Haemopoietic colony-stimulating factors (CSFs) have been known to worsen autoimmune disorders, 1 Vial T Descotes J Immune-mediated side-effects of cytokines in humans. Toxicology. 1995; 105: 31-57 Crossref PubMed Scopus (150) Google Scholar , 2 De Luis DA Romero E Reversible thyroid dysfunction with filgrastim. Lancet. 1996; 348: 1595-1596 Summary Full Text Full Text PDF PubMed Scopus (7) Google Scholar whereas granulocyte-macrophage colony-stimulating factor 3 Wakefield D Lloyd A A role of cytokines in the pathogenesis of inflammatory eye disease. Cytokine. 1992; 4: 1-5 Crossref PubMed Scopus (121) Google Scholar and granulocyte colony-stimulating factor (G-CSF) 4 Parkkali T Volin L Siren M-K Ruutu T Acute iritis induced by granulocyte colony-stimulating factor used for mobilization in a volunteer unrelated peripheral blood progenitor cell donor. Bone Marrow Transplant. 1996; 17: 433-434 PubMed Google Scholar activate preexisting inflammatory eye disease or even induce the disease. We report here a girl in whom G-CSF induced subretinal haemorrhage resulting in irreversible loss of vision.