Increase In Quality Of Life Research Articles

The Current Role of Metastasis-Directed Therapy for Oligometastatic Renal Cell Carcinoma

Approximately 20% of newly diagnosed renal cell carcinoma (RCC) cases exhibit synchronous metastases, while 20% to 40% of initially localized RCC cases subsequently develop distant metastases after surgical intervention. In the management of oligometastatic RCC with a restricted number of metastatic sites, metastasis-directed therapy (MDT) plays a crucial role within the multimodal therapeutic framework. MDT, which encompasses surgical metastasectomy and stereotactic body radiation therapy (SBRT), seeks to prolong survival and increase quality of life by offering an interruption of systemic therapy. Research has demonstrated that complete metastasectomy is essential for attaining an optimal survival advantage. The criteria for patient selection remain ambiguous; nonetheless, it is crucial to consider the location of metastases and patient risk stratification. SBRT is demonstrably successful in RCC and is being progressively utilized in oligometastatic RCC. The sequencing of advanced systemic agents with comprehensive local treatment of primary and metastatic sites for oligometastatic RCC has demonstrated potential.

Effect of yoga-based exercise program in female patients with myofacial pain of temporomandibular disorders.

The study was conducted to investigate the effect of Yoga-based exercise program on pain, range of motion (ROM), quality of sleep, depression and quality of life in female patients with myofacial pain of temporomandibular disorders (TMD). 39 Female patients with myofacial pain of TMD were included in the study. Yoga based exercise program was performed to the first group and second group was control group. Visual Analog Scale (VAS), Neck Pain and Disability Scale (NPDS), neck and jaw ROM, Pittsburg Sleep Quality Index (PUQI), Beck Depression Inventory (BDI) and Short Form 36 (SF36) were evaluated. Evaluations were repeated before treatment and 6 weeks later. From the measurements, a decrease in Temporomandibular Joint (TMJ) (p = 0.005) and neck pain (p = 0.031) was found to be significant in favor of Yoga Group. It was also observed that the increase in ROM in the neck right lateral flexion (p = 0.001) in favor of Yoga Group. The sleep quality did not change. In yoga group, a decrease in depression level (p = 0,023) and increase Quality of life in parameters of physical function (p = 0.023), vital capacity (p = 0.026), emotional health (p = 0.002), mental health (p = 0.080) were found as significant, statistically. It was concluded that yoga-based exercise program can be used as an alternative program in patients with myofacial pain of TMD. Further study on myofascial pain of TMD is recommended. Yoga-based exercise program can be used in patients with myofascial pain due to TMD.

Development of Family Empowerment Model in Diabetes Management Among Type 2 DM Patients

Background: Diabetes management has not been optimally implemented by patients, considering the high incidence of diabetes complications. Therefore, family empowerment is important for diabetes management. Objective: This study aims to determine factors related to diabetes management, inhibiting, and supporting factors for diabetes management to develop a family-based educational model in diabetes management through expert testing.Methods: This research used Mixed Methods design with an Explanatory Sequential Design approach. A cross-sectional approach to 207 people with DM selection using a multistage sampling technique. Data was collected by questionnaire, in-depth interview, and Delphi study. Data analysis using chi-square and logistic regression. The development of family empowerment model is based on the theory Ladder of Empowerment, Social Cohesion, and Family Support. Results: Research results showed that good knowledge of patients, good family empowerment, and absence of DM risk factors are related to diabetes management. Model development and expert testing (Delphi Study) of the model find that a family-based diabetes management module is needed. Conclusion: A good family-based diabetes management module includes aspects of Self-Instructional, Self-Contained, Stand Alone, Adaptive, and User-Friendly aspects. This module is expected to improve diabetes management for patients and their families so that diabetes complications can be prevented and the patient's quality of life increases.

Exploring Preventive Measures and Disease Dynamics of Hereditary Polymorphic Light Eruption in American Indian Children

Hereditary polymorphic light eruption (HPLE) is a condition related to polymorphic light eruption (PLE). Unlike PLE, HPLE is unique to American Indian populations demonstrating autosomal dominant inheritance pattern with incomplete penetrance. Affected individuals possess hypersensitivity to long UV radiation, which heightens the risk for skin damage. Onset is typically childhood and disease severity results in complications including psychosocial trauma, streptococcal pyoderma, and glomerulonephritis. HPLE can be difficult to diagnose due to its overlapping qualities with other conditions, underscoring the importance of accurate diagnosis and management. Preventive measures play critical roles in mitigating disease occurrence and complications. Literature analysis of five articles using PubMed and Google was conducted to understand HPLE among the Native American community, particularly children. Search terms included hereditary polymorphic light eruption, Native Americans, American Indians, polymorphic light eruption, actinic prurigo, UV toxicity, and photosensitivity. Literature delineated the disease process of HPLE and preventive measures. Studies revealed a higher incidence among children/adolescents who presented with rashes within two hours of sun exposure. Rash severity increased as seasons progressed to summertime. It is imperative that affected individuals utilize broad spectrum coverage sunscreen, covering UVA and UVB rays. Other measures proven to be effective include protective clothing, limiting time outdoors during peak sun hours, and using specially formulated lip balm. HPLE creates a unique challenge among American Indian populations necessitating increased awareness and educational strategies to minimize and avoid complications. Providing education on prevention and actively implementing measures can help decrease the complications of HPLE and increase quality of life.

Integrating brief exposure exercises to support cognitive processing therapy for treatment of PTSD: A case study

Posttraumatic stress disorder (PTSD) is a prevalent and concerning mental health diagnosis across the globe. There are multiple evidence-based treatments that have been shown to effectively treat PTSD, including cognitive processing therapy (CPT) and exposure-based interventions. This case study depicts using CPT for treating uncomplicated PTSD in a 28-year-old woman, while integrating brief exposure exercises in the client’s homework. These exercises helped target avoidance symptoms and acute distress as well as increase quality of life, such that the client was better able to engage in CPT. Follow up data indicated a significant reduction in PTSD symptoms as measured by the Posttraumatic Stress Disorder Checklist (PCL-5) such that she no longer met clinical criteria for a diagnosis of PTSD or experienced significant distress related to her trauma. This data reflects the utility of integrating other evidence-based exercises into manualized treatment to create nuanced, individualized treatment plans. Clinical and research implications regarding the utility of implementing an integrated, conceptualization-driven treatment approach are discussed.

Road Traffic Enforcement: Using Technology Through Public-Private Partnerships (PPP)

The past two decades have seen a wide - ranging wave of privatizations in formerly government owned or - controlled activities. A government task or service which is funded and operated through a partnership between a public sector authority and private sector company based on guidelines and performance standards set by a public party is typically referred to as a Public Private Partnership (PPP). In most countries traffic enforcement cameras and other equipment are purchased, owned, and operated by government organisations. Back - offices, where violation data are processed, citations issued, and traffic fines collected, have traditionally been government - run activities. In a PPP model, a private party invests and installs enforcement equipment (e. g. speed or red - light cameras) and conducts back office processing, such as sending out violation notices and managing and confirming fine collection. The investment in equipment and related processing and support activities are funded by fine revenues collected from the motoring public over the contract term. Gaining public support, and ultimately acceptance, for the PPP model is crucial, which is why transparency, publicity and continuous communication are key factors for successful and sustainable implementation. Full service PPPs are often organised on a municipal level in close consultation with the local administration and police. Due to the high initial investment and gradual repayment, such PPPs are typically based on longer term contracts. Moreover, the regulatory environment may require some changes to allow involvement of a private party. One process that is difficult to outsource is the formal confirmation of a violation by a review of the photo or video evidence. Generally, this can only be validly performed by an authorised government official, such as a police officer. Depending on laws and regulations applicable to specific jurisdictions, there could be more issues that may limit the extent of the private party’s involvement in these PPPs. When properly implemented, PPP’s in traffic enforcement can considerably contribute to the reduction of casualties, injuries and crashes, as well as improve traffic flow, and increase quality of life with more safety, lower emissions and less noise pollution. Speed reduction also significantly benefits the safety of vulnerable road users such as pedestrians, and two - wheelers Personal injury and death on roadways also have a significant impact on the economy through medical costs, lost resources and wages and disability pay outs. These costs are significant and are estimated by the WHO to amount to an average of around 3% of a country’s GNP. This figure rises to 5% in some low - and middle - income countries

The limits of right-sizing: analyzing social housing strategies in French shrinking cities

ABSTRACT Right-sizing is becoming an increasingly relevant topic within the burgeoning literature on shrinking cities, specifically as a means for cities to cope with population loss. It encompasses various measures, such as demolishing vacant housing, consolidating urban development, and reusing vacant land for community gardens. Right-sizing promises to reduce financial concerns and increase quality of life. However, several studies have pointed out the limitations of its application, as it is bound by the principles of austerity. Recent research has argued for a more nuanced interpretation of the concept, as right-sizing can have differing impacts and outcomes depending on the local context. Following these recent contributions, this paper aims to deconstruct the right-sizing approach by analyzing social housing strategies in two shrinking cities in France (Le Creusot and Montluçon). The analysis shows that these two cities have been implementing strategies that include some quantitative adjustments of supply to demand. However, the strategies adopted are considerably more complex than mere quantitative adjustment and include a variety of synergistic lines of action. Thus, the aim of this paper is twofold: first, to highlight the limitations of right-sizing as an analytical concept, and second, to contribute to identifying appropriate social housing policies for shrinking cities.

Design and Implementation of a Web-Based Self-Care Application for Patients with Kidney Stone Treated with Extracorporeal Shock Wave Lithotripsy

Background: The prevalence of kidney stones reduces the patients’ quality of life and imposes high costs on patients and health care system. Extracorporeal shock wave lithotripsy is a safe procedure to treat urinary stones. Appropriate strategies such as self-care programs can effectively reduce the prevalence and recurrence of this disease, and increase quality of life, save costs, and prevent diseases by increasing patient participation. The aim of this study is to design and implement a web-based self-care application for patients with kidney stones undergoing extracorporeal shock wave lithotripsy. Methods: This paper is an applied study and was performed in Sabalan Hospital in Ardabil affiliated to the Social Security Organization of Iran in three stages including needs assessment, design and evaluation. For needs assessment and application design, a questionnaire was designed by searching library resources. The questionnaire was completed by clinical specialists and specialists in health information management and information technology. Then, based on the approved information elements and capabilities, a web-based self-care application was designed. The usability of the designed program was evaluated with the participation of 20 users. Results: The results of the survey showed that the experts confirmed all the identified items and components, and considered them necessary. Users rated the usability of the self-care program at a good level with an average score of 7.9 out of 9. Conclusion: The usability of the self-care application was satisfactory to users in various areas of overall application performance, screen, terminology and information, learning and general impressions.

Comparative analysis of laparoscopic nissen fundoplication and rossetti modification in gastroesophageal reflux disease: A focus on life quality enhancement

ObjectiveThis study aims to investigate the focus of surgical treatment of gastroesophageal reflux disease (GERD) on enhancing life quality beyond symptom relief. The comparison involves laparoscopic Nissen fundoplication and Rossetti modification techniques. MethodsPatients intolerant to or experiencing relapse after medical therapy underwent either standard Nissen procedure (Group 1, n=61) or Rossetti modification (Group 2, n=42). A disease-specific quality of life questionnaire for GERD was utilized for evaluating life quality preoperatively and 2 years postoperatively. Symptom scores and patient satisfaction were also assessed. ResultsPreoperatively, groups were similar in symptom duration, hiatal hernia presence, and DeMeester scores (p=0.127, p=0.427, and 0.584, respectively). Both groups exhibited a statistically significant increase in life quality postoperatively (p<0.001), with no significant intergroup difference. Symptoms decreased after both surgeries, except for dysphagia and bloating. Bloating significantly increased in both groups after surgery (p=0.018 and p=0.017, respectively), and dysphagia increased significantly only in Group 2 (p=0.007). The surgery refusal rate was significantly higher in Group 2 for similar preoperative symptoms (p=0.040). ConclusionDespite increased life quality scores, the combination of increased dysphagia and bloating in patients undergoing Rossetti modification resulted in a decreased satisfaction rate.

#511 Inadequate diagnostic investigations and low treatment rates in CKD anemia: an inertia that can only change with long-term follow-up

Abstract Background and Aims Anemia is observed from the early stages in the course of chronic kidney disease (CKD), and as the stage progresses, the severity of anemia and its impact on quality of life increase. Early diagnosis of anemia in chronic kidney disease, assessments related to its etiology, and treatment are therefore crucial. There is no comprehensive and long-term study in Turkey addressing the diagnostic and therapeutic management of anemia seen in the course of chronic kidney disease. The aim of this study is to investigate the frequency of anemia in different stages of CKD in patients diagnosed with Stage 3 and more advanced stages, to evaluate the effectiveness of diagnostic approaches, and management of iron parameters and anemia, and to investigate the effect of anemia on patient survival. We aim to present “real-life” data from this study to guide clinical practice and correct errors or deficiencies in anemia management. Method This study is a single-center, observational-descriptive retrospective study. 1321 outpatients with Stage 3A and advanced CKD and anemia who admitted to Hacettepe University Faculty of Medicine Nephrology Clinic between 2014 and 2018 were included in the study. Data for demographics, CKD etiologies and stages, anemia severities, comorbid diseases were collected from electronic health system (Table 1). Diagnostic investigations for anemia evaluation and therapeutic interventions such as administration of iron, folic acid, vitamin B12, erythropoiesis stimulating agents (ESA) were assessed. The long-term yield of diagnostic and therapeutic approaches and their effects on survival were also evaluated. The study investigated whether the severity of anemia and improvement in anemia had an effect on survival. Results Ferritin is the most commonly performed test for the etiology of anemia (76.4%). Request rates for tests such as B12, folic acid, transferrin saturation and reticulocyte are below 20%. More than half of the patients with anemia (59.4%) have not received any form of anemia treatment. Even among those whose ferritin test was checked and the value was &amp;lt;100 µg/dL, only 41.4% were given iron treatment. As the clinical follow-up period of the patients increased, it was observed that anemia treatment was applied better and target values were reached more frequently (p &amp;lt; 0.001). More than one third of the patients (34.8%) died during follow-up. The overall survival in patients whose anemia improved was 79.8%, and it was 62.8% in patients whose anemia did not improve the overall survival was (p = 0.002) (Fig. 1). When examining the relationship between survival status and anemia severity for the non-dialysis-dependent CKD Stage 3-5 group, there was a statistically significant survival difference between the Hb group of 10-11.9 g/dL to Hb group of &amp;lt;10 g/dL (p = 0.004). Conclusion This study has shown that diagnostic tests for etiology of anemia were insufficiently ordered. It was also found that a significant majority of anemic patients who underwent etiological evaluation were not even adequately treated. Long-term follow up improved anemia treatment, and patients with improved anemia had better survival. In conclusion, we recommend an optimal evaluation of CKD patients with anemia and initiating treatment as early as possible.

Examining dietary supplements containing Euterpe oleracea Mart. (açaí) for potential botanical-drug interactions involving CYP3A4 inhibition

BackgroundBotanical dietary supplements (BDS) are consumed more by cancer patients than otherwise healthier patients to alleviate side effects of chemotherapy drugs or increase quality of life. The enzyme responsible for the metabolism of most anticancer drugs is CYP3A4, an enzyme predominantly located in the liver. HypothesisOur research team examined the potential risk between CYP3A4-interactive cancer drugs and Euterpe oleracea Mart. (açaí) berry and found that the compounds that passively and non-passively diffused from methanol açaí extract displayed significant inhibition of liver CYP3A4 – suggesting the potential for interactions between açaí and drugs metabolized by CYP3A4 if used synchronously. This study aims to identify the compounds responsible for the CYP3A4 inhibition using the newly automated Bioactivity – Global Natural Product Social Molecular Networking (GNPS) tool. MethodsDietary supplement capsules from two manufacturers (F1 and F2) containing aqueous extracts of açaí fruits were extracted separately by methanol (ME) and acidic methanol (AC) and standardized to cyanidin-3-O-glucoside (CG) concentration at a human-relevant dose. After solvent removal, a parallel artificial membrane permeability assay (PAMPA) was utilized to filter intestinal passive diffusion of the four extract constituents so that compounds could be tested for inhibition of hepatic CYP3A4. Passively and non-passively diffused constituents of extracts from PAMPA assays were injected into the liquid chromatography-mass spectrometry (LC–MS) and characterized for visualization and comparison of chemical entities. To elucidate the non-passively diffused compounds responsible for significant CYP3A4 inhibition, the Bioactivity – GNPS tool was used to hypothesize which compounds within the formulation extract were potentially active to accelerate their identification. ResultsThere was no significant inhibition of CYP3A4 by passively diffused constituents for any extract. There was, however, significant inhibition by non-passively diffused constituents of both F1ME and F1AC extracts with 50 % CYP3A4 inhibition at the donor compartment concentrations 5.764 and 15.58 ng/ml CG, respectively. Six compounds were predicted to be inhibitors of CYP3A4 from methanol F1 extract, including betaine and 5 unknown compounds. ConclusionThis indicates that BDS containing açaí may not inhibit CYP3A4 through passively diffused compounds. Compounds from açaí BDS that inhibit CYP3A4 may be absorbed through other mechanisms, such as transporters.

Nerve Bypass Surgery for Spinal Cord Reconstruction

ObjectiveSpinal cord injury (SCI) is a devastating condition that significantly decreases the patient's quality of life. Therefore, treatments that can facilitate nerve regeneration, reduce complications, and increase quality of life are valuable for these patients. In this study, we aimed to assess nerve bypass surgery's feasibility and clinical outcomes by transferring the intercostal nerves (ICNs) into the spinal cord. MethodsEight patients with complete thoracic SCI and delayed presentation more than a year after the injury were analyzed retrospectively. All patients underwent nerve bypass surgery with the transfer of two pairs of ICNs from proximal to the injury site to the anterolateral spinal cord, followed by duraplasty with fascia grafting to close the dura. ResultsSix of the eight (75%) patients demonstrated motor and sensory improvements, based on the American Spinal Cord Injury Association score. Three patients demonstrated a limited recovery of motor function that could be independently triggered without ICN initiation. Five patients demonstrated evidence of cerebrospinal fluid (CSF) leakage after surgery; however, only one patient complained of a headache. ConclusionSpinal cord bypass surgery is a potential reconstruction method to treat chronic complete thoracic SCI with functional improvements, and is worth further investigation.

A Study on Fragrance Preference of Aroma Oil by Sleep Habits

The importance of sleep is being emphasized as interest in improving health and quality of life increases. In particular, the use of aroma oil has been expanded as a complementary therapy for sleep disorders. Aroma oil can be selected according to individual preferences and characteristics because it has various effects depending on the type. Therefore, the use of aroma oil suitable for individual preferences and characteristics can have a positive effect on the sleep habits of modern people who value health. Therefore, it is necessary to revitalize the beauty industry by developing customized aroma products based on the diversity of health-related lifestyle habits. In this study, 200 adult women over the age of 20 living in Jeollabuk-do were surveyed for general characteristics, sleep habits, sleep habits type, differences in sleep habits according to general characteristics, aroma oil aroma preference, and aroma oil aroma preference according to sleep habits and general characteristics. For the analysis, frequency analysis, factor analysis, cluster analysis, cross-analysis, independent sample t-test, one-way variance analysis, and Duncan test were used using the SPSS program. As a result of the analysis, it was found that there was a significant difference in aroma oil preference according to the final academic background and sleep habits of the subjects. In particular, high school graduates tended to prefer the scent of rosemary, the sleep-type group preferred the scent of lemon and lavender, and the insomnia group preferred the scent of rosemary. As such, it was confirmed that individual sleep habits and aroma oil preference were closely related. This is a study that proves the need for aroma product development and marketing, and is intended to be provided as basic data for revitalizing the beauty industry.

Barriers and Facilitators to Implementing an Evidence-Based Community Health Worker Model

Community health worker (CHW) programs may improve health outcomes, increase quality of life, and reduce hospitalizations and cost of care. However, knowledge is limited on the barriers and facilitators associated with scaling evidence-based CHW programs to maximize their public health outcomes. To identify barriers and facilitators to implementing an evidence-based CHW model. This qualitative study examined perspectives of Individualized Management of Person-Centered Targets (IMPaCT) program staff (health system leaders, program managers, and community health workers) and patients receiving the intervention between March 9, 2020, and July 22, 2021, at 5 institutionally and geographically diverse health systems across the US. The collected data were analyzed between December 1, 2021, and April 27, 2022. Program staff were recruited via purposive sampling, and patients were recruited via convenience sampling. The disease-agnostic IMPaCT CHW model includes a standardized implementation approach and a structured set of theory-informed intervention components to create and achieve individualized action plans. Interview guides were informed by the Consolidated Framework for Implementation Research. A rapid qualitative analytic technique was used to identify key themes, which were categorized into barriers and facilitators associated with framework ecological domains. Of a total 41 individuals invited, 39 agreed to participate (95% response rate; mean [SD] age, 45.0 [12.6] years; 30 women). General barriers included economic and policy constraints, including insufficient funding for CHW programs, clinical integration challenges, and CHW difficulty with maintaining boundaries. Program-specific barriers included insufficiently tailored materials for certain populations and upfront and ongoing program costs. General facilitators included CHWs' interpersonal skills and life experiences. Program-specific facilitators included the model's strong evidence base, supportive implementation team, and program design that enabled relationship building and engagement. Additional themes were cited as both barriers and facilitators, including the COVID-19 pandemic, organizational leadership, IMPaCT training, and program fidelity. These findings suggest growing recognition of the importance of CHWs to improving health equity and population health. Barriers identified point to important policy and practice implications for CHW programs more broadly, including the need for continued attention to improving clinical integration and the need for sustainable program financing to preserve the longevity of this workforce.

Do spirituality and emotional intelligence improve the perception of the ability to provide care at the end of life? The role of knowledge and self-efficacy.

Spirituality, emotional intelligence, and palliative care (PC) knowledge have a positive and direct influence on self-efficacy and on perception of preparation and ability to provide end-of-life (EOL) care. The aim of this work is to propose a conceptual model that relates spirituality, emotional intelligence, PC knowledge, self-efficacy, and the preparation and ability to provide EOL care by doctors and nurses. Quantitative, exploratory, descriptive, and inferential study applied to doctors and nurses in a hospital in the north of Portugal, between May and July 2022. The data collection instrument includes a questionnaire. The relationships between latent variables were evaluated using structural equation models by the partial least squares method using the Smart PLS 3.0 software. It was obtained the previous authorization of the ethics committee. The results (n = 380) indicate that self-efficacy, spirituality, and PC knowledge have a positive influence on the ability to provide EOL care. Emotional intelligence and spirituality have a direct and positive effect on self-efficacy. There is no direct influence of emotional intelligence on the ability to provide EOL care, but emotional intelligence has an indirect effect mediated by self-efficacy. Spirituality, self-efficacy, and emotional intelligence are very important for the ability of doctors and nurses to provide EOL care. The identification of predictive factors of the ability to provide EOL care and the determination of the relationship between them can improve the provision of EOL care, reduction of health costs, timely and early referral of people to PC, and increase life quality.

Conceptual Playworld as a Method of Facilitating Learning Beyond Subject Matter in Elementary School

Children experience less time to play due to the focus on learning in early childhood education and earlier school starting times. Paradoxically, play is important for children’s learning and contributes to increased curiosity, wonder, and learning motivation. It is also important for children’s sense of belonging in society, social relationships, as well as physical and mental quality of life. In Norway, a new curriculum demands that pupils learn about increased life quality through interdisciplinary teaching but also suggests that play should be included in teaching to promote creative and meaningful learning. Research shows that teachers often let pupils play, but they have little experience and knowledge of how play can both promote learning and secure the quality of life of their pupils. One teacher educator and six student teachers constructed a “Conceptual Playworld” for 18 pupils in 2nd grade. The certified teacher acted as observer together with another teacher educator. Through interviews, we investigated what those who taught and observed experienced and observed. The results show that “Conceptual Playworld” is a method that seems to promote a holistic approach to learning where the pupils acquire social skills in combination with subject knowledge.

KOMPARASI KONSEP “TERAPI JIWA” IBNU QAYYIM AL JAUZYYAH DAN KAREN HORNEY

Soul therapy in the perspective of Sufism is defined as a process of purifying the soul which involves two main elements, namely tazkiyah (purification) of the soul from the negative traits that exist in every person and tahliyah (decorating the soul with positive traits). Characteristics. From this research is to compare the concept of mental therapy from Ibn-Qayyim Al-Jauziyyah and Karen Horney. This research method is qualitative based on a library research approach (qualitative research). The results of this study are (1) The concept of soul therapy from Ibn Qayyim Al-Jauziyyah, namely purification of a dirty soul with scientific therapy, tadzakkur and riyadha. (2) According to Karen Horney, the concept of mental health therapy that defines mental health disorders better known as neurosis arises from the following actions: Take time, reassess, practice paying attention, focus on relationships and speak as it is. Such mental disorders for treatment are born in a person who expects healing and can be accepted by the environment and if a person has a pure soul then he is closer to the Almighty so that his quality of life increases. Life will be higher.

Properties of Dietary Fatty Acids and Implications on Cancer

Known as one of the most significant noncommunicable diseases, cancer has a high morbidity and mortality rate worldwide. Dietary fatty acids’ effect can be varied upon the structure of components. Saturated fatty acids (SFAs) and Monounsaturated fatty acids (MUFAs) intakes have positive relation with the risk of dıfferent types of cancers. However, this conclusion alters based on the type of polyunsaturated fatty acids (PUFAs). Omega-3 fatty acids illustrate protective effects against cancer, while omega-6 fatty acids have pro-inflammatory activities. Moreover, ratio of omega-3: omega-6 fatty acids plays a crucial role related to cancer. Ketogenic diet is contraindication for some types of cancer. This diet in cancer patients can be used as secondary treatment, and complications peculiarly cancer cachexia could be improved which increases life quality of cancer patients. In conclusion, decreasing the risk of cancer will be possible by shifting fatty acids consumption toward more omega-3 and less omeg-6 fatty acids and decreased intake of SFAs (via less consuming of processed foods).

Dental prosthesis extraoral indexing and pick-up technique for mandibular full arch immediate rehabilitation in fibula free flap reconstruction.

Same-day ablative and reconstructive surgeries for the treatment of head and neck pathologies are gaining in popularity with the recognition that single-day surgeries reduce morbidity and increase quality of life. Implant-borne prosthetics on the donor graft provide immediate dental reconstruction. This report describes a novel technique for extraoral pickup of a full arch immediate prosthesis from the donor site free flap. This technique minimizes intraoperative occlusal adjustments, saves intraoperative time, prevents undesirable "rolling" of a fibula segment, and immediately rehabilitates patients with dental prosthetics. This article is protected by copyright. All rights reserved.

Economic and Social Implications of Negative Population Growth

With the rapid development of China’s socioeconomic status, the increasing life quality, and the changing attitudes on marriage and childbearing among people of childbearing age, China has entered an era of negative population growth since 2022. Although China has introduced various policies to encourage births since 2013, the number of births has not increased as expected, but has declined rapidly. Looking back at the historical trend of population change in some developed countries, population decline is an “inevitable” process that many countries have to go through in the process of social and economic development. For China, after more than 30 years of its one-child policy, its population situation has some unique features. Although the willingness of young couples to have children is declining and the number of births is decreasing, there are significant problems such as advanced pregnancy, infertility, and childbearing after caesarean section, which in turn pose a threat to the health of mothers and children and lead to heavy medical burdens. Therefore, how to improve the treatment effectiveness and safety of infertility, the quality of maternal and child health care and the ability to treat high-risk maternal and foetal complications are major issues that China’s maternal and child health care system has to face and deal with urgently.