Purpose – This Special Issue of the European Journal of Innovation Management sheds new light on the burning issue of Research and Innovation Strategies for Smart Specialisation (RIS3), both in terms of their policy formulation and their practical implementation in the field. This new policy approach refers to the process of priority setting in national and regional research and innovation strategies in order to build “place-based” competitive advantages and help regions and countries develop an innovation-driven economic transformation agenda. The paper aims to discuss these issues. Design/methodology/approach – This is an important topic both in the current debate about a new industrial policy for Europe and as a policy option for a successful crisis exit strategy led by public investments in the real economy. Moreover, smart specialisation is promoted by the European Commission as an ex ante conditionality for all regions in Europe to receive European Structural and Investment Funds in the field of innovation. Thus, it has become a pre-requisite for accessing fresh funds for investing in badly needed innovation-driven productivity growth throughout the European Union (EU). Findings – The six papers in this Special Issue are the fruit of ground-breaking research and policy testing by nearly 20 leading academics and policy makers throughout the EU. They explore the early smart specialisation concept and its further developments, examine the methodological tools at its disposal and advance specific policy proposals and governance considerations based on actual experimentation in the field. Originality/value – All these make the present Special Issue of the European Journal of Innovation Management an important research milestone. This Special Issue is the fruit of a call towards the European academic and research community to help shaping and advancing the smart specialisation concept and thus contribute to better position regions and countries in the global economy through innovation-driven policies.