Important Factor Research Articles

A Proposed Agent System for Network Monitoring

The traditional centralized network management approach presents severe efficiency and scalability limitations in large scale networks. The process of data collection and analysis typically involves huge transfers of management data to the manager which cause considerable network throughput and bottlenecks at the manager side. All these problems processed using the Agent technology as a solution to distribute the management functionality over the network elements. The proposed system consists of the server agent that is working together with clients agents to monitor the logging (off, on) of the clients computers and which user is working on it. file system watcher mechanism is used to indicate any change in files. The results were presented in real time which is minimizing the cost that represents the important factor to successful management of networks that was achieved using agents.

RELATIONSHIP CHANGES ACROSS THE CAREGIVING TRANSITION

Abstract The majority of aging individuals’ care needs are met by family caregivers (CGs), often at great costs to CGs’ well-being. There is, however, significant heterogeneity in CG outcomes, and social capital, or the quality of marital, family, and friend relationships, is widely recognized as an im-portant factor underlying individual differences in CG outcomes. Because empirical work to date largely focuses on either cross-sectional differences or changes in social capital post-caregiving on-set, it is unclear, however, whether social capital disparities across different populations are a func-tion of the transition to CG or whether such disparities exist prior to taking on a CG role. Thus, we used data from the Health and Retirement Study (N=366; 8-waves) and Bayesian multi-phase latent growth curve models to examine social capital changes across the caregiving transition. Results sug-gested that CGs, on average, do not show significant changes in their social capital across the transi-tion to caregiving. Yet, there were significant individual differences, and individual differences in pre-caregiving social capital were significantly associated with social capital changes following tak-ing on a caregiving role: CGs with higher initial levels of social capital showed less declines in rela-tionship quality leading up to caregiving onset, but steeper declines in relationship quality at caregiv-ing onset and smaller relationship quality increases in the years following caregiving onset. This suggests that the social capital of individuals with initially satisfying relationships are most impacted by caregiving. We discuss the implications of these findings for refining and developing personal-ized social support interventions for CG populations.

Minimally Invasive Ivor Lewis Esophagectomy

The two main types of esophageal cancer are squamous cell carcinoma, which comprises the majority of cases world-wide, and adenocarcinoma, which is diagnosed with increasing frequency and now accounts for more than 50% of cases in the western hemisphere. Smoking and alcohol consumption are strongly linked to squamous cell carcinoma, and the most important etiologic risk factor for adenocarcinoma is Barrett's esophagus, which occurs in 10 to 15% of patients with gastro-oesophageal reflux disease. Patients generally present with dysphagia and weight loss, and diagnosis is made via endoscopy and biopsy. The surgical treatment of esophageal cancer is dependent upon the location of the cancer, the depth of invasion, and the presence of lymph node metastasis. Smaller tumors that only involve the mucosal layer of the esophagus may be removed by endoscopic mucosal resection, but larger, more invasive tumors require esophageal resection. Esophagectomy can be approached via the trans-hiatal (Orringer), trans-thoracic (Ivor-Lewis), or three-field (McKeown) techniques, and anastomosis between the stomach and the shortened esophagus is achieved through either a gastric pull up or colonic/jejunal interposition. The addition of neoadjuvant chemotherapy for locally-advanced adenocarcinoma has been shown to increase survival compared with surgery alone, and is the standard treatment in these cases. Here, we present the case of a female patient with dysphagia who was found to have a locally-advanced distal esophageal adenocarcinoma. In this case, a minimally-invasive Ivor Lewis esophagectomy was performed with neoadjuvant chemotherapy.

ОПРЕДЕЛЕНИЕ АСПЕКТОВ СМЕШАННОГО ЗЕМЛЕПОЛЬЗОВАНИЯ В РАМКАХ ГОРОДСКОГО ПРОСТРАНСТВА

This study examined various aspects of mixed development; these included density, land use di-versity, social (and cultural) diversity, design. An empirical study was conducted to identify im-portant factors that need to be considered in transport planning and architectural design to make mixed developments attractive to nearby residents

A Multicriteria Approach for Ship Bunkering System

Abstract This research aims to enhance maritime fuel supply’s efficiency, safety, and sustainability by advocating for the standardization of bunkering systems in ports. Through the application of Multi-Criteria Decision Making (MCDM) and the Analytical Hierarchy Process (AHP), this study assesses three primary bunkering methods: Ship to Ship, Truck to Ship, and Onshore to Ship. The criteria for evaluation encompass safety, economic factors, operational efficiency, technical considerations, and additional relevant aspects. Stakeholder feedback underscores the significance of safety (0.281) and economic (0.274) criteria, eclipsing operational (0.274), technical (0.137), and other factors (0.033) in importance. The findings prominently advocate for the Onshore to Ship method as the superior option for standardization in principal ports, marked by a value of 0.480, with Truck to Ship and Ship to Ship methods trailing in preference. Sensitivity analysis reinforces the stability of this outcome, indicating that adjustments in criteria weightings scarcely affect the overall conclusion, thereby affirming the Onshore to Ship method’s predominance. This method, characterized by a pipeline connecting the jetty to ships, holds considerable potential for both research and practical applications in port logistics.

The Gut Microbiota and Major Depressive Disorder: Current Understanding and Novel Therapeutic Strategies.

Major depressive disorder (MDD) is a common neuropsychiatric challenge that primarily targets young females. MDD as a global disorder has a multifactorial etiology related to the environment and genetic background. A balanced gut microbiota is one of the most important environmental factors involved in human physiological health. The interaction of gut microbiota components and metabolic products with the hypothalamic-pituitary-adrenal system and immune mediators can reverse depression phenotypes in vulnerable individuals. Therefore, abnormalities in the quantitative and qualitative structure of the gut microbiota may lead to the progression of MDD. In this review, we have presented an overview of the bidirectional relationship between gut microbiota and MDD, and the effect of pre-treatments and microbiomebased approaches, such as probiotics, prebiotics, synbiotics, fecal microbiota transplantation, and a new generation of microbial alternatives, on the improvement of unstable clinical conditions caused by MDD.

The Role of Local Angiotensin II/Angiotensin Type 1-receptor Mechanisms in Adipose Tissue Dysfunction to Promote Pancreatic Cancer.

Obesity and adipose tissue dysfunction are important risk factors for pancreatic cancer. Pancreatic cancer is one of the most lethal cancers globally. The renin-angiotensin system (RAS) is expressed in many tissues, including adipose tissue. Dysregulation of angiotensin II and angiotensin II receptors in adipose tissue through the activation of different signaling pathways leads to adipose tissue dysfunction, including insulin resistance, adipose tissue inflammation, adipocytokines secretion, and metabolic alterations. The pathogenesis of pancreatic cancer remains uncertain. However, there is evidence that dysregulation of local angiotensin II in adipose tissue that occurs in association with obesity is, in part, responsible for the initiation and progression of pancreatic cancer. Due to the role of local angiotensin II in the dysfunction of adipose tissue, angiotensin receptor blockers may be considered a new therapeutic strategy in the amelioration of the complications related to adipose tissue dysfunction and prevention of pancreatic cancer. This review aims to consider the biological roles of local angiotensin II and angiotensin II receptors in adipose tissue dysfunction to promote pancreatic cancer progression with a focus on adipose tissue inflammation and metabolic reprogramming.

The Link between miRNAs and PCKS9 in Atherosclerosis.

Cardiovascular disease (CDV) represents the major cause of death globally. Atherosclerosis, as the primary cause of CVD, is a chronic immune-inflammatory disorder with complex multifactorial pathophysiology encompassing oxidative stress, enhanced immune-inflammatory cascade, endothelial dysfunction, and thrombosis. An initiating event in atherosclerosis is the subendothelial accumulation of low-density lipoprotein (LDL), followed by the localization of macrophages to fatty deposits on blood vessel walls, forming lipid-laden macrophages (foam cells) that secrete compounds involved in plaque formation. Given the fact that foam cells are one of the key culprits that underlie the pathophysiology of atherosclerosis, special attention has been paid to the investigation of the efficient therapeutic approach to overcome the dysregulation of metabolism of cholesterol in macrophages, decrease the foam cell formation and/or to force its degradation. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secretory serine proteinase that has emerged as a significant regulator of the lipid metabolism pathway. PCSK9 activation leads to the degradation of LDL receptors (LDLRs), increasing LDL cholesterol (LDL-C) levels in the circulation. PCSK9 pathway dysregulation has been identified as one of the mechanisms involved in atherosclerosis. In addition, microRNAs (miRNAs) are investigated as important epigenetic factors in the pathophysiology of atherosclerosis and dysregulation of lipid metabolism. This review article summarizes the recent findings connecting the role of PCSK9 in atherosclerosis and the involvement of various miRNAs in regulating the expression of PCSK9-related genes. We also discuss PCSK9 pathway-targeting therapeutic interventions based on PCSK9 inhibition, and miRNA levels manipulation by therapeutic agents.

Recent Patents of Thermal Error Modeling and Thermal Error Prediction of CNC Machine Tool Spindle

: With the development of machine tools to high precision and high automation, thermal error has become the key reason to hinder the improvement of thermal stability of machine tools. The spindle electrothermal error is an important factor affecting the machining accuracy of highspeed CNC machine tools. The thermal error model of a high-speed motorized spindle is established to compensate the thermal error, which can effectively improve the influence of thermal error on the machining accuracy of machine tools. The thermal displacement during the operation of motorized spindle is the main reason that affects the machining stability and precision of motorized spindle. The thermal error compensation of CNC machine tool spindle can improve the machining efficiency, the machining quality of parts and the service life of CNC machine tools. This paper summarizes the representative patents and papers on thermal error modeling and thermal error prediction in China. By summarizing a large number of patents and papers on modeling, prediction and compensation of thermal error of spindle of CNC machine tools, the modeling method is analyzed and the development trend is discussed. The improvement of thermal error modeling method of CNC machine tool spindle has an important influence on improving machining accuracy, efficiency, and stability. Therefore, in the future, there will be more and more patents for thermal error modeling of CNC machine tools and spindles.

Predictors of Fertility Desire During COVID-19 Pandemic: A Cross Sectional Study

Background: Fertility, the most important factor in population growth, is affected by various factors, including pandemics. COVID-19 (CV) was a global challenge that spread rapidly around the world. Objective: This study aimed to investigate predictors of fertility desire during the covid virus pandemic. Methods: In this cross-sectional study, 315 women who visited health centers in northern Iran for vaccination against covid virus were recruited using convenient sampling. The participants completed the sociodemographic information, Fertility Desire Scale, and Fear of covid virus scale. Logistic regression analysis was employed to assess the predictive factors of fertility desire. Results: The participants' mean age and marriage duration were 34.4 ± 6.7, and 7.3±11.5 years, respectively. It showed fertility desire among household women was about twofold more compared to employed ones [Odds Ratio (OR) = 1.96, p = 0.009)]. The fertility desire was decreased among more educated women (OR = 0.43, p= 0.035), women with one child (OR = 0.44, p= 0.030), and women with no infant gender preferences (OR = 0.53, p= 0.032). Fear of covid virus and any history of covid virus infection in the participants or their close relatives did not change fertility desire (P > 0.05). Conclusion: In conclusion, health policymakers should pay more attention to the potential effects of women's employment, their educational status, and their attitude toward infant gender preferences on fertility desire during the development of programs. Further research is needed to examine this empirical association on a global scale and its effect on trying to conceive.

Reputable and affordable programs with a strong commitment to diversity: Factors influencing school psychology student admission decisions.

A current issue in the field of school psychology is the extreme shortage of school psychologists, and this is likely to persist in the future. Effective recruitment into school psychology programs is one of the most important strategies to increase the number of school psychologists. Within the present study, researchers created the Graduate Enrollment Admissions Rating Scale (GEARS), a survey measuring several different factors that school psychology students consider when applying to graduate programs, to determine what factors contributed to school psychology students' choice of program. The GEARS was sent via email to current school psychology graduate students. Overall, current students rated program quality, including faculty friendliness, as the most important factor influencing their decision. Second, considerations reflecting the program cost were influential. Diversity issues were the third most important factor in students choosing their school psychology programs. Costs and research/teaching opportunities were more important in the recruitment of doctoral students than specialist students, but specialist students valued convenience of a program more than doctoral students. Results of this study suggest that faculty members in charge of recruiting need to consider ways to manage tuition costs, develop relationships with future students, and strive toward high-quality programs as the best ways to increase the likelihood that students will attend their university. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Prevalence and Related Factors of Dizziness Among Older Adults: A Cross-Sectional Study in Ardakan City, Iran.

Dizziness and balance disorders are directly related to aging in humans- Dizziness is one of the most important factors causing the burden of disability after the age of 65. Bearing in mind the increase in the elderly population in Iran and the world and the prevalence of dizziness in old age, early diagnosis of dizziness and determination of the factors affecting its severity facilitate its treatment and are effective in preventing its adverse consequences. To determine the prevalence of dizziness and its related factors among older adults in Ardakan city, Yazd province, Iran, in 2022. This cross-sectional study was conducted in four comprehensive health centers of Ardakan city with the participation of 260 elderly people aged ≥60 years, who were randomly included in the study. Data were collected using a series of questionnaires which were completed by interviewing the participants. The variables of this study included demographic information, information related to the dizziness status, diseases, medications, use of mobility aids, physical activity level, fear of falling, quality of life and depression. The prevalence of dizziness among older adults of Ardakan city was 48.5%. In terms of the severity of dizziness, 38.8% had substantial dizziness, and 9.6% had mild dizziness. Dizziness was significantly related to physical activity (p<0.05), fear of falling (p <0.01), depression (p <0.05), history of falling (p <0.01), use of mobility aids (p <0.01), age (p<0.01), education level (p<0.01), gender (p <0.05) and diseases such as high blood pressure (p<0.05), hypothyroidism (p <0.01) and ear diseases(p <0.01). Also, elderly people with dizziness used significantly more medications such as sedatives (p<0.01), antihypertensive drugs (p <0.05) and cytotoxic drugs (p <0.01). About half of the older adults experience dizziness, and this problem is associated with depression, fear of falling, history of falling, low physical activity, age, female gender, ear diseases, high blood pressure, and hypothyroidism. In addition, the use of medications such as anti- hypertensives, sedatives and cytotoxic drugs is related to dizziness. Families with elderly people, doctors and healthcare workers need to be educated and pay more attention to the above.

Potential Correlation between Gene Mutations and Metabolic Changes in Acute Myeloid Leukemia

Abstract: Acute myeloid leukemia (AML) is a common type of leukemia. However, the understanding of AML remains insufficient. The pathological progression of AML is closely related to chromosome abnormalities and genetic mutations. Gene mutation is an important factor in the pathogenesis of AML and a potential cause of drug resistance. Recent studies have shown that gene mutations in AML can cause metabolic changes. Metabolites, as downstream products of human physiological activities, can amplify physiological and disease-related signals. Therefore, the analysis of metabolite markers related to gene mutations can be used for early prediction of the occurrence of the disease. This review describes the types and significance of AML gene mutations and analyzes the characteristics of metabolic changes related to gene mutations.

Non-oxidative modified low-density lipoproteins: The underappreciated risk factors for atherosclerosis.

Atherosclerosis, the pathological basis of most cardiovascular diseases, is a main risk factor causing about 20 million deaths each year worldwide. Oxidized low-density lipoprotein is recognized as the most important and independent risk factor in initiating and promoting atherosclerosis. Numerous antioxidants are extensively used in clinical practice, but they have no significant effect on reducing the morbidity and mortality of cardiovascular diseases. This finding suggests that researchers should pay more attention to the important role of non-oxidative modified low-density lipoprotein in atherosclerosis with a focus on oxidized low-density lipoprotein. This review briefly summarizes several important non-oxidative modified low-density lipoproteins associated with atherosclerosis, introduces the pathways through which these non-oxidative modified low-density lipoproteins induce the development of atherosclerosis in vivo, and discusses the mechanism of atherogenesis induced by these non-oxidative modified low-density lipoproteins. New therapeutic strategies and potential drug targets are provided for the prevention and treatment of atherosclerotic cardiovascular diseases.

The transcriptional response of cortical neurons to concussion reveals divergent fates after injury.

Traumatic brain injury (TBI) is a risk factor for neurodegeneration, however little is known about how different neuron types respond to this kind of injury. In this study, we follow neuronal populations over several months after a single mild TBI (mTBI) to assess long ranging consequences of injury at the level of single, transcriptionally defined neuronal classes. We find that the stress responsive Activating Transcription Factor 3 (ATF3) defines a population of cortical neurons after mTBI. We show that neurons that activate ATF3 upregulate stress-related genes while repressing many genes, including commonly used markers for these cell types. Using an inducible reporter linked to ATF3, we genetically mark damaged cells to track them over time. Notably, we find that a population in layer V undergoes cell death acutely after injury, while another in layer II/III survives long term and retains the ability to fire action potentials. To investigate the mechanism controlling layer V neuron death, we genetically silenced candidate stress response pathways. We found that the axon injury responsive kinase MAP3K12, also known as dual leucine zipper kinase (DLK), is required for the layer V neuron death. This work provides a rationale for targeting the DLK signaling pathway as a therapeutic intervention for traumatic brain injury. Beyond this, our novel approach to track neurons after a mild, subclinical injury can inform our understanding of neuronal susceptibility to repeated impacts.

Effect of screen configuration on the neck angle, muscle activity, and simulator sickness symptoms in virtual reality.

There is a lack of information about the optimal setup of multiple screen configurations in virtual reality (VR) office work. The objective of this study was to evaluate the effects of different screen configurations on neck flexion, rotation, neck muscle activity, and simulator sickness symptoms during Virtual Reality (VR) office work. Twelve participants (7 males; 21 to 27 years old) performed copy-paste and drag-drop tasks in three different screen configurations (single screen, primary-secondary screen, and double screen) in a randomized order. Optical motion capture system, electromyography (EMG) device, and simulator sickness questionnaire (SSQ) were used to measure the users' responses. Neck rotation angles, muscle activities, and VR sickness were significantly affected by the screen configurations (p < 0.021). The primary-secondary screen showed the highest right rotation angle (median: -33.47°) and left sternocleidomastoid (SCM) muscle activities (median: 12.57% MVC). Both single (median: 22.42) and primary-secondary (median: 22.40) screen showed the highest value of SSQ. The screen configurations in VR could be an important design factor affecting the users' physical demands of the neck and VR sickness symptoms. Asymmetric neck rotations caused by the primary-secondary screen conditions should be avoided.

Gender Differences in the Predictive Value of Obesity Indices for Insulin Resistance in Adult Mexican Individuals.

Obesity-linked insulin resistance (IR) is an important risk factor for metabolic diseases, and anthropometric indices are commonly used for risk assessment. The study aimed to assess possible differences between women and men in the predictive value and association of nine obesity indices with IR, as assessed by HOMA-IR, in a nondiabetic adult population. The cross-sectional study included individuals recruited from a hospital in Mexico City. Indices evaluated were waist circumference (WC), hip circumference (HC), body mass index (BMI), waist-to-hip ratio, waist-to-height ratio, visceral adiposity index, body adiposity index (BAI), relative fat mass (RFM), and conicity index (CI). Fasting plasma glucose and insulin were measured to calculate HOMA-IR. Correlation analysis was performed between obesity indices and HOMA-IR. Receiver operating characteristics curve analyses were performed to determine predictive accuracy and cut-off values of obesity indices for IR. A binary logistic regression (BLR) analysis with OR calculation was performed to determine the strength of association with HOMA-IR. We included 378 individuals (59% females, mean age 46.38 ±12.25 years). The highest Pearson coefficient value was observed for BMI among women, while among men, the highest values were found for BMI and BAI. WC among women, and BAI and RFM among men showed the highest sensitivity, while the highest specificity was observed for WHR among women and WC among men with respect to insulin prediction. In the adjusted BLR model, BMI, WC, and WHR among women and WC and RFM and BAI among men were independently associated with IR, showing the highest odds ratio (OR). In Mexican adults, WC, WHR, RFM and BAI could be complementary tools for BMI in screening for IR.

Density-dependent population regulation in freshwater fishes and small mammals: A literature review and insights for Ecological Risk Assessment.

The regulation of populations through density dependence (DD) has long been a central tenet of studies of ecological systems. As an important factor in regulating populations, DD is also crucial for understanding risks to populations from stressors, including its incorporation into population models applied for this purpose. However, study of density-dependent regulation is challenging because it can occur through various mechanisms, and their identification in the field, as well as the quantification of the consequences on individuals and populations, can be difficult. We conducted a targeted literature review specifically focusing on empirical laboratory or field studies addressing negative DD in freshwater fish and small rodent populations, two vertebrate groups considered in pesticide Ecological Risk Assessment (ERA). We found that the most commonly recognized causes of negative DD were food (63% of 19 reviewed fish studies, 40% of 25 mammal studies) or space limitations (32% of mammal studies). In addition, trophic interactions were reported as causes of population regulation, with predation shaping mostly small mammal populations (36% of the mammal studies) and cannibalism impacting freshwater fish (26%). In the case of freshwater fish, 63% of the studies were experimental (i.e., with a length of weeks or months). They generally focused on the individual-level causes and effects of DD, and had a short duration. Moreover, DD affected mostly juvenile growth and survival of fish (68%). On the other hand, studies on small mammals were mainly based on time series analyzing field population properties over longer timespans (68%). Density dependence primarily affected survival in subadult and adult mammal stages and, to a lesser extent, reproduction (60% vs. 36%). Furthermore, delayed DD was often observed (56%). We conclude by making suggestions on future research paths, providing recommendations for including DD in population models developed for ERA, and making the best use of the available data. Integr Environ Assess Manag 2024;20:1225-1236. © 2023 Syngenta Crop Protection. Integrated Environmental Assessment and Management published by Wiley Periodicals LLC on behalf of Society of Environmental Toxicology & Chemistry (SETAC).

Gout and Nutrition

Gout, the most common arthritis worldwide, is closely linked to cardiovascular disease and metabolic syndrome. The most impor-tant risk factor for developing gout is hyperuricemia. Serum uric acid is the end product of purine metabolism and can be partially influenced by dietary changes. Since a quarter of serum uric acid is excreted via the intestine, there is also a connection with diet here - keyword microbiome. Recently, genetic predispositions and drug therapy for gout have come to the fore. However, since cardiovascular comorbidities exist in high frequency, a dietary adjustment also makes sense to improve the comorbidities. Recently, the focus has shifted away from simply reducing purine intake in favor of introducing a largely plant-based diet. Reducing alcohol consumption makes sense for many reasons but does not lead to a significant reduction in serum uric acid. In addition to drug therapy, however, all possibilities should be exploited to enable a rapid reduction in serum uric acid to the target range; a change in diet can contribute to this. A change in diet can also have a positive effect on the frequency of gout flares. Targeted, structured information for patients promotes their knowledge of the disease and motivation to achieve their serum uric acid (SUA) goal. The right diet may be the personal contribution to quickly reaching the SUA target level and freedom from gout flares.

Asymmetric Dimethylarginine (ADMA) in Cardiovascular Disease, Cardiac Ischemia/reperfusion Injury, and Ischemic Non-obstructive Coronary Artery Disease: Biochemical and Pharmacological Implications

: Several studies have shown that high plasma concentrations of asymmetric dimethylarginine (ADMA), a known endogenous competitive inhibitor of endothelial nitric oxide synthase (eNOS), correlate with the severity of coronary artery disease (CAD), with worsening of cardiac ischemia/reperfusion (I/R) injury and coronary atherosclerosis. It is believed that it may be an important risk factor for myocardial infarction. ADMA, when in high concentrations, can determine a significant decrease in the synthesis and bioavailability of NO (Nitric oxide) and therefore alter the mechanisms of regulation of coronary vasodilation and vasomotor function of epicardial coronary arteries. Higher serum ADMA concentration is associated with worsening of post-ischemic remodeling since coronary angiogenesis, vasculogenesis, and collateral coronary growth are seriously impaired. In addition, there are reasons to believe that elevated plasma ADMA levels are related to the development of diseases affecting coronary microcirculation, such as ischemic non-obstructive coronary artery disease (INOCA). With the aim of providing the pharmacologist engaged in the design and discovery of new ADMA-lowering drugs with a complete examination of the subject, in this review, we discuss the most important studies related to the correlations between serum ADMA levels and cardiovascular diseases mentioned above. In addition, we critically discuss the main aspects of enzymology, synthesis, and metabolism of ADMA as a prerequisite for understanding the molecular mechanisms through which high concentrations of ADMA could contribute to promoting cardiovascular diseases. ADMA represents a new target for pharmacological modulation of cardiovascular endothelial function and therefore, there is a possibility of using selective pharmacological ADMA lowering drugs in cardiovascular disease with endothelial dysfunction and high plasma ADMA levels.