Initial Stage Of Degradation Research Articles

Determination of the lower limits of antibiotic biodegradation and the fate of antibiotic resistant genes in activated sludge: Both nitrifying bacteria and heterotrophic bacteria matter

Antibiotics can be biodegraded in activated sludge via co-metabolism and metabolism. In this study, we investigated the biodegradation pathways of sulfamethoxazole (SMX) and antibiotic resistant genes’ (ARGs) fate in different autotrophic and heterotrophic microorganisms, by employing aerobic sludge, mixed sludge, and nitrifying sludge. A threshold concentration of SMX activating the degradation pathways in the initial stage of antibiotics degradation was found and proved in different activated sludge systems. Heterotrophic bacteria played an important role in SMX biodegradation. However, ammonia-oxidizing bacteria (AOB) had a faster metabolic rate, which was about 15 times higher than heterotrophic bacteria, contributing much to SMX removal via co-metabolism. As SMX concentration increases, the amoA gene and AOB relative abundance decreased in aerobic sludge due to the enrichment of functional heterotrophic bacteria, while it increased in nitrifying sludge. Microbial community analysis showed that functional bacteria which possess the capacity of SMX removal and antibiotic resistance were selected by SMX pressure. Potential ARGs hosts could increase their resistance to the biotoxicity of SMX and maintain system performance. These findings are of practical significance to guide antibiotic biodegradation and ARGs control in wastewater treatment plants.

An experimental investigation into the physical, thermal and mechanical degradation of a polymeric bioresorbable scaffold

This study presents a comprehensive evaluation of the mechanical, micro-mechanical and physical properties of Reva Medical Fantom Encore Bioresorbable Scaffolds (BRS) subjected to a thermally-accelerated degradation protocol. The Fantom Encore BRS were immersed in phosphate buffered saline solution at 50 °C for 112 days with radial compression testing, nanoindentation, differential scanning calorimetry, gel permeation chromatography and mass loss characterisation performed at consecutive time points. In the initial stages of degradation (Days 0–21), the Fantom Encore BRS showed increases in radial strength and stiffness, despite a substantial reduction in in molecular weight, with a slight increase in the melt temperature also observed. In the second phase (Days 35–54), the radial strength of the BRS samples were maintained despite a continued loss in molecular weight. However, during this phase, the ductility of the stent showed a reduction, with stent fracture occurring earlier in the crimp process and with lower amounts of plastic deformation evident under visual examination post-fracture. In the final phase (Days 63–112), the load-bearing capacity of the Fantom Encore BRS showed continued reduction, with decreases in radial stiffness and strength, and drastic reduction in the work-to-fracture of the devices. Throughout each phase, there was a steady increase in the relative crystallinity, with limited mass loss until day 112 and only minor changes in glass transition and melt temperatures. Limited changes were observed in nano-mechanical properties, with measured local elastic moduli and hardness values remaining largely similar throughout degradation. Given that the thermally-accelerated in vitro conditions represented a four-fold acceleration of physiological conditions, these results suggest that the BRS scaffolds could exhibit substantially brittle behaviour after ∼ one year of implantation.

Cathodoluminescence evaluation of the degradation of Mg, Ca and Dy Co-doped BaTiO3 Ceramics

Mg, Ca and Dy co-doped BaTiO3 ceramics were prepared by conventional solid-state method. About 25% of grains possessed core-rim structure, which was caused by different Ca and Mg solutions. Cathodoluminescence, an efficient tool to obtain defect information with high spatial and spectral resolution, was applied to investigate the degradation mechanism of the ceramics. Oxygen vacancy concentration in the core is higher than that in the rim due to the higher Ca content in the rim. In the initial stage of degradation, oxygen vacancies mainly migrated within the core region. In the middle stage, oxygen vacancies migration in the grains with core-rim structure was confined to the grains, from the core to the rim. In contrast, oxygen vacancies in the grains without core-rim structure migrated across the grain boundaries to the cathodic region. Core-rim structure could delay oxygen vacancy migration to prolong the lifetime.

Fault Detection and RUL Estimation for Railway HVAC Systems Using a Hybrid Model-Based Approach

Heating, ventilation, and air conditioning (HVAC) systems installed in a passenger train carriage are critical systems, whose failures can affect people or the environment. This, together with restrictive regulations, results in the replacement of critical components in initial stages of degradation, as well as a lack of data on advanced stages of degradation. This paper proposes a hybrid model-based approach (HyMA) to overcome the lack of failure data on a HVAC system installed in a passenger train carriage. The proposed HyMA combines physics-based models with data-driven models to deploy diagnostic and prognostic processes for a complex and critical system. The physics-based model generates data on healthy and faulty working conditions; the faults are generated in different levels of degradation and can appear individually or together. A fusion of synthetic data and measured data is used to train, validate, and test the proposed hybrid model (HyM) for fault detection and diagnostics (FDD) of the HVAC system. The model obtains an accuracy of 92.60%. In addition, the physics-based model generates run-to-failure data for the HVAC air filter to develop a remaining useful life (RUL) prediction model, the RUL estimations performed obtained an accuracy in the range of 95.21–97.80% Both models obtain a remarkable accuracy. The development presented will result in a tool which provides relevant information on the health state of the HVAC system, extends its useful life, reduces its life cycle cost, and improves its reliability and availability; thus enhancing the sustainability of the system.

Exotic forage grasses in the Brazilian semi-arid region: Forage mass, competitiveness, and botanical similarities of non-native pastures

This study evaluated the competitiveness and productivity of four non-native grass species from Africa introduced in the Brazilian semi-arid region. The experiment had a randomized block design with four replications. The grasses evaluated were Cenchrus ciliaris L., Digitaria pentzii Stent, Urochloa mosambicensis Hackel Dandy, and Megathyrsus maximus (Jacq.) B. K. Simon & S. W. L. Jacobs. Megathyrsus maximus and Urochloa mosambicensis showed the best combination of greater forage mass per harvesting (1818 and 1141 kg dry matter (DM) ha−1 per 35-day, respectively) and lesser herbage accumulation of weeds (453 and 156 kg DM ha−1 per 35-day, respectively). Despite the differences in suppressing the weed mass between different non-native grass species, all grasses showed a considerable level of similarity between their floristic composition (family-level 70%, species-level 60%). All pastures were characterized by a higher number of herb weeds than shrubs and trees, however, there was more mass accumulation from shrubs. The tallest grass in the study (Megathyrsus maximus), and the one with the best dispersing capacity (Urochloa mosambicensis), showed advantages in outcompeting the native weeds and accumulate forage mass. The intense incidence of broad-leaf shrub species must be taken as a signal of the initial stages of pasture degradation and ecological succession.

Preparation of heat resistant boron-containing phenyl silicone oil and its initial degradation mechanism in air

Boron-containing phenyl silicone oil (BCPSO) with terminal boronic hydroxyl groups was synthesized by acid-catalyzed balance condensation polymerization using phenylboric acid, dimethyldichlorosilane and diphenyldichlorosilane as raw materials. The structure of BCPSO was characterized by 1H, 13C and 29Si nuclear magnetic resonance (NMR) and Fourier transform infrared spectrometry (FTIR). The thermal degradation behavior of BCPSO was tested by thermogravimetry-Fourier transform infrared spectrometry (TG-FTIR) analysis. The TG-FTIR results indicated that thermal decomposition of BCPSO had significant hysteresis over that of phenyl silicone oil. The empty electron orbital of boron atom could accept electron of peroxide free radical to generate conjugation effect at initial degradation stage of BCPSO, and this phenomenon was confirmed by 11B NMR, FTIR and Raman spectroscopies. As a result, temporarily stable intermediate was formed which increased the heat resistant of BCPSO.

Accelerated liquefaction of vulcanized natural rubber by thermo-oxidative degradation

Liquefaction of vulcanized natural rubber presents a high value-added way out to the challenge of ever-increasing waste rubber. In this work, accelerated liquefaction of vulcanized natural rubber (NR) into liquid rubber through thermo-oxidative degradation was carried out at 210 ℃ in 15 min. The structural evolution of degraded NR was characterized by attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), elemental analysis (EA) and X-ray photoelectron spectroscopy (XPS). The results showed that vulcanized NR underwent a rapid process of oxygen absorption at the initial stage of degradation, which led to fast liquefaction. It was also illustrated by more oxygen-containing functional groups (–S=O and –C=O) increased with time in the liquid rubber. The Mn of the sol part sharply decreased to 1.259 $$\times$$ 104 g mol−1 in 15 min. The volatile gases generated in the degradation process were characterized by thermogravimetric analysis coupled with Fourier transform infrared spectroscopy and mass spectrometry. These results indicated that the liquid rubber was obtained by efficient oxidative scission of the cross-linked sulfur bonds and the main chains. A liquefaction mechanism of vulcanized NR was proposed, which was also confirmed by density functional theory (DFT) calculations. This study provides a promising efficient approach to liquefy waste NR into a raw material for the recycling circle of rubber.

A Cracking Model for Reinforced Concrete Cover, Taking Account of the Accumulation of Corrosion Products in the ITZ Layer, and Including Computational and Experimental Verification.

The paper presents the finite element method model (FEM) which allows the forecasting of the evolution of damage in a concrete cover together with experimental verification of the model. The objective of the model is to define the corrosive volume strain tensor rate effected by corrosion, which comprises the accumulation of corrosion products in pore spaces as well as in micro-cracks which develop at the initial stage of cover degradation. The propagation of damage in the contact zone was captured by taking into account the function describing the degradation of the interface transition zone depending on the cover tightening time–critical time. The method of determining the critical time along with the method of taking into account the effective electrochemical equivalent of iron was also analyzed in this paper. The work presents the experimental verification of the model using an accelerated corrosion test of reinforcement in concrete and strain measurements with optical methods. The conducted tests demonstrate satisfactory compliance of the model with the test results.

(Invited) Selective Response of Magnesium Corrosion Inhibitors Incorporated in PEO Coatings

Corrosion inhibitors are the integral components of protective coatings used by aerospace, automotive, and consumer goods industries. Despite recent achievements in discovering new, effective magnesium corrosion inhibitors [1,2], the quest to replace the highly effective but carcinogenic Cr(VI) from corrosion inhibiting processes continues and has now become urgent. Plasma electrolyte oxidation (PEO), also known as Micro-Arc Oxidation (MAO), is widely used to form coatings on magnesium with reasonable wear and corrosion resistant properties. Unexpectedly, we found out that not all of the corrosion inhibitors, efficient for a bare magnesium alloy, can effectively inhibit its corrosion once loaded in PEO coating. In an effort to unravel the mechanism behind this phenomenon and to formulate the criteria for selecting inhibitors that maintain their efficiency in PEO coatings, a number of inhibitor-loaded PEO coatings have been synthesized. Several electrochemical and surface analysis techniques were used to thoroughly characterize the reference PEO, those loaded with the corrosion inhibitors, and compare all PEO-based coatings with the Chromate Conversion Coating as an industrial reference.Electrochemical Impedance Spectroscopy (EIS) was the main method to rank the corrosion protection properties of the inhibitor-loaded PEO coatings. The inhibitors were ranked based on their ability to suppress the corrosion onset of inhibitor-loaded PEO coating. ToF-SIMS and XPS characterization exposed that specific magnesium corrosion inhibitors can promote fast formation of conversion layer that assures further corrosion inhibition. This, however, does not occur on the ceramic-like surface of PEO that, at first approximation, can be represented as MgO/Mg(OH)2. On the contrary, effective adsorption or precipitation inhibitors typically maintain their inhibiting efficiency once loaded in PEO coatings.In particular, one of the salicylate derivatives, 4-methyl-salicylate, shown to be prone to chemisorption on Mg [3,4], revealed high inhibiting efficiency on both: bare and PEO treated magnesium. The SVET measurements coupled with time lapse optical microscopy revealed the initial stages of PEO degradation followed by the outbreak of filiform corrosion and its decay observed only for the sample protected by the inhibitor-loaded PEO coating. The reference PEO sample resisted the corrosion outbreak for ca. 45h, which is only 10 hours less that the inhibitor-loaded PEO sample, but once the filiform corrosion started it remained in its active phase for the duration of the measurement, 94 hours. Surprisingly, the sample protected by the Chromate Conversion Coating revealed persistent, albeit moderate, corrosion activity throughout the measurement. In contrast, the sample containing the corrosion inhibitor, 4-methyl-salicylate, demonstrated the active corrosion protection evident from the decay of the initial filiform corrosion. The second event of filiform corrosion also faded away after some hours of activity. This clearly demonstrates the active corrosion protection provided by the inhibitor-loaded PEO coating. The inhibitor loaded PEO coating revealed a corrosion protection superior to that provided by the industrially accepted Chromate Conversion Coating.The criteria of an effective corrosion inhibitor for PEO-coated magnesium will be discussed based on the inhibitor interaction with the bare magnesium and PEO coating. Acknowledgement The authors acknowledge the financial support of the following projects: H2020 Clean Sky 2 “Almagic” Grant Agreement Number 755515, and HZG IDEA project MMDi. Di Mei thanks China Scholarship Council for the award of fellowship and funding (No. 20160704051).

Peculiar failure mechanisms in GaN power transistors

Commercial GaN power amplifiers for RF applications, made of a pair of discrete transistors for operation in Doherty configuration, failed during the HAST tests. Failure Analysis pointed out a layout-specific issue related to thermal expansion at the level of the field plates. Anyway, the search for initial degradation stages using Optical Beam Induced Resistance Change and Photon Emission Microscopy revealed a subtle second mechanism, involving Ga interdiffusion into the gate metal lines, coming from hollow pipes in GaN. Both mechanisms are discussed.

Topochemical and light microscopic investigations of non-enzymatic oxidative changes at the initial decay stage of furfuryl alcohol-modified radiata pine (Pinus radiata) degraded by the brown rot fungus Rhodonia placenta

The aim of this study was to visualize non-enzymatic oxidative degradation damages in the initial decay stage of the brown rot fungus Rhodonia placenta degradation in furfuryl alcohol (FA) modified wood cell walls and untreated wood cell walls of radiata pine (Pinus radiata) sapwood. A decay test with small wood blocks (1.5 × 1.5 × 5 mm³) of untreated and furfurylated radiata pine selected from two different furfurylation processes was performed until the first mass loss occurred. The samples were exposed to the brown rot fungus R. placenta, monitored by light microscopy and analyzed topochemically by cellular UV microspectrophotometry (UMSP). The results showed that the FA modification process directly influenced: i) the fungal colonization and hyphal growth, ii) the spectral UV behavior, and iii) degradation patterns of the entire cell wall layers. For the first time, UMSP area scans and selective line scans of individual cell wall regions provide topochemical insights into oxidative degradation at the initial decay stage of furfuryl alcohol-modified P. radiata visualizing oxidative degradation in situ. Knowledge of the initial decay stage of brown rot degradation in FA-modified wood compared to untreated wood extends our understanding of the brown rot decay processes of cell wall compounds.

Impact of intermediate products on benzene photocatalytic oxidation in pulp mills: Experimental and adsorption simulation study

The refractory benzene is revealed in the gaseous pollutants of pulp mills. Although it can be decomposed by photooxidation, the intermediates impact during benzene photooxidation needs to be studied comprehensively. Herein, the benzene photocatalysis was investigated in a reactor with nano-TiO2 colloid under different reaction conditions. The adsorption behavior of mixed benzene and intermediates on TiO2 (101) surface was simulated based on density functional theory, and the influencing mechanism of intermediates was also investigated. Experimental results showed that benzene degradation rate firstly stabilized and then decreased at high initial concentration, accompanying the photocatalyst deactivation and conversion of intermediates into aliphatic carboxylates. Adsorption simulations showed that benzene adsorption was promoted firstly and weakened finally due to the formations of several intermediates. Combined experimental results, adsorption simulation and influencing mechanisms showed that, the enhanced benzene adsorption and weakened photocatalysis contributed to a high and stable rate in the initial stage of benzene degradation. Then, the formed intermediate products weakened the adsorption and photocatalytic reaction of benzene, causing the decrease of degradation rate. The formed aliphatic carboxylates occupied almost all adsorption and catalytic sites, leading to the deactivation of nano-TiO2 photocatalyst. This study provides a comprehensive understanding of intermediates impact on benzene photooxidation.

Albumins inhibit the corrosion of absorbable Zn alloys at initial stages of degradation

Understanding the surface interactions and reactivity of zinc (Zn)-based biomaterials with constituents of physiological fluids such as proteins and ions is essential for an accurate evaluation of biomaterial corrosion initiation and progression. In this paper, the effect of the albumin addition on the corrosion behavior of pure Zn and Zn–4Ag alloy is discussed. The corrosion behavior of Zn-based materials was studied using potentiodynamic polarization, electrochemical impedance spectroscopy, immersion tests and X-ray photoelectron spectroscopy. It was found that the addition of albumins largely affects the chemical composition, morphology and compactness of the protective films formed on biomaterials. A shift of the corrosion regime from localized to more general was observed in the protein-containing electrolytes. The proteins acted as corrosion inhibitors, reducing the corrosion current density and promoting passivation of the metallic surfaces. The increase in the corrosion resistance of the Zn–4Ag alloy is attributed to a selective Zn ion leaching that leaves the metal surface enriched with electrochemically more stable alloying element.

Фильтрат полигонов ТКО: образование, характеристика и обезвреживание

The present article discusses the negative impact of municipal solid waste (MSW) landfills on the environment due to the migration of leachate formed during waste decomposition. The leachate contains an extensive list of pollutants that migrates in soils, surface and underground waters. The article provides a review of literature regarding the main stages of leachate formation and changes in its chemical composition during the landfill’s life cycle. Landfill waste undergo biogeochemical decomposition in aerobic and anaerobic conditions. At the initial stages of waste degradation, easily decomposable organic compounds oxidize leading to high values of chemical and biological oxygen demand (COD and BOD) in the formed leachate, lowering the pH of the medium to 4-5. This in turn leads to the transition of metal ions to the liquid phase due to an increase of their activity in acidic mediums. In anaerobic conditions, further waste degradation takes place producing carbon dioxide, methane, ammonia, mercaptans, hydrogen sulfide, organic acids and water. In the leachate formed after 10 years of landfill operation, the content of organic carbon decreases, the fraction of bioresistant components increases, the pH of the medium increases to 7.5-8.5, metal ions form hardly soluble compounds and sulfates are reduced to sulfides. The chemical composition of the leachate, presented in this article, demonstrates its changes depending on the stage of the landfill’s life cycle. Also, basic schemes of treatment plants for MSW leachate used in Russia and abroad are described based on a combination of traditional wastewater treatment methods (mechanical, biological and physicochemical methods).

Damage to porous SiCOH low-k dielectrics by O, N and F atoms at lowered temperatures

Information on the degradation of porous organosilicate glasses (OSGs) by active radicals and atoms is of high importance for their integration as low-k dielectrics in the next generation of ultra large scale integration (ULSI) production. The films’ degradation is caused by depletion of coverage of the pore surface methyl. OSG samples with differing porosities and pore sizes were treated by O, N, and F atoms at lowered temperatures (down to −45 °С) downstream of O2, N2, and SF6 inductively coupled plasma discharges, respectively. It has been shown that lowering the temperature reduces film degradation. In the case of O atoms, this reduction is insignificant, while the effect is much more noticeable for F atoms. In addition, an accumulation of F atoms forms a fluorocarbon layer during F atom treatment. The accumulated fluorine can interact with surface Si atoms, giving rise to film etching. The film degradation under O and F atoms increases with pore size and porosity, due to deeper atom penetration. In the case of N atoms, even a small temperature reduction essentially decreases OSG degradation, while –CH3 modification is less clear in the cases of O and F atoms. Density functional theory and ab initio molecular dynamics simulations of reaction mechanisms show that atom reactions with surface Si–CH3 groups are the initial stages of OSG degradation. Subsequent mechanisms include branched reaction pathways with the formation, modification, and destruction of different surface groups. In the cases of O and F atoms, these reactions lead to the formation of HxCО and CFx bonds. For the direct reaction of N(4S) atoms with –СН3 groups, significant activation energy is required. Under downstream plasma conditions, –СН3 groups are destroyed in reactions with metastable particles, and first of all, with metastable atoms N(2D), N(2P) and molecules , which are also produced inside the pores in the surface recombination of nitrogen atoms.

Density Functional Theory Study of the Initial Stages of Cl-Induced Degradation of α-Cr2O3 Passive Film

The ion exchange and point defect models are two prominent models describing the role of anions, such as chlorides, in the degradation of passive oxide films. Here the thermodynamic feasibility of critical steps of Cl-induced degradation of a hydroxylated α-Cr2O3 (0001) surface, as proposed by these two models, are studied. Both models begin with Cl substitution of surface OH and H2O, which becomes less favorable with increasing Cl coverage. The initial stages of Cl-induced breakdown of the α-Cr2O3 depend on Cl coverage and the presence of O vacancy near the surface as follows: (1) neither Cl insertion (supporting the ion exchange model) nor Cr vacancy formation (supporting the point defect model) is feasible at low Cl coverages except in the presence of O vacancies near the surface, where Cl insertion is thermodynamically feasible even at low coverages, (2) in the absence of O vacancies, Cr vacancy formation becomes feasible from 10/12 ML onwards whereas Cl insertion by exchange with subsurface OH only becomes feasible at full coverage. This implies that at higher coverages Cl-induced degradation first initiatesthrough a vacancy formation mechanism, but both insertion and vacancy formation would be feasible at full coverage.

Density functional theory and experimental study of cellulose initial degradation stage under inert and oxidative atmosphere

Lignocellulose oxidative degradation at low temperature is an important question in fire disaster and biomass utilization. Experimental and theoretical methods were used to investigate the initial stage of cellulose degradation under inert and oxidative atmosphere. TG-FTIR results show that the initial degradation and peak temperatures were lower in oxidative atmosphere. CO2 became the dominant component under oxidative atmosphere, which was attributed to the oxidation of carbon element. Oxygen promoted the formation of acids and aldehydes (-CO) but decreased the yields of alcohols/ethers (-C-O-). Density functional theory calculation results show that thermal cleavage of glucosidic bond is endothermic reaction. The chemisorption of oxygen with reactive cellulose radical released a great amount of heat that drove cellulose pyrolysis to an exothermic process. The formation of lactone structure is a kind source of CO2. Experimental and theoretical results agree with each other well and a possible cellulose oxidative pyrolysis pathway was put forward.

Inverted Hydration Layers on Bio-Magnesium Surfaces in the Initial Degradation Stage and their Influence on Adsorption of Amino Acid Analogues: The Metadynamics Simulations.

Deeply exploring the interaction of biomolecules with magnesium in solution is essential to understand the formation of complex bio-magnesium interfaces accompanied with corrosion products. Using the accelerated metadynamics simulations, we have investigated the interactions of amino acid analogues on clean and hydroxylated Mg(0001) surfaces by identifying their free energy barriers and adsorption sites. We find that there are two hydration layers stacked on the clean Mg(0001) surfaces and the hydroxylated Mg(0001) surfaces, which mainly determine the free energy barriers and adsorbed configurations. Further studies reveal that the water molecules in double hydration layers present two opposite orientations, depending on the charge distribution of the substrate. Specifically, oxygen atoms of water concentrate in the center of double hydration layers for a clean Mg surface but transfer to the outside surface once the Mg substrate is degraded. The reversed hydration layers greatly reduce the binding affinities of positively charged and electroneutral analogues. Overall, our simulation findings provide new insights into the interaction mechanism of biomolecules on a bio-magnesium device in the implantation initial stage, which is noteworthy for revealing the magnesium degradation mechanism in vivo.

TCAD simulations and accurate extraction of reliability-aware statistical compact models

In this paper, we focus on the TCAD simulation and accurate compact model extraction of the time evolution of statistical variability in conventional (bulk) CMOS transistors, due to bias temperature instability (BTI). The 25-nm physical gate length MOSFETs, typical for 20 nm bulk CMOS technology, are used as test-bed transistors to illustrate our approach. Statistical physical simulations of fresh devices and devices at initial, middle and final stages of BTI degradation are performed and the corresponding nominal and statistical compact models are extracted using a two-stage extraction strategy. The extracted compact models not only accurately capture time evolution of the statistical distribution of the key MOSFET figures of merit, but also the complex correlations between them. An excellent agreement with the original physical TCAD simulation results provides a high degree of confidence that the extracted compact models deliver accurate representation of the operation of each device for the purposes of reliable circuit simulation and verification.

Zn-Mg Biodegradable Composite: Novel Material with Tailored Mechanical and Corrosion Properties.

Zinc-based alloys represent one of the most highly developed areas regarding biodegradable materials. Despite this, some general deficiencies such as cytotoxicity and poor mechanical properties (especially elongation), are not properly solved. In this work, a Zn-5Mg (5 wt.% Mg) composite material with tailored mechanical and superior corrosion properties is prepared by powder metallurgy techniques. Pure Zn and Mg are mixed and subsequently compacted by extrusion at 200 °C and an extrusion ratio of 10. The final product possesses appropriate mechanical properties (tensile yield strength = 148 MPa, ultimate tensile strength = 183 MPa, and elongation = 16%) and decreased by four times the release of Zn in the initial stage of degradation compared to pure Zn, which can highly decrease cytotoxicity effects and therefore positively affect the initial stage of the healing process.