Hypergranulation Tissue Research Articles

Use of topical corticosteroids on chronic leg ulcers

Topical corticosteroids are widely used in the management of chronic wounds, yet there is little evidence to support this. This pilot study aimed to identify current practice by three specialist nurses and to assess the efficacy of topical corticosteroids. Data on healing, pain relief, exudate reduction and control of hypergranulation tissue were collected on 34 patients whose wounds were treated with topical corticosteroids prospectively in three centres over a three-month period. Twenty-seven patients (79%) benefited from the application of topical corticosteroid either in terms of healing, pain relief, exudate reduction or the control of hypergranulation tissue. Two wounds deteriorated and treatment was immediately withdrawn. Suppression of inflammation plays an important role in healing and pain relief. Applying topical corticosteroids to the wound can accelerate healing and reduce pain in certain cases. However, careful monitoring is essential as there is a risk of sensitisation with prolonged use as well as a potential increased risk of infection.

P0762 CRYOTHERAPY ON COMPLICATING HYPERGRANULATION TISSUE IN PERCUTANEOUS GASTROSCOPIC ENTEROSTOMY

Introduction: Enteral feeding via Percutaneous Endoscopic Gastrostomy PEG is a widely used method to handle nutritional problems in children with a variety of disorders. Problems in the ability to swallow due to neurological impairment, difficulties in the proper intake of calories in metabolic diseases or continuous enteral administration of nutrition in gastroenterological diseases are typical reasons for PEG placement. In about one third to one fourth of the patients hypergranulation tissue (caro luxurians) develops at the PEG insertion site 1, 2sometimes with subsequent hypersecretion and bleeding or recurrent infections. Mostly frequent applications with silver nitrate solution are used to treat these cases. In order to faciliate handling and to minimize visits at medical facilities for the patients we used contact-cryotherapy, typically applied to superficial cutaneous hemangiomas, to treat only such patients with fast growing or bleeding hypergranulation tissue (10 patients, 2–13 years). Methods: Prior to starting the application of cryotherapy on hypergranulation tissue tests were performed in cooperation with PEG manufacturers to guarantee the integrity of the PEG tube in case it had been cooled through the surrounding tissue or directly come into contact with the ultracold cryoprobe. On the patient the PEG insertion site was cleaned with octenidine hydrochloride and anaesthesized with lidocaine/prilocaine cream. Afterwards the iced cryoprobe (−196° C) was pressed onto the tissue for 10 seconds, multiple times, if indicated. Results: Experiments with PEG tubes showed no damage even after directly freezing the plastic in liquid nitrogen if not being bent in this state. So the cryotherapy could be regarded as safe as far as the integrity of the tube was concerned. Most patients needed a single session with a subsequent decrease in the hypergranulation tissue. Only two patients received multiple sessions over a period of about two years due to recurrent infections. In these cases each cryosession resulted in a marked improvement of the lesion. Conclusion: The cryotherapy seems to be a valuable method in children with PEG and hypergranulation tissue. The disadvantage of being a little painful can be antagonized easily with anaesthetic cream. Advantages lie in the low frequency of relapses and in the low frequency of treatment sessions in comparison to silver nitrate applications.

Treatment of a nonhealing wound with hypergranulation tissue and rolled edges

Treatment of a nonhealing wound with hypergranulation tissue and rolled edges

Treatment of a Nonhealing Wound With Hypergranulation Tissue and Rolled Edges

Hawkins-Bradley, Beth RN, MN, CWOCN; Walden, Mary RN, BSN, CWOCNEditor(s): Hanlon, Maureen RN, MN, CWOCN Author Information

Human cadaveric allograft for repair of nasal defects after extirpation of Basal cell carcinoma by Mohs micrographic surgery.

Immediate reconstruction after removal of skin cancer by Mohs micrographic surgery (MMS) may not be feasible in patients unwilling or unable to undergo an extensive procedure. Human cadaveric allograft (HCA) may offer a useful alternative to granulation. To examine the usefulness of HCA in resurfacing nasal defects after extirpation of basal cell carcinoma (BCC) by MMS. Case histories of seven patients treated with HCA were reviewed with respect to primary skin cancer histology, defect size, medical status, healing time, and cosmesis. Five of seven tumors were infiltrative BCCs. Defects ranged from 2.7 to 20 cm2. Average healing times for wounds with and without exposed cartilage were 42 and 35 days, respectively. There were no wound infections. Hypergranulation tissue was noted in three patients and had no effect on cosmesis, which was adequate in five patients and poor in two patients. HCA may be a useful alternative to granulation following MMS for treatment of skin cancers involving the nose.

Human Cadaveric Allograft for Repair of Nasal Defects After Extirpation of Basal Cell Carcinoma by Mohs Micrographic Surgery

BACKGROUND Immediate reconstruction after removal of skin cancer by Mohs micrographic surgery (MMS) may not be feasible in patients unwilling or unable to undergo an extensive procedure. Human cadaveric allograft (HCA) may offer a useful alternative to granulation. OBJECTIVE To examine the usefulness of HCA in resurfacing nasal defects after extirpation of basal cell carcinoma (BCC) by MMS. METHODS Case histories of seven patients treated with HCA were reviewed with respect to primary skin cancer histology, defect size, medical status, healing time, and cosmesis. RESULTS Five of seven tumors were infiltrative BCCs. Defects ranged from 2.7 to 20 cm2. Average healing times for wounds with and without exposed cartilage were 42 and 35 days, respectively. There were no wound infections. Hypergranulation tissue was noted in three patients and had no effect on cosmesis, which was adequate in five patients and poor in two patients. CONCLUSION HCA may be a useful alternative to granulation following MMS for treatment of skin cancers involving the nose.

Hypergranulation tissue at gastrostomy sites

This paper looks at some of the wound-care issues surrounding enteral tube feeding, and questions the evidence base for current practices, which can be ritualistic

Hypergranulation tissue.

A review of the formation, causes and management of hypergranulation tissue.

Mucocutaneous and systemic toxicity of retinoids: monitoring and management.

Oral retinoid therapy is associated with significant mucocutaneous and systemic toxicity similar to that found in hypervitaminosis A. Beside the well-known mucocutaneous adverse effects like cheilitis, xerosis, desquamation, dryness of mucous membranes, more troublesome findings are ocular effects, hair loss or hypergranulation tissue. The most unwanted systemic side effects under both retinoids (isotretinoin and etretinate) are teratogenicity, bone toxicity and serum lipid increments. Careful patient counselling and monitoring will enable the physician to modulate these effects and reduce their impact on patient compliance.

Sorbsan calcium alginate fibre dressings in footcare

This report outlines the successful application of Sorbsan-calcium alginate fibre dressings in footcare. This biomaterial has been found in clinical trials to have quite outstanding merit and can be used for sinus drainage and in the treatment of fissures, hypergranulation tissue, interdigital maceration, heloma molle and other lesions. Sorbsan bonds with and aids natural healing scabs and effects drainage of moist sites thus assisting in creating an environment conducive to the healing process. Similar promise has ben demonstrated for this material in ongoing trials in hospitals in Sunderland 4 where Sorbsan has been used effectively in the treatment of diabetic and trophic ulcers.

Congenital Atresio Vagina

SummaryMcindoe's method of vaginal reconstruction is simple.Instead of using hard vaginel mould foam form is suggested.Common complications like contraction of cavity, hypergranulation tissue, V.V.F., R.V.F. etc. could be avoided.