This study investigated nanomaterial safety management through semistructured interviews with 14 subject matter experts across industry, research, and regulatory domains. Expert perceptions, practical implementation of exposure controls, and barriers to effective safety management in Singapore's nanotechnology sector were examined. Thematic analysis using MAXQDA software identified 6 key themes: information management and organizational practices (28%), training and knowledge management (26%), documentation and risk management (21%), advanced manufacturing and implementation insights (14%), geographic and regulatory framework variations (11%), and measurement and characterization challenges (6%). The study identified significant variations in how organizations approach safety management, particularly in information sharing, training delivery, and control measure implementation. Technical challenges in exposure measurement and characterization emerged as critical barriers, while documentation and risk management practices varied considerably across different organizational contexts. This research contributes to nanomaterial safety management by providing insights into practical implementation challenges across diverse organizational contexts.
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