Modern experiments in hadronic physics require detector systems capable of identifying and reconstructing all final-state particles and their momentum vectors. Imaging Cherenkov counters (RICH and DIRC) are frequently employed in nuclear and particle physics experiments. These detectors require high-rate, single-photon capable light detection system with sufficient granularity and position resolution. Several candidate systems are available, ranging from multi-anode photomultiplier tubes to micro-channel plate systems to silicon photomultipliers. Each of these detection solutions has particular advantages and disadvantages. Detailed studies of rate dependence, cross-talk, time-resolution and position resolution for a range of available photon detection solutions are presented. These properties make these photon detection systems ideal for radionuclide imaging applications. Cherenkov radiation can also be used for medical imaging applications. Two different applications using the Cherenkov effect for radionuclide imaging will be reviewed.