Relevance. The modern stage of innovative development in the "triple helix" model is realized not by itself, but through the activities of institutional agents of its structure. Therefore, the study of their dispositions is especially important. The real quality of transinstitutional interaction largely depends on their condition.The purpose of this study is to consider and analyze the subjective dispositions of institutional agents of the "triple helix". Among the institutional structures, special attention was paid to the state and role of the modern higher education system, primarily to the regional universities themselves, directly involved in the territorial processes of "spiralization".The objectives are to describe and generalize the structure of dispositions of institutional agents of the triple helix.Methodology. The research was carried out using sociological methods of surveys and interviews based on systemic principles of interpretation.Results. As a result of the study, a generalized structured empirical picture of the subjective dispositions of institutional agents of the "triple helix" was formed. According to the expert positions of the study, today it is not only premature, but also dangerous to deny the traditional institutional predestination of "spiral" processes. However, it is necessary to create platforms for using relevant morphologies of collective intelligence, including hybrid intelligence, as a tool to overcome the exclusively institutional "predestination" of the innovation process.Conclusions. It can be argued that despite the institutional peculiarities of representatives of government, business, and education, as bearers of various professional cultures, all of them are united in their judgments by a common umbrella project of the "breakthrough of Russia". One of the unique synergetic trends, claiming, in our opinion, for the fastest possible development and achievement of scientific, political and economic "hype", is the University 4.0 platform.