Ideal Mode Research Articles

Ligand and Structure-Based In Silico Determination of the Most Promising SARS-CoV-2 nsp16-nsp10 2'-o-Methyltransferase Complex Inhibitors among 3009 FDA Approved Drugs.

As a continuation of our earlier work against SARS-CoV-2, seven FDA-approved drugs were designated as the best SARS-CoV-2 nsp16-nsp10 2′-o-methyltransferase (2′OMTase) inhibitors through 3009 compounds. The in silico inhibitory potential of the examined compounds against SARS-CoV-2 nsp16-nsp10 2′-o-methyltransferase (PDB ID: (6W4H) was conducted through a multi-step screening approach. At the beginning, molecular fingerprints experiment with SAM (S-Adenosylmethionine), the co-crystallized ligand of the targeted enzyme, unveiled the resemblance of 147 drugs. Then, a structural similarity experiment recommended 26 compounds. Therefore, the 26 compounds were docked against 2′OMTase to reveal the potential inhibitory effect of seven promising compounds (Protirelin, (1187), Calcium folinate (1913), Raltegravir (1995), Regadenoson (2176), Ertapenem (2396), Methylergometrine (2532), and Thiamine pyrophosphate hydrochloride (2612)). Out of the docked ligands, Ertapenem (2396) showed an ideal binding mode like that of the co-crystallized ligand (SAM). It occupied all sub-pockets of the active site and bound the crucial amino acids. Accordingly, some MD simulation experiments (RMSD, RMSF, Rg, SASA, and H-bonding) have been conducted for the 2′OMTase—Ertapenem complex over 100 ns. The performed MD experiments verified the correct binding mode of Ertapenem against 2′OMTase exhibiting low energy and optimal dynamics. Finally, MM-PBSA studies indicated that Ertapenem bonded advantageously to the targeted protein with a free energy value of −43 KJ/mol. Furthermore, the binding free energy analysis revealed the essential amino acids of 2′OMTase that served positively to the binding. The achieved results bring hope to find a treatment for COVID-19 via in vitro and in vivo studies for the pointed compounds.

Influence of coupling ratio on seismic behavior of hybrid coupled partially encased composite wall system

SummaryPartially encased composite (PEC) members are novel composite members that efficiently exploit the advantages of mechanical properties of concrete and steel. However, the application of PEC members is limited to low‐ and mid‐rise buildings. To overcome this limitation, a study was conducted to assess the seismic performance of a newly proposed steel–concrete hybrid coupled wall consisting of PEC wall piers coupled by means of steel beams. Parametric analysis was conducted to investigate the elastic coupling ratio (CRelastic) and the way of changing CRelastic on the seismic behavior of the hybrid coupled PEC wall. The results showed that the CRelastic was the main parameter that affected the seismic performance of the wall. The way of changing CRelastic had little influence on the trend of the energy dissipation capacity and strength reservation of the wall. The failure mode and the development of plastic hinges of the wall were also not affected by the way of changing CRelastic. Both too large and too small CRelastic were detrimental to the seismic performance of the wall. To form an ideal plastic hinge development mode and experience good seismic performance, it is suggested that the reasonable range of CRelastic for the wall was 60%–70%.

CRMP2 modulates mossy fiber sprouting in dentate gyrus of pilocarpine induced rat model of epilepsy

As a hallmark of epilepsy, mossy fiber sprouting was regarded as an ideal mode to study neural rewiring upon injury. The process of mossy fiber sprouting constitutes key steps for neural circuit formation, including axon collateral formation and outgrowth, reversed pathfinding and synapse connection. The canonical function of CRMP2 is to promote neurite/axon outgrowth via binding to tubulin heterodimers, which is mainly regulated by its phosphorylation state. CRMP2 expression and phosphorylation were reported to change in medial temporal epilepsy patients and animal modes of epilepsy. As a novel anti-epilepsy drug, Lacosamide is able to impair CRMP2 mediated tubulin polymerization. Previous studies suggested possible roles of CRMP2 in mossy fiber sprouting. Here, we provide direct evidence to support the role of CRMP2 in the process of mossy fiber sprouting in an animal model of epilepsy. We found that CRMP2 phosphorylation was downregulated specifically in the hippocampus during latent phase of epileptic rats. In addition, with the reduction of CRMP2 expression levels in dentate gyrus by CRMP2 shRNA, we observed decreased mossy fiber sprouting in these CRMP2 knockdown rats. Our results demonstrated that CRMP2 modulates mossy fiber sprouting in dentate gyrus of pilocarpine induced rat model of epilepsy.

Always Something Missing

What does it take to experience grace? I argue that for followers of the Chinese Christian reformers Watchman Nee and Witness Lee, in China, Taiwan, and the United States, grace is experienced as an intended gift with a missing motivating intention. For a group in which God’s intentions are rigorously mapped out, experiencing God’s grace is thus no simple feat. In particular, I show how the experience of grace occurs in moments of apparent wrongdoing when reward is least comprehensible. As this wrongdoing becomes institutionalised as an ideal mode of grace, however, it paradoxically becomes less graceful in practice. Therefore, grace here is an inherently transgressive, destabilising, contradictory phenomenon. Extrapolating beyond Nee and Lee’s followers, I suggest that at a time of gratitudinous secularism, of givenness without a Giver, blessedness without a Blesser, grace is more abundant than ever. But that with this grace comes gratitude, an emotion often resistant to social change.

Ultra-secure optical encryption based on tightly focused perfect optical vortex beams

Abstract Light’s orbital angular momentum (OAM) with inherent mode orthogonality has been suggested as a new way to the optical encryption. However, the dependence of annular intensity profiles on the topological charge complicates nanoscale light–matter interactions and hampers the ultra-secure encryption application. In this paper, we demonstrate ultra-secure image encryption by tightly focusing perfect optical vortex (POV) beams with controllable annular intensity profiles and OAM states. A simple scheme composed of single spatial light modulator to implement Fourier transform of an ideal Bessel mode with both amplitude and phase modulations is proposed to generate radius-controllable POV in tightly focused beams. Such focused POV beams with identical intensity profiles but varied local OAM density are applied to disorder-coupled gold nanorod aggregates to selectively excite electromagnetic hot spots for encoding information through photothermal deformation. As such, ultra-secure image encryption in OAM states of POV beams in combination with different polarizations can be achieved. Our results lay the ground for diverse nanophotonic applications harnessing the OAM division of POV beams.

Falling in and out of love: With and beyond Bourdieu on individual enchantment and disenchantment

AbstractThis paper engages with the theme of individual disenchantment, that is, the process of falling out of love with something that once gave pleasure and purpose. Drawing on the conceptual tools of Pierre Bourdieu, it sketches the process by which individuals become ‘enchanted’ with the stakes of different fields, the phenomenology of enchantment and disenchantment and several ideal typical modes of genesis of disenchantment. Attention is given to intra‐field dynamics but also, going beyond Bourdieu, inter‐field dynamics too. The final section considers the epistemological consequences of constructing trans‐field objects of inquiry.

An organic cocrystal based on phthalocyanine with ideal packing mode towards high-performance ambipolar property

The identical macrocyclic pair promotes desired packing mode with tight and large-overlapped π–π stacking in phthalocyanine-based cocrystal, which ensures high-performance ambipolar property.

Неизвестные свойства однофазного реактивного синхронного двигателя

На математической и физической модели однофазного реактивного синхронного двигателя (IФРСД) показана возможность его «самозапуска» при достаточно малом моменте сопротивления, вызванная неустойчивостью статических состояний равновесия. Реакция на включение напряжения к обмотке статора зависит как от исходного положения ротора, так и от величины и фазы напряжения. Установлена неустойчивость режима вращения с постоянной составляющей скорости, равной синхронной скорости. В режиме идеального холостого хода установлена постоянная составляющая скорости, равная примерно 40% от синхронной скорости. Экспериментально на математической модели получена механическая характеристика IФРСД при допущении исчезающе малых пульсаций частоты вращения. Приложение момента нагрузки вызывает снижение частоты вращения при положительном моменте и увеличение - при отрицательном. Превышение максимального момента нагрузки, как и у асинхронного двигателя, вызывает «опрокидывание» IФРСД.

The Effect of Blended Learning Instruction using Simplified Science Module on Students’ Academic Performance

In the new normal set-up, one of the ideal modes of teaching and learning used in the K-12 curriculum that is engaging and motivating is blended learning instruction. This study focused on the effect of blended learning instruction using simplified science module on the academic performance of Grade 11 students of Tawi-Tawi School of Arts and Trades (TTSAT) and Tawi-Tawi School of Fisheries (TTSF). This study made use of quasi-experimental design and had two sets of research instruments: the simplified science module used in blended learning instruction and the Pre-test and Post-test Questionnaire. The result revealed that there was an increase in the level of academic performance of students in both schools with blended learning instruction using simplified science module. It also revealed that blended learning instruction using simplified science module exhibits large effect in content standards such as Stellar Formation and Origin of Elements, Atomic Concept, and Chemical Reaction while medium effect on Properties of matter and Its Chemical Structure. There is a significant difference on the level of performance from pre-test to post-test of the said students in both schools. There is no significant difference on the extent of effect of blended learning instruction using simplified science module on the academic performance of the concerned students in both schools along the four content standards. Consequently, blended learning instruction using simplified science module is an effective way of engaging and motivating students to learn in both schools. Thus, schools should encourage teachers to engage students in blended learning instruction to achieve effective and meaningful learning.

Critical Logical Link Assessment for Improving Industrial Wireless Communication Systems

Wireless communication is an important power for moving Industry 4.0 and intelligent manufacturing, where its dependability is challenging industry and academia. Dependability research has two phases: dependability assessment and control. Dependability control based on assessment feedback is the ideal mode for future complex industrial wireless communication systems (WCSs). However, the state-of-the-art automated control methods are focused on improving dependability indicators which ignore the boundary that only killing some logical links may improve the whole WCS. Therefore, this paper proposes the critical logical link assessment method with steps of measurement, experience-based labeling, feature extraction, link assessment, and critical link calculation. In particular, the feature extraction and link assessment are based on two deep neural networks and work together to obtain a correlation coefficient between two logical links. At last, we conducted experiments on realistic measurements in three WCSs which proves both usability and novelty.

Complex coordinated functional groups: A great genes for nonlinear optical materials

Complex coordinated functional groups [MAxBy] (M = Central coordination element; A, B = P, O, S, Se, F, Cl, Br or I) are composed of different types of anions A, B jointly linked to the same central cation M, which are in high potential to tune the physical properties of materials, e.g., second-order susceptibility, energy gaps and birefringence. Recently, Compound containing complex coordinated functional groups have attracted great attention in the nonlinear optical (NLO) field and a large number of this type crystals exhibit promising NLO performance. However, the inherent relationship between ionic group structure and optical properties of complex coordinated NLO materials have not been systematically studied. This article systematically summarizes complex coordinated NLO materials in recent five years from the perspective of the internal relationship between crystal structure and optical properties. In addition, we propose the ideal combination and arrangement modes for structural building units, and also reveal the influence of complex coordinated functional groups [MAxBy] toward the NLO response, optical band gap and phase matching ability of complex coordinated NLO materials.

Preventive maintenance model analysis on wind-turbine gearbox under stochastic disturbance

In recent, with the rapid scientific and technical developments, condition-based maintenance(CBM) has already been broadly applied in modern large-scale wind plants increasingly and reported that tremendous achievements are gained. However, in the real world, many large modern wind plants still stick with the time-based maintenance(TBM) mechanism, called a planned repairing. CBM only acts as auxiliary maintenance means although it is considered forceful. To achieve this, this paper firstly analysis the general operating characteristics of TBM and CBM, and then establishes a stochastic differential equation(SDE) model to investigate their similarities and differences. The research shows that under the TBM, the system has good long-term and global behavior, but there are over-maintenance and under-maintenance problems. Under the action of CBM, the system has significant short-term and local characteristics. The combination of the two strategies is an ideal and necessary mode. Finally, applying examples verify the effectiveness and correctness of the proposed method, which quite corresponds to current maintenance modes in many enterprises.

Reduction in Noise Pollution of a Gas Power Plant under Construction Using Synthesis of Copper and Nickel Alloy Foam in a Simulated Setting

Noise pollution is one of the challenges of installing equipment and developing industries. The control of noise generated by small power plants is a necessity for its use development. Designing the synthesis of copper and nickel alloy foam and using this foam to reduce noise pollution in the exhaust is one of the effective methods to control and reduce noise pollution from power plants. The purpose of this study was to synthesize copper and nickel alloy foam and compare the effect of results of spl changes in software ANSYS for three ductless, ideal wall and multilayer wall modes at different frequencies. In this regard, the adjunct duct is modeled as 3D by software ANSYS, and the output sound intensity of the duct in the acoustic setting is analyzed in several different modes. The results show that three different modes in the exhaust output indicate that the multilayer wall at most frequencies reduces the sound pressure level relative to the ductless or ideal wall modes.

Correction of residence time distributions and hydraulic indexes affected by tracer release duration in surface flow constructed wetlands

In tracer experiments of surface flow constructed wetlands, residence time distributions (RTDs) are generally originated from the normalized concentration data of recovered tracers based on ideal instantaneous tracer release mode. However, this tracer release mode is commonly approximated by finite-continuous tracer release over a relatively short duration. As a result, the accuracy of RTDs and hydraulic indexes cannot be guaranteed if the RTD data and index values were still calculated based on the instantaneous release. To solve this problem, a method for correcting the original RTD data and the index values affected by tracer release duration was proposed. The correction of hydraulic indexes can be performed using analytical formulas, whereas the correction of the RTDs requires an RTD model (such as the gamma distribution and one-dimensional advection-dispersion model) or a smoothing algorithm (such as the simple moving average algorithm) to avoid the increasing effect of random measurement errors caused by the direct use of the RTD correction formulas. The correction method was successfully verified by a specially designed tracer test, and its practical application effect was exemplified. A Monte Carlo test also proved that the RTD correction owed certain robustness to tracer release instability, while the correction of some hydraulic indexes that reflect flow dispersion and comprehensive hydraulic efficiency had inferior robustness. Aside from this, the influence of tracer release duration on RTDs and hydraulic indexes without any correction was analyzed. It was found that the release duration caused the shape of the original RTDs to be more skewed in the positive direction of the x-axis and changed from “thin and high” to “fat and short”, while the duration of the release caused the positive relative errors of most indexes, which became more serious with an increase in the duration or worsening hydraulic performance. Based on these influence rules, 0.01 was defined as the threshold of the normalized release duration which needs to correct RTDs and hydraulic indexes, considering that the relative errors between the uncorrected and corrected indexes were less than 5% when the normalized duration was less than this threshold.

Integrative Analysis to Uncover the Molecular Mechanisms of Caesalpinia sappan L. for Anti-Cancer Activity

Objectives: Caesalpinia Sappan L. is a traditional Chinese medicine with a long history. Recent studies have confirmed that Sappan has an antitumor effect, but its specific mechanism is still unclear. Methods: In this study, we used network pharmacology to predict the target and signal pathway of Sappan. In addition, the Cancer Genome Atlas and cancer cell lines encyclopedia large-scale genomic databases were used to analyze the relationship between different subtypes of Akt. Based on molecular docking technology, the interaction mode between small molecule compounds and protein targets was explored. Finally, we studied the effect of Sappan on Akt protein expression by Western blot in vitro. Results: AKT1 and AKT2 were significantly expressed in breast cancer cells, but they were significantly different from AKT3. Finally, molecular docking analysis showed that (3R,5R)-1,3,4,5-tetrakis(((E)-3-(3,4-dihydroxyphenyl)acryloyl)oxy)cyclohexane-1-carboxylic acid had a very ideal binding mode with Akt. Subsequent experiments showed that Sappan extract could induce apoptosis of HepG2 cells in a dose-dependent manner, and down regulate the phosphorylation level of Akt protein thr308 in a dose-dependent manner. Conclusions: This study provides new ideas for Sappan's anticancer research through the strategy of system pharmacology.

Research on seismic performance of precast steel–concrete composite tube shear walls with horizontal joint

An innovative precast steel–concrete composite tube (SCCT) shear wall with horizontal joints is proposed, in which the horizontal joints are arranged in the middle of shear walls, the thin-walled steel tube, piercing bars and cover concrete provide restraint for the concrete inside the tube to improve the strength and deformation capacity of internal concrete, and the internal and outer concrete, piercing bars are used to avoid the out-of-plane deformation of the thin-walled steel tube. The experimental program was conducted on five full scale models of SCCT shear walls and one cast-in-situ RC shear wall (SW) subjected to cyclic loading. The results revealed that the precast SCCT shear walls with horizontal joints had high strength, stiffness, ductility and energy dissipation, verifying the reliability of the horizontal joints. Moreover, the horizontal joints had little impact on the overall seismic performance of the SCCT shear walls. In addition, two types of failure modes were observed in the SCCT shear walls, where type A was the ideal failure mode making full use of the steel materials and type B with the characteristics of brittle failure should be avoided. Based on the test results, an analytical model was established to calculate the normal section bearing capacity of the SCCT shear walls, and the proposed model was validated using the test results. Finally, finite element analysis (FEA) models of specimens were proposed based on a multilayer shell element, and a parameter study based on the proposed FEA model was conducted to investigate the influence of critical parameters on the mechanical performance of the SCCT shear walls.

Self-organized confinement in whole-device modeling of laboratory magnetospheres

Turbulent self-organization driven by global ideal interchange modes in a dipole-confined plasma is explored with self-consistent, whole-plasma simulations using a flux-tube averaged magnetohydrodynamic model in dipole magnetic geometry. We show the existence of robust particle pinch driven by ideal interchange-mode fluctuations, in which the particles are transported up the density gradient. It is found that the plasma profiles in a dipole field spontaneously relax to a marginally stable state as centrally peaked pressure and density are created by global interchange-mode transport.

Further aspects of I K-convergence in topological spaces

In this paper, we obtain some results on the relationships between different ideal convergence modes namely, I K, I K∗ , I, K, I ∪ K and (I ∪K) ∗ . We introduce a topological space namely I K-sequential space and show that the class of I K-sequential spaces contain the sequential spaces. Further I K-notions of cluster points and limit points of a function are also introduced here. For a given sequence in a topological space X, we characterize the set of I K-cluster points of the sequence as closed subsets of X.

Design and Implementation of a High Step-Up DC-DC Converter Based on the Conventional Boost and Buck-Boost Converters with High Value of the Efficiency Suitable for Renewable Application

This paper introduces a novel topology of the proposed converter that has these merits: (i) the topology of the converter is based on conventional boost and buck-boost converters, which has caused its simplicity; (ii) the voltage gain of the converter has provided higher values by the lower value of the duty cycle; (iii) due to the use of high-efficiency conventional topologies in its structure, the efficiency of the converter keeps its high value for a great interval of duty cycle; (iv) besides the increase of the voltage gain, the current/voltage stresses of the semiconductors have been kept low; (v) the continuous input current of this converter reduces the current stress of the capacitor in the input filter. It is worth noting that the proposed converter has been discussed in both ideal and non-ideal modes. Moreover, the operation of the converter has been discussed in both continuous/discontinuous current modes. The advantages of the converter have been compared with recently suggested converters. In addition, the different features of the converter have been discussed for different conditions. In the small-signal analysis, the appropriate compensator has been designed. Finally, the simulation and experimental results have been reported for 90 W output power, 90 V output voltage, 3-times voltage gain, and 100 kHz switching frequency.

The Research on the Product Humanization Model Based on the Evolution of Consumer Purchase Pat

Digital economy gives new connotation to business model. In the process of business model changing from vertical to horizontal, from exclusive to inclusive, and from individual to social, the central activity of enterprise marketing should be transferred to how to actively interact with consumers, so that consumers can more participate in the process of enterprise marketing value creation. This paper focuses on the model of consumers’ participation in marketing value creation. Firstly, this paper studies the basic model of consumer purchase path evolution, and proposes 5A +1D model based on the basic model. Then, based on the 5A+1D model, an important carrier for consumers to participate in the value creation of marketing is proposed: the product humanization model. Secondly, the paper analyzes the ideal migration mode of consumer purchase path under humanistic products: “W” model, which finally reaches the balance at both ends of 5A+1D model. Under the ecological background of open innovation, this paper extends the chain of consumers’ purchase path and realizes the co-creation of consumers and enterprises’ value, and designs a human-oriented product model based on the chain of consumers’ extended purchase path. The W model achieves the balance between the beginning and the end of the consumer purchase path model, which provides a theoretical basis for the intervention points of enterprises on the overall consumers’ purchase path.