Moderate Influence Research Articles

VILLAGE SAVINGS AND LENDING ACTIVITIES (VSLAs) AND SOCIO-ECONOMIC TRANSFORMATION OF COMMUNITY MEMBERS IN RWANDA, A CASE OF MASAKA SECTOR IN KICUKIRO DISTRICT

This project aimed to assess the impact of village savings and lending associations (VSLAs) on socio-economic development of local community in Rwanda, with a particular focus on Masaka Sector of Kicukiro District. More specifically, this project aimed of assessing the VSLAs income generating activities or their main sources of savings in the local community; evaluating the VSLAs types of savings in the local community; evaluating the VSLAs types of lending in the local community; and comparing the socio-economic transformation of the community members before and after joining VSLAs. In the research design, the researcher adopted a descriptive approach and employed a specific case study approach of Masaka Sector in Kicukiro District. For study population, the total study population was 258 members of VSLAs. For sampling, the total sample of 221 was calculated using random sampling technique and for data collection, the researcher used questionnaires and interview guides and for data analysis, the researcher used SPSS. The results showed that VSLAs significantly impacted income sources, prominently empowering agricultural activities (mean = 0.368), while showing moderate influence on trading (mean = 0.319) and lesser impact on handcrafts and tailoring. The results also showed that VSLAs’ savings mechanisms exhibit distinct impacts: emergency and long-term savings display substantial, consistent influences (means = 0.282, 0.395) with differing member engagements. The practical suggestions proposed were that Masaka sector should establish connections with other initiatives, like VUP and BDF, to enhance the socio-economic progress of rural communities. KEYWORDS: Economic development, Income generating activities, social development, types of lending and types of savings

The moderating effect of Social Support on the Relationship between Cultural Intelligence and Cross-Cultural Adjustment of Chinese Expatriates in Ghana

Literature shows that not all individuals are equally suited to embark on a new life in another country, and self-initiated expatriates (SIEs) could be particularly susceptible to failure since they have no support from a home organization. The study sought to examine the moderation role of Social Support in relation to Cultural intelligence (CQ) Cross-Cultural Adjustment of Chinese Self-initiated Expatriates (SIEs) in Ghana. A sample of 400 respondents was selected for the study. Questionnaires were used to collect data via an online survey. Data was analyzed using PLS-SEM for the analysis, PLS algorithms and Bootstrapping tests were performed. Findings suggested that social support acquired by Chinese SIEs from host country citizens had no moderating influence on the relationship between their CQ and their capacity to adapt cross culturally to Ghanaian cultural situations. The study's findings will help SIEs, human resource practitioners, and cross-cultural managers who work with SIEs to understand the requirements for effective cross-cultural management towards reducing expats failure.

Mental Health, Spirituality, and Self-Compassion Among K–12 Music Teachers During the COVID-19 Pandemic

Abstract We examined the influence of gender, age, and death of loved ones due to COVID-19, race/ethnicity, mode of instruction (hybrid, in-person, etc.), general religiosity, dispositional spirituality, and self-compassion among kindergarten through 12th-grade (K–12) music educators (N = 637) in order to assess how these factors impacted their mental health approximately 1 year after the onset of the COVID-19 pandemic. Our findings indicate a weak to moderate influence on mental health attributable to religiosity and spirituality, with feelings of connection to a higher power predicting better mental health while feelings of connection to other human beings and nature predicting the opposite. Additionally, there was a strong and statistically significant relationship between self-compassion and positive mental health, accounting for between a .87 to 1.09 decrease in stress, depression, and anxiety among participants based on one-unit increases in self-compassion. We discuss implications for music education research as well as preservice and in-service professional development based on these findings.

LEADERSHIP PRACTICES AND RISK MANAGEMENT AND ITS RELATIONSHIP WITH SCHOOL PERFORMANCE: EVIDENCE THROUGH PLS-SEM AND IPMA ANALYSIS

A key component of running a tahfiz school is the system of educational governance. A school's reputation can be destroyed and community trust can be lost if it is unable to manage academics, stakeholder satisfaction, internal processes, as well as learning and growth in school. The school's progress towards reaching the Malaysia Education Development Plan 2015-2025, which focuses on producing holistic human capital, will be hampered by ineffective educational governance. Tahfiz school's performance can be enhanced by implementing leadership practices and risk management to address the problem. The purpose of this study was to identify the level of leadership practices and risk management, as well as the level of performance in tahfiz schools. Furthermore, an investigation was conducted into the correlation between leadership practices and risk management with the performance of tahfiz school. This research examines 190 school administrators from Negeri Sembilan, Kedah, Kelantan, Terengganu, Pahang, Perak, Selangor, and Johor through a quantitative survey approach. A series of questionnaires were used as instruments for data collection, and the statistical packages Partial Least Squares Structural Equation Modeling (PLS-SEM) and Statistical Package for Social Science (SPSS) were used for analysis. A descriptive analysis reveals that tahfiz schools perform exceptionally well and have moderate and very high standards for leadership practices and risk management. The results of the structural model test indicate a moderate positive influence of leadership practices (β=0.308, t=4.276, p<0.01, f2=0.132) and a strong positive influence of risk management (β=0.618, t=5.225, p<0.01, f2=0.531) on the performance of tahfiz schools. This study also used IPMA analysis to identify the overall effect, indicating the significance of the risk management dimension in predicting tahfiz school performance. The findings of the study can help the Malaysian Ministry of Education develop a number of efforts to assist the administration of tahfiz school in reaching their goal of 125,000 professional huffaz by the year 2050.

Paranormal beliefs and core knowledge confusions: A meta-analysis

This meta-analysis examines the relationship between paranormal beliefs and Core Knowledge Confusions (CKC), a concept introduced by Lindeman and Aarnio (2007) to explore the link between ontological errors and belief in the paranormal. The CKC, which uses metaphor classification to assess ontological confusion, suggests that cognitive processes organize information into ontologies, and our interpretation of literal versus metaphorical expressions reflects these categorizations. Despite advancements in education, ontological confusion persists, manifesting in various forms like mentalization of matter, physicalization of the mental, and biologization of the mental. Our analysis, encompassing 25 effect sizes with 16,129 participants from 11 countries and publications over 14 years, found a significant average effect size (r = 0.40) in the relationship between paranormal beliefs and the CKC, indicating a robust and consistent association across various populations and contexts. The study observed that contextual factors specific to data from Finland enhance the estimated magnitude of the effect size. Despite considerable heterogeneity and potential influences of unexamined moderators, the results suggest a universal cognitive pattern linking paranormal beliefs with certain types of ontological confusion. This meta-analysis underscores the need for further exploration into contextual variations in understanding the complex relationship between paranormal beliefs and ontological errors.

Analysis of the international competitiveness of domestic metallurgical enterprises

Introduction. The relevance of the research topic is determined by the globalization trends of economic development, the growing competitive activity of enterprises, the increase in competitive tension in world markets, the formation of specific forms of competition. The purpose of the paper is to determine and structure the factors of international competitiveness of domestic metallurgical enterprises at the mega-, macro-, meso- and micro-levels, to identify the most priority positions for winning and maintaining the market. Results. Based on the analysis of the dynamics of metal products production during 2021-2023, the current state of operation of the largest metallurgical enterprises, the dynamics of foreign investments in the metallurgical industry of Ukraine, the main reasons for the deterioration of the competitive positions of the domestic MMC on the international market of metal products are determined. The negative and positive factors that determine the international competitiveness of MMC of Ukraine at the mega-, macro-, meso- and micro-levels are analyzed. The result of the analysis is the conclusion regarding the absolute predominance of the influence of external factors in the conditions of full-scale military aggression of the Russian Federation, the significant dependence of the development of MMC of Ukraine on the state of world markets. And vice versa, domestic metallurgy has an inverse effect on the global production of metal products, because it has significant resource, production and scientific potential. Considering the specifics of metallurgical enterprises, the state of the world economy and globalization processes, the factors of competitiveness of metallurgical enterprises are structured according to the degree of susceptibility to changes in the conditions of globalization (flexible, difficult to change) and according to the degree of influence on the level of global competitiveness (moderate influence, significant impact). Conclusions. The analysis of the factors of international competitiveness of the domestic metallurgy showed that in the conditions of its sharp decline, the priority for the industry is not to lose its own competitive advantages, including through the search and effective use of positive factors of international competitiveness. At the same time, the basis of increasing the international competitiveness of the metallurgical industry is to increase the competitiveness of domestic metallurgical enterprises both on the domestic and international markets. It has been proven that when developing a strategy for increasing international competitiveness, it is appropriate to determine the result of focusing on the factors of a more intensive manifestation of the classification feature, that is, on flexible factors of significant influence.

Problematic smartphone use and academic achievement: A systematic review and meta-analysis.

The present study aimed to synthesize existing quantitative evidence on the relationship between problematic smartphone use (PSU) and academic achievement with a focus on quantifying its magnitude and examining its potential moderators. Eligible studies were searched for up to February 10, 2023 in six different databases (i.e., MEDLINE, Current Contents Connect, PsycINFO, Web of Science, SciELO, and Dissertations & Theses Global). Studies were considered eligible if they provided information derived from self-report instruments that allowed statistical calculation of the relationship between PSU and academic achievement. Pooled effect sizes (r) were computed using a random-effects model. Meta-regressions were conducted to test the influence of study-level moderators on the relationship of interest. Influence analyses and a three-parameter selection model (3PSM) were conducted to examine the robustness of the results and publication bias, respectively. A total of 33 effect sizes from 29 studies (n = 48,490) were retrieved. Results showed a small effect size (r = -0.110), which tended to be larger in samples consisting of students from elementary and middle schools. Findings from the present study contribute to the understanding of a potential determinant of decreased academic achievement by providing evidence that PSU may be one of them.

How Islamic Rural Bank Overcomes the Trade-off Between Sustainability and Outreach: Does Market Competition Matter?

There was no consensus how to deal the trade-off between maintaining sustainability and outreach of microfinance institutions among researchers. The paper provides time series data which includes monthly industry data from Islamic Rural Bank for a period of more than 14 years starting from January 2009 to March 2023. In the first analysis, an estimate of the level of market competition is compute by the Lerner Index (LI) of each period. Furthermore, the efficiency analysis of Data Envelopment Analysis (DEA) is used to measure efficiency which allows estimation of efficiency performance using multiple inputs and outputs to understand how Islamic Rural Bank deal with sustainability and outreach. In the end, a Vector Autoregression/Vector Error Correction Model (VAR/VECM) analysis is used to analyse the relationship between the level of market competition and the efficiency of Islamic Rural Bank in achieving sustainability and outreach objectives. The results of the study suggest that by using a production approach Islamic Rural Bank is able to operate efficiently while maintaining the sustainability and outreach objectives without trade-offs. In addition, market competition has a moderate influence on achieving sustainability goals and their outreach. This research examines how Islamic Rural Bank as one of the microfinances to overcome the trade-off between the goals among high competition and the increasing of financial needs by customers. The Microfinance model from Islamic Rural Banks can be replicated to other microfinance institutions (MFIs) to reach both outreach and sustainability goals.

Ab Initio Electronic, Magnetic, and Optical Properties of Fe Phthalocyanine on Cr2O3(0001).

The organic molecules adsorbed on antiferromagnetic surfaces can produce interesting interface states, characterized by charge transfer mechanisms, hybridization of molecular-substrate orbitals, as well as magnetic couplings. Here, we apply an ab initio approach to study the adsorption of Fe phthalocyanine on stoichiometric Cr2O3(0001). The molecule binds via a bidentate configuration forming bonds between two opposite imide N atoms and two protruding Cr ones, making this preferred over the various possible adsorption structures. In addition to the local modifications at these sites, the electronic structure of the molecule is weakly influenced. The magnetic structure of the surface Cr atoms shows a moderate influence of molecule adsorption, not limited to the atoms in the close proximity of the molecule. Upon optical excitation at the onset, electron density moves toward the molecule, enhancing the ground state charge transfer. We investigate this movement of charge as a mechanism at the base of light-induced modifications of the magnetic structure at the interface.

Limestone filler as a mineral additive on the compressive strength and durability of self-compacting concrete with limestone manufactured sand

Using limestone filler (LF) as a mineral additive of concrete with manufactured sand (MS) raises concerns about the long-term performance because of the high LF content in mixtures, particularly in high-binder content self-consolidating concrete (SCC). Herein, this paper evaluates the effects of LF as a mineral additive on the compressive strength and durability of SCC incorporating manufactured sand (MS_SCC). Results indicate that LF decreases the compressive strength of MS-SCC akin to that observed with FA, albeit with a more moderate decrease observed at a lower w/b ratio. Both LF and FA contribute to decreasing carbonation resistances, while MS_SCC with LF exhibits a gradual reduction in carbonation rate over time. Furthermore, LF reduces the chloride migration resistance of MS-SCC, unlike FA. However, LF improves the drying shrinkage of MS_SCC, particularly notable at a lower w/b ratio. Microstructure analysis indicates that LF induces a coarsening effect on the pore structure of MS_SCC, with a moderate influence observed for mixtures characterized by a lower w/b ratio.

Response of Stand Spatial Structure to Nitrogen Addition in Deciduous Broad-Leaved Forest in Jigong Mountain

Significant influences on tree growth and forest functionality are attributed to nitrogen (N) addition. However, limited research has been conducted on the effects of N addition on forest spatial structure. In this study, we examined the effects of different N addition methods and concentrations on the stand spatial structure of a deciduous broad-leaved forest over the period 2012 to 2017. Five N addition treatments were implemented: CK (control group without N addition), CN25 (low N concentration added to the canopy), CN50 (high N concentration added to the canopy), UN25 (low N concentration added to the understory), and UN50 (high N concentration added to the understory). The results showed a moderate influence of N addition (CN25, CN50, UN25, UN50) on optimizing the stand spatial structure. CN25, CN50, and UN25 increased the mean values of the mingling degree (M) and neighborhood comparison (U), while decreasing the mean value of the uniform angle index (W), although these effects were not significant. Enhancements in the average value of the crowding degree (C) and comprehensive spatial structure index (CSSI) between 2012 and 2017 were found in all five treatments, demonstrating statistical significance. Assessing the distribution of the stand spatial structure index, CN25, CN50, and UN25 increased the proportion of M at an intensity (M = 0.75) and extreme intensity (M = 1), while decreasing the proportion at zero intensity (M = 0), weak intensity (M = 0.25), and moderate intensity (M = 0.5). A decrease in the proportion of trees was noted when U = 0 (excluding UN50), with no discernible pattern found in the frequency distribution of other values. CN50 and UN25 increased the proportion of W at a moderate level (W = 0.5), while CN25 and UN50 reduced it. No clear pattern was detected in the frequency distributions of other values. All five treatments increased the proportion of C at the maximum level (C = 1), while decreasing the proportions at levels of 0, 0.25, and 0.5 in 2017. Intriguingly, nitrogen addition treatments appeared to optimize the stand spatial structure to some extent and stimulated the growth of trees with larger diameters. Nevertheless, the short duration of the data collection period, spanning only five years, may have influenced the significance of the outcomes, underlining the requirement for extended studies. Conclusively, N deposition adjusted and enhanced the stand spatial structure to various degrees within the research region, providing valuable insights for further optimization of forest management.

Examining Moderator Influences on the Effect of Information and Motivation on Infant-Survival Behavioural Skills of Mothers in Selected PHC Facilities

Examining Moderator Influences on the Effect of Information and Motivation on Infant-Survival Behavioural Skills of Mothers in Selected PHC Facilities

Analysis Overconfidence, Herding, and Anchoring in Investment Decisions Among ESOP at PT Bank Central Asia

This This study aims to determine the influence of behavioral finance or psychological bias on investment decisions made by Employee Stock Ownership holders of PT Bank Central Asia. Tbk focuses on variables such as overconfidence, herding, and anchoring. This research is based on qualitative data and uses multiple linear regression for its analysis and research tools using SPSS. This research questionnaire was spread across 155 holders of Employee Stock Ownership of PT Bank Central Asia.Tbk. The results showed that overconfidence and anchoring have a significant effect on influencing investment decisions. Overconfidence has the most significant influence on decision-making while herding has a more moderate influence. This research is expected to help understand what factors can influence investment decisions and can help to make better decisions and avoid potential biases that can lead to suboptimal results.

How does digital transformation affect the total factor productivity of China's A-share listed enterprises in the mineral resource-based sector?

In light of the escalating constraints on resources and the complexities of sustainable development, the conventional extensive production approaches employed by mineral resource-based enterprises are ill-suited to fulfill the demands for efficient and eco-friendly operations. Such circumstances call for the adoption of novel development paradigms that promote sustainable practices. Particularly, the digital transformation has become a pivotal pathway towards the realization of high-quality development within the context of the ongoing technological revolution and the shift in economic frameworks. Based on the comprehensive dataset of the annual reports and input-output data of Chinese A-share listed enterprises between 2009 and 2021, this study seeks to examine the net impact and potential channels through which digital transformation affects the total factor productivity of these specific enterprises. The empirical results confirm the promoting effect of digital transformation on enterprises' total factor productivity. This highlight persists valid after a series of thorough robustness checks. Notably, this beneficial role can be achieved by the enhancement of corporate capabilities, the mitigation of financial constraints, and the improvement of economic advantages. And the heterogeneity in this promoting effect is evident across enterprises with different characteristics. The positive moderating influence of government competitions in this context is a factor that warrants consideration. Thereby, the research highlights not only furnish a rigorous scientific foundation and direction guide for the strategic formulation of mineral resource-based enterprises, but also proffer critical insights for policymakers to accelerate the modernization endeavor of resource-based cities as well as entire regional domains.

Hypersonic turbulent boundary layer over the windward side of a lifting body

In the present study, we performed direct numerical simulations for a hypersonic turbulent boundary layer over the windward side of a lifting body, the HyTRV model, at Mach number $6$ and attack angle 2 $^{\circ }$ to investigate the global and local turbulent features, and evaluate its difference from canonical turbulent boundary layers. By scrutinizing the instantaneous and averaged flow fields, we found that the transverse curvature on the windward side of the HyTRV model induces the transverse opposing pressure gradients that push the flow on both sides towards the windward symmetry plane, yielding significant effects of the azimuthal inhomogeneity and large-scale cross-stream circulations, moderate and azimuthal independent influences of adverse pressure gradient, and negligible impact of the mean flow three-dimensionality. Further inspecting the local turbulent statistics, we identified that the mean and fluctuating velocity become increasingly similar to the highly decelerated turbulent boundary layers over flat plates in that the mean velocity deficit is enhanced, and the outer layer Reynolds stresses are amplified as it approaches the windward symmetry plane, and prove to be self-similar under the scaling of Wei & Knopp (J. Fluid Mech., vol. 958, 2023, A9) for adverse-pressure-gradient turbulent boundary layers. Conditionally averaged Reynolds stresses based on strong sweeping and ejection events demonstrated that the Kelvin–Helmholtz instability of the strong embedded shear layer induced by the large-scale cross-stream circulations is responsible for the turbulence amplification in the outer layer. The strong Reynolds analogy that relates the mean velocity and temperature was refined to incorporate the non-canonical effects, showing considerable improvements in the accuracy of such a formula. On the other hand, the temperature fluctuations are still transported passively, as indicated by their resemblance to the velocity. The conclusions obtained in the present study provide potentially profitable information for turbulent modelling modification for the accurate predictions of skin friction and wall heat transfer.

New Media's Influence in Shaping Political Awareness, Attitudes and Behaviours: The Media Literacy as a Moderator and Peer Influence as a Mediator

This comparative study delves into the intricate dynamics of new media's influence on political awareness, attitudes, and behaviors among university students in China and Malaysia. It examines how various factors, including media literacy and peer influence, moderate and mediate the relationship between new media consumption habits and political education outcomes. Through a mixed-methods approach, data were collected from Chinese and Malaysian university students, exploring their engagement with different types of new media platforms, content delivery methods, frequency of exposure, perceived credibility of sources, and the influence of peer networks. The study identifies significant challenges and opportunities posed by the evolving digital landscape in both countries, addressing issues such as misinformation, echo chambers, commercialization, digital divide, and disparities in access. Findings reveal nuanced differences in the impact of new media on political education between the two cultural contexts, highlighting the importance of context-specific interventions and educational strategies.

Investigating the Physical and Operational Characteristics of Manufacturing Processes for MFI-Type Zeolite Membranes for Ethanol/Water Separation via Principal Component Analysis

In this study, Principal Component Analysis (PCA) was applied to discern the underlying trends for 31 distinct MFI (Mobil No. 5)-zeolite membranes of 11 textural, chemical, and operational factors related to manufacturing processes. Initially, a comprehensive PCA approach was employed for the entire dataset, revealing a moderate influence of the first two principal components (PCs), which collectively accounted for around 38% of the variance. Membrane samples exhibited close proximity, which prevented the formation of any clusters. To address this limitation, a subset acquisition strategy was followed, based on the findings of the PCA for the entire dataset. This resulted in an enhanced overall contribution and the revelation of diverse patterns among the membranes and the considered manufacturing factors (total variance between 55% and 77%). The segmentation of the data unveiled a robust correlation between silica (SiO2) concentration and pervaporation conditions. Additionally, a notable clustering of the chemical compositions of the preparation solutions underscored their significant influence on the operational efficacy of MFI zeolite membranes. On the other hand, an exclusive chemical composition of the preparation solution was noticed. This highlighted the high influence of the chemical composition on the operational efficiency of MFI zeolite membranes. The coupling of PCA with experimental results can provide a data-driven enhancement strategy for the manufacturing of MFI-type zeolite membranes used for ethanol/water separation.

Green as the new status symbol: Examining green signaling effects among Gen Z and Millennial consumers

PurposeGreen signaling refers to the notion that environmentally friendly purchases signal consumers' prosociality and willingness to pay more, thus enhancing their social status. This study investigated the green signaling effect among Gen Z and Millennial consumers on social media by adopting costly signaling theory.Design/methodology/approachA series of experimental studies were conducted to test the hypotheses. Thus, a 2 (organic vs. nonorganic) × 2 (luxury vs. non-luxury) between-subjects design was used in Study 1 (150 participants) and a 2 (organic vs. nonorganic) × 2 (high vs. low brand authenticity) between-subjects design was employed in Study 2 (148 participants).FindingsThe results of Studies 1 and 2 confirmed the mediating role of perceived status in the relationship between apparel greenness and purchase intention. However, brand label and authenticity did not have a moderating influence. The overall findings confirmed the green signaling effect of organic apparel in the social media marketing context.Originality/valueThis study contributes to the existing literature by suggesting a cultural capital perspective for promoting green products among Gen Z and Millennial consumers. It also encourages marketers to implement green messaging on social media, highlighting the amount of resources and efforts invested in sustainable production.Research limitations/implicationsThis study adopted existing brands to test the hypotheses, using images of female influencers.

Together or Apart? Revealing the Impact of Dietary Interventions on Bioavailability of Quinolones: A Systematic Review with Meta-analyses.

Managing drug-food interactions is essential for optimizing the effectiveness and safety profile of quinolones. Following PRISMA guidelines, we systematically reviewed the influence of dietary interventions on the bioavailability of 22 quinolones. All studies describing or investigating the impact of food, beverages, antacids, and mineral supplements on pharmacokinetic parameters or pharmacokinetic/pharmacodynamic indices of orally taken quinolones were considered for inclusion. We excluded reviews, in vitro and in silico studies, studies performed on animals, and those involving alcohol. We performed the search in Medline (via PubMed), Embase, and Cochrane Library, covering reports from database inception to December 2022. We used the following tools to assess the risk of bias: version 2 of the Cochrane risk-of-bias tool for parallel trials, the Cochrane risk-of-bias tool for cross-over studies, and the NIH quality assessment tool for before-after studies. We performed quantitative analyses for each quinolone if two or more food-effect studies with specified and comparable study designs were available. If meta-analyses were not applicable, we qualitatively summarized the results. We included 109 studies from 101 reports. Meta-analyses were conducted for 12 antibiotics and qualitative synthesis was employed for the remaining drugs. Of the studies, 60.5% were open-label, cross-over, as recommended by FDA. We judged 46% of studies as having a high risk of bias and only 4% of having a low risk of bias. Among 19 quinolones with available food impact data, 14 (74%) had potentially clinically important interactions. For nalidixic acid, oxolinic acid, and tosufloxacin, food exerted a high positive impact on bioavailability (AUC or Cmax increased by > 45%), whereas, for all the remaining drugs, postprandial absorption was lower. The most significant negative influence of food (AUC or Cmax decreased by > 40%) occurred for delafloxacin capsules and norfloxacin, whereas the moderate influence (AUC or Cmax decreased by 30-40%) occurred for nemonoxacin and rufloxacin. All 14 analysed quinolones showed a substantial reduction in bioavailability when co-administered with antacids and mineral supplements, except for calcium preparations. The impact of beverages was evaluated for 10 quinolones, with 50% experiencing significantly reduced absorption in the presence of milk (the highest negative impact for ciprofloxacin). Moreover, both ciprofloxacin and levofloxacin demonstrated compromised bioavailability when consumed with orange juice, particularly calcium-fortified. Several factors may influence interactions, including the physicochemical characteristics of quinolones, the type of intervention, drug formulation, and the patient's health status. We assessed the quality of evidence as low due to the poor actuality of included studies, their methodological diversity, and uneven data availability for individual drugs.

Moderating effect of shift work on sleep and depression in individuals at high risk of bipolar disorder

BackgroundSocial Zeitgeber Theory posits that disruptions in social rhythms can increase susceptibility to bipolar disorder (BD). Shift work (SW) is one of the external factors that cause instability in social rhythms and the sleep-wake cycle. This study evaluated the moderating influences of SW on the risks of BD and sleep-related parameters and depressive symptoms. Furthermore, we evaluated the specific work schedules including daytime, nighttime, and regular and irregular rotating SW. MethodsAn online survey was administered to 6665 participants, with 3379 (50.7 %) classified as individuals with high scores of Mood Disorder Questionnaire (MDQ). The survey included the Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Scale (ISI), Epworth Sleepiness Scale (ESS), and Center for Epidemiologic Studies Depression Scale (CES-D). ResultsA multivariate regression model revealed significant interactive effects of MDQ positivity and SW on PSQI, ISI, and CES-D scores, but not ESS scores. In a secondary analysis of the high MDQ screen group, daytime workers had lower scores in sleep disturbances and depressive symptoms compared to those engaged in other forms of SW. LimitationsOnline surveys were accessible voluntarily, leading to potential selection bias. Cross-sectional data identified associations, not causal relationships. Only a self-reported questionnaire was used. ConclusionsOur findings emphasize the advantages of a daytime work schedule for individuals at high risk of BD. In accordance with the principles of social rhythm interpersonal therapy, sleep interventions for individuals at high risk of BD should include the maintenance of a consistent daytime schedule.