Industrial Research Research Articles

Comparative analysis of FDA approvals by top 20 pharma companies (2014–2023)

This article addresses the research and development (R&D) productivity challenge of the pharmaceutical industry, focusing on United States Food and Drug Administration (FDA)-related new drug approvals of the top 20 pharmaceutical companies (2014-2023). We evaluated the degree of innovation in new drugs to determine the innovativeness of these leading companies. A key finding of our analysis is the decline in the number of new drugs approved by the FDA for these leading companies over the investigated time period. This trend suggests that some of the leading companies are losing ground in R&D innovation, raising concerns about their ability to sustain competitive advantage, ensure long-term market success, and maintain viable business models.

Exploring the intersection of digitalization and sustainability in oil palm production: challenges, opportunities, and future research agenda.

The increasing global demand for palm oil and its derivatives has led to significant environmental and social concerns, prompting the need for sustainable practices in oil palm production. In recent years, digital technologies have emerged as a potential solution to enhance sustainability in this sector. The objective of this review was to provide insights into the potential benefits and limitations of digital technologies in promoting sustainable practices in the oil palm industry, and to identify key challenges that must be addressed to ensure that digitalization contributes to sustainable development in this sector. To obtain valuable insights on this topic, this review employed a thorough analysis and exploration of relevant literature. Our findings highlight the transformative potential of digital technologies such as precision agriculture, data analytics, blockchain, and robotics to optimize resource utilization, improving efficiency, promoting social welfare, improving supply chain transparency, mitigating environmental impacts, and enhancing sustainability in oil palm production. However, the adoption of these technologies is hindered by several challenges, including high cost, lack of knowledge, and inadequate infrastructure. Our findings emphasize the importance of supportive policies, collaborative efforts, and targeted research to promote technology adoption and ensure equitable benefits across the oil palm industry. Recommendations are provided for industry stakeholders, policymakers, and researchers to leverage digitalization effectively and promote sustainable practices in the oil palm industry, ultimately contributing to global sustainability goals.

Assemblies design and modeling analysis of a new fine mesh neutronics/thermal-hydraulics coupling benchmark for plate-type PWR core

In order to support the verification of neutronics/thermal-hydraulics coupling calculation method or simulation codes at the fine mesh for plate-type pressurized water reactor (PWR) with high parameters (which the ratio of power to mass flow rate is greater than 235 kW/kg, the core outlet enthalpy exceeds 1500 kJ/kg), a set of coupling calculation of plate-type PWR based on high parameters (COPHP) is design by Nuclear Power Institute of China (NPIC). Multiple industry research teams, including Tsinghua University, Xi'an Jiaotong University, and Huazhong University of Science and Technology, participated in the production of COPHP benchmark. This article provides a detailed explanation of the completed assembly design and modeling calculations, and provides the keff, pin-by-pin wise fine mesh relative power distribution, and deviation results calculated for 10 conditions of 6 assemblies using RMC, OpenMC, and KYLIN V2 software. The results show that: 1) when using the same cross-sectional library, the OpenMC calculation results are in good agreement with the RMC results. Taking ENDF/B-VII.1 as an example, the maximum deviation of keff in the entire burnup process of all assemblies is −157pcm, the maximum deviation of relative power is −1.13 %, and the maximum power weight error(PWE) is 0.226 %. 2) Compared between KYLIN V2 and the RMC by using ENDF/B-VII.1, the maximum deviation of keff is −468pcm, the maximum deviation of relative power is −1.49 %, and the maximum PWE is 0.316 % when calculating the standard assemblies with all control rod out(ARO) condition and two burnable poison assemblies. The maximum deviation of keff is −795pcm, the maximum deviation of relative power is 1.81 %, and the maximum PWE is 0.369 % when calculating the standard assemblies with all control rod inserted(ARI) conditions.

Exploring the Role of Destination Resilience Plans in Promoting Tourism: A Literature Review

The study investigates the critical importance of destination resilience in enhancing tourism, particularly in the wake of challenges such as the COVID-19 pandemic. The primary aim of the research is to analyze how effective governance, stakeholder engagement, resource management, and risk assessment contribute to the resilience of tourist destinations and micro, small, and medium enterprises (MSMEs). To achieve this, the study employs a comprehensive literature review methodology, synthesizing existing research on destination resilience strategies and their implications for tourism promotion. The findings reveal that destination resilience plans significantly impact tourism performance, stakeholder participation, and sustainable development. Additionally, the study highlights the necessity of integrating innovative practices and technology to bolster the resilience of tourism sectors. In conclusion, this research provides valuable insights for destination management organizations, policymakers, and industry researchers, emphasizing the need for strategic planning and collaboration to foster long-term sustainability and resilience in tourism. The study serves as a foundation for future investigations and policy-making in the realm of sustainable tourism, addressing existing gaps in the literature and offering practical recommendations for enhancing destination resilience.

An Overview of Esports Business Model Research

Nowadays, e-sports has become one of the rapidly growing emerging industries in the world, and its business model is becoming increasingly mature. This paper provides a systematic review of academic literature on the eSports industry through the documentary method, demonstrates the rise of eSports as a cultural and economic phenomenon, and analyzes the dynamic development of eSports as an emerging industry and its business potential. By examining eSports business models, this paper not only discusses how eSports can attract a wide range of audiences and investors through innovative business models, but also explores the major challenges facing this industry and their implications for future business strategies, aiming to provide valuable recommendations for policymakers and researchers in the eSports industry. The study shows that the business model of eSports relies on diversified revenues, and its rapid development has not only benefited from technological innovation and globalization trends but also from policy support and the positive response and investment of the capital market. The eSports industry has become an important part of the global digital economy, with strong market potential and the possibility of sustained growth.

Exploring the Role of Robotics in Maritime Technology: Innovations, Challenges, and Future Prospects

Robotics has emerged as a disruptive force in the maritime sector, offering promising solutions for various applications, including underwater exploration, offshore operations, port logistics, and vessel maintenance. The paper begins by presenting an overview of the current state of robotics in the maritime industry, highlighting the key advancements and the impact they have had on traditional practices. It then delves into the various innovative applications of robotics, such as autonomous underwater vehicles (AUVs) for oceanographic research and inspection robots for offshore structures, discussing their capabilities and potential benefits. However, the integration of robotics in maritime technology also brings forth a unique set of challenges. These challenges encompass technical, regulatory, and ethical aspects, including issues related to safety, cyber security, legal frameworks, and public acceptance. The paper critically examines these challenges and discusses potential strategies to overcome them, emphasizing the importance of collaboration between industry stakeholders, policymakers, and researchers. It discusses emerging trends, such as swarm robotics, human-robot collaboration, and the utilization of artificial intelligence for decision-making. The potential benefits of these advancements, including increased efficiency, reduced costs, and enhanced safety, are highlighted.

CORRELATIONS OF SHIFT WORK 2-2-2(2) ROTATION ON SLEEP QUALITY AND FATIGUE OF NURSES IBNU SINA GRESIK GENERAL HOSPITAL

Background: Working as a nurse in a hospital required to work with a shift system. Working with the shift system (morning, afternoon, and night) can affect the circadian rhythm, which has the potential to cause sleep disturbances and fatigue. Purpose: This research aims to analyze the influence of shift work rotation 2-2-2(2) on sleep quality and fatigue in nurses with shift work systems in inpatient rooms at General Hospital Ibnu Sina Gresik. Method: This research was an observational analytics study with a cross-sectional design. The total sample was 80 nurses in an inpatient care unit with a shift work system chosen through purposive sampling techniques. The Subjective Self-Rating Test (SSRT) issued by the Industrial Fatigue Research Committee (IFRC) questionnaire was used for the measurement of fatigue, and the Pittsburgh Sleep Quality Index questionnaire (PSQI) was used for the assessment of sleep quality. Univariate and bivariate analyses were done with a Chi-square statistical test. Result: The study showed that most respondents had good sleep quality (87.5%), and most had low tiredness (71.2%). The Chi-square test results obtained a p-value of 0.224 > 0.05 and a p-value of 0.108 > 0.05, meaning there were no correlations between shift work and sleep quality and fatigue. Conclusion: Shift work had no relationship with sleep quality and fatigue. Appropriate shift work arrangements can contribute to reducing the negative impact of shift work.

Optimization-based approach for high-fidelity phase retrieval from sparse interferometric data: implications for industry and biological research

Optical profilometers provide a non-contact, non-destructive method for swiftly profiling 3D surfaces. White light interferometers, often used for this purpose, employ a 5-phase shifting technique for precise phase maps. However, capturing multiple frames introduces mechanical movement, which impedes imaging of dynamic objects. White light’s low spatial-temporal coherence mitigates speckles and spurious fringes while offering high axial resolution. Creating a high fringe density interferogram with low-coherence light is challenging. Introducing a tilt angle in the interferometer can increase the fringe density, which is still insufficient for phase map retrieval using the single-shot Fourier transform method. We propose an adaptive optimization framework to recover phase maps from single low fringe density interferograms. This method iteratively extracts reference beam information, eliminating mechanical movement and enhancing system stability while reducing costs and system bulkiness. The simulation and experimental results on a step-phase object (etched on silicon) and biological MG63 osteosarcoma cells validate the efficacy of a single-shot optimization scheme. For comparison, the phase maps of the same objects were obtained using the single-shot Fourier transform and multi-shot 5-phase shifted methods. The single-shot optimization technique shows efficient performance, yielding phase maps with reasonable accuracy, potentially replacing the 5-phase shifting technique in industrial and biological diagnostics.

A software-agnostic benchmark for DEM simulation of cohesive and non-cohesive materials

Although DEM (Discrete Element Method) was introduced >40 years ago, there are still various challenges in applying it with a certain level of confidence. To develop a realistic material model, calibration, validation, particle shape representation and scaling are well-known challenges that have been studied by various researchers over the past two decades. In addition, once a realistic DEM material model is developed and published in line with open science principles, it is unknown to what extent the calibrated values can be used across software packages. Although a benchmark between 8 open source codes was recently published, it did not cover cohesive materials, rolling friction models, realistic calibrated material behaviour, and commercial software that is widely used in industries.The aim of this study is to investigate the portability of input parameters between different codes and to identify if software independent calibration is possible. We propose a framework to assist DEM users in industry and academia to reach a software independent DEM simulation when required.To compare the results between software packages, the framework considers the following aspects: 1) identical implementation of contact models, 2) single contact modelling, 3) bulk level simulation, and 4) identical post-processing. This framework is demonstrated for two contact models (Hertz-Mindlin and Edinburgh Elasto Plastic Adhesive) with rolling friction model and two commercial software packages (EDEM and PFC) but is applicable for any other (open-source) software. Moreover, two realistic calibrated material models are included to cover a range of material characteristics, from free-flowing incompressible materials to cohesive compressible materials. This study shows that individual particle level simulations give identical results, bulk level simulations show differences for both contact models. In general, users should use parameter values from other software packages with caution, especially where critical or sensitive applications are modelled. This paper also highlights the use of novel computation techniques, such as the GPU engine, to achieve practical computation times when modelling industrial applications.

Maximizing Waste-to-Energy Potential: Optimizing Batch Torrefaction Reactor of Refused-Derived Fuel for Efficient Gasification

Abstract Refuse-derived fuel (RDF) from municipal solid waste (MSW) is a promising alternative to fossil fuels, but its varied composition can impede direct gasification. This industrial research project conducted a series of batch experiments to assess four key parameters: energy yield, mass yield, energy density, and combustion characteristics in the context of RDF torrefaction. The batch reactor processed RDF samples at temperatures of 250°C, 300°C, and 350°C, each with a 30- minute residence time under an inert atmosphere. In addition, Combustion TGA experiments, involving heating torrefied RDF up to 1000°C at a rate of 20°C/min, provided further insights into the robust combustion properties of the torrefied material. Unlocking the secrets of torrefaction magic, we've achieved remarkable energy content boosts. Torrefaction at 250°C, 300°C, and 350°C led to energy content enhancements of 22%, 29%, and 37%, respectively, compared to the original RDF. Notably, the most favorable energy yield was achieved during torrefaction at 250°C, attributed to both its relatively high energy content and mass yield. At a torrefaction temperature of 250 °C and above, the torrefied RDF samples exhibited heating values comparable to standard coal ranges between 25-35 MJ/kg. It is suggested that torrefaction of RDF is an effective pre-treatment process to be used in entrained flow gasifier due to the improved higher heating value, higher energy density, and superior combustion characteristics, proved by the ignition index, flammability index, and burnout index, highlight the effectiveness of the torrefaction process.

Pendampingan Wirausaha Start-Up Animasi Berbasis Jasa

Over the past year, there have been developments in Indonesia’s creative industry, the animation subsector, both in providing services and producing IP independently. Although the animation sector industry researchers are presented with an effective and efficient animation industry model from ideation to distribution, the model is still difficult to use in Indonesia because of existing limitations so that they are still dependent on government funding. Whereas for the last 65 years there is still no real role that has been done by the Indonesian government to help the growth sector of this sector. So this raises the question of what other things can we do as private parties in developing IP by not relying on funding by the government? Animation, especially in IP production, ia a business with enormous prospects for its impact on the recovery, growth, and development of the Indonesian economy. There are author who have thought about methods that can be carried out or used in efforts to manage this sector. In an effort to realize the things that are dreams of creative industry business actors will be briefly discussed through this critical literature review.

A Bibliometric Analysis of the Implementation of Diversity, Equity, and Inclusion (DEI) in the Technology Industry

This study presents a comprehensive bibliometric analysis of research on Diversity, Equity, and Inclusion (DEI) in the technology industry, focusing on thematic clusters, research trends, potential research topics, and author collaborations. The analysis reveals that diversity and inclusion are central themes, with significant attention also given to gender diversity, equality, and innovation. Recent research trends highlight emerging areas such as accessibility, disability, and artificial intelligence. Potential research topics identified include accessibility and inclusive design, intersectionality, and the role of leadership in promoting DEI. The author collaboration network shows strong intra-group collaborations but limited inter-group interactions, suggesting opportunities for broader interdisciplinary research. This analysis provides valuable insights into the current state of DEI research in the tech industry and identifies key areas for future exploration to foster more inclusive and equitable environments.

CGP sessions

Persuasive communication is at the center of the object of study of advertising graphic communication. However, it is not so easy to recognize what is persuasive, how it is persuaded and what are the ways in which it circulates in society. This podcast is a research + creation product that arises from a series of projects that investigate new trends in advertising, graphic and persuasive communication. The podcast series includes in-depth sessions with industry experts, researchers and employers, in dialogue with the specialized literature and leading advertising campaigns. This format integrates a critical and current look at communication and the persuasive in society. The present work shows the paths from which the conceptualization of the product was advanced.

INTEGRATED PEST MANAGEMENT AND ENTOMOPATHOGENIC FUNGAL BIOTECHNOLOGY IN THE LATIN AMERICAS: II. KEY RESEARCH AND DEVELOPMENT PREREQUISITES

In the first part of this review article (Valencia & Khachatourians, 1998) we presented the special opportunity that entomopathogenic fungi (EPF) offer for integrated pest management (IPM) in the Latin Americas. As expected, along with the opportunities, there are challenges for the use of EPF. First that there are only two fungi, Beauveria bassiana and Metarhizium anisopliae, for which sorne prerequisite knowledge of basic and applied mycology for industrial research and development (R & D) are in place. Because of precedent setting leadership in the development of certain EPF, e.g., B. bassiana in 1PM, Latin America stands to contribute to and gain from future discovery research coupled to a strong and dependable industrialization effort. There is also need to develop the framework for public acceptance, newer commercialization potential and widespread use of EPF in 1PM. Here we examine issues that are prerequisites for industrial R & D.

Novel nano composites from Citrus limon and Citrullus colocynthis agricultural wastes for biomedical applications

In recent years, academic and industrial research has focused on using agro-waste for energy and new material production to promote sustainable development and lessen environmental issues. In this study, new nanocomposites based on polyvinyl alcohol (PVA)-Starch using two affordable agricultural wastes, Citrus limon peels (LP) and Citrullus colocynthis (Cc) shells and seeds powders with different concentrations (2, 5, 10, and 15 wt%) as bio-fillers were prepared. The nanocomposites were characterized by Dielectric Spectroscopy, Fourier-Transform Infrared (FTIR), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), and water swelling ratio. The antimicrobial properties of the nanocomposites against Escherichia coli, Staphylococcus aureus, and Candida albicans were examined to investigate the possibility of using such composites in biomedical applications. Additionally, the biocompatibility of the composites on human normal fibroblast cell lines (HSF) was tested using MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay. The results demonstrate that the filler type and concentration strongly affect the film's properties. The permittivity ε′, dielectric loss ε″ and conductivity σdc increased by increasing filler content but still in the insulators range that recommend such composites to be used in the insulation purposes. Both bio fillers control the water uptake, and the samples filled with LP were more water resistant. The polyvinyl alcohol/starch incorporated with 5 wt% LP and Cc have antimicrobial effects against all the tested microorganisms. Increasing the filler content has a negative impact on cell viability.

Chinese Artichoke (Stachys affinis Bunge): The Nutritional Profile, Bioactive Profile and Food Applications-A Review.

Stachys affinis Bunge, known as Chinese artichoke, is a perennial plant originating from China, which has uprising scientific interest due to its complex and beneficial content. Chinese artichoke is rich in bioactive compounds useful for human health, including antioxidants, polyphenols, and prebiotics, and its edible tubers are high in essential nutrients and dietary fiber. Studies show its potential as a functional food ingredient in various products like rice bars, bread, and chocolate, enhancing their nutritional and sensory properties. Additionally, Chinese artichoke exhibits significant anti-inflammatory, neuroprotective, and antibacterial activities, warranting further research and utilization in the food industry. This review aims to summarize the existing knowledge of the S. affinis Bunge plant, focusing on its health-promoting aspects.

The Influence of Mobile Application User Experience, Service Quality, and Social Interaction on Customer Satisfaction Quantitative Research in the Online Service Industry

The Influence of Mobile Application User Experience, Service Quality, and Social Interaction on Customer Satisfaction Quantitative Research in the Online Service Industry

Book Review Carbon Membrane Technology Fundamentals and Applications

Carbon membrane has shown great advantages with high separation performance, especially under high temperature and pressure condition with its strong mechanical and chemical stabilities, as well as well-defined pores structures [1]. An overview of the fundamental aspect and industrial application of carbon membrane is thus important to demonstrate the potential development of the membrane. This recent published book summarized both aspects in two parts. For the first part, the formation, state-of-art of the performance, characterization and transport mechanism of carbon membranes were discussed. For the second part, the application of carbon membrane in biogas upgrading, natural gas sweetening, hydrogen purification, micro-, ultra- or nanofiltration and other applications were reported. Subsequently, future perspectives of the carbon membrane were also analysed. In short, the book offers a thorough discussion on the fundamentals and applications of carbon membrane towards a sustainable development, which is a valuable resource for both academic and industrial researchers.

Design frameworks for ventilative cooling: Perceptions from building design practitioners in Ireland and the United Kingdom

The global increase in building cooling demands poses a challenge for designers striving for net zero energy consumption. The prevalent use of mechanical cooling underscores the necessity for designers to consider Ventilative Cooling as a viable alternative in the early stages of building design. This paper presents findings from an exploratory survey and semi-structured interviews of industry experts in Ireland and the United Kingdom about their design processes and experienced-based approaches to designing Ventilative Cooling. The findings suggest that the pre-design stage has the same influence for promoting ventilative cooling strategies as the schematic and detailed design stages for practitioners, yet limited impactful decision making occurs at this stage. Over 70 % of the survey respondents reported satisfaction with current Ventilative Cooling tools used in building design. Only 8 % of architects use a ventilative cooling tool, while engineers always do, showing that separate design advice is needed for architects and engineers. The interview findings indicate that early-stage design interventions for Ventilative Cooling can be improved if there was more empirical evidence of how strategies perform available as design guidance in ventilative cooling design guidelines. Additionally, engineers highlighted that post-occupancy evaluation and site monitoring of existing buildings are crucial stages of further research that can identify the effectiveness of Ventilative Cooling design decisions. In their building designs, the practitioners reported a need for preparedness to assess resilience to extreme future climate events such as heat waves. Effective communication between industry and academic research can help improve the built environment industry's future readiness.

Engagement as Revenue in Journalism: Turning Community, Comments, and Access into Economic Viability

ABSTRACT While both the journalism industry and journalism studies research have long celebrated engagement as both a normative goal and a potential revenue source, scant evidence exists illustrating how an organization can turn engagement into profit. This study, utilizing a case study of the sports and culture news organization Defector, examines how one newsroom monetizes engagement. Through the lens of market theory for news production, the study examines what engagement practices Defector enacts, and how those successfully catalyze subscribers to pay almost 50% more annually for the ability to engage with the organization. Lastly, the study introduces, to journalism studies, the concept of market alignment, a necessity for monetizing engagement.