and anonymity was strictly maintained throughout the data analysis process.FindingsThe analysis revealed three core themes: (1) Spatial Constraints and Privacy Dilemmas: The lack of auditory privacy in crowded wards created a "panopticon" environment, transforming sensitive narratives into public performances and compelling patients to engage in self-censorship, thereby compromising dignity; (2) Systemic Barriers and Moral Distress: The conflict between "fast time" (task completion) and "slow time" (narrative engagement) rendered narrative care as invisible work that is unrecognized by performance appraisals. Nurses faced the risk of becoming containers of trauma due to a lack of institutional emotional support; (3) Strategies to Maintain Moral Agency: Nurses reclaimed agency by utilizing fragmented time to construct ethical moments. They derived reciprocal professional nourishment and cognitive reframing from patient interactions, which served as a sustainable source of moral resilience.ConclusionImplementing narrative nursing in this context is a profound struggle against spatial injustice and structural devaluation. Relying solely on nurses' individual volunteerism to sustain this practice is inherently unsustainable. To foster a genuine ethical climate, healthcare institutions must move beyond rhetoric to legitimate narrative engagement as a core competency, re-engineer clinical spaces for privacy, and establish systemic safety valves for emotional labor.

  • New
  • Research Article
  • 10.1177/19367244261424191
When Protection Becomes Prevention: The Impact of the Ethics Review Process on Graduate Researchers
  • Mar 7, 2026
  • Journal of Applied Social Science
  • Alexandra Pulchny + 2 more

This article presents results from a national online survey on the unintended effects of research ethics board (REB) processes on research, teaching, and learning in the Social Sciences and Humanities across Canada ( N = 620). Focusing on student responses ( n = 93), key findings reveal how REB proceduralism, inconsistent risk assessments, and ethics creep disproportionately burden graduate students and restrict innovative, culturally responsive research. Students indicate that REB processes prioritize institutional liability over meaningful ethical engagement, often resulting in delays, emotional strain, and reduced academic motivation. Using DiMaggio and Powell’s framework of institutional isomorphism, the authors identify a paradox: while ethics processes are intended to be standardized, their implementation varies significantly across institutions. The authors recommend reducing barriers for low-risk studies, streamlining multi-institutional reviews, and enhancing REB transparency and cultural responsiveness, alongside offering student-informed strategies for reforming ethics review to better support early-career researchers.

  • New
  • Research Article
  • 10.29309/tpmj/2026.33.03.10078
An audit of pre-analytical errors and specimen rejection in the haematology laboratory of a tertiary care transplant center: Clinical and financial impact: Root cause analysis of specimen rejection in haematology laboratory.
  • Mar 7, 2026
  • The Professional Medical Journal
  • Hira Hassan + 6 more

Objective: To identify specific problems regarding pre-analytic processes susceptible to errors and their impact on sample rejection in a haematology laboratory. Study Design: A retrospective audit. Setting: The study was conducted at the Haematology laboratory of the Pakistan Kidney and Liver Institute and Research Center (PKLI&amp;RC). Period: The audit covered a four-year period from 2019 to 2022. Methods: A retrospective audit of all samples rejected in the Haematology laboratory was performed. The reasons for rejection and the potential clinical impact of these rejections were investigated. The study was approved by the Institutional Review Board (IRB) of PKLI&amp;RC (Ref No.: PKLI-IRB/AP/110, Approval date: 28 March 2023). Results: Out of 250,000 samples received, 568 specimens were rejected, yielding a rejection rate of 0.22%. The most common reasons for rejection were clotted samples (n=274, 48%), results not matching the patient's given history (n=142, 25%), hemolyzed samples (n=40, 7%), insufficient quantity (QNS) (n=34, 5.9%), vial defects (n=15, 2.6%), patient identification errors (n=6, 1%), and sample switches (n=4, 0.7%). Conclusion: The implementation of a barcoding system and positive patient ID can help prevent mislabelling and patient ID issues. Proper training and continuing education for all healthcare professionals involved in collecting, handling, and transporting patient samples is crucial to the mitigation of pre-analytical errors. Standardization of processes and procedures can efficiently prevent pre-analytical errors.

  • New
  • Research Article
  • 10.1136/bmjopen-2025-111221
Examining social camouflaging and its cognitive, mental health and neurophysiological correlates in autistic adolescents through triangulation-based assessment using self, parent and daily diary reports: a study protocol.
  • Mar 6, 2026
  • BMJ open
  • Jessica Klein + 7 more

Social camouflaging (SC; ie, the concealing of autistic traits to socially assimilate) is associated with poor mental health, self-identity and quality of life outcomes, yet its typology, consequences and contextual triggers remain unexplored in autistic adolescents. Further study is necessary to identify protective factors against the potentially negative outcomes associated with SC to promote long-term well-being. The current project will investigate SC in youth and its mental health, cognitive and neurophysiological correlates. Camouflaging will be captured by triangulating self-reported and caregiver-reported SC behaviours, as well as SC behaviours in day-to-day contexts using intensive longitudinal methods (ie, daily diaries). Non-autistic, self-identifying autistic and formally diagnosed autistic adolescents aged 15-18 years (N=150) will be recruited. Adolescents and caregivers will complete rating scales to assess mental health, and adolescents will complete in-lab cognitive assessments of attention, executive function, intellectual ability and theory of mind. Brain neurophysiological function and cortisol concentration over time will be measured during the same visit using electroencephalography and hair samples, respectively. Over the following 7 days, adolescents will complete daily diaries using their smartphones. The daily diaries pose survey questions about the type and degree of SC behaviour used within their daily environment, including the social context, individuals who are present and current well-being. Adolescents will also complete brief performance-based cognitive assessments of attention and executive function integrated within the daily diary surveys. Finally, adolescents and their parents will complete a follow-up of SC behaviours and mental health at 3 months. Correlations and regression analyses will be conducted to explore the associations between SC and mental health/cognitive outcomes and how baseline measures of cognition, mental health and SC predict patterns seen on the daily diaries. Multilevel modelling will be used, nesting daily data to capture within-person and between-group differences in contextual predictors of camouflaging behaviour. Results will contribute to current understanding of the typology of camouflaging, as well as inform intervention to mitigate mental health challenges for autistic youth. This project is approved by the University of Victoria Human Research Ethics Board (#23-0013) and the University of Calgary Conjoint Faculties Research Ethics Board (#23-0641). Informed consent will be obtained from caregivers and adolescent participants, and safety procedures will be put in place to support the adolescent should mental health concerns arise. Results will be disseminated through academic publications and conferences, as well as summarised and communicated to interested participants and relevant stakeholders.

  • New
  • Research Article
  • 10.1093/aje/kwag043
Requirement for Written Informed Consent and Selection Bias in a Chart-Review Prostate Cancer Study.
  • Mar 4, 2026
  • American journal of epidemiology
  • Renning Zheng + 10 more

Although retrospective chart-review studies are typically performed using waiver of written informed consent, many institutional review boards (IRB) do not approve such waiver for chart-review studies using prospective enrollment, which could introduce selection bias in participant characteristics and outcomes, thereby impairing representativeness and validity. We aim to determine this bias in a chart-review prostate cancer (PCa) study using prospective enrollment. Using an IRB-approved chart-review protocol with waiver of written informed consent for prospective enrollment, we identified 2,202 patients scheduled for initial prostate biopsy from 2007-2021 at Durham Veterans Affairs Healthcare System. These patients were simultaneously approached for enrollment into a separate minimal-risk prospective observational study protocol requiring blood collection and written consent. 1,238 subjects provided written consent to the blood collection protocol; 964 did not. Patients who provided written consent differed in several key characteristics, including younger age, but had a similar racial distribution. Importantly, participants providing written consent had a significantly lower risk of PCa (multivariable OR=0.41,95%CI=0.31-0.54,p<0.001). As such, patients who provided written consent had younger age, similar race and lower PCa risk and therefore might not accurately represent the full eligible population. To minimize selection bias, waiver of written consent should be allowed for chart-review studies using prospective enrollment.

  • New
  • Research Article
  • 10.7759/cureus.104662
A Reliable Low-Cost Three-Dimensional (3D)-Printed Brachial Plexus Model for Enhanced Anatomical Learning.
  • Mar 4, 2026
  • Cureus
  • Manuel Cevallos + 3 more

The brachial plexus is a complex network of nerve branches with a three-dimensional (3D) distribution, which can make it difficult for students at any level to identify its structures. Spatial visualization skills are required, but two-dimensional images are not idealto learn about this neurological network. Despite the availability of commercial models and digital tools, substantial upfront costs, including but not limited to annual subscription fees, can pose a challenge for most resource-limited institutions,thus hindering effective learning. This technical report proposes a practical and cost-effective solution. Researchers demonstrate how direct 3D scanning of cadaveric structures is used to create an affordable 3D-printed model that captures key anatomical details. The 3D brachial plexus model preserves the traditional structure (no variants), facilitating student learning and enabling use in the lab or at home. In a brief pilot study using a voluntary, anonymous survey with Likert-style questions (institutional review board(IRB)-approved), the model was tested with current physician assistant students who took the anatomy course; their feedback is discussed in the article. This model can enhance learning and help bridge the educational gap at low-resource universities. Researchers believe in the universality of education; for that reason, the 3D-printed brachial plexus model is available to any academic faculty interested in using and evaluating it in their anatomical courses.

  • New
  • Research Article
  • 10.1177/01939459251414538
Mitigating Fraud in Online Surveys: A Methodological Approach.
  • Mar 4, 2026
  • Western journal of nursing research
  • Karen M Towne + 1 more

Online surveys offer data collection benefits and pitfalls, especially when utilizing crowdsourcing platforms such as Research Match and Prolific for recruitment. The purpose of this methodology report was to describe strategies used to fortify an online REDCap research survey in which fraudulent and suspicious responses were identified and mitigated. A two-pronged approach was designed to identify initial design limitations and engage in evidence-based redesign, which included scam alert features, study design changes, survey structure improvements, and crowdsourcing platform considerations. A proactive, eight-step data cleaning protocol was designed and implemented in collaboration with the institutional review board and REDCap data experts. The same fraudulent records were identified within multiple steps of data cleaning, suggesting fraudulent records demonstrate multiple suspicious indicators. Exciting opportunities in online data collection come with the risks of compromised data quality, resource waste, and damage to population health. Evidence-based protocols must be proactively designed to deter and detect early fraudulent results.

  • New
  • Research Article
  • 10.1136/bmjopen-2026-116180
Common factors and unique pathways for linkages between HIV/STI prevention and syndemic behaviours in high-risk youth: protocol for a secondary analysis of harmonised data from six clinical trials.
  • Mar 4, 2026
  • BMJ open
  • Sarah W Feldstein Ewing + 4 more

HIV/sexually transmitted infection (STI) prevention interventions are only modestly successful among youth, particularly for young people of colour and sexual and gender minority (SGM) youth. Even among disparate intervention modalities delivered with high fidelity, differences between intervention types have been minimal. One consistent theme has emerged: the role of the youth:provider relationship in predicting intervention response. In line with calls for examination of relational factors, the next essential step is a harmonised analysis to evaluate connections between the youth:provider relationship and co-occurrence of alcohol and cannabis use, in youth HIV/STI prevention intervention response. Our team has completed six sizeable HIV/STI behavioural prevention studies, generating n=1136 independent youth (baseline Mage=17, range=13-24; 43% female; 21% SGM; 54% Hispanic; 9% African American; 7% Native American/Alaska Native) who received prevention programming and were followed at 1-, 3-, 6-, and/or 12 months. We will harmonise these studies and build a longitudinal mixed-effects machine learning model, with youth:provider relationship as a predictor of intervention response. Participant factors, provider factors and their interaction will be included in the model. Given high rates of alcohol and cannabis comorbidity, we will also examine syndemic outcomes (co-occurring HIV/STI risk behaviours, alcohol use and cannabis use). These data are crucial to informing next step HIV/STI and syndemic intervention programming with this age group. This secondary analysis study is exempt from human subjects regulations under category 4(iii) as determined by the Institutional Review Board at UConn Health. Results will be disseminated via presentations at annual scientific conferences, submissions to peer-reviewed journals, to mental health and substance use providers, as well as community programmes for youth at high risk for HIV/STI and substance use.

  • New
  • Research Article
  • 10.1159/000551334
Multinational Pediatric Critical Care Research in the Arab Gulf Region Across 35 Pediatric Intensive Care Units: Ethical Approval Timelines and Lessons Learned.
  • Mar 3, 2026
  • Medical principles and practice : international journal of the Kuwait University, Health Science Centre
  • Abdulla Alfraij + 4 more

Regional multicenter research collaborations in pediatric critical care provide valuable insights through diverse patient data and increased sample sizes. However, cross-border studies face challenges related to ethical approvals and logistical constraints. We aimed to describe the process of conducting a multinational study across Arab Gulf region, the Institutional Review Board (IRB) approval time, and the challenges encountered. A multinational, multicenter retrospective cohort study was conducted for pediatric intensive care units (PICUs) across the six Gulf countries, comprising Bahrain, Kuwait, Oman, Qatar, Saudi Arabia and the United Arab Emirates (UAE). Participating centers obtained independent ethical approvals, and data sharing agreements were executed to ensure compliance with local regulations. Site-level data on institutional characteristics and IRB timelines were collected. Median approval durations and interquartile range (IQR) were compared between group-based and individual IRB submissions across the region. A total of 35 regional PICUs participated and completed the study requirements successfully. Challenges included variable IRB approval times across facility types: private hospitals 28 days (IQR 18-55), governmental hospitals 29 days (IQR 24-146), and university hospitals 52 days (IQR 30.25- 108.75). This study demonstrates the feasibility of regional pediatric critical care research across the Arab Gulf region, despite variability in IRB timelines among private, governmental, and academic institutions. Structured coordination and collaborative planning enabled successful implementation and may serve as a model for future multicenter initiatives.

  • New
  • Research Article
  • 10.3390/architecture6010035
Correction: Khonsari, T. Community Action: An Architecture and Design Pedagogy. Architecture 2025, 5, 115
  • Mar 3, 2026
  • Architecture
  • Torange Khonsari

The Institutional Review Board Statement and Informed Consent Statement need to be updated in the original publication [...]

  • New
  • Research Article
  • 10.60110/medforum.370113
Single Stage Versus Two Stage Hepatectomy: A Comparative Analysis of Outcomes, Safety, and Clinical Applications
  • Mar 2, 2026
  • Medical Forum Monthly
  • Muhammad Arsalan + 4 more

Objective: The current study aims to compare the results, safety, and clinical use of single-stage and two-stage hepatectomy, their effectiveness, complications, and long-term survival of patients who need liver tumor resections. Study Design: Retrospective studyPlace and Duration of Study: This study was conducted at the Hepato-Pancreato-Biliary &amp; Liver Transplant Surgery Department, Pir Abdul Qadir Shah Jeelani Institute of Medical Sciences, Gambat from August 2025 toOctober 2025. Methods: One hundred and fifty patients with liver tumors subjected to either single-stage or two-stage hepatectomy at our institution were then examined retrospectively. The patients were grouped according to tumor burden, sufficiency of FLR, and general health status. Demographic information, surgical results, complications, and survival rates were obtained. Statistical analysis was done with SPSS, which involved t-tests of continuous variables and chi-square of categorical variables. The average age of the patients and p-values were obtained to determine the significance of group differences. The institutional review board gave its ethical approval, and informed consent was obtained from all the participants. Results: Of the 100 patients 50 underwent single-stage hepatectomy, and 50 underwent two-stage hepatectomy. The mean age of the patients was 58 years (SD = 6.4). The overall survival rate was 75% for the single-stage group and 72% for the two-stage group. Complications were more common in the two-stage group, with 12% experiencing bile leaks compared to 4% in the single-stage group. The average hospital stay was significantly longer for the two-stage group (16 days, SD = 5.1) compared to the single-stage group (10 days, SD = 3.2). R0 resection rates were 88% in the two-stage group versus 80% in the single-stage group, though the difference was not statistically significant (p = 0.08). Postoperative liver failure occurred in 5% of patients in the two-stage group and 12% in the single-stage group, with no significant difference (p = 0.12). Conclusion: Single-stage as well as two-stage hepatectomy are both feasible surgical methods used in the resection of liver tumors. Although single-stage hepatectomy is related to fewer complications and reduced hospitalization, two-stage hepatectomy is more appropriate in patients with bilobar tumors or insufficient FLR. Survival rates are also similar in the long term, and proper patient selection on the basis of tumor burden and liver performance is a key to success.

  • New
  • Research Article
  • 10.1016/j.srhc.2025.101175
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