Initial Stages Of Development Research Articles

Irrigation Scheduling of Pawale Project using FAO-CROPWAT 8.0

Introduction: The application of irrigation water to various crops in the command area based on daily crop water requirements considering the water holding capacity of different irrigated soils is a vital aspect of irrigation management. Considering the importance of irrigation scheduling, the FAO CROPWAT 8.0 is a patent tool, as it gives crop water requirements and irrigation schedules based on climatological and physiographic factors. Method: In this patent study, the CROPWAT 8.0 model is used to integrate the Cropwat model, long-term climate data is used, soil sensitivity analysis is performed and crop-specific water need is identified for the command area of the Pawale irrigation project which is a novelty as cropwat is not used previously for the study area. Pawale irrigation project is located in the Thane district of Maharashtra, India. Nineteen years of climatic data are used for the analysis, considering seven crops to calculate the crop water and net irrigation requirement for the kharif and rabi seasons. Result: The result indicates that crop-wise and season-wise variation of crop water requirement is from 2.5 to 1055.1 mm, and the net irrigation requirement for the year is 618.6 mm. It is also observed that rice requires more water from the initial stage up to the development stage than other crops considered in this study. Conclusion: In conclusion, we can say that the cropwat model with long-term climate data can develop effective data for crop's specific water needs. The results indicate that evapotranspiration has a greater impact on crop water and net irrigation requirements because, in both cases, the increase or decrease of ETo will affect the crops and their water requirement. The sensitivity analysis for different types of soils is also carried out for groundnut. The result indicates that, apart from crops, soil water-holding capacity is essential for irrigation scheduling. It is seen that nine rotations are required for red sandy soil as compared to six rotations and four rotations for red sandy, loamy soil and black clay soil, respectively.

Formulation and Development of Nanoparticulate Drug Delivery System in the Treatment of Cancer.

Cancer is a leading cause of death worldwide. Owing to increased prevalence of cancer globally, it has posed a major challenge to healthcare professionals. The main types of cancer that account for high mortality are lung, stomach, liver, colon, and breast cancer. For many decades and even today, the major portion of chemotherapy is based on intravenous administration of drugs, which has its limitations including lack of safety, inconvenience, and poor patient compliance. In present study, formulated a novel nanoparticulate drug delivery system for the treatment of cancer. Pre- formulation is the initial stage in drug development where the physical and chemical properties of a drug candidate are studied. This phase involves characterizing solubility, stability, pH, and compatibility with excipients to guide the formulation of a safe, effective, and stable dosage form. Pre-formulation studies are crucial for optimizing drug delivery, bioavailability, and shelf-life.

The Role of Parents in Early Childhood Social Emotional Development

Early childhood education is the initial stage in a child's development. Development that starts from the family environment and involves the role of parents, also focuses on developing social emotional skills. The role of parents in children's emotional development is needed, because parents can accompany and develop children's intelligence as much as possible. The aim of this research is to describe the role of parents in the social emotions of early childhood and the factors that influence children's emotions. This research method is qualitative descriptive research. The type of research is Literature Study (Literature Study). The results of this research show that the role of parents in developing the social-emotional abilities of early childhood is as first and foremost educators as capital and as friends for children. The second result shows that the factors that influence children's emotions include maturity factors, conflict factors and learning environment factors.

ECOLOGICAL CONSCIOUSNESS AND ECOLOGICAL ACTIVITY AS FORMS MANIFESTATIONS OF ECOLOGICAL CULTURE

The article deals with the problems of the cultural determination of the formation of ecological consciousness and ecological activity in the modern world. In the scientific literature, this question is at the stage of initial development. The existing range of concepts, beliefs, and ideas in this area are characterized by extreme instability, and polyphony, which makes it timely, in this regard, to study the cultural and ideological prerequisites for the formation of an ecological culture system. Another aspect of the actualization of the problem is the need to concretize the goals of applying the concept of the formation of ecological consciousness in practice, that is, the need for a methodological analysis of the ways of its concrete implementation. Determining the direction and effectiveness of the impact of conceptual values can become the basis for rebuilding existing and creating new cultural and ideological programs.

Deriving learning outcomes for an applied health technology course for PhD students

This study discusses the initial stage of development of a PhD course within the Applied Health Technology (AHT) area, in a multi-professional and transdisciplinary environment. The research aimed to align stakeholders' and PhD graduates' perspectives to create learning outcomes for a proposed AHT course. Semi-structured interviews were conducted with stakeholders and graduates of the program, and the results were analysed using a qualitative content analysis method. The identified themes related to AHT perspectives, issues with working with AHT projects, program goals and course goals. These guided the creation of four strategically aligned learning outcomes for the proposed course.

A study on site selection of wind power plant based on prospect theory and VIKOR: a case study in China

PurposeWith the continuous development of the wind power industry, wind power plant (WPP) has become the focus of resource development within the industry. Site selection, as the initial stage of WPP development, is directly related to the feasibility of construction and the future revenue of WPP. Therefore, the purpose of this paper is to study the siting of WPP and establish a framework for siting decision-making.Design/methodology/approachFirstly, a site selection evaluation index system is constructed from four aspects of economy, geography, environment and society using the literature review method and the Delphi method, and the weights of each index are comprehensively determined by combining the Decision-making Trial and Evaluation Laboratory (DEMATEL) and the entropy weight method (EW). Then, prospect theory and the multi-criteria compromise solution ranking method (VIKOR) are introduced to rank the potential options and determine the best site.FindingsChina is used as a case study, and the robustness and reliability of the methodology are demonstrated through sensitivity analysis, comparative analysis and ablation experiment analysis. This paper aims to provide a useful reference for WPP siting research.Originality/valueIn this paper, DEMATEL and EW are used to determine the weights of indicators, which overcome the disadvantage of single assignment. Prospect theory and VIKOR are combined to construct a decision model, which also considers the attitude of the decision-maker and the compromise solution of the decision result. For the first time, this framework is applied to WPP siting research.

Начальный этап разработки математической модели для управления процессом магнитно-гравитационной сепарации в режиме реального времени

The initial stage of the mathematical model development designed to control in real time the enrichment of magnetite ores in magnetic gravity separators is presented the article. A significantly lower computational complexity in comparison with models using computational fluid dynamics tools is a main requirement for the created model. The study uses physical modeling and applies similarity criteria which well-known in hydrodynamics. As a result of processing of the laboratory experiments data, the structure of the model was established, the values of its parameters for boundary cases were obtained and the directions of further research on improving the model were determined.

Technological advancements, digital transformation, and future trends in blood transfusion services

Misidentification, mistransfusion, and pre-analytical errors are all regarded as major challenges and risks in safe blood transfusion procedures. To provide a high level of accuracy, traceability, automation, and reliability in blood transfusion services, traditional methods should be upgraded with modern technologies such as block chain technology, machine learning, artificial intelligence (AI), artificial neural networks, algorithm-based learning, and the implementation of radio frequency identification (RFID) and the internet of things (IoT). This technology helps reduce errors, retrieve data, forecast blood demand, reduce blood waste, manage blood storage, and manage workload, ensuring transfusion safety. The technology is still in the initial stages of development and by addressing issues such as data loss, patient data privacy, and cost-effectiveness, the technology will become a revolution in transfusion services.

Ground subsidence and polygon development due to thermokarst in the Lena-Aldan interfluve, eastern Siberia, revealed by satellite remote sensing data

Thermokarst development is a topographic change in the landscape that is commonly associated with permafrost degradation in ice-rich permafrost regions. The Lena-Aldan interfluvial area in Central Yakutia in eastern Siberia has undergone extensive thermokarst development in the last three decades, particularly in the vicinity of settlements. Despite the negative effects of thermokarst development on the inhabitants of these settlements, no quantitative observation methods have been developed to investigate the surface displacement due to thermokarst development over entire towns. This study utilized interferometric synthetic aperture radar to reveal ground-surface displacement associated with thermokarst near the settlements of selected towns. The findings showed that significant subsidence was detected in disturbed areas (farming and abundant arable land) near the towns. The magnitude of subsidence in the Tyungyulyu and Mayya areas was less than that in Churapcha and Amga. Polygon density in a defined area in each town was examined using high-resolution optical images. The polygon density in Churapcha was considerably lower than that in Mayya, whereas polygonal texture in some areas in Tyungyulyu and Amga was unclear. Spatial frequency analysis using satellite optical images showed clear differences in averaged spectrum models between well-developed and less-developed polygons, which may reflect trough depths and density of vegetation between polygons. Satellite-based subsidence maps and statistics describing polygon development may be useful for evaluating both initial and subsequent stages of thermokarst development.

New Library of Iodo-Quinoline Derivatives Obtained by an Alternative Synthetic Pathway and Their Antimicrobial Activity.

6-Iodo-substituted carboxy-quinolines were obtained using a one-pot, three-component method with trifluoroacetic acid as a catalyst under acidic conditions. Iodo-aniline, pyruvic acid and 22 phenyl-substituted aldehydes (we varied the type and number of radicals) or O-heterocycles, resulting in different electronic effects, were the starting components. This approach offers advantages such as rapid response times, cost-effective catalysts, high product yields and efficient purification procedures. A comprehensive investigation was conducted to examine the impact of aldehyde structure on the synthesis pathway. A library of compounds was obtained and characterized by FT-IR, MS, 1H NMR and 13C NMR spectroscopy and single-ray crystal diffractometry. Their antimicrobial activity against S. epidermidis, K. pneumonie and C. parapsilosis was tested in vitro. The effect of iodo-quinoline derivatives on microbial adhesion, the initial stage of microbial biofilm development, was also investigated. This study suggests that carboxy-quinoline derivatives bearing an iodine atom are interesting scaffolds for the development of novel antimicrobial agents.

Caffeic acid 3,4-dihydroxyphenethyl ester prevents colorectal cancer through inhibition of multiple cancer-promoting signal pathways in 1,2-Dimethylhydrazine/dextran sodium sulphate mouse model.

To elucidate the potential feature and mechanism of the caffeic acid 3,4-dihydroxyphenethyl ester (CADPE) molecule, which can prevent colorectal cancer (CRC) in the 1,2-Dimethylhydrazine (DMH)/dextran sodium sulphate (DSS)-induced mouse model. Institute of cancer research (ICR) male mice were injected with 20 mg/kg DMH for a week. After that, 2% DSS was administered in the drinking water for another 7 d. The CADPE treatment was given to the DMH/DSS induced male mice at three different periods until their sacrifice. Histopathological examination was used for observing the CRC development at colonic mucosa. Immunohistochemistry (IHC), blood cells smearing and crypt damage scoring methods were used for investigating the anti-inflammation feature of CADPE related to CRC. The reversing targets searching method was applied with artificial intelligence (AI), computer-aided drug designing (CADD) and Ingenuity Pathway Analysis (IPA) techniques for predicting the potential targets and mechanism of CADPE highly related to CRC. The data indicated that CADPE inhibited CRC tumor development in the colitis-associated DMH/DSS induced mouse model after giving the early treatment. CADPE also impeded the acute inflammation by decreasing the infiltration of neutrophils significantly during the initial stage of CRC development. Finally, our data showed that CADPE prevented CRC by blocking active sites of three pivotal protein targets including epidermal growth factor receptor (EGFR), extracellular signal-regulated kinase (ERK) and mammalian target of rapamycin (mTOR) in two major cancer development pathways. CADPE effectively prevented CRC at early stage of tumor germination in the DMH/DSS mouse model highly likely due to its anti-acute inflammation characteristic and the ability of blocking EGFR, ERK and mTOR activities in two highly related CRC developing pathways.

System Design Singel Vendor Marketplace

Single Vendor Marketplace is a web-based application or mobile-based application where there is only one seller who provides products. Seller sales transactions only involve sellers and buyers directly without any third parties or intermediaries. The advantage of this system is that you can manage your profits directly yourself. Some also call this application a Stand Alone Website.
 The revised Borg and Gall research and development method allows the system design of this information system to be completed well. This design process has several stages. The Borg and Gall development model has a series of steps or stages consisting of information gathering, planning stage, initial product design development stage, field trial stage, main product revision stage, field test stage, operational product revision, field testing stage, product revision stage final, and also the socialization and implementation stages.
 A structured system design is needed at this stage where in general the design consists of system design, database design, interface design and prototype product design. It is hoped that this marketplace application with a single vendor system can improve the quality of management thereby increasing business profits

Evaluation of enriched freshwater rotifer, Brachionus calyciflorus as first feed on growth performance, nutrient availability and fatty acid composition of Anabas testudineus (Bloch, 1792) larvae

Evaluation of enriched freshwater rotifer, Brachionus calyciflorus as first feed on growth performance, nutrient availability and fatty acid composition of Anabas testudineus (Bloch, 1792) larvae

Первопроходцы дошкольного образования в России С. А. Люгебиль и А. С. Симонович

The aim of the study is to characterize the efforts of Sofia Andreevna Lyugebil (1824-1914) and Adelaida Semyonovna Simonovich (1844-1933) to open the very first preschool institutions in Russia. The article reveals little-known facts of their biographies and provides data on their practical teaching activities. The text of the article includes memoirs of contemporaries (E. N. Vodovozova, the ‘Sovremennik’ journal), as well as those of former students (A. N. Benois, I. V. Petrashen) of K. I. May’s private gymnasium, where S. A. Lyugebil worked. The scientific novelty of the study lies in introducing into scientific use factual material related to the initial stage of preschool education development in Russia, which remains little known. The participation of S. A. Lyugebil, A. S. Simonovich and their spouses in the work of the first Russian pedagogical society is noted. The contribution of A. S. Simonovich to the development of the theory of preschool education is characterized, her efforts to open the ‘Detsky sad’ journal, the first Russian periodical on preschool subjects, are shown. Information is provided on the initial stage of the organization of preschool education abroad, as well as in Russia (in the pre-Soviet period). The publication of the article coincides with the 200th anniversary of the birth of S. A. Lyugebil and the 180th anniversary of the birth of A. S. Simonovich.

Differential expression of miRNAs associated with pectoral myopathies in young broilers: insights from a comparative transcriptome analysis

IntroductionWhite Striping (WS) and Wooden Breast (WB) pectoral myopathies are relevant disorders for contemporary broiler production worldwide. Several studies aimed to elucidate the genetic components associated with the occurrence of these myopathies. However, epigenetic factors that trigger or differentiate these two conditions are still unclear. The aim of this study was to identify miRNAs differentially expressed (DE) between normal and WS and WB-affected broilers, and to verify the possible role of these miRNAs in metabolic pathways related to the manifestation of these pectoral myopathies in 28-day-old broilers.ResultsFive miRNAs were DE in the WS vs control (gga-miR-375, gga-miR-200b-3p, gga-miR-429-3p, gga-miR-1769-5p, gga-miR-200a-3p), 82 between WB vs control and 62 between WB vs WS. Several known miRNAs were associated with WB, such as gga-miR-155, gga-miR-146b, gga-miR-222, gga-miR-146-5p, gga-miR- 29, gga-miR-21-5p, gga-miR-133a-3p and gga-miR-133b. Most of them had not previously been associated with the development of this myopathy in broilers. We also have predicted 17 new miRNAs expressed in the broilers pectoral muscle. DE miRNA target gene ontology analysis enriched 6 common pathways for WS and WB compared to control: autophagy, insulin signaling, FoxO signaling, endocytosis, and metabolic pathways. The WS vs control contrast had two unique pathways, ERBB signaling and the mTOR signaling, while WB vs control had 14 unique pathways, with ubiquitin-mediated proteolysis and endoplasmic reticulum protein processing being the most significant.ConclusionsWe found miRNAs DE between normal broilers and those affected with breast myopathies at 28 days of age. Our results also provide novel evidence of the miRNAs role on the regulation of WS and in the differentiation of both WS and WB myopathies. Overall, our study provides insights into miRNA-mediated and pathways involved in the occurrence of WS and WB helping to better understand these chicken growth disorders in an early age. These findings can help developing new approaches to reduce these complex issues in poultry production possibly by adjustments in nutrition and management conditions. Moreover, the miRNAs and target genes associated with the initial stages of WS and WB development could be potential biomarkers to be used in selection to reduce the occurrence of these myopathies in broiler production.

How will the public health committees develop after COVID-19 pandemic in China? Exploration from mixed methods study in Pingshan District, Shenzhen.

The Public Health Committee has a long-standing presence in the Chinese Constitution. During the pandemic, it served as a grassroots self-governance organization and made significant contributions to China's community epidemic prevention and control system. Currently, 24 provinces in China have promoted the establishment of community public health committees. To gather data, we conducted semi-structured interviews (n = 48) with the heads of superior departments of public health committees, the heads of public health committees, and the heads of community health centers, exploring aspects such as organizational structure, job responsibilities, and job security. In parallel, we administered a capacity-building survey to a sample of 23 community residents (n = 1,986) and performed regression analysis. Finally, we examined the impact of gender, age, and education level on the development of public health committees. Our study reveals that the development of public health committees displays features of administration across various dimensions, including personnel appointment, top-level design, medical professionalism, funding path dependence, and data path dependence. However, the decision-making function of the organization does not exhibit a significant impact. The construction of the Public Health Committee should demonstrate an "autonomization-administration" pendulum effect. Currently, due to the absence of decision-making functions within the Public Health Committee, autonomous organizations are exhibiting characteristics of administration. To prevent excessive autonomization or administrative nature in the development of committees, public health policies are continuously being refined based on the unique characteristics of public health committee construction. During exceptional circumstances or the initial stages of development, the establishment of public health committees should be primarily guided by administrative principles, utilizing political momentum to drive their progress. In contrast, during routine establishment phases or later stages of development, the establishment of public health committees should be primarily led by autonomization, restoring their capacity for self-decision making. It is essential to fully leverage the role of grassroots self-governance organizations, relying on the community to engage in self-management, self-education, and self-service within public health committees.

Evolution of motivation in co‐creation: Recruit, retain and complete in a project on new food product co‐creation

The study explores the motivation of consumers to join and participate in new product co‐creation, distinguishing between recruitment before, retainment during and finalizing of a co‐creation project. The research is based on follow‐up interviews with participants in a project covering the initial stages of new food product development (i.e., idea generation, idea screening and concept development) involving older consumers and carried out in a physical environment. Different motivation factors were deemed important by consumers before, during and at the closure of the project. Consumers joined the project motivated by curiosity and desire to meet new people. While performing the creative tasks, they continued the engagement due to the positive anticipation and enjoyment of new activities, as well as positive feedback loops. At the closure of the project, the usefulness of outcomes and the received recognition became important and strengthened the perceived creative self‐efficacy of participants. The findings offer useful recommendations for organizers of co‐creation, enabling the recruitment and retainment of consumers who could successfully deliver creative outputs and complete the project. The study offers novel insights relevant to participatory innovations looking at the temporal dimension of motivation to co‐create and highlights the dynamic changes in salience of the motivation factors.

A study of splenic notches in human cadavers and its clinical implications

: Spleen is the largest and secondary lymphoid organ with high vascularity which has important role in immunological and haematological functions of human body. Spleen developes from mesoderm and in the initial stages of development, different lobules are formed, which fuses later. The lobulated structure of spleen disappears, but is indicated by the presence of notches in superior border in adults. The aim of study was to find morphological variations of spleen with respect to its number of notches in borders and anomalous fissure on its surfaces.: The study was done on 40 formalin fixed cadaveric spleens from the department of Anatomy, Sri Siddhartha Medical College, Tumkur, and Karnataka. Out of 40 spleens studied, the various shapes such as wedge shaped, tetrahedral, oval and triangular were found. The number of spleen showing notches in superior border was 28(70%) and in the inferior border it was 3(7.5%). Absence of Splenic notches was observed in 5(12.5%) and 2(5%) spleens had notches in both borders. The anomalous fissure was found in 2(5%) spleen on its diaphragmatic surface.: The knowledge of variations in morphology of spleen are essential for physician, surgeon, radiologists and forensic surgeon to differentiate from the splenic pathology and splenic injury. Morphological variations of spleen and its clinical importance need to be discussed at dissection tables during routine anatomy dissection hours.

Harmonized Physical and Electrochemical Process Design for Densely Dispersed Cu Catalysts on Cu2O Absorbers for Efficient Photoelectrochemical CO2 Reduction Reaction

AbstractThe photoelectrochemical CO2 reduction reaction (photo‐CO2RR) is a promising technology to convert CO2 into high‐value‐added carbon‐based chemicals using a relatively low voltage, which can economically solve the problem of CO2 emissions. Nevertheless, unlike the conventional electrochemical CO2RR approach, photo‐CO2RR technology is in its initial development stage. Particularly, when sunlight is applied to photoelectrodes for photo‐CO2RR, severe photocorrosion is unavoidable, resulting in the deterioration of fundamental functions including device long‐term stability and conversion performance. This study proposes an innovative two‐step catalyst formation strategy to enable the efficient photo‐CO2RR with Cu catalysts prepared using intrinsic photocorrosion of the Cu2O absorption layer. This approach is based on the harmonized process design of the i) growth of physically generated Cu nanoparticles and ii) construction of improved photoelectrochemical Cu cluster catalysts. The vacuum‐evaporated Cu seeds are designed to induce an evenly dispersed electrical path on Cu2O, and the selectively concentrated electrical field from the Cu seeds provides preferential sites for metallic Cu catalysts in subsequent photoelectrochemical reduction. This harmonized combination process of Cu catalysts on Cu2O demonstrates a synergistic performance of −1.2 mA cm−2 at 0 VRHE with suppression of photocorrosion and produces ≈95% CO product gas (0.4 VRHE).

Content and ultrastructure of natural killer cells in the blood of patients with newly diagnosed type 2 diabetes mellitus

Background. In patients with newly diagnosed type 2 diabetes mellitus (T2DM), a small but statistically significant decrease in absolute number of natural killer (NK) cells (CD56+) in the peripheral blood (PB) was found, especially pronounced with concomitant obesity. In connection with the above, one of the main aims of the present report was to further study the role of NK cells in patients with newly diagnosed T2DM, including those with obesity. For this purpose, a combination of flow cytometry methods with scanning and transmission electron microscopy was used to determine the number and function of CD56+ cells in the PB of patients with T2DM. Materials and methods. We examined 144 patients of both sexes with newly diagnosed T2DM aged 40–70 years who had no other acute or chronic diseases and had not previously taken any hypoglycemic drugs. The control group consisted of 50 healthy individuals with normoglycemia aged 40–65 years who had not COVID-19 disease. Results. Our studies have found that in untreated patients with newly diagnosed T2DM compared to healthy controls, there is a very small statistically significant decrease in the absolute number of CD56+ cells in the PB. When combining flow cytometry (FACS method), transmission and scanning electron microscopy in patients with T2DM, a significant change in the ultrastructure of CD56+ cells was revealed, indicating a decrease in their function (an increase in the number of cells with a smoother surface of the cell membrane, a sharp decrease in the number of azurophilic granules in the cytoplasm considered the main producer of cytokines and perforins, the appearance of parallel tubular structures, biomarkers of decreased cell function, a disruption of the Golgi apparatus structure, granular endoplasmic reticulum, etc.). The data obtained indicate that at the initial stage of T2DM development in humans, there is a pronounced weakening in the function of NK cells and, consequently, the natural immune defense of the body and explain the increased susceptibility of diabetics to various viruses and infections, including COVID-19, and also more severe clinical course and increased mortality. Conclusions. The conducted studies show that in patients with T2DM who are at the initial stage of T2DM, there is a sharp disturbance in the submicroscopic organization of CD56+ cells, the most important cellular element of natural immunity, which suggests a weakening of the function of natural immune defense. It is the main cause of increased sensitivity of diabetic patients to infection with various pathogens, including the SARS-CoV-2, as well as more severe clinical course and increased mortality rate.