The proliferation of micro- and nano-plastics (MNPs) in the ocean has become critical due to possible toxicological impacts on the environment, food web (FW) interactions, and human well-being. These plastic fragments originate from various sources, including degrading bigger plastic debris, goods, and emissions. This paper presents a comprehensive analysis of the distribution and hazards of MNPs in ocean habitats, their ecological conduct, and relationships within ocean food-webs, highlighting their harmful effects on ocean organisms. It examines the correlation between the size of particles and toxicity, their distribution throughout various organs, and the mechanism of transferring trophic status within the FW. Upon ingestion, MNPs are detected in multiple organs. The ingestion by the lowest-trophic-level creatures enables the advancement down the food chain (FC). This results in bioaccumulation and biomagnification, potentially damaging aquatic creatures’ health, development, and actions. This study examines how MNPs, due to their persistence and metabolism, threaten marine ecosystems and disturb trophic interactions. The article discusses the ramifications of MNPs on human wellness, especially via ingesting contaminated seafoods, emphasizing the direct and indirect routes via which humans encounter these contaminants. The assessment underscores suggestions for further study, stressing the need for a combination of environmentally friendly and human wellness research to enhance risk evaluations and formulate mitigation plans to tackle the worldwide problem of plastic contamination in ocean ecosystems
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