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  • Research Article
  • 10.36948/ijfmr.2026.v08i02.72513
Revisiting Subjugated Masculinities in Gajendrakumar Mitra’s Ekti Galpa
  • Mar 26, 2026
  • International Journal For Multidisciplinary Research
  • Sanjeev Bali

Gajendrakumar Mitra’s short story Ekti Galpa (trans. A Story) (1954), translated from Bengali to English as The Family Retainer (2006) by Aruna Chakravarti, follows the tragic life of a subordinated man who gets degraded and exploited by his own family. It explores multiple aspects of the gendered positioning of an average Indian man juggling his identity and existence between ideal masculinity, male honour, pride, privilege, and oppression. Haran, the central character of the story, is introduced as the son-in-law of the wealthy Rai Bahadur who served as the medical advisor of some large business firms in Burma. He was brought to the Bahadur family when he was a schoolboy as a suitable groom for Rajbala, Bahadur’s elder daughter. Haran’s father sold him for ten thousand rupees to the Bahadur family. In between the economic and business transactions of the two dominant men, Haran lost his boyhood and dreams. The story is narrated through the perspective of his neighbour, and Haran is given a voice only at the end of the story, reflecting his long-repressed plight of being a servant in his own home. Through the neighbour who tries to understand Haran’s pathetic life and help him escape from the space to lead an independent and dignified life, the story points towards the role of power, money, and position in the marginalisation of men.

  • Research Article
  • 10.21275/sr26122090218
Reducing the Hypothyroidism of a Middle Aged Patient with Ill Effects on Diabetes and Mental Health through Donkey and Bull Testicles via Deafer (Flax and Chia Seeds): A Brief Report
  • Jan 27, 2026
  • International Journal of Science and Research (IJSR)
  • A Smitha Kranthi + 2 more

Background: Pathologies in hormone growth results in over secretion or under secretion. The Under secretion produces a mass on the front side of neck (Graves? disease) which is hypothyroidism. This Hypo thyroidism makes myxedema coma which includes fatigue, feeling cold, weight gain, dry skin, sleepiness & also slow deteoration in mental disorder. Thyroid can increase the chance of diabetes mellitus in which body doesn?t produce insulin and makes insulin resistant body. Hypothyroidism and pre diabetes later diabetes and type 2 diabetes makes obesity, hypertension, and bull eyes. Case Presentation: A middle-aged Indian man with hypothyroidism is brought to the emergency-room frequently with the symptoms of diabetes and mental disorder. Further examinations of patient showed bowx of vocal cords; penetrated gap; hoarsness of voice; hypoglycaemic symptoms & psychic disorder. Therefore, TS was diagnosed with coexistence of diabetes and psychicness. Medication for hypothyroidism, diabetes and mental illness were continued. With these treatments in addition with donkey/bull testicles along with chia / flax seed in diet with fine examination made the patient recovered from all ill effects and improved his health. Conclusions: In severe cases of diabetes & psychic disorder the presence of TS should be examined and imparting diet and early treated makes patients with better health condition.

  • Abstract
  • 10.1210/jcemcr/luaf297.049
O-29 SEVERE HYPERTRIGLYCERIDAEMIA-INDUCED PANCREATITIS WITH NON-CARDIOGENIC PULMONARY OEDEMA IN A YOUNG INDIAN MAN WITH NEWLY DIAGNOSED DIABETES: A RARE AND CHALLENGING PRESENTATION
  • Jan 13, 2026
  • JCEM Case Reports
  • Elena Virgo + 2 more

IntroductionHypertriglyceridaemia-induced acute pancreatitis (HTG-AP) accounts for up 4% of pancreatitis cases. Risk rises significantly when triglycerides exceed 11 mmol/L, though values above 50 mmol/L are rare and usually associated with severe systemic complications and multi-organ dysfunction. Pulmonary oedema, especially non-cardiogenic in origin, is an unusual and life-threatening complication that complicates acute management.Clinical CaseA 30-year-old Indian man with no prior medical history presented with sudden severe epigastric pain, recurrent vomiting, and acute dyspnoea. Investigations revealed newly diagnosed diabetes mellitus (HbA1c 78 mmol/mol), acute pancreatitis (CT - showing peripancreatic inflammation), triglycerides (65 mmol/L). Despite initial resuscitation, he developed acute hypoxia with bilateral pulmonary infiltrates on chest X-ray, consistent with non-cardiogenic pulmonary oedema. Echocardiography confirmed preserved left ventricular systolic function, effectively excluding a cardiogenic cause. He was transferred to intensive care for ventilatory support.Management included variable-rate intravenous insulin infusion, and electrolyte monitoring. Insulin played a dual role: achieving glycaemic control and lowering triglycerides by enhancing lipoprotein lipase activity and accelerating clearance of chylomicrons. Over several days, triglycerides progressively declined, avoiding the need for plasmapheresis. Once stabilised, a basal-bolus subcutaneous insulin regimen was initiated, commenced on a low-fat diabetic diet, and provided with a continuous glucose monitor to support ongoing glycaemic management. Long-term therapy was planned with rosuvastatin 10 mg, lifestyle modification, and diabetes clinic follow-up.This case is remarkable for three key reasons:Severity of hypertriglyceridemia – at 65 mmol/L, far above the threshold for pancreatitis.Dual acute complications – concurrent pancreatitis and non-cardiogenic pulmonary oedema.Underlying risk factors – strong family history and South Asian ethnicity raising suspicion of familial combined hyperlipidaemia or other inherited metabolic disorder.Although plasmapheresis has been advocated in severe HTG-AP, insulin therapy proved highly effective here, emphasising its role as first-line therapy in resource-limited and urgent settings. Long-term management requires a comprehensive approach integrating lipid control, diabetes management, dietary modification, and family risk assessment.ConclusionThis case illustrates an unusual and life-threatening initial presentation of diabetes with severe hypertriglyceridemia, acute pancreatitis, and non-cardiogenic pulmonary oedema. It reinforces the importance of high clinical suspicion, urgent ITU support, and early triglyceride-lowering strategies. The integration of digital glucose monitoring and specialist lipid evaluation supports recovery and optimises long-term control.

  • Research Article
  • Cite Count Icon 2
  • 10.1016/s2352-3018(25)00233-4
Functional cure of HIV-1 infection in an exceptional elite controller: a case report.
  • Dec 1, 2025
  • The lancet. HIV
  • José M Benito + 9 more

Functional cure of HIV-1 infection in an exceptional elite controller: a case report.

  • Research Article
  • 10.4103/jpbs.jpbs_1477_25
Digital Forensic Facial Reconstruction using Population Specific Soft Tissue Thickness Data: A Comparative Study of Indian Regional Datasets
  • Nov 19, 2025
  • Journal of Pharmacy & Bioallied Sciences
  • Arjun Kundu + 6 more

ABSTRACTAim:Present study evaluates the impact of different regional FSTT datasets on the accuracy of computerized forensic facial reconstructions in a contemporary Indian context.Material and Method:A 40-year-old Indian man’s CT image was converted into a 3D skull model in InVesalius 3.1. Geomagic Freeform Plus (2022.1.31) and Touch X hardware sculpted facial reconstructions. Use FSTT values from Gujarati, North Indian, and South Indian datasets to place landmark-specific soft tissue markers. RMS error and color-coded deviation maps were calculated by comparing each generated face to the subject’s facial surface to assess reconstruction accuracy.Result:Quantitative research showed the South Indian model has the lowest RMS error (3.351 mm), followed by North Indian (3.754 mm) and Gujarati (4.376 mm). This suggests population matching increases geometric integrity. The population-matched model had less error for the highest orbital and cheek deviations in qualitative assessments with consistent error patterns.Conclusion:Population-specific soft-tissue reference data significantly enhance the anatomical accuracy of forensic facial reconstruction. Comprehensive regional FSTT databases and advanced digital modeling are recommended for reliable human identification. Persistent data gaps and anatomical variability highlight the need for ongoing research.

  • Research Article
  • Cite Count Icon 1
  • 10.12659/ajcr.949163
Klebsiella pneumoniae Invasive Syndrome without Liver Abscess: A Case Report
  • Oct 14, 2025
  • The American Journal of Case Reports
  • Parth M Dhamelia + 4 more

Patient: Male, 45-year-oldFinal DiagnosisKlebsiella pneumoniae invasive syndromeSymptoms: Abscess • back pain • chills • dysarthria • facial asymmetry • fever • right sided weaknessClinical Procedure: —Specialty: Dermatology • Gastroenterology and Hepatology • Infectious DiseasesObjective: Rare coexistence of disease or pathologyBackgroundKlebsiella pneumoniae invasive syndrome (KPIS), a rare severe multi-site infection, typically caused by hypervirulent Klebsiella pneumonia, has a high mortality rate, usually ranging from 10% for antimicrobial-sensitive strains to 24% for resistant strains, and often requires prolonged treatment. Most cases have been reported in East Asia, with a handful documented in India, to date. The incidence is also rising in Western countries.Case ReportWe report the case of a 45-year-old Indian man who presented with fever, low back pain, and asymmetric arthralgia for the past 20 days, along with new acute-onset right-sided hemiparesis and slurred speech. Laboratory test results were significant for elevated leukocyte counts and inflammatory markers (ESR and CRP). MRI of the brain revealed multiple lesions, with accompanying hemorrhage and edema at grey white-matter junction. PET-CT revealed septic collections at multiple sites, including the spleen, kidney, left knee joint, and L5–L6 vertebrae, along with paravertebral and psoas abscesses. Cultures of vertebral abscess confirmed Klebsiella pneumoniae, with a positive string test, consistent with a hypermucoviscous phenotype; however, genetic testing for hypervirulent genes could not be performed, due to unavailability. Given these findings, KPIS diagnosis was likely. Treatment was 6 weeks of antibiotics, empiric vancomycin and gentamicin, followed by de-escalation to amoxicillin-clavulanic acid.ConclusionsKPIS can occur in immunocompetent hosts and should be considered in cases of unexplained systemic inflammation with multifocal abscesses. Hepatic involvement, while characteristic, is not essential for diagnosis. When genotypic testing is unavailable, a positive string test can serve as a useful surrogate marker for identifying hypervirulent strains.

  • Research Article
  • 10.59556/japi.73.0972
Skin Deep and Lung Bound: A Tale of Disseminated Kaposi's Sarcoma.
  • Jul 1, 2025
  • The Journal of the Association of Physicians of India
  • Sanjana Pant + 5 more

We present the case of an Indian man in his 40s with acquired immunodeficiency syndrome (AIDS)-related Kaposi's sarcoma (KS), involving the skin, oral mucosa, and lungs. Fewer than 30 cases of KS have been reported in India to date. This case report emphasizes the challenges and confounding factors in diagnosing pulmonary KS, as well as the complexities involved in initiating treatment. The patient presented with multiple skin lesions, worsening dyspnea, and chest pain. A skin biopsy confirmed KS, and chest imaging revealed bilateral infiltrates. Pulmonary KS was diagnosed through polymerase chain reaction test from bronchoalveolar lavage fluid. Despite the initiation of antiretroviral therapy, the patient's condition deteriorated, leading to his demise. Diagnosing pulmonary KS remains a complex and nuanced process, often hindered by overlapping symptoms and confounding factors that can obscure its presentation. Early recognition and prompt intervention are essential but challenging, underscoring the need for a high index of suspicion and a multidisciplinary approach to optimize patient outcomes.

  • Research Article
  • 10.5693/djo.02.2024.10.002
CASE REPORTS: Focal choroidal excavation and choroidal neovascular membrane following sildenafil intake
  • Jun 8, 2025
  • Digital Journal of Ophthalmology
  • Aashul Chawla + 2 more

Sildenafil citrate is widely abused as a recreational drug. The ocular side effects of this drug are often overlooked, because they tend to be mild and transient. Commonly reported side effects include light sensitivity and dyschromatopsia resulting in impairment of blue-green discrimination. We present a rare occurrence of a focal choroidal excavation (FCE) in a healthy 34-year-old Asian Indian man after sildenafil intake. Sudden diminution of vision was noted a day after taking 50 mg/day sildenafil for 3 consecutive days. An FCE was seen on the optical coherence tomography in the left eye, with visual acuity of 20/30. Choroidal and outer retinal layers were disturbed superior to the fovea. Color vision disturbance was also noted. A choroidal neovascular membrane developed after 8 months, which was treated with ranibizumab injection. Final visual acuity was 20/80, due to macular scarring in the left eye. Sildenafil has been shown to cause choroidal thickening. We hypothesize that the sudden turgescence of the choroid might have led to the FCE.

  • Research Article
  • 10.1093/ced/llaf157
A case of rapidly progressive, ulcerating nodules and plaques.
  • Apr 2, 2025
  • Clinical and experimental dermatology
  • Conor Larney + 4 more

A 73-year-old Indian man with Fitzpatrick skin phototype V presented to the emergency department with a 1-month history of extensive, painful, rapidly progressive ulcerating nodules and plaques on the arms, trunk and thighs and features of leonine facies. The patient had previously been treated with two courses of oral antibiotics and oral corticosteroids in the community for presumed infected eczema. A skin biopsy sent for histopathology showed epidermotropism and sheets of atypical lymphoid infiltrate extending into the subcutis. The cells were positive for CD2, CD5, CD8, BF1, TIA and granzyme B. They were negative for CD4, CD7, CD30, CD56, delta and EBER. Ki-67 showed a proliferative index of almost 100%.

  • Research Article
  • 10.15406/mojph.2025.14.00493
Alcoholism: a case report on the silent epidemic affecting urban Indian men
  • Jan 1, 2025
  • MOJ Public Health
  • Rushabh Shah + 3 more

This case report examines alcohol use disorder (AUD) in a 39-year-old urban Indian man with chronic alcohol consumption, hypertension, diabetes, and withdrawal symptoms, highlighting broader public health concerns. Alcohol use disorder (AUD) is a common public health problem in both developing and developed nations of the world. In India, historically, alcohol use has been an issue of great ambivalence throughout the subcontinent, with the most recent factors at play being colonial influences and state-specific policies (Sharma et al., 2010). In this case, urban stressors and weakened family support may contribute to problematic drinking, while family denial and limited access to treatment reflect potential barriers observed in urban settings. This case report explores AUD’s biological, psychological, and social dimensions in urban Indian men, contextualizing the case within historical, regional, and demographic data, and advocates for interventions like counseling and psychotherapy.

  • Research Article
  • 10.48175/ijarsct-22900c
Identity Crisis of an Immigrant in Desai’s Bye Bye Blackbird
  • Dec 30, 2024
  • International Journal of Advanced Research in Science, Communication and Technology
  • Koushik Nandi + 1 more

One important aspect of postcolonial studies is the experience of Diaspora, which has been a common theme in English literature. Diaspora is not only a physical mobility of the immigrants from their homeland to the foreign land, but a kind of psychological dislocation in which the immigrants experience a sense of displacement, marginalization and a loss of identity. Some immigrants experience ambivalent feelings of in-betweeness and are torn between the two cultures, thus they suffer from a broken and split identity. On the other hand, other immigrants try to fully adjust themselves and assimilate with the new culture and live as expatriates. The image of a journey to settle down somewhere else is central to the notion of diaspora. Diaspora has habitually been comprehended as a yearning for a lost home. It is a phenomenon, which is associated with the process of shifting, moving, settling and unsettling of the person or community involved in the act. Bye Bye Blackbird deals with the experience of an Indian man who lived in Britain and married to a British wife

  • Research Article
  • 10.18231/j.jdpo.2024.046
Peripheral hemophagocytosis- A key to decifer hemophagocytic lymphohistiocytosis, an extremely rare case report
  • Dec 15, 2024
  • IP Journal of Diagnostic Pathology and Oncology
  • Swati Raj

Hemophagocytic lymphohistiocytosis(HLH) is an uncommon and probably underdiagnosed disorder that requires quick medical attention because of its high and rapid mortality rate. The present criteria are the only ones used to diagnose HLH. For a laboratory diagnosis of HLH-2007(an upgraded version of HLH-2004), five of the eight requirements must be satisfied. We report an exceedingly rare case of a thirty-year-old Indian man who has been clinically presenting with a high-grade fever, weakness, oligouria, and speech slurring for 20 days. While screening peripheral blood smear(PBS) in order to correct complete blood counts, peripheral circulating hemophagocytic histiocytes were identified and further testing was advised as suspicion of HLH was taken into account. Our case fulfilled the WHO 2009 diagnostic criteria of HLH, hence a diagnosis of Hemophagocytic Lymphohistiocytosis was awarded. To the best of our knowledge, no HLH case has ever been recorded in India based on suspicion raised by PBS findings. Globally, only six similar cases of HLH with peripheral findings have been posted online.

  • Research Article
  • 10.18231/j.yjom.2024.029
Pulmonary mucoepidermoid carcinoma with endobronchial involvement: A case report
  • Dec 15, 2024
  • Yemen Journal of Medicine
  • Theeb Sulaiman + 4 more

Although mucoepidermoid carcinomas (MEC) commonly occur in the salivary glands, they are rarely encountered in the lungs. In this case report, we present a rare case of pulmonary mucoepidermoid carcinoma with endobronchial involvement in a 36-year-old Indian man who presented to our pulmonary outpatient clinic with a 10-year history of recurrent lower respiratory tract infections. A comprehensive workup was performed in his home country, but did not lead to a definitive diagnosis. At our hospital, high-resolution chest computed tomography was repeated, confirming a well-demarcated soft tissue mass measuring 1.7 x 1.8 x 1.1 cm in the right lower lobe bronchus. This was followed by positron emission tomography (PET) showing intense fluorodeoxyglucose (FDG) uptake in the mass with a standardized uptake value (SUV) of 7.9. The final diagnosis was made by histopathological examination of a resected right lower lobe, which confirmed the diagnosis of low-grade mucoepidermoid carcinoma, with no metastases found in the lymph nodes. The patient was then referred to a multidisciplinary oncology team, which opted for regular surveillance and follow-up.

  • Open Access Icon
  • Research Article
  • 10.1097/coa.0000000000000055
A Rare Case of Intraocular Gold Foreign Body Induced Traumatic Corneal Endothelial Decompensation Managed With Descemet Stripping Automated Endothelial Keratoplasty
  • Dec 1, 2024
  • Cornea Open
  • Ashis Majumdar + 3 more

Purpose: This report presents a rare case of a gold intraocular foreign body (IOFB) that remained in the anterior chamber for 28 years, leading to subsequent traumatic corneal endothelial decompensation and cataract development. The purpose is to describe the successful treatment approach. Methods: A 54-year-old Indian man with a history of accidental injury to the left eye involving a burst gold ball in 1994 was examined in September 2023. Results: The patient presented with painless dimness of vision, redness, and watering of the left eye. Examination revealed a gold-colored IOFB in the anterior chamber that adhered to the iris tissue, without an obvious entry wound in the cornea or iris defect. Slit-lamp examination revealed corneal edema, and specular microscopy revealed significantly reduced endothelial cell density. anterior segment optical coherence tomography, UBM, and computed tomography scan confirmed the presence and position of the metallic IOFB. Treatment involved IOFB removal, phacoemulsification, intraocular lens placement, and Descemet stripping automated endothelial keratoplasty in a single setting. The gold foreign body was an alloy of gold, silver, copper, and zinc, which was nonmagnetic in nature and the copper content was significantly less to cause chalcosis. The patient's visual acuity improved significantly postoperatively. Conclusions: Gold IOFBs are uncommon, but they can persist for extended periods without causing noticeable symptoms owing to the inertness and biocompatibility of gold. However, the foreign body was nonmagnetic in nature, mechanical trauma by the foreign body to the endothelium can lead to delayed corneal decompensation. This case demonstrates the successful treatment procedure. Early detection and appropriate management could have averted DSAEK; however, even in the late stage with combined DSAEK, better results can still be obtained.

  • Research Article
  • 10.1177/09760016241284360
A Rare Case Report on Definitive Radiotherapy in Sebaceous Carcinoma of the Eyelid
  • Oct 8, 2024
  • Apollo Medicine
  • Kesav Ajith + 2 more

Introduction: Sebaceous carcinomas are rare but potentially aggressive cutaneous malignancies. Surgical excision, albeit the primary modality of treatment, is associated with functional as well as cosmetic impairments. Radiotherapy offers an alternative treatment modality for those in whom surgical excision is not an option either due to medical reasons or patient preferences. Materials and Methods: Here we present a rare case report of an elderly Indian man with sebaceous carcinoma of the eyelid, for whom definitive radiotherapy was delivered as the primary modality of treatment. Results: There was a near complete response of the tumour to the definitive radiotherapy with acceptable toxicity. Discussion: Radiotherapy is a non-invasive alternative to surgical excision that has the advantage of better functional and cosmetic outcomes.

  • Research Article
  • Cite Count Icon 2
  • 10.7146/mk.v40i76.143565
The gendered dress of DALL-E 2: Exploring profession-based images in the Indian context
  • Aug 30, 2024
  • MedieKultur: Journal of media and communication research
  • Musthafa Mubashir

This study delves into the intricate realm of gender and artificial intelligence (AI) through an examination of DALL-E 2 generated images within the Indian context. The study takes a methodological approach that focuses on assessing images generated in response to prompts such as ‘a farmer cultivating crops in rural Punjab’ or ‘a nurse providing care in a hospital in Delhi’ to reveal the dynamics of gender performativity within profession-based visual content. The generated images were analysed using the dress as a phenomenon to visualise Indian man, Indian woman and ambiguous Indian. The study concludes that DALL-E 2’s algorithm reiterates the binary gender norms leaving no space for ambiguous Indian in its responses. Though the generated image is centred on female professions, it is largely employed by male surroundings. Hindu religious symbols are largely used among male professionals denoting its predominance. In its aesthetics, the individuals portrayed exhibit a brown complexion, echoing the demographic landscape irrespective of gender.

  • Research Article
  • 10.5325/resoamerlitestud.45.1.0198
The Secret of the Writing: James Welch and the Drafting of Winter in the Blood
  • Jul 17, 2024
  • Resources for American Literary Study
  • David Buchanan

ABSTRACT Winter in the Blood has an extremely interesting archival back story. Buchanan discovered in James Welch’s archives at the Beinecke Library at Yale University that, as a student at the University of Montana, Welch had already formed the thematic core of the novel nearly ten years before its publication. In a folder with a sticky note on it that reads “In his box in closet. ORIGINAL stuff from writing class!” rests a number of short stories that Welch wrote for a 1964 creative writing course. One of these documents is a short snippet of a story that features a young Indian man named Moses First Raise discovering a dead man lying along a trail in a ravine near a pen of cows. This plot event points to a similar plot event in the opening pages of the novel, though the point of view shifts around and confuses the relationship between the narrator, Moses, and the dead man. Moreover, it is the first time that the brother Moses appears in any of Welch’s other papers or published work. The article explores this and other elements of the compositional history of Welch’s masterpiece, Winter in the Blood.

  • Research Article
  • Cite Count Icon 1
  • 10.1016/j.endeavour.2024.100942
Gentlemen, husbandmen, and industrious wives: The role of gender in imagining Indian agriculture
  • Jun 1, 2024
  • Endeavour
  • Laura Tavolacci

Gentlemen, husbandmen, and industrious wives: The role of gender in imagining Indian agriculture

  • Research Article
  • 10.63475/j.yjom.2024.029
Pulmonary mucoepidermoid carcinoma with endobronchial involvement: A case report
  • Jan 1, 2024
  • Yemen Journal of Medicine
  • Theeb Sulaiman + 4 more

Although mucoepidermoid carcinomas (MEC) commonly occur in the salivary glands, they are rarely encountered in the lungs. In this case report, we present a rare case of pulmonary mucoepidermoid carcinoma with endobronchial involvement in a 36-year-old Indian man who presented to our pulmonary outpatient clinic with a 10-year history of recurrent lower respiratory tract infections. A comprehensive workup was performed in his home country, but did not lead to a definitive diagnosis. At our hospital, high-resolution chest computed tomography was repeated, confirming a well-demarcated soft tissue mass measuring 1.7 x 1.8 x 1.1 cm in the right lower lobe bronchus. This was followed by positron emission tomography (PET) showing intense fluorodeoxyglucose (FDG) uptake in the mass with a standardized uptake value (SUV) of 7.9. The final diagnosis was made by histopathological examination of a resected right lower lobe, which confirmed the diagnosis of low-grade mucoepidermoid carcinoma, with no metastases found in the lymph nodes. The patient was then referred to a multidisciplinary oncology team, which opted for regular surveillance and follow-up.Although mucoepidermoid carcinomas (MEC) commonly occur in the salivary glands, they are rarely encountered in the lungs. In this case report, we present a rare case of pulmonary mucoepidermoid carcinoma with endobronchial involvement in a 36-year-old Indian man who presented to our pulmonary outpatient clinic with a 10-year history of recurrent lower respiratory tract infections. A comprehensive workup was performed in his home country, but did not lead to a definitive diagnosis. At our hospital, high-resolution chest computed tomography was repeated, confirming a well-demarcated soft tissue mass measuring 1.7 x 1.8 x 1.1 cm in the right lower lobe bronchus. This was followed by positron emission tomography (PET) showing intense fluorodeoxyglucose (FDG) uptake in the mass with a standardized uptake value (SUV) of 7.9. The final diagnosis was made by histopathological examination of a resected right lower lobe, which confirmed the diagnosis of low-grade mucoepidermoid carcinoma, with no metastases found in the lymph nodes. The patient was then referred to a multidisciplinary oncology team, which opted for regular surveillance and follow-up.

  • Research Article
  • 10.24911/sjemed.72-1710091410
Lessons learned from a fatal case of Tuberculosis Meningitis: A case report
  • Jan 1, 2024
  • Saudi Journal of Emergency Medicine
  • Farya Rehman + 3 more

BACKGROUND In 2023, 10 million cases of Tuberculosis were reported by the WHO. Tuberculous meningitis (TBM) may be the sole manifestation of Tuberculosis (TB) and does not require prior pulmonary or extrapulmonary disease[1]. Approximately one-half of all TBM infections lead to severe neurological disability with a mortality rate of 30% with death in 6 months and 50% overall[2-4]. Despite being inarguably the most devastating clinical presentation of TB, frequent diagnostic delays are common due to low clinical suspicion or misdiagnosis as current diagnostic tests still have a limited yield[5]. The best way to reduce mortality and morbidity associated with TBM is by maintaining a high index of suspicion, timely diagnosis and initiation of treatment. This case report aims to highlight the clinical presentation, imaging findings, and diagnostic pitfalls in the diagnosis of TBM. CASE PRESENTATION A 36-year-old Indian man with no significant medical, social, or travel history initially sought treatment at a private hospital in Abu Dhabi for fever, intermittent headaches, and confusion. Investigations at the hospital included a negative QuantiFERON TB gold (QTF) test and a negative cerebrospinal fluid (CSF) culture, but the CSF analysis was not included in the provided reports. Consequently, he received acyclovir treatment for suspected viral encephalitis but was discharged without complete symptom resolution. Following discharge, he experienced worsening confusion over three days. Upon presentation to our Emergency Department (ED), he was febrile, disoriented, and difficult to rouse, with a GCS score of 11/15, displaying terminal neck stiffness. There were no signs of lateralization, cranial nerve deficits, or cerebellar abnormalities. A computerized tomography (CT) scan conducted in the ED revealed hydrocephalus with diffuse leptomeningeal enhancement. Laboratory results indicated significant hyponatremia at 121 mmol/L. He was started on broad-spectrum antibiotics and anti-tuberculosis medication empirically based on the clinical scenario and CT findings. During his Intensive Care Unit (ICU) stay, a CSF analysis suggested TB meningitis, and a positive Mycobacterium tuberculosis polymerase chain reaction (MTB-PCR) confirmed the diagnosis. An MRI of the brain showed meningoencephalitis with tuberculoma formation in the left cerebellar hemisphere. Unfortunately, despite treatment, his condition deteriorated, necessitating endotracheal intubation, multiple EVD revisions, and ventriculoperitoneal shunt placement. A follow-up MRI revealed worsening hydrocephalus and cerebral vessel thromboses, ultimately leading to his unfortunate demise in the ICU. CONCLUSION This case highlights that Tuberculous meningitis is a highly lethal, under-recognized disease with characteristic clinical and imaging features in which delay in diagnosis and subsequent treatment can lead to fatal consequences. Emergency Medicine physicians should maintain a high index of suspicion for TBM in patients with fever and vomiting and signs of altered mental status and keep in mind that a normal CXR, negative QuantiFERON test, and the absence of TB exposure history does not exclude TBM from the differential when clinical and Brain imaging findings raise concern. Prompt identification prevents delay in initiation of management and ultimately may lead to better long-term outcomes.

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