Immunoglobulin Scintigraphy Research Articles

Detection of Orchitis and Sacroiliitis due to Brucellosis by 99mTc Polyclonal Human Immunoglobulin Scintigraphy

Here, we report 1 case of Brucella orchitis detected by 99mTc human immunoglobulin scintigraphy and confirmed by testicular ultrasound. A 29-year-old farmer was admitted to our hospital with fever, fatigue, arthralgia, and painful scrotal swelling that had appeared 12 days before admission. Clinically, right sacroiliitis was recorded through the Fabere test Unilateral sacroiliitis and orchitis were detected by 99mTc human immunoglobulin scintigraphy. Hypoechoic left testicular lesions and swelling of the concurrent epididymis were seen on a testicular ultrasound examination. Wright agglutination test and blood specimen culture for Brucella species were positive.

The Agreement Between Blood Pool - Delayed Bone Scintigraphy and Tc-99m Human Immunoglobulin G (HIG) Scintigraphy in the Determination of the Presence and Severity of Inflammatory Arthritis

Objective: In this study, it was aimed to investigate the agreement between early phase of bone scintigraphy – human immunoglobulin scintigraphy (EPBS-HIG) and late phase bone scintigraphy – HIG (LPBS-HIG) in the determination of the presence and also the severity of inflammatory arthritis. Material and Methods: Twenty-eight patients (23 female, 5 male; between 19 to 80 years of age) with inflammatory arthritis were included in the study. Tc-99m HIG and blood pool/late phase bone scintigraphies were performed in all patients. In scintigraphic examinations, the joints were scored with the degree of accumulation of the radiopharmaceutical by the semiquantitative analysis (0=Background activity, 1=Faint uptake, 2=Moderate uptake, 3=Marked uptake) which is called as visually active joint score as severity index of the disease. To estimate the agreement between EPBS – HIG and LPBS - HIG in the determination of the presence and severity of inflammatory arthritis, 2x2 kappa coefficients were calculated. Results: Our results showed good agreement between EPBS - HIG for the presence of inflammation (kappa: 0.72) but not for the severity of the disease (kappa: 0.29), poor agreement between LPBS - HIG for both the presence (kappa: 0.51) and severity (kappa: 0.01) of inflammatory arthritis. Conclusion: The blood pool scintigraphy could be used in the investigation of the presence of inflammatory arthritis because the good agreement with HIG and the lower cost but not for the severity of the diseaseConflict of interest:None declared.

Lymphatic transfer studies with immunoglobulin scintigraphy after axillary surgery

Aims The study objective was to investigate the effects of axillary lymph node clearance surgery on the function and morphology of the lymphatic system of the upper limb in women with breast cancer. Methods Nineteen women were studied before and 3 months after surgery. Fifteen were studied again 12 months after surgery. On each occasion, scintigraphy following intradermal hand webspace injection of Tc-99m-human polyclonal immunoglobulin was performed to include the affected upper limb and torso. Results There was considerable functional variability in response to surgery. Seven patients subsequently developed breast cancer-related lymphedema (BCRL). Neither lymph re-routing (defined as a change in lymph vessel morphology or definition) nor linear velocity of protein transit up the arm was associated with the development of BCRL. Blood pool activity, judged from visual inspection of the cardiac blood pool on the whole body images, was earlier and more marked 3 and 12 months after surgery than before. The count rate (per 100 pixels/MBq injected activity), measured in a cardiac region of interest, was significantly higher after surgery than before, was higher in patients who developed BCRL and, in the patient population as a whole, correlated positively with arm swelling. Conclusion The consequences of axillary lymph node clearance were variable, unexpected and largely persistent. An increased rate of access of intradermally injected protein into the blood pool is significantly associated with BCRL.

Bone scintigraphy versus human immunoglobulin scintigraphy in the clinical investigation of psoriatic arthropathy

Bone scintigraphy versus human immunoglobulin scintigraphy in the clinical investigation of psoriatic arthropathy

Technetium-99m human immunoglobulin scintigraphy in psoriatic arthropathy: first results

Standard bone scintigraphy [using technetium-99m methylene diphosphonate (MDP)] is widely held to be the most sensitive method for the early detection of psoriatic arthropathy. Preliminary results of this study reveal that 99mTc human immunoglobulin (HIG) scintigraphy demonstrates a typical premature pattern of extradermal psoriatic disease in digits indicative of the early stage of psoriatic arthritis. This pattern was also found in a rare case of psoriatic arthropathy without skin lesions. 99mTc-HIG scintigraphy appears to reveal the initial inflammatory characteristics of later bone lesions. In the advanced stage of psoriatic arthritis, 99mTc-MDP and 99mTc-HIG scans were found to be equally sensitive in the detection of the affected joints. Thus 99mTc-HIG scintigraphy seems to be useful in the early detection of psoriatic arthropathy and also in advanced psoriatic arthritis, as well as for the detection of psoriatic arthropathy without skin lesions.

Technetium-99m human immunoglobulin scintigraphy in psoriatic arthropathy: first results

Technetium-99m human immunoglobulin scintigraphy in psoriatic arthropathy: first results

Removal from skin of plasma protein labeled with radioactive iodine.

ArticleRemoval From Skin of Plasma Protein Labeled With Radioactive IodineR. P. Jepson, F. A. Simeone, and B. M. DobynsR. P. JepsonFrom the Department of Surgery of Western Reserve University School of Medicine at City Hospital, Cleveland, Ohio, F. A. SimeoneFrom the Department of Surgery of Western Reserve University School of Medicine at City Hospital, Cleveland, Ohio, and B. M. DobynsFrom the Department of Surgery of Western Reserve University School of Medicine at City Hospital, Cleveland, OhioPublished Online:30 Nov 1953https://doi.org/10.1152/ajplegacy.1953.175.3.443MoreSectionsPDF (941 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByLymphoscintigraphy, lymphangiography, magnetic resonance imaging21 April 2017Lymphoscintigraphy and lymphangiography3 January 2013Lymphatic transfer studies with immunoglobulin scintigraphy after axillary surgeryEuropean Journal of Surgical Oncology (EJSO), Vol. 33, No. 9Clinical Assessment of Human Lymph Flow Using Removal Rate Constants of Interstitial Macromolecules: A Critical Review of LymphoscintigraphyLymphatic Research and Biology, Vol. 5, No. 3Isotope lymphography: a new method of investigating the role of the lymphatics in chronic limb oedema8 December 2005 | British Journal of Surgery, Vol. 72, No. 11Short-term effects of axillary lymph node clearance surgery on lymphatic physiology of the arm in breast cancerSimon J. Pain, Robert W. Barber, Chandra K. Solanki, James R. Ballinger, Tom Bennett Britton, Peter S. Mortimer, Anand D. Purushotham, and A. Michael Peters1 December 2005 | Journal of Applied Physiology, Vol. 99, No. 6Regional Distribution of Epifascial Swelling and Epifascial Lymph Drainage Rate Constants in Breast Cancer-Related LymphedemaLymphatic Research and Biology, Vol. 3, No. 1Diffusional transport of albumin from interstitium to blood across small pores in the capillary walls of rat skeletal muscleActa Physiologica Scandinavica, Vol. 133, No. 1Functional Study of the Limb Lymphatic System23 June 2016 | Phlebology: The Journal of Venous Disease, Vol. 1, No. 2Permeability of muscle capillaries to interstitially microinjected horseradish peroxidaseMicrovascular Research, Vol. 16, No. 3Transcapillary efflux of gamma globulin in rabbit skeletal muscleMicrovascular Research, Vol. 9, No. 1The lymphatic transport of lactate dehydrogenase. Effect of tissue anoxia and shockResearch in Experimental Medicine, Vol. 161, No. 1Physiologie und Pathophysiologie des LymphgefäßsystemsThe Chemistry of LymphEndothelial fenestrae in intestinal villi: Differences between the arterial and venous ends of the capillariesMicrovascular Research, Vol. 3, No. 1LYMPHATIC FUNCTION: THE DISAPPEARANCE RATE OF 131I ALBUMIN FROM THE DERMISBritish Journal of Dermatology, Vol. 82, No. 6Experimental and clinical study on the lymph circulationAmerican Heart Journal, Vol. 75, No. 5The use of I131 albumin tissue clearance measurements and other physiological tests for the clinical assessment of patients with lymphœdemaBritish Journal of Plastic Surgery, Vol. 20On the resorption of parenterally administered saline solutions in experimental shockBulletin of Experimental Biology and Medicine, Vol. 51, No. 2Kreislaufdiagnostik mit Hilfe radioaktiver IsotopeCapillary circulation in experimental plagueBulletin of Experimental Biology and Medicine, Vol. 46, No. 4Studies Directed Toward the use of Antibodies as Carriers of Radioactivity for TherapyULTRASONIC IRRADIATION OF THE FRONTAL LOBESThe Lancet, Vol. 265, No. 6853LYMPHŒDEMA PRÆCOXThe Lancet, Vol. 265, No. 6853 More from this issue > Volume 175Issue 3November 1953Pages 443-448 Copyright & PermissionsCopyright © 1953 by American Physiological Societyhttps://doi.org/10.1152/ajplegacy.1953.175.3.443PubMed13114426History Received 20 July 1953 Published online 30 November 1953 Published in print 30 November 1953 Metrics