Initial Template Research Articles

Processing and properties of Na-doped porous calcium polyphosphates – Mechanical properties and in vitro degradation characteristics

Porous calcium polyphosphate (CPP) is being investigated for use as a biodegradable bone substitute and for repair of osteochondral defects. The necessary requirements for these applications, particularly in load-bearing sites, include sufficient strength to withstand functional forces prior to bone ingrowth and substitution of the initial porous CPP template with new bone and cartilage (for osteochondral implants) in a timely and efficacious manner. The present study explored the effects of Na+ doping and processing to form porous structures of both higher strength and faster degradation than previously reported for ‘pure’ (non-doped) CPP structures of similar geometry. Compressive and tensile strengths were determined before and after 30-day in vitro degradation (PBS, pH 7.1 at 37 °C) and degradation rates assessed. Scanning electron microscopy (SEM), x-ray diffraction (XRD) and solid state nuclear magnetic resonance (31P SS NMR) were used to evaluate ‘pure’ and Na-doped CPP samples before and after degradation. The results indicated that the different processing protocols required to prepare samples of similar volume % porosity (a 2-step procedure with a Step-1 sintering temperatures equal to 575 °C being used with the Na-doped samples versus a 585 °C Step-1 treatment for ‘pure’ CPP) resulted in an approximate 1.5- to 2-fold increase in strength (tensile & compressive respectively) and 2-fold increase in degradation rate of Na-doped CPP compared with ‘pure’ CPP. This difference was attributed to the different Step-1 sintering temperatures used for sample processing.

Pitching research: ‘Qualitative cousins’, the ‘extended family’ and ‘living harmoniously’

AbstractThis paper reviews Faff (2018) with particular emphasis on the Qualitative Pitch proposed by Lodhia (2017). In the spirit of constructive engagement envisioned by Faff (2018), the purpose of this paper is to revisit the Qualitative Pitch and to clarify any misconceptions or misunderstandings. This paper is not a critique but rather a reflective piece on the potential offered by the Qualitative Pitch as a viable tool for pitching qualitative research ideas. The basic premise of this paper is that the Qualitative Pitch, drawing upon Faff's (2015) pitching template, provides qualitative researchers with specific tools and a consistent framework for articulating qualitative research. It is therefore proposed that the Qualitative Pitch should be the used as the initial template for designing qualitative research projects rather than being transitioned to once a threshold barrier is reached.

Line-preserving video stitching for asymmetric cameras

The narrow FOV on mobile phones is becoming unsatisfying with the development of video live broadcast. Fast and stable video stitching algorithm is urgently needed with the advent of multi-device bracket and other equipment. In this paper, we propose a novel stitching method to stitch multiple synchronized video streams which are captured from different fixed cameras. This procedure can be divided into two stages: initial template construction and seam updating. In the stage of initialization, we align the extracted background with proposed line-preserving alignment, and save the mesh for future stitching. Especially, scale estimation allows the algorithm to be applied to videos from asymmetric cameras of different resolutions and scales. In the seam updating stage, we propose a last-frame-guided seam updating method to find a smooth transition on spatial-temporal volumes. Experimental results demonstrate that our method can efficiently stitch videos without ghosting and artifacts.

Establishment and application of real-time fluorescence-based quantitative PCR for detection of infectious laryngotracheitis virus using SYBR Green I.

In this study, a pair of primers were designed and synthesized for the gB gene of infectious laryngotracheitis virus (ILTV) (GenBank accession number: EU104985). The recombinant plasmid was constructed as the positive reference material, and a real-time fluorescence-based quantitative PCR (RFQ-PCR) method was established to detect ILTV using synergy brands (SYBR) Green I. This method could detect 3.34 × 103 copies/μL viral nucleic acid in the initial template, the sensitivity of this method was higher than that of the conventional PCR, and the coefficient of variation (CV) in the repeatability test by this method was 3.35%. At the same time, the method was used to detect 14 suspected pathological samples for clinical analysis, and the results showed that 10 positive samples were detected, and the standard S-shaped curve was amplified. It was concluded that the RFQ-PCR method established in this study was highly sensitive, specific and repeatable, it was suitable for early clinical detection and epidemiological investigation of ILTV, and was significant in effectively controlling the occurrence and transmission of ILTV.

Detection of chronic bee paralysis virus using ultra-rapid PCR and nested ultra-rapid PCR

The chronic bee paralysis virus (CBPV), which causes paralysis in bees, is very difficult to visually differentiate from other pathogens causing symptoms of paralysis. In addition, low numbers of viral gene molecules are difficult to detect. Therefore, this study was conducted to develop an ultra-rapid quantitative polymerase chain reaction (PCR) and nested PCR method for specifically detecting CBPV. This method is based on rapid and precise quantification of the RNA virus CBPV, using ultra-rapid reverse transcription PCR and nested PCR to overcome difficulties in detecting low numbers of viral gene molecules. Under optimal conditions, CBPV-specific ultra-rapid PCR confirmed that 1.0 × 108 CBPV-specific genes could be detected in 4 min and 17 s, and 1.0 × 102 CBPV-specific genes could be detected in 11 min and 16 s. The detection of 1.0 × 102 CBPV-specific genes was conducted by nested PCR using the inner primer set CBPV-NF/NR. High-sensitivity detection was demonstrated by confirming that the PCR product for the initial template of 1.0 × 10° CBPV-specific gene was detectable. The CBPV-specific ultra-rapid quantitative PCR and nested PCR methods are applicable for infected honey bee samples to rapidly and accurately detect low numbers of viral gene molecules. This method can be used on-site where the infected sample is collected as well as in the laboratory. This method may also be applied to detect for other honey bee pathogens with a suitable primer for each pathogen.

Discovery of a periosteal stem cell mediating intramembranous bone formation.

Bone is comprised of separate inner endosteal and outer periosteal compartments, each with distinct contributions to bone physiology and each maintaining separate pools of cells due to physical separation by the bone cortex. While the skeletal stem cell giving rise to endosteal osteoblasts has been extensively studied, the identification of a periosteal stem cell has been elusive1–5. Here, we identify a periosteal stem cell (PSC) present in the long bones and calvarium of mice that displays clonal multipotency, self-renewal and sits at the apex of a differentiation hierarchy. Single cell and bulk transcriptional profiling show that PSCs display distinct transcriptional signatures in comparison with both other skeletal stem cells and mature mesenchymal cells. While other skeletal stem cells form bone via an initial cartilage template using the endochondral pathway4, PSCs form bone via a direct intramembranous route, providing a cellular basis for the divergence between intramembranous versus endochondral developmental pathways. However there is plasticity in this division, as PSCs acquire endochondral bone formation capacity in response to injury. Genetic blockade of the ability of PSCs to give rise to bone-forming osteoblasts results in selective impairments in cortical bone architecture and defects in fracture healing. A cell analogous to PSCs is present in the human periosteum, raising the possibility that PSCs are attractive targets for drug and cellular therapy for skeletal disorders. Moreover, the identification of PSCs provides evidence that bone contains multiple pools of stem cells, each with distinct physiologic functions.

Utilization of metal–polymer interactions for self-aligned directed self-assembly of device relevant features

Self-aligned strategies are required because today’s feature sizes are beyond the resolution limit of the exposure tools. One self-aligned strategy is directed self-assembly (DSA), where block copolymers (BCP) are thermodynamically driven to self-align with a lithographically defined template with chemical contrast and/or topography. It would be particularly advantageous to also encode existing structures into thermodynamic information, then thermodynamics would cause BCP to self-align to these existing structures rectifying placement error. These existing features could be cut masks, which are required to fabricate devices from line and space arrays, or they could be interconnects. Here, we show a technique, by which metal–polymer interactions can be used in place of polymer–polymer interactions. These metal–polymer interactions, which cannot be adequately described by conventional surface energy comparisons, allow for a true self-aligned process. We begin by classifying process relevant metals including gold, aluminum, copper, tungsten, and cobalt, based upon their thermodynamic interactions with poly(styrene-block-methyl methacrylate). We then created guide patterns using metal and dielectric line space arrays. These patterns, when combined with DSA, allow for lines and space patterns to be self-aligned to any exposed metal features and reduce process constraints on exposure tools. Our process can also be used to align line and space patterns to metal layers during the back end of the line processing. A similar process could also be used to guide contact hole shrink to correct for placement error in the initial lithographic template.

Biotemplate synthesis of porous alumina fibers and filters with controlled structure and properties

Abstract The focus of this study is to investigate influence of template functional groups on properties and morphology of alumina materials obtained by a combination of template and sol-gel synthesis. Cyanoethyl-, amidoethyl- and carboxymethylcellulose were synthesized and used as templates for alumina materials preparation. Alumina nanoparticles due to their small size penetrate in porous structure of cellulose fibres and are distributed there uniformly. Alumina nanoparticles located in cellulose are monodisperse ellipsoids and ∼12 nm in length which follows from SAXS. Scanning electron microscopy and nitrogen physical sorption showed that properties and type of template functional groups influence morphology and textural characteristics of ceramic materials. Alumina materials prepared using the modified templates have higher surface area and pore volume values in comparison with ones obtained using initial template. Comparing results with our previous work we conclude that the type of alumina precursor has great impact on resulted materials properties. Also, we showed that alumina fibers can be used to prepare porous ceramics for filtration of biological liquids (cell suspension).

Investigating US medical students' motivation to respond to lapses in professionalism.

ContextAs unprofessional behaviour in physicians can compromise patient safety, all physicians should be willing and able to respond to lapses in professionalism. Although students endorse an obligation to respond to lapses, they experience difficulties in doing so. If medical educators knew how students respond and why they choose certain responses, they could support students in responding appropriately.ObjectivesThe aim of this study was to describe medical students' responses to professionalism lapses in peers and faculty staff, and to understand students' motivation for responding or not responding.MethodsWe conducted an explorative, qualitative study using template analysis, in which three researchers independently coded transcripts of semi‐structured, face‐to‐face interviews. We purposefully sampled 18 student representatives convening at a medical education conference. Preliminary open coding of a data subset yielded an initial template, which was applied to further data and modified as necessary. All transcripts were coded using the final template. Finally, three sensitising concepts from the Expectancy–Value–Cost model were used to map participants' responses.ResultsStudents mentioned having observed lapses in professionalism in both faculty staff and peers. Students' responses to these lapses were avoiding, addressing, reporting or initiating policy change. Generally, students were not motivated to respond if they did not know how to respond, if they believed responding was futile and if they feared retaliation. Students were motivated to respond if they were personally affected, if they perceived the individual as approachable and if they thought that the whole group of students could benefit from their actions. Expectancy of success, value and costs each appeared to be influenced by (inter)personal and system factors.ConclusionsThe Expectancy–Value–Cost model effectively explains students' motivation for responding to lapses. The (inter)personal and system factors influencing students' motivation to respond are modifiable and can be used by medical educators to enhance students' motivation to respond to lapses in professionalism observed in medical school.

The Influence of Modularity, Seeding, and Product Inhibition on Peptide Autocatalytic Network Dynamics.

Chemical networks often exhibit emergent, systems-level properties that cannot be simply derived from the linear sum of the individual components. The design and analysis of increasingly complex chemical networks thus constitute a major area of research in Systems Chemistry. In particular, much research is focused on the emergence of functional properties in prebiotic chemical networks relevant to the origin and early evolution of life. Here, we apply a formal framework known as RAF theory to study the dynamics of a complex network of mutually catalytic peptides. We investigate in detail the influence of network modularity, initial template seeding, and product inhibition on the network dynamics. We show that these results can be useful for designing new experiments, and further argue how they are relevant to origin of life studies.

Reconstruction From Multiple Particles for 3D Isotropic Resolution in Fluorescence Microscopy

The imaging of proteins within macromolecular complexes has been limited by the low axial resolution of optical microscopes. To overcome this problem, we propose a novel computational reconstruction method that yields isotropic resolution in fluorescence imaging. The guiding principle is to reconstruct a single volume from the observations of multiple rotated particles. Our new operational framework detects particles, estimates their orientation, and reconstructs the final volume. The main challenge comes from the absence of initial template and a priori knowledge about the orientations. We formulate the estimation as a blind inverse problem, and propose a block-coordinate stochastic approach to solve the associated non-convex optimization problem. The reconstruction is performed jointly in multiple channels. We demonstrate that our method is able to reconstruct volumes with 3D isotropic resolution on simulated data. We also perform isotropic reconstructions from real experimental data of doubly labeled purified human centrioles. Our approach revealed the precise localization of the centriolar protein Cep63 around the centriole microtubule barrel. Overall, our method offers new perspectives for applications in biology that require the isotropic mapping of proteins within macromolecular assemblies.

PD56-03 DETECTION OF PRIVATE CLONAL MUTATIONS IN LOCALISED PROSTATE CANCER FROM RARE MOLECULES OF CIRCULATING TUMOUR DNA

You have accessJournal of UrologyProstate Cancer: Markers II1 Apr 2018PD56-03 DETECTION OF PRIVATE CLONAL MUTATIONS IN LOCALISED PROSTATE CANCER FROM RARE MOLECULES OF CIRCULATING TUMOUR DNA Keval Patel, Charlie Massie, Francesco Marass, James Morris, Andy Lynch, Florent Mouliere, David Neal, Vincent Gnanapragasam, Tim Forshew, and Nitzan Rosenfeld Keval PatelKeval Patel More articles by this author , Charlie MassieCharlie Massie More articles by this author , Francesco MarassFrancesco Marass More articles by this author , James MorrisJames Morris More articles by this author , Andy LynchAndy Lynch More articles by this author , Florent MouliereFlorent Mouliere More articles by this author , David NealDavid Neal More articles by this author , Vincent GnanapragasamVincent Gnanapragasam More articles by this author , Tim ForshewTim Forshew More articles by this author , and Nitzan RosenfeldNitzan Rosenfeld More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.2635AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Prostate cancer (PCa) is the most common solid tumour in men. Current methods of distinguishing between indolent and aggressive PCa can be inaccurate due to PCa heterogeneity and multi-focality. To compensate, many centres now take upwards of 20 biopsies of the prostate in one sitting, and monitor men with further biopsies to ensure that the disease is not progressing. There is therefore a need for a non-invasive biomarker than can monitor tumour heterogeneity and aggression. Circulating-tumour DNA (ctDNA) represents an exciting opportunity to monitor cancer status non-invasively. We developed a method for analysis of multiple genomic regions whilst retaining sensitivity for detection of individual mutant molecules, using multiplex replicate dilution sequencing, or MRD-Seq. METHODS MRD-Seq distributes a DNA sample into multiple replicate PCR reactions, where each reaction contains a small number of initial template molecules. As a result, the detection of a single mutant molecule generates a signal that is clearly discernible above the background noise. Dilutions series determined the limit of detection (0.09% AF) and background noise (0.02%AF). To assess ctDNA detection in the context of intra-tumoural heterogeneity, prostatectomy specimens and pre-operative plasma was obtained from 2 men with localised but multifocal PCa, with appropriate ethical approval (MREC:01/4/061). Whole genome sequencing of spatially 5-7 distinct regions of prostate cancer for each man was used to design probes to interrogate private mutations. RESULTS Plasma MRD-Seq demonstrated a mutant AF of 0.9% and 0.4% in the 2 men from ~1,000 genomic equivalent copies input. MRD-Seq detected the presence of private mutations from multiple private clones in the plasma, with evidence that more aggressive tumour regions (according to Gleason Grade) were over-represented in the plasma. CONCLUSIONS This proof of principle study suggests that ctDNA is detectable in the plasma of localised PCa patients and could be used to monitor men on active surveillance and identify aggressive changes at an early stage. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e1062-e1063 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Keval Patel More articles by this author Charlie Massie More articles by this author Francesco Marass More articles by this author James Morris More articles by this author Andy Lynch More articles by this author Florent Mouliere More articles by this author David Neal More articles by this author Vincent Gnanapragasam More articles by this author Tim Forshew More articles by this author Nitzan Rosenfeld More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...

3D reconstruction of skeletal mesh models and human foot biomodel generation using semantic parametric-based deformation

ABSTRACTThis paper introduces two methodologies for the reconstruction of skeletal mesh models and for the generation of parametric bone models of the human foot. First, a new Parametric-Based Deformation methodology is presented, which deforms a template 3D mesh according to user-defined semantic parameters in order to derive a new bone model. The proposed method allows the parameterization of dense and detailed 3D meshes of human foot bones. An extensive evaluation is performed to examine the accuracy, quality, and performance of the proposed method with human and animal bones, and versus existing statistical-based methods in the literature. Also, a novel methodology is proposed for the generation of parametric bone models of the human foot using non-calibrated biplanar X-rays. The proposed method has been applied for the production of detail 3D foot biomodels from an initial template biomodel and has been evaluated using human and animal bones.

Foundation Year 2 doctors’ reasons for leaving UK medicine: an in-depth analysis of decision-making using semistructured interviews

ObjectivesTo explore the reasons that doctors choose to leave UK medicine after their foundation year two posts.SettingAll four regions of Scotland.ParticipantsFoundation year two doctors (F2s) working throughout Scotland who were...

Structural and magnetic properties of nickel nanowires grown in porous anodic aluminium oxide template by electrochemical deposition technique

We study the formation of nickel nanowires (Ni NWs) grown in porous anodic aluminium oxide (AAO) template by the electrochemical deposition technique. Here, the initial AAO template was grown by anodization of aluminium substrate in sulphuric acid solution. The cross-section, crystal structure, and magnetic properties of Ni NWs system were characterized by field-emission SEM, XRD, and SQUID. As a result, the highly-ordered Ni NWs are observed with the uniform diameter of 27 nm and the length from 31 to 163 nm. Based on XRD spectra analysis, Ni NWs have the face-centered cubic structure with the lattice parameter of 0.35 nm and average crystallite size of 17.19 nm. From SQUID measurement at room temperature, by maintaining the magnetic field perpendicular to Ni NWs axis, the magnetic hysteresis of Ni NWs system show the strong ferromagnetism with the coercivity and remanence ratio of ∼148 Oe and ∼0.23, respectively. The magnetic properties are also calculated by means of generalized gradient approximation methods. From the calculation result, we show that the ferromagnetism behavior comes from Ni NWs without any contribution from AAO template or the substrate. This study opens the potential application of Ni NWs system for novel functional magnetic devices.

Periodic Porous Alloyed Au-Ag Nanosphere Arrays and Their Highly Sensitive SERS Performance with Good Reproducibility and High Density of Hotspots.

Periodic porous alloyed Au-Ag nanosphere (NS) arrays with different periodic lengths and tunable composition ratios were prepared on Si substrates on a large scale (∼cm2) using stepwise metal deposition-annealing and subsequent chemical corrosion from a monolayer of colloidal polystyrene (PS) microspheres as the initial template. The porous alloyed Au-Ag NSs possessed a high porosity and bicontinuous morphology composed of hierarchically interconnected ligaments, which were obtained from an optimized dealloying process in nitric acid. Interestingly, when the dealloying time was prolonged, the average size of the porous alloyed NSs slightly decreased, and the width of the ligaments gradually increased. The periodic length of the array could be facilely changed by controlling the initial particle size of the PS template. Moreover, the porous alloyed Au-Ag NS arrays were explored as a platform for the surface-enhanced Raman scattering (SERS) detection of 4-aminothiophenol (4-ATP) and exhibited excellent reproducibility and high sensitivity because of the periodic structure of the arrays and the abundance of inherent "hotspots". After optimization experiments, a low concentration of 10-10 M 4-ATP could be detected on these porous Au-Ag NS array substrates. Such highly reproducible SERS activity is meaningful for improving the practical application of portable Raman detection equipment.

Manganese Oxides for Environmental Assessment

Core Ideas Synthesis of birnessite that forms a durable coating requires both high lactate and high Na to K ratios. A high lactate to permanganate ratio facilitates a rapid (<10 min) nucleation of birnessite crystals. The high Na/K ratio facilitates crystal growth along the c axis because Na+ ions fit well within the triclinic structure. Early‐formed birnessite is initially poorly ordered, but ordering along the c axis occurs over 2 to 3 d. Differences in durability of birnessites are likely related to crystal morphology. Following on earlier work that has shown the value of iron‐based IRIS (Indicator of Reduction In Soils) technology, recent efforts have focused on developing a manganese‐based IRIS coating. A synthesis procedure developed utilizing a high Na lactate to KMnO4 molar ratio followed by 3 d of dialysis, forms a crystalline birnessite that can be easily applied to PVC tubing and which forms a durable manganese oxide coating. In this study, a series of experiments were run to evaluate the impact of the following parameters on the synthesis of the birnessite: Na/K ratio; lactate/permanganate ratio; lactate source; reaction time; centrifuge washing; dialysis and ageing of the samples. Results confirm that to synthesize birnessite that forms a durable coating both high lactate and high Na/K ratios are required. The high lactate/permanganate ratio (6.7) facilitates a rapid nucleation of triclinic birnessite crystals within 10 min during which time the initial structural template is established, and where some of the manganese (approximately 38%) is reduced to Mn3+. The high Na/K facilitates the ordering of the triclinic birnessite along the c axis following synthesis, and based on analyses of x‐ray diffraction (XRD) patterns, the crystallites grow from 2 to 12 nm in direction of c axis over the course of several days. Scanning electron microscopy (SEM) analyses show that oriented structured particles up to 1 μm form. X‐ray photoelectron spectroscopy (XPS) analyses demonstrate that there is no difference in the charge structure of the Mn between birnessites that will, or will not, form a durable coating. We conclude that the differences in durability are related primarily to physical interaction and/or interlocking of crystals.

Applications of Probe Capture Enrichment Next Generation Sequencing for Whole Mitochondrial Genome and 426 Nuclear SNPs for Forensically Challenging Samples.

The application of next generation sequencing (NGS) for the analysis of mitochondrial (mt) DNA, short tandem repeats (STRs), and single nucleotide polymorphism (SNPs) has demonstrated great promise for challenging forensic specimens, such as degraded, limited, and mixed samples. Target enrichment using probe capture rather than PCR amplification offers advantages for analysis of degraded DNA since two intact PCR primer sites in the template DNA molecule are not required. Furthermore, NGS software programs can help remove PCR duplicates to determine initial template copy numbers of a shotgun library. Moreover, the same shotgun library prepared from a limited DNA source can be enriched for mtDNA as well as nuclear markers by hybrid capture with the relevant probe panels. Here, we demonstrate the use of this strategy in the analysis of limited and mock degraded samples using our custom probe capture panels for massively parallel sequencing of the whole mtgenome and 426 SNP markers. We also applied the mtgenome capture panel in a mixed sample and analyzed using both phylogenetic and variant frequency based bioinformatics tools to resolve the minor and major contributors. Finally, the results obtained on individual telogen hairs demonstrate the potential of probe capture NGS analysis for both mtDNA and nuclear SNPs for challenging forensic specimens.

Periosteum Extracellular-Matrix-Mediated Acellular Mineralization during Bone Formation.

Cell-mediated mineralization is essential for bone formation and regeneration. In this study, it is proven that extracellular matrix (ECM) of decellularized periosteum can play an initiative and independent role in bone-like apatite formation. Using decellularized periosteum scaffold, it is revealed that ECM scaffold itself can promote critical bone defect regeneration and nude mouse ectopic ossification. The natural collagen matrix of decellularized periosteum can serve as a 3D structural template for Ca-P nuclei initiation, controlling the size and orientation of bone-like mineral crystals. The naturally cross-linked and highly ordered 3D fibrillar network of decellularized periosteum not only provides a model for mimicking mineralization in vitro and in vivo to elucidate the important functions of ECM in bone formation and regeneration, but also can be a promising biomaterial for bone tissue engineering and clinical application.

Hybrid Top‐Down/Bottom‐Up Fabrication of Regular Arrays of AlN Nanorods for Deep‐UV Core–Shell LEDs

Core–shell nanostructures are predicted to highly improve the efficiency of deep‐UV light emitting diodes (LEDs), owing to their low defect density, reduced quantum‐confined Stark effect, high‐quality non‐polar growth and improved extraction efficiency. In this paper, we report on the nanofabrication of high‐quality AlN nanorod arrays using a hybrid top‐down/bottom‐up approach for use as a scaffold for UV LED structures. We describe the use of Displacement Talbot Lithography to fabricate a metallic hard etch mask to allow AlN nanorod arrays to be dry etched from a planar AlN template. In particular, we investigate the impact of etching parameters on the nanorod etch rate, tapering profile and mask selectivity in order to achieve vertical‐sided nanorod arrays with high aspect ratios. AlN facet recovery is subsequently explored by means of regrowth using Metal Organic Vapor Phase Epitaxy. Low pressure and high V/III ratio promote straight and smooth sidewall faceting, which results in an improvement of the optical quality compared to the initial AlN template. The promising results open new perspectives for the fabrication of high‐efficiency deep‐UV‐emitting core–shell LEDs.