Vol. 121, No. 9 EditorialOpen AccessEHP Classic Paper of the Year, 2013 Hugh A. Tilson Hugh A. Tilson Search for more papers by this author Published:1 September 2013https://doi.org/10.1289/ehp.1307395Cited by:1AboutSectionsPDF ToolsDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InReddit Environmental Health Perspectives (EHP) established the Paper of the Year in 2008 (Tilson 2008) as a way of highlighting high-quality articles published in the journal. The EHP Classic Paper of the Year is given to the most highly cited Research Article, Commentary, or Review Article over the preceding 60 months. We are proud to announce that the 2013 EHP Classic Paper of the Year is “Effects of Particulate Matter on Genomic DNA Methylation Content and iNOS Promoter Methylation” by Letizia Tarantini, Matteo Bonzini, Pietro Apostoli, Valeria Pegoraro, Valentina Bollati, Barbara Marinelli, Laura Cantone, Giovanna Rizzo, Lifang Hou, Joel Schwartz, Pier Alberto Bertazzi, and Andrea Baccarelli, published in the February 2009 issue of EHP.Tarantini et al. (2009) investigated molecular mechanisms underlying health effects of particulate matter exposures using biomarkers of DNA methylation that reflect reprogramming of gene expression. Their 2009 publication was one of the first to report application of epigenetic markers in an environmental or occupational health context.This research has had a significant influence on human environmental health research. The study by Tarantini et al. (2009) was one of the first studies to report evidence that DNA methylation may be altered in response to short-term exposures, and that it may reflect effects of usual levels of exposure over longer periods of time as well. This study also showed that easy-to-collect biospecimens, such as whole blood samples, and stored archival samples could be used to study effects of exposures on the epigenome. Novel laboratory and statistical approaches used in the study have since become routine in research on the epigenetic effects of environmental agents.EHP congratulates Tarantini and colleagues for their sustained contribution to the environmental health science literature. They should be recognized for their outstanding contribution to the rapidly evolving field of environmental epigenetics.ReferencesTarantini L, Bonzini M, Apostoli P, Pegoraro V, Bollati V, Marinelli Bet al.. 2009. Effects of particulate matter on genomic DNA methylation content and iNOS promoter methylation.Environ Health Perspect 117:217-222;doi:10.1289/ehp.1189819270791. Link, Google ScholarTilson H. 2008. EHP papers of the year, 2008.Environ Health Perspect 116:A234;doi:10.1289/ehp.11684. Link, Google ScholarFiguresReferencesRelatedDetailsCited byTilson H (2013) EHP Paper of the Year, 2013, Environmental Health Perspectives, 121:11-12, (A322-A322), Online publication date: 1-Nov-2013. Vol. 121, No. 9 September 2013Metrics About Article Metrics Publication History Originally published1 September 2013Published in print1 September 2013 Financial disclosuresPDF download License information EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted. Note to readers with disabilities EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact [email protected]. Our staff will work with you to assess and meet your accessibility needs within 3 working days.