Influence Of Osteoporosis Research Articles

The Impact of Strontium Ranelate on Implant Osseointegration of Osteoporosis in Vivo Experiment

Objective: To investigate the impact of strontium ranelate on implant osseointergration of osteoporotic rats in vivo experiment. Method: Thirty-six female rats were randomly divided into three groups: ovariectomization group (A=12), strontium ranelate low-dose treatment group (B=12) and strontium ranelate high-dose treatment group (C=12). After the success of the osteoporosis model building, HA coated titanium implants were inserted into proximal metaphyses of tibiae, meanwhile, the rats of group B and C received oral medication of strontium ranelate (B: 450 mg/kg.d C: 900 mg/kg.d), 12 weeks after surgery, animals were killed and decalcified sections were prepared and examined histologically and histomorphometrically, as well as micro-CT examination. Results: 12 weeks after implantation surgery, bone mineral density (BMD), implant bone contact rate (IBCR) and new bone volume (NBV) in group B and C were significantly higher compared with group A (p<0.01). Conclusion: Strontium ranelate may resist the negative influence of osteoporosis and promote osseointergration of implant.

Influence of osteoporosis on the osteocyte density of human mandibular bone samples: a controlled histological human study.

Osteocytes have emerged as key regulators of skeletal and mineral homeostasis. The number of these cells could be influenced by the presence of osteoporosis and osteopenia. Hence, the aim this study was to evaluate the osteocyte density in patients with osteopenia, and in patients with osteoporosis treated with bisphosphonates. Thirty-nine patients were selected for this study and divided into three groups: (A) nine healthy patients (control), (B) 15 patients with osteopenia, and (C) 15 patients with osteoporosis. During the surgical insertion of dental implants in the lower jaw, bone samples were retrieved and processed for histological analysis of osteocyte density, measured as number of osteocytes/bone tissue area (μm(2) ). Patients with osteopenia showed statistically higher values of osteocyte density than patients with osteoporosis (P<0.05) No significant differences were detected between osteopenia and osteoporosis subjects vs. healthy patients (P>0.05). Bone metabolism diseases (osteoporosis and osteopenia) do not seem to influence the osteocyte density; this could be due to the administration of bisphosphonates in patients with osteoporosis. This information could play a fundamental role in the diagnosis and treatment of patients in a postmenopausal stage.

Increase of TRPV1-immunoreactivity in dorsal root ganglia neurons innervating the femur in a rat model of osteoporosis.

PurposeTransient receptor potential vanilloid 1 (TRPV1) is a ligand-gated nonselective cation channel, which can be activated by capsaicin and other noxious stimuli. Recently, an association between bone pain and TRPV1 has been reported. However, the influence of osteoporosis on TRPV1 in the sensory system innervating the femur has not been reported.Materials and MethodsTRPV1-immunoreactive (ir) in dorsal root ganglia (DRG) neurons labeled with neurotracer [Fluoro-Gold (FG)] innervating the femurs of Sprague Dawley rats were examined in control, sham, and ovariectomized (OVX) rats. We evaluated osteoporosis in the femurs and compared the proportion of TRPV1-ir DRG neurons innervating femur between the 3 groups of rats.ResultsOVX rats showed osteoporotic cancellous bone in the femur. FG labeled neurons were distributed from L1 to L6 DRG, but there was no significant difference in the proportion of labeled neurons between the 3 groups (p>0.05). The proportions of FG labeled TRPV1-ir DRG neurons were 1.7%, 1.7%, and 2.8% of DRG neurons innervating the femur, in control, sham-operated, and OVX rats, respectively. The proportion of TRPV1-ir neurons in DRG innervating the femur in OVX rats was significantly higher than that in control and sham-operated rats (p<0.05).ConclusionUnder physiological conditions, DRG neurons innervating femurs in rats contain TRPV1. Osteoporosis increases the numbers of TRPV1-ir neurons in DRG innervating osteoporotic femurs in rats. These findings suggest that TRPV1 may have a role in sensory perception of osteoporotic femurs.

Smoking, radiotherapy, diabetes and osteoporosis as risk factors for dental implant failure: a meta-analysis.

BackgroundThere are conflicting reports as to the association between smoking, radiotherapy, diabetes and osteoporosis and the risk of dental implant failure. We undertook a meta-analysis to evaluate the association between smoking, radiotherapy, diabetes and osteoporosis and the risk of dental implant failure.MethodsA comprehensive research on MEDLINE and EMBASE, up to January 2013, was conducted to identify potential studies. References of relevant studies were also searched. Screening, data extraction and quality assessment were conducted independently and in duplicate. A random-effects meta-analysis was used to pool estimates of relative risks (RRs) with 95% confidence intervals (CIs).ResultsA total of 51 studies were identified in this meta-analysis, with more than 40,000 dental implants placed under risk-threatening conditions. The pooled RRs showed a direct association between smoking (n = 33; RR = 1.92; 95% CI, 1.67–2.21) and radiotherapy (n = 16; RR = 2.28; 95% CI, 1.49–3.51) and the risk of dental implant failure, whereas no inverse impact of diabetes (n = 5; RR = 0.90; 95% CI, 0.62–1.32) on the risk of dental implant failure was found. The influence of osteoporosis on the risk of dental implant failure was direct but not significant (n = 4; RR = 1.09; 95% CI, 0.79–1.52). The subgroup analysis indicated no influence of study design, geographical location, length of follow-up, sample size, or mean age of recruited patients.ConclusionsSmoking and radiotherapy were associated with an increased risk of dental implant failure. The relationship between diabetes and osteoporosis and the risk of implant failure warrant further study.

Influence of osteoporosis on wear particles-induced osteolysis in animal model

Objective To study the influence of osteoporosis (OP) on wear particles-induced osteolysis in an animal model.Methods Forty-two female Sprague-Dawley (SD) rats aged 6 months were randomly divided into 3 groups:A,B and C.Groups A and B contained 18 rats each,and group C contained 6 rats.The rats in group A were operated by bilateral ovariectomy,no operation was done on rats of group B,and that in group C was sham.After 3 months,6 rats in group A,6 rats in group B and all the rats in group C were harvested.Bone mineral density (BMD),μCT and bone histomorphometry were analyzed.The rest of rats in group A were randomly divided into two subgroups:subgroup A1 and subgroup A2,and the same as group B.Five mg titanium particles were implanted onto the calvaria of subgroups A1 and B1,and PBS was injected to subgroups A2 and B2.Calvarias were harvested after 14 days and analyzed by μCT,and histomorphometry was done to measure the osteolysis area of calvarial sagittal suture.Results As compared with groups B and C,BMD and bone histomorphometry index in A group were significantly reduced (P ＜ 0.05).The area of calvarial sagittal suture osteolysis was (0.262 ± 0.009),(0.130±0.013),(0.307±0.013) and (0.178 ±0.011) mm2 in subgroups A1,A2,B1 and B2 respectively.There was significant difference among the groups.Conclusion Ostoporosis may reduce the particles-induced osteolysis in a rat model. Key words: Osteoporosis; Prosthesis; Osteolysis

Evaluation of inorganic profile and anti-nutritional values of Cocculus hirsutus

The influence of osteoporosis on fracture healing is a complex phenomenon. Oxidative stress is considered as a pathogenic factor for bone loss and delayed fracture healing. Piper sarmentosum is known to possess an antioxidant and anti-inflammatory properties. This study aimed to investigate the fracture healing properties of P. sarmentosum aqueous extract in ovariectomised rats by observing changes in the biomechanical properties of femora. Forty female Sprague-Dawley rats (200 to 250 g) assigned into 4 groups: Sham-operated; ovariectomised-control; ovariectomised + conjugated equine oestrogen, 100 µg/kg/day, and ovariectomised + P. sarmentosum extract, 125 mg/kg/day. All the rats underwent mid-diaphyseal closed fracture of the right femur with K-wire fixation 6 weeks postovariectomy. Following the fracture, all the rats received the aforementioned treatment orally for 6 weeks. Biomechanical analysis revealed that, the flexure load, flexure stress and Young’s modulus for the P. sarmentosum -treated group increased significantly compared to the control group (P 0.05). The biomechanical strength parameters in the sham, oestrogen and P. sarmentosum groups were identical (P>0.05). In conclusion, effective supplementation of P. sarmentosum extract restored the biomechanical property of the healed bone. Hence, it may be beneficial for fracture healing in the oestrogen deficient state.

The influence of osteoporosis in femoral fracture healing time

In order to assess the effect of osteoporosis on healing time we retrospectively reviewed the files of 165 patients with femoral shaft fractures that were treated in our service by locked, intramedullary nailing. Patients were divided in two age groups; Group A (study group) consisted of patients over 65 years old with radiological evidence of osteoporosis and group B (control group) of patients between 18 and 40 years old with no signs of osteoporosis. Sixty-six out of 165 patients fulfilled the inclusion criteria for this study. Patients with open fractures, pathological fractures, revision surgery, severe brain injuries, prolonged ITU stay and severe co morbidities were excluded. Twenty-nine patients were classified in group A and 37 in group B. All patients had been assigned the Injury Severity Score (ISS) and had been followed-up clinically and radiographically until fracture union. In all patients the Singh Index Score for osteoporosis was assigned. In all group A patients Singh score 4 or less was assigned, suggesting the presence of installed osteoporosis, whereas group B patients were assigned with Sighn score 5 or 6. Fracture healing was significantly different between the groups. Fractures of Group A healed in 19.38±5.9 weeks (12–30) and in group B 16.19±5.07 weeks (10–28) (P=0.02) Fracture healing of nailed femoral diaphyseal fractures significantly delays in older osteoporotic patients. Further studies are mandatory to clarify the exact impact of osteoporosis in the whole healing process and the possible future therapeutic strategies.

The influence of osteoporosis in femoral fracture healing time

Aim In order to assess the effect of osteoporosis on healing time, the files of 165 patients with femoral shaft fractures that were treated in our institution with locked-reamed intramedullary nailing were retrospectively reviewed. Patients and methods Patients with open fractures, pathological fractures, revision surgery, severe brain injuries and prolonged ITU stay were excluded. In all patients the Singh-index score for osteoporosis and the canal bone ratio (CBR) were assigned. Sixty-six patients fulfilled the inclusion criteria. Patients were divided into two groups; group A (29 patients) consisted of patients over 65 years old with radiological evidence of osteoporosis and group B (37 patients) of patients between 18 and 40 years old with no signs of osteoporosis. Results In all group A patients Singh score ≤4 and CBR > 0.50 were assigned, suggesting the presence of osteoporosis, whereas all group B patients were assigned with Singh score ≥5 and CBR < 0.48. Fractures of group A healed in 19.38 ± 5.9 weeks (12–30) and in group B 16.19 ± 5.07 weeks (10–28), P = 0.02. Conclusions Fracture healing of nailed femoral diaphyseal fractures is significantly delayed in older osteoporotic patients. Further studies are required to clarify the exact impact of osteoporosis in the whole healing process.

Influence of Osteoporosis on Bone Formation by Bone Morphogenetic Protein-2

Influence of Osteoporosis on Bone Formation by Bone Morphogenetic Protein-2

Significance of osteoporosis in craniomaxillofacial surgery: A review of the literature

Osteoporosis is a common problem in orthopedic surgery. The purpose of this review of the literature was to examine whether osteoporosis is also an important factor in patient treatment in the field of craniomaxillofacial surgery. Emphasis was given to the consequences of osteoporosis for the maxilla and mandible, the influence of osteoporosis on fracture treatment, the use of dental implants, the importance of soft tissues and the effect of osteoporosis therapies. It was found that osteoporosis does affect the bones of the skull. The effect of osteoporosis on treatment, however, is controversial and necessitates better ways of quantifying bone loss. Large inter-individual and site-specific differences in bone density, as well as other effects such as removal of teeth, periodontitis, implant insertion, augmentation procedures and altered loading with dystrophic consequences need to be considered in future studies. Special attention should be given to osteoporosis during fracture treatment.

The Influence of Osteoporosis on the Marital Relationship of Older Couples

Thirty-four older wives and their husbands participated in interviews about adaptation to the wives’osteoporosis and its influence on their relationship. For most couples, the wives’osteopo-rosis resulted in changes in the structure of their marital relationship but not the overall quality of the marriage. Discrepancies in pain perceptions were associated with lower marital adjustment for wives but not for husbands. The findings suggest the need to focus on the dynamics of the marital relationship to understand chronic illness in late-life families.

Osteoporosis impairs fracture healing of tibia in a rat osteoporotic model

To evaluate the influence of osteoporosis on fracture healing. Eighty-four 4 months old female Sprague-Dawley rats were randomly divided into osteoporosis (OP) group and sham operation (SO) group, 42 in each. Rats in OP group were performed ovariectomy operation while those in SO group with sham operation. When osteoporosis formed 10 weeks after ovariectomy, midshaft tibia fracture model was established. Tibias were harvested 2 weeks (2 rats per group), 4 weeks (9 rats per group), 6 weeks (9 rats per group), 12 weeks (9 rats per group) and 18 weeks (7 rats per group) after fracture for bone mineral density (BMD), histomorphological and biomechanical evaluation. Compared with the SO group: (1) Callus BMD was significantly lower about 12.8%, 18.0%, 17.0% in OP group 6, 12, 18 weeks after fracture, respectively (P < 0.05). (2) Callus failure load was significantly lower about 24.3%, 31.5%, 26.6%, 28.8% in OP group, and callus failure stress was also significantly lower about 23.9%, 33.6%, 19.1%, 24.9% in OP group 4, 6, 12, 18 weeks after fracture, respectively (P < 0.05). (3) In OP group, endochondral bone formation was delayed, more osteoclast cell could be seen around the trabecula, and the new bone trabecula arranged loosely and irregularly. Osteoporosis influences the middle and late periods of fracture healing in the rat osteoporostic model. The impairment is considered to be the result of the combined effects of the prolonged endochondral calcification, high activated osteoclast cell and the deceleration of the increase in bone mineral density.

卵巣摘出ラットにおける下顎骨実験的骨欠損の修復に関する研究

The incidence of osteoporosis has been increasing with the increase in the number of elderly. Osteoporosis is a disease characterized by low bone mineral density (BMD), and the age of patients who require dental implant matches the age of patients with osteoporosis.The influence of osteoporosis on the healing of an experimental bone defect in the mandible of rats was studied. Twenty-six-week-old female Sprague-Dawley rats underwent ovariectomy or a sham operation. Eight weeks after the operation, experimental bone defect was prepared in the left mandible of all rats by the guided bone regeneration (GBR) method. The left mandible of the rats was extracted at 2, 4 or 6 weeks after the operation, and the degree of bone healing in the experimental bone defect was evaluated by soft X-ray photography of the extracted left mandible followed by image analysis.It was found that osteoporosis induced by ovariectomy has a negligible effect on the healing of experimental bone defect in the mandible. The result suggested that osteoporosis of the cortical area of the mandible is slow and less as compared with that of other long bones.

The influence of osteoporosis in trauma

Osteoporosis is a descriptive term for a loss of bone mass and structure which predisposes to fracture in response to minimal trauma. These fractures cause pain, disability and significant mortality, with enormous resource costs to health and other services. Proximal femoral (hip) fractures account for most of the mortality and cost, and an estimated six million osteoporosis-related hip fractures occur world-wide each year, a number likely to increase dramatically due to changes in population demographics. The diagnosis of osteoporosis should be considered in all patients over the age of 50 years who sustain a fracture, unless there is obvious major trauma. Not only will this inform immediate management but it also allows measures aimed at prevention of further fractures to be implemented. Early surgery is often effective in limiting morbidity from osteoporotic fractures and in older people is best planned in collaboration with other health care professionals.

The influence of osteoporosis in trauma

The influence of osteoporosis in trauma