Improve Blood Circulation Research Articles

Zhongfeng decoction attenuates cerebral ischemia-reperfusion injury by inhibiting autophagy via regulating the AGE-RAGE signaling pathway

Ethnopharmacological relevanceTackling phlegm and improving blood circulation is vital in the treatment of ischemic stroke (IS), culminating in the development of Zhongfeng Decoction (ZFD), a method grounded in this approach and serving as an effective therapy for IS. Nonetheless, the defensive mechanism of the ZFD in preventing cerebral ischemia-reperfusion damage remains ambiguous. Aim of the studyDetermine the active ingredients in ZFD that have neuroprotective effects, and identify its mechanism of action against IS. Materials and methodsA cerebral ischemia model in rats was developed, utilizing TTC, Nissl staining, and an oxidative stress kit to evaluate the neuroprotective impact of ZFD on this rat model. Following this, an amalgamation of LC-MS and network pharmacology techniques was employed to pinpoint potential active components, primary targets, and crucial action mechanisms of ZFD in treating IS. Finally, key targets and signaling pathways were detected using qRT-PCR, ELISA, Western blotting, electron microscopy, and other methods. ResultsThrough LC-MS and network analysis, 15 active ingredients and 6 hub targets were identified from ZFD. Analysis of pathway enrichment revealed that ZFD predominantly engages in the AGE-RAGE signaling route. Kaempferol, quercetin, luteolin, baicalein, and nobiletin in ZFD are the main active ingredients for treating IS. In vivo validation showed that ZFD can improve nerve damage in cerebral ischemic rats, reduce the mRNA expression of IL6, SERPINE1, CCL2, and TGFB1 related to inflammation. Furthermore, we also confirmed that ZFD can inhibit the protein expression of AGEs, RAGE, p-IKBα/IKBα, p-NF-κB p65/NF-κB p65, reduce autophagy levels, and thus decrease neuronal apoptosis. ConclusionsThe mechanism of action of ZFD in treating IS primarily includes inflammation suppression, oxidative stress response alleviation, post-stroke cell autophagy and apoptosis regulation, and potential mediation of the AGE-RAGE signaling pathway. This study elucidates how ZFD functions in treating IS, establishing a theoretical basis for its clinical application.

Biologically based strategies for overcoming in vivo barriers with functional nano-delivery systems.

Nanomedicine has been developed to reduce or eliminate the side effects and toxicity upon systemic therapy of chemotherapeutic agents and to improve their therapeutic efficacy. However, the translation of non-sized or nano-encapsulated drugs is hampered by the low penetration and accumulation of engineered nanoparticles (NPs) in sites of tumors as well as their poor pharmacokinetics. This may be due to the synthetic structure of NPs and also complicated and unknown characteristics of the solid tumor microenvironment (TME). As a result, the TME is being better identified, and the interactions between NPs and the TME or human body are being discovered or predicted. These findings have led to the development of more biocompatible, intelligent, and controllable bio-based nanoformulations that could overcome current barriers and provide sufficient drug delivery to the TME, as discussed in this paper. These formulations are designed to (i) modify the surface of NPs to improve blood circulation while reducing their off-target accumulation and side effects in vivo, (ii) pass through the tumor vasculature by modulating or targeting angiogenesis, (iii) promote NPs distribution in solid tumor regions by applying biological/physical stimuli or extracellular matrix remodeling, and (iv) overcome the cell membrane barrier and other compartments of the cell by specific cell targeting to release the payload drug into the cytoplasm or nucleoplasm.

The Effect Of Laughter Therapy On Blood Pressure In Hypertensive Patients In Rw 05 Cicaheum Urban Village, Bandung

Hypertension is an increase in blood pressure of more than 140/90 mmHg. Hypertension is a disease that increases every year and it is estimated that by 2025 there will be 1.5 billion people affected by hypertension. Hypertension is usually called the silent killer because it can cause complex complications that cause death. Management of hypertension can be in the form of pharmacological and non-pharmacological therapies. One of the non-pharmacological therapies that is effective in overcoming hypertension is laughter therapy, because it can help improve blood circulation. The purpose of this study was to determine the effect of laughing therapy on blood pressure in patients with hypertension in the RW 05 area of Cicaheum Village, Bandung City. This research method uses quasi experiment method with one group design pretest-posttest, using purposive sampling technique, with a total sample of 18 respondents. The instruments used were blood pressure measurement SOP and laughing therapy SOP. Therapy was carried out twice a week for three weeks with a total of 6 interventions. Previously, a normality test was carried out with the results of p-value <0.05, so the analysis of this study used the Wilcoxon Rank Test non-parametric test. The results of the study with the results of the analysis of the p-value of systolic blood pressure 0.001 (<0.05) and the p-value of diastolic blood pressure 0.001 (<0.05), showed the effect of laughter therapy on blood pressure in hypertensive patients in RW 05 Cicaheum Village. This research suggests that laughter therapy can be applied as a complementary therapy to help lower blood pressure.

EFEKTIFITAS OPERASI SC ERACS TERHADAP MOBILISASI PASIEN DAN LAMA PERAWATAN

Background: Sectio Caesarea is a birth operation that has been proven to reduce maternal mortality when vaginal delivery is indicated to be risky. Wound healing in Sectio Caesarea surgery patients requires good blood circulation for cell growth or repair. Mobilization will improve blood circulation and you may soon experience recovery or healing. Method: A literature search was carried out based on articles published between 2018-2023 according to the inclusion and exclusion criteria that had been determined using 1 data base, namely Google Schoolar. This literature search uses the PRISMA guideline in carrying out the screening process. From the search results, 200 articles were obtained. After carrying out the screening process, there were 8 articles that met the criteria and will be analyzed. Results: Based on a review of 8 literature, it was found that SC ERACS was effective in speeding up patient mobilization and shortening the length of treatment Conclusion: From the results of a literature review of 8 journals, it was found that SC ERACS was effective in speeding up patient mobilization and shortening the length of treatment.

The Effect of Diabetic Foot Gymnastics on Lowering Blood Sugar in Patients with Diabetes Mellitus in the Gisting Health Center Working Area

Diabetic foot exercise is an exercise designed for people with diabetes mellitus to improve blood circulation and prevent foot ulcers. This exercise activates more insulin receptors and increases blood flow, so the muscles use more glucose and lower blood sugar levels. The study was conducted to find out the effect of diabetic foot exercises on lowering blood sugar in people with diabetes mellitus in the Gisting Health Center working area. The study used a quasi-experimental design using a nonequivalent control group design and involved 16 samples selected through purposive sampling. Data analysis began with the Shapiro-Wilk normality test, followed by the dependent sample t-test to evaluate significant differences in blood sugar levels. The results obtained based on statistical analysis showed a ρ-value of 0.000 and below the significance of α=0.05. The results obtained show the effect of diabetic foot exercises on significantly reducing blood sugar levels in patients with diabetes mellitus. Based on these results, the study recommends that people with diabetes mellitus routinely do diabetic foot exercises because this exercise is proven effective in lowering blood sugar levels.

The effect of warm water compresses on gout pain in the elderly at Takalar Community Health Center Makassar

Background: Gout arthritis, commonly referred to as gout, is a chronic non-communicable disease characterized by joint inflammation caused by elevated uric acid levels. This condition can persist for years or even a lifetime, leading to recurrent pain. One non-pharmacological treatment for managing gout pain is the application of warm water compresses, which may help alleviate discomfort by improving blood circulation and reducing inflammation. Purpose: This study aimed to assess the effectiveness of warm water compresses in reducing gout-related pain in elderly patients. Methods: The study used a quasi-experimental design with a control group and a pretest-posttest approach. A total of 32 elderly respondents suffering from gout pain at Takalar Community Health Center Makassar, were selected through purposive sampling. Pain levels were measured before and after the intervention using standardized pain scales. An independent t-test was conducted to analyze the differences between the experimental and control groups. Results: The independent t-test revealed a statistically significant effect of warm water compresses on reducing gout pain, with a p-value of 0.00 (p < 0.05). This indicates that warm water compresses effectively alleviate gout-related pain in the elderly. Conclusion: Warm water compresses significantly reduce gout pain in elderly patients at Takalar Community Health Center, Makassar. These findings suggest that warm water compresses can be a simple, non-invasive, and effective treatment option for managing gout pain in older adults.

Adverse Effects Associated with Dermal Filler Treatments: Part II Vascular Complication.

Vascular complications arising from dermal filler treatments pose significant risks, including ischemia, tissue necrosis, and severe outcomes like blindness and pulmonary embolism. This study investigates the mechanisms of vascular complications, categorizing them into extravascular compression and intravascular emboli. Extravascular compression occurs when injected fillers compress adjacent blood vessels, leading to ischemia and potential necrosis, while intravascular emboli result from fillers entering blood vessels, causing blockages. The study emphasizes the importance of anatomical knowledge, careful injection techniques, and early intervention. Management strategies include the use of hyaluronidase to dissolve HA fillers, vasodilators to improve blood circulation, and hyperbaric oxygen therapy. The regions most susceptible to complications align with major arterial pathways, particularly the nasolabial folds and nasal region. The study also highlights the need for meticulous injection techniques, the use of cannulas over needles in high-risk areas, and the aspiration test to detect vessel penetration. Early detection and immediate intervention are crucial to mitigate adverse outcomes. Continuous education and training for practitioners, along with advancements in filler materials and injection methods, are essential for improving the safety of cosmetic procedures. This comprehensive understanding aids in preventing and managing vascular complications, ensuring better patient outcomes. The field of dermal filler treatments is advancing with new techniques and technologies, such as High-Resolution Ultrasound, Infrared Imaging, self-crossing hyaluronic acid filler, biodegradable microspheres, and microinjection.

Xiaoke Bitong capsule alleviates inflammatory impairment via inhibition of the TNF signaling pathway to against diabetic peripheral neuropathy

BackgroundXiaoke Bitong capsule (XBC) is a crude herbal compound believed to tonify qi, improve blood circulation, and alleviate blood stasis. It has been used as an herbal formula for the prevention and treatment of diabetic peripheral neuropathy (DPN) under the guidance of traditional Chinese medicine (TCM). However, the pharmacological mechanisms by which XBC ameliorates DPN remain poorly understood. The interaction between pro-inflammatory factors and the activation of tumor necrosis factor (TNF) plays a critical role in the underlying mechanisms of DPN. XBC may protect against DPN through the regulation of the TNF pathway. PurposeMany studies show the association between DPN and nerve dysfunction, however, treatment options are limited. To identify specific therapeutic targets and active components of XBC that contribute to its anti-DPN effects, our study aimed to investigate the potential mechanism of action of XBC during the progression of DPN using a system pharmacology approach. MethodsAn approach involving UPLC-Q-TOF/MS and network pharmacology was used to analyze the compositions, potential targets, and active pathways of XBC. Further, models of streptozocin (STZ) induced mouse and glucose induced RSC96 cells were established to explore the therapeutic effects of XBC. High glucose induced RSC96 cells were pretreated with small interfering RNA (siRNA) to identify potential therapeutic targets of DPN. ResultsSeventy-one active compositions of XBC and five potential targets, including mitogen-activated protein kinase 8 (MAPK), interleukin-6 (IL-6), poly-ADP-ribose polymerase-1 (PARP1), vascular endothelial growth factor A (VEGFA), and transcription factor p65 (NF-κB), were considered as the potential regulators of DPN. In addition, the results revealed that the TNF signaling pathway was closely related to DPN. Moreover, DPN contributed to the decreased expressions of PI3K and AKT, increased TNF-α and IL-1β in RSC96 cells, which were both reversed by XBC or TNF-α siRNA. ConclusionXBC could protect against DPN by inhibiting the release of pro-inflammatory cytokines and regulating the activation of the TNF signaling pathway, further accelerating neurogenesis, and alleviating peripheral nerve lesions. Therefore, this study highlights the therapeutic value of XBC for DPN.

ANALISIS KONSUMSI KAFEIN SEBELUM LATIHAN OLAHRAGA

This study aims to determine the effect of caffeine consumption before exercise on athlete endurance in the sports of soccer, badminton, and karate. Caffeine can help make the body stronger, help maintain overall body fitness and reduce the risk of injury during sports. In addition, caffeine is also able to improve blood circulation by increasing oxygen diffusion to tissues. The research method used is a descriptive qualitative method with a literature study approach to 3 articles with different sports. From the results of the analysis, it was found that caffeine has an effect on increasing the endurance of athletes during exercise.

The Clinical Effect and Safety of Dihuang Decoction in Henoch-Schönlein Purpura Compared With Different Traditional Programs: A Network Meta-Analysis.

This systematic review aims to evaluate the therapeutic efficacy of Dihuang decoction (DD), anti-inflammatory drugs (AIDs), blood circulation improvement drugs (BCIDs), and conventional therapy (CT) in the management of Henoch-Schönlein purpura (HSP)and to establish their comparative effectiveness rankings. Using the Population, Intervention, Comparison, Outcome, Study (PICOS) design framework, we developed a detailed search strategy. The literature search included databases such as PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, Wanfang Data, Weipu Journal Data, and the Chinese Biomedical Database, covering studies published up to June2024. We included randomized controlled trials that featured the DD as the experimental intervention, with three remaining treatments as comparators.Our analysis encompassed 63 studies with 5,435 participants, divided into 2,817 in the experimental group and 2,618 in the control group. The network meta-analysis suggested that theDD potentially surpasses AIDs, BCIDs, and CT in the management of HSP. This conclusion is supported by its superior SUCRA (Surface Under the Cumulative Ranking) scores across various measures, including the overall effective rate of medication, time to relief or disappearance of the rash, incidence of adverse reactions, time to relief or disappearance of abdominal pain, time to relief or disappearance of arthritic swelling or pain, IgA levels, and the relapse rate within six months (SUCRA scores: 100.0%, 88.3%, 79.8%, 94.4%, 99.9%, 88.3%, and 95.4%, respectively). In terms of overall effectiveness rate, the SUCRA efficacy rankings are as follows: DD > AIDs > AIDs+BCID > BCID > CT. Regarding rash relief and regression time, the SUCRA efficacy rankings are as follows: DD > CT > AIDs+BCID > AIDs. For the incidence rate of adverse reactions, the SUCRA efficacy rankings are as follows: DD > CT > AIDs > BCID > AIDs+BCID. For the relief and disappearance of abdominal pain, the SUCRA efficacy rankings are as follows: DD > CT > AIDs+BCID > AIDs. In terms of relief and disappearance of joint swelling and pain, the SUCRA efficacy rankings are as follows: DD > AIDs+BCID > AIDs. Regarding IgA changes, the SUCRA efficacy rankings are as follows: DD > CT > BCID > AIDs+BCID > AIDs. For the six-month recurrence rate, the SUCRA efficacy rankings are as follows: DD > AIDs > AIDs+BCID > CT. The DD appears to be a more effective alternative for treating HSP compared to AIDs, BCIDs, and CT.We hope that this study will provide better assistance to clinical practice.

Ethnobotanical Analysis of Mangroves as Food Resources in East Lampung

The world is experiencing a food crisis due to climate change, and mangroves as a blue ecosystem have a significant potential to mitigate this crisis. This research seeks to record the ethnobotanical practices of utilising mangroves, as a food source in East Lampung. We employed the snowball sampling method in Margasari village, Purwerejo village, and Karya Makmur village. In addition, we gathered data on mangrove species, parts of used, processing methods, products, and their properties, through interviews and observations. Also, we analysed the data using descriptive analysis to provide a comprehensive overview of the varieties of mangroves, their processing, and the resulting products. This research revealed that the communities employs five distinct varieties of mangroves as sustenance sources. Mangroves produce various food products from their four components: fruit, juvenile leaves, old leaves, and propagules. Notably, processed products, including pidada fruit (Sonneratia caseolaris), are anti-hypertensive, canker sores, and heartburn treatments. Jeruju leaves (Acanthus ilicifolius) are known to improve stamina, and seeds without the root of Rhizophora mucronata propagules act as anti-gastritis agents, improve blood circulation, and prevent anaemia. Although there are ten processed mangrove products, they are still considered traditional and are not as popular among the newer generation.

Formulation and evaluation of herbal scrub soap

Scrubbing Soap are the agents which are use to remove the dead cell from skin, pigmentation and blackheads, white heads and make skin glowing, smooth, soft and healthy. Scrubbing soap can be directly applied onto the skin by gently massage is recommended on application of the scrubbing soap which helps to improve blood circulation and increase oxygen supply to all surface of the skin. Due to some environmental factors many people face some problem like pigmentation and uneven skin tone. Solution for this problem is use of scrubbing soap which consist ingredients which increases cleansing, softening, moisturizing, fairness of skin. In this preparation neem, tulsi and poppy seeds are use as main active ingredients. Other ingredients like glycerin base, essential oil and rose water, ritha powder, alovera, turmeric vitamin E are use in the formulation. Thus, the developed formulation can be used as an effective scrubbing soap for using it to bear a healthy and glowing skin. Ayurvedic cosmetics are also known as the herbal cosmetics the natural content in the herbs does not have any side effect on the human body most herbal supplement are based on several botanical ingredients with long histories of traditional or folk medicine usage. Among the numerous botonical ingredients available in the market today. Numerous chemical toxins microorganism present in the atmosphere may cause chemical infection and damage to skin cosmetics alone are not sufficient to take care of skin and body parts. Neem (Azadirachta indica) tree has attracted worldwide prominance owing to its wide range of medicinal properties, neem leaves and its constituents have been demonstrated to exhibit anti–inflammatory, antihyperglycemic, antiulcer, antimalarial, antifungal, antibacterial, antimutagenic and anticarcinogenic properties. This study was conducted to evaluate the effect of aqueous, ethanolic and ethyl acetate extract from neem leaves.

Implementasi Dukungan Ambulasi pada Ny.E Post Sectio Caesarea dengan Intoleransi Aktivitas di Ruang Gincu 4 RSUD Indramayu

Background: In clients post Sectio Caesaria (SC), many problems arise, including anxiety. The reason for anxiety in mothers post Sectio Caesaria (SC) is because they don't know how to care for post partum including post Sectio Caesaria (SC) wound care, breast care, exclusive breastfeeding, giving nutrition to babies, caring for newborns and anxiety because they are afraid of the stitches coming out. , afraid of infection in the wound. From this problem, activity intolerance nursing problems will arise where the client is unable to carry out daily activities independently and abnormal vital signs are found during or after activities. Early mobilization exercises are useful for improving blood circulation, preventing thromboembolism, surgical muscle stiffness, stimulates gastrointestinal function and reduces pain. The aim is to explore nursing care for clients with acute pain problems in post SC clients. The aim is to explore nursing care for clients with acute pain problems in post SC clients. The data collection method used in this case study is descriptive, namely interviews, observation and physical examination, documentation studies and collecting results from diagnostic examinations. The results of this nursing care show that after implementing ambulation support for 3 days, the patient began to improve from being previously still lying in bed to now being able to move and be active again, the ease of carrying out daily activities increased. Walking distance increases, lower body strength increases, dyspnea during activity decreases, dyspnea after activity decreases, oxygen saturation improves, respiratory frequency improves. It was concluded that from the results of this case study over 3 visits, the problem could be resolved by teaching clients to carry out physical mobilization techniques aimed at increasing their ability to do activities. Advice for clients is that clients can maintain their physical condition.

Pharmacognostic Studies on Christia obcordata (Poir.) Bakh. f. and Christia vespertilionis (L.f.) Bakh. f

Knowledge of pharmacognostic standardisation is crucial in the field of herbal research. Christia obcordata (Poir.) Bakh.f. and Christia vespertilionis (L.f.) Bakh.f., commonly known as ‘butterfly wing’ are ornamental plants belonging to the family Fabacae. Christia vespertilionis is believed as a promising anti-cancer agent and is consumed by the old folks of Malaysia in the form of decoction. Moreover, these plants have also been used to treat bronchitis, urinary blockage, and improve blood circulation. Despite the listed medicinal properties, there is no evidence in literature of the pharmacognostic standardization on the aerial parts of these plants.Hence, the current study will evaluate the pharmacognostic standardization parameters on the aerial parts of Christia obcordata (Poir.) Bakh.f. and Christia vespertilionis (L.f.) Bakh.f. Standardisation of these plants was carried out using macroscopic studies, microscopic studies, physicochemical parameters, and phytochemical investigation. Macroscopic showed both plants have similar characteristics in the followings, shape, phyllo taxis, margin-entire, leaf type, and powder microscopy results showed the upper cuticle, upper epidermis, palisade cells, vascular bundle, spongy mesophyll, phloem fibers, sclerenchyma, xylem vessels, collenchyma, sclerenchyma, lower epidermis, lower cuticle, parenchyma, stomatal index, vein number, vein islet, and palisade cells are studied as important key differentiating features on the selected plants. Phytochemical screening on the aerial part extracts presence of steroid, flavonoid, tannin, alkaloid, and carbohydrate on both plants. Fluorescence analysis was carried out individually on the four different extracts and was examined under daylight and U.V light at a wavelength of 254nm and 365nm. To conclude, based on this research finding, the study can be a standardization tool for these plants, providing ease in identifying and determining the purity and quality of the investigated plant.

Formulation and Evaluation of Polyherbal Face Pack

The prime objective of this research work is to formulate a cosmetic herbal face pack by using natural ingredients for all kinds of skin and evaluate the formulation by employing several evaluation parameters. Formulation containing multanimitti, turmeric, green tea, amla, neem, liquorice, sandal wood powder, honey, aloe vera gel and rose water was prepared. Formulation was evaluated for different evaluating parameters and stability check along with the test of irritancy and spreadability. Herbal face packs are generally utilized from ancient times for healthy and glowing natural skin. It is used to prevent acne, pimples, and dirt from skin pores. It rejuvenates the muscles and improves blood circulation. In this study it is concluded that the prepared formulation was effective in all parameters, non-irritant and compatible with skin. All the ingredients used in formulation are herbs and therefore possess minimal or no side effects. One can use this face pack by adding honey and storing the formulation in refrigerator. Further the studies regarding optimization are required to be done on this work and this study will also acts as a standardization tool for further research work in this area.

What is the effectiveness of the combination of massage therapy and heat therapy on joint range of motion? Experimental study in patients with shoulder pain

This study aims to evaluate the effectiveness of a combination of massage therapy and heat therapy on improving joint range of motion in patients with shoulder pain. Shoulder pain is often accompanied by limited range of motion, which can affect daily activities and quality of life. Massage therapy is known to relieve muscle tension and improve blood circulation, while heat therapy has the effect of reducing muscle stiffness and increasing tissue elasticity. The combination of these two therapies is expected to provide synergistic benefits in overcoming shoulder pain problems and improving joint range of motion. This research method is pre-experimental with a one group pretest and posttest design approach. The study involved giving a combination of masage therapy and heat therapy regularly to a group of patients with shoulder pain. Joint range of motion was evaluated before and after the intervention using a pretest-posttest design. Statistical analysis, including t-test and significance test, was used to assess the difference between the mean pretest and posttest. The results showed a significant increase in the mean posttest compared to the pretest. The results of the significance test also showed that the effect that occurred was significant (0.001 <0.05), indicating the effectiveness of the combination of massage therapy and heat therapy in increasing joint range of motion in patients with shoulder pain.These findings provide strong support for the implementation of a combination of massage therapy and heat therapy as an effective approach in shoulder pain rehabilitation by improving joint range of motion limitations. This study contributes to the scientific understanding of the synergistic benefits of both therapies and provides a basis for the development of improved treatment guidelines for individuals with similar conditions. Keywords: Massage therapy, heat therapy, joint range of motion, shoulder pain.

The Role Of Swimming Training In Preventing Preeclampsia During Pregnancy

Introduction: Preeclampsia is a serious complication that affects pregnant women and poses risks to both maternal and fetal health. Understanding the relationship between swimming training and the risk of preeclampsia is crucial in developing comprehensive guidelines and exercise programs. This knowledge can empower pregnant women and healthcare professionals to utilize swimming as part of a strategy for preventing and managing preeclampsia. Materials & Methods: The research method involved a thorough literature search in various sources such as electronic databases, journals, and other related articles. Inclusion criteria were set to select studies relevant to the research topic. The results of the literature search were systematically analyzed and synthesized. Results: According to the findings of this study, swimming training has a significant role in preventing preeclampsia during pregnancy. Engaging in regular swimming exercises during pregnancy can effectively reduce the risk of developing preeclampsia. The underlying mechanisms that contribute to this preventive effect include improved blood circulation, better control of blood pressure, and a reduction in inflammation within the body. These research findings hold important implications for the development of comprehensive guidelines and exercise programs specifically designed for pregnant women. By incorporating swimming as a part of the prevention and management strategy for preeclampsia, pregnant women and healthcare professionals can benefit greatly Conclusions: The effectiveness of swimming training in preventing preeclampsia during pregnancy by improving blood circulation, blood pressure control, and reducing inflammation

Clinical comprehensive treatment protocol for managing diabetic foot ulcers: A retrospective cohort study.

Diabetic foot ulcers (DFUs) are a common complication of diabetes, often leading to severe infections, amputations, and reduced quality of life. The current standard treatment protocols for DFUs have limitations in promoting efficient wound healing and preventing complications. A comprehensive treatment approach targeting multiple aspects of wound care may offer improved outcomes for patients with DFUs. The hypothesis of this study is that a comprehensive treatment protocol for DFUs will result in faster wound healing, reduced amputation rates, and improved overall patient outcomes compared to standard treatment protocols. To compare the efficacy and safety of a comprehensive treatment protocol for DFUs with those of the standard treatment protocol. This retrospective study included 62 patients with DFUs, enrolled between January 2022 and January 2024, randomly assigned to the experimental (n = 32) or control (n = 30) group. The experimental group received a comprehensive treatment comprising blood circulation improvement, debridement, vacuum sealing drainage, recombinant human epidermal growth factor and anti-inflammatory dressing, and skin grafting. The control group received standard treatment, which included wound cleaning and dressing, antibiotics administration, and surgical debridement or amputation, if necessary. Time taken to reduce the white blood cell count, number of dressing changes, wound healing rate and time, and amputation rate were assessed. The experimental group exhibited significantly better outcomes than those of the control group in terms of the wound healing rate, wound healing time, and amputation rate. Additionally, the comprehensive treatment protocol was safe and well tolerated by the patients. Comprehensive treatment for DFUs is more effective than standard treatment, promoting granulation tissue growth, shortening hospitalization time, reducing pain and amputation rate, improving wound healing, and enhancing quality of life.

In vivo efficacy evaluation of white‐spotted flower chafer (Protaetia brevitarsis seulensis) extract for improving blood circulation

AbstractRecent studies have suggested the use of insects to enhance various bioactivities in the treatment of many diseases or as alternative sources of nutrients. White‐spotted flower chafer (Protaetia brevitarsis seulensis; PBS) extract, which is used for medicinal purposes, appears to be effective in improving blood circulation. However, few studies have investigated the efficacy of PBS extract in improving blood circulation. Here, we investigated the effects of PBS extract on serum cholesterol metabolites (total cholesterol, high‐density lipoprotein cholesterol, and low‐density lipoprotein cholesterol) and anticoagulant activities (prothrombin time [PT], activated partial thromboplastin time [aPTT], and fibrinogen [Fib]) in very‐high‐fat diet (VHFD)‐induced hyperlipidemic rats. The experimental groups comprised a control group that was not treated with PBS and five PBS treatment groups (50, 100, 150, 200, and 250 mg/kg) in a randomized complete block design. In the efficacy evaluation for health functionality to reduce cholesterol levels, no beneficial effects on serum cholesterol metabolites were observed in the control and PBS treatment groups. In addition, the cholesterol data indicated that the effect of the PBS extract was not related to antioxidant activity. Moreover, the PT, aPPT, and Fib values were prolonged by increasing the PBS extract concentration, and PBS extract concentrations of 150–250 mg/kg were recommended for the VHFD model based on the anticoagulant activity. In conclusion, the PBS extract can be used in a potential therapeutic strategy for improving anticoagulant activity rather than improving the serum cholesterol profile.

NEUROMUSCULAR TAPING IMPROVES MICROVASCULAR CIRCULATION IN TYPE 2 DIABETES MELLITUS PATIENTS

Background: The most common complications in Diabetes Mellitus patients are foot problems and high risk for amputation. Factors that trigger problems in diabetic feet in the form of neuropathy factors, namely loss of sensory nerve function and circulatory disorders. One of the non-pharmacological therapies to prevent these problems is safe Neuromuscular Taping (NMT) which is applied to the skin with elastic plaster through a decompression method to prevent a decrease in peripheral blood circulation and improve blood circulation. Objectives: The purpose of this study was to determine the comparison of the effectiveness of Neuromuscular Taping (NMT) intervention on microvascular circulation which was assessed by Ankle Brachial Pressure Index (ABPI) measurement in type 2 Diabetes Mellitus patients. Methods: This study used a quasi-experimental research design with a pretest-posttest control group approach. The number of respondents to this study was 60 type 2 DM patients divided into treatment group respondents and control group respondents. The intervention group was given NMT intervention for 2 weeks with daily plaster changes while the control group was given standard foot care education. The data collected is an ABPI score that describes microvascular circulation using a sphygmomanometer. Analysis was carried out using paired sample t-tests which were used to determine the effectiveness of the intervention. Results: Based on the results of the study, significant changes were obtained in the microvascular circulation of the treatment group (p = 0.000) α 0.05 which is the category of normal microvascular circulation or no disturbance. Increased microvascular circulation is caused by the application of NMT for 2 weeks. Conclusion: There was an increase in microvascular circulation seen through changes in Ankle Brachial Pressure Index (ABPI) values before and after Neuromuscular Taping (NMT) intervention. There were significant differences between the intervention and control groups in changes in ABPI scores.