Aldehydes and ketone sensitive fluorescence sensor constructed by hydroxylamine hydrochloride and carbon quantum dots for baijiu recognition.

Synergistic effect of potassium ferrate and hydroxylamine for in-situ coagulation toward algae-laden water treatment.

A simple and efficient strategy for visible aldehydes and ketones detection and its application in baijiu grade discrimination.

ABSTRACT Heavy metal contaminated soils have attracted worldwide attention, and there is a growing interest in the use of detergents to remediate heavy metal contaminated soils. In this study, the response surface methodology was used to determine the optimal drenching parameters by combining the interaction between the factors and the pollution safety index. The elution of heavy metals by the two-step elution method and the mixed elution method was investigated under optimal conditions (77.66 mmol.L−1 MGDA, 145.01 mmol.L−1 HH, pH 3.29, 90 min, S/L = 1:10, 25 °C). The results showed that the mixed solution was more effective in the elution of heavy metals, and the removal of lead, copper and nickel was 8.11%, 16.27% and 1.36%, respectively. The different forms of heavy metals were extracted by the modified Tessier method after water washing, and the results showed that the iron-manganese oxide-bound and carbonate-bound fractions of Pb, Cu and Ni were significantly reduced after water washing. Among them, the carbonate-bound state of Pb, Cu and Ni decreased by 90.30, 256.85 and 4.00 mg.kg−1, respectively; the ferromanganese-oxidised state of Pb, Cu and Ni decreased by 531.00, 1493.33 and 48.74 mg.kg−1, respectively; before and after drenching MCSI decreased by 10.85% compared with that before drenching. FTIR analysis of heavy metals after water washing showed that the mixture had no significant effect on soil properties after water washing. The above results indicated that the mixture of HH and MGDA can be used as a washing solution for heavy metal contaminated soil.

New ruthenium(II) anthracenyl-heterocyclic hydrazone catalyst for the synthesis of amides from aldehydes using hydroxylamine hydrochloride

Comparison of hydroxylamine hydrochloride and hydrogen peroxide in activated Fe(VI) for fracturing flowback fluid treatment: Efficiency, mechanism, and toxicity analysis.

Hydroxylammonium Chloride Cocrystals: Structural and Hygroscopicity Trends

This study aimed to design and synthesize new ferrocene derivatives for the development of potent anticancer drugs. Cancer is a major cause of death globally. Some small-molecule anticancer drugs have been used in clinics for the treatment of cancer, and several candidates are in different phases of clinical trials. However, cancer chemotherapy is still highly inadequate due to the side effects of the clinical drugs. Thus, developing novel anticancer drugs is essential. Firstly, we synthesized the R-substituted benzaldoxime intermediates (2a-2s) using R-substituted benzaldehyde (1a-1s) and hydroxylamine hydrochloride. Then, the target compounds (3a-3s) were synthesized using ferrocene carboxylic acid and R-substituted benzaldoxime intermediates (2a-2s) as starting materials, and using DCC and DMAP as catalysts. The purity of the target compounds was determined by HPLC, and their structures were characterized using NMR, SC-XRD, and HR-ESIMS. Subsequently, the preliminary in vitro cytotoxicity against HeLa, A549, and A2780 cell lines was evaluated using MTT assay. The results showed that compound 3a exhibited cytotoxicity against both HeLa and A549 cancer cell lines with IC50 values of 0.691 and 0.876 mM, respectively. Compound 3k showed potent cytotoxicity against HeLa cell lines with an IC50 value of 0.097 mM, compounds 3n and 3o exhibited potent cytotoxicity against three cancer cell lines, compound 3q showed potent cytotoxicity against HeLa cell lines with an IC50 value of 0.175 mM, while compound 3s exhibited potent cytotoxicity against HeLa and A549 cell lines with IC50 values of 0.470 and 0.298 mM, respectively. In this work, 19 new ferrocene derivatives containing R-substituted benzaldoxime moieties (3a-3s) were synthesized and their structures were confirmed. Their cytotoxicity against HeLa, A549, and A2780 cell lines was tested, and the results showed that several compounds exhibited potent cytotoxicity against the tested cancer cell lines. This work developed a variety of ferrocene compounds, providing lead compounds based on ferrocene pharmacophore for the development of anticancer drugs.

Enhanced degradation of levofloxacin hydrochloride synergistically with hydroxylamine hydrochloride via Fe3O4-loaded Medulla Tetrapanacis residue in a Fenton-like process

Abstract This study presents an optimized synthesis of 2‐methyl‐4,5‐dinitro‐1,2,3‐triazole‐1‐oxide (DNMTO), an insensitive high‐energy compound, via one‐pot method with pulsed ultrasound‐assisted extraction (PUAE). Glyoxal reacted with methylhydrazine and hydroxylamine hydrochloride to form intermediate 2‐methyltriazole (MTO, 21% yield) under CuSO4/pyridine catalysis, followed by nitration (HNO3/H2SO4, 1:3) to achieve DNMTO with 80% yield. Structural characterization by IR, elemental analysis, and single‐crystal X‐ray diffraction confirmed DNMTO's orthorhombic lattice (crystal space group: P bca; crystal density: 1.729 g/cm3). Thermal analysis revealed a melting point of 130.5 °C and decomposition onset at 245 °C. DNMTO exhibited low mechanical sensitivity (H50 = 53 cm, friction sensitivity = 12%) and competitive detonation performance (theoretical density: 1.793 g/cm3, velocity: 8,889 m/s, and pressure: 34.90 GPa), comparable to RDX. These results validate DNMTO as a promising insensitive explosive candidate.

Hydroxylamine hydrochloride enhanced Fe-C nano-microelectrolytic material for efficient peracetic acid activation: Proton/electron synergistic effect

Abstract Cyclotetrabenzil, a shape‐persistent macrocyclic octaketone, is found to undergo eightfold condensation with hydroxylamine hydrochloride to yield its octaoxime. Subsequent acetylation of this macrocyclic oxime afforded the corresponding octaoxime acetate. Single‐crystal X‐ray diffraction reveals that both new derivatives assemble into nanotubular structures. However, their packing differs: the oxime forms hydrogen‐bonded tubes that bundle via included dimethyl sulfoxide (DMSO) molecules, whereas the acetate—lacking hydrogen‐bond donors—forms more loosely packed tubes with molecules tilted ∼54.5° relative to the tube axis. Gas sorption studies (CO2, C2, and C3 hydrocarbons) show that cyclotetrabenzil is nonporous, whereas the oxime and acetate exhibit modest microporosity with BET surface areas of ∼200 m2 g−1. Both derivatives display preferential uptake of propyne over propene and propane, and the acetate also adsorbs more acetylene than ethylene or ethane. Nonetheless, these capacities and selectivities are suboptimal for dynamic separation of C2 and C3 hydrocarbons. This study illustrates how oxime functionalization can modulate macrocyclic assembly and gas uptake behavior, providing insights for the design of future porous organic macrocycles.

5-[2-(N-Tosylamino)phenyl]-5-oxopentanoic acid was obtained by ozonation of N-tosyl-2-(cyclopent-1-en-1-yl)aniline followed by treatment of the reaction mixture with hydrogen peroxide in the presence of selenium dioxide. The reaction of the ozonation product of N-mesyl-2-(cyclohex-1-en-1-yl)aniline with hydroxylamine hydrochloride in isopropyl alcohol afforded 6-{2-[(methylsulfonyl)amino]phenyl}-6-oxohexanoic acid isopropyl ester, N-[2-(5-cyanopentanoyl)phenyl]methanesulfonamide, 6-(2-aminophenyl)-6-oxohexanoic acid N-mesylate and, presumably, N-mesyl-2-(2-oxocyclohex-1-yl)aniline in a ratio of 25 : 16 : 15 : 9. The corresponding oximes were obtained by reacting 5-[2-(N-tosylamino)phenyl]-5-oxopentanoic acid or 6-{2-[(methylsulfonyl)amino]phenyl}-6-oxohexanoic acid isopropyl ester with hydroxylamine. Further treatment of [(N-tosylamino)phenyl]oxopentanoic acid ketoxime with methanesulfonyl chloride in the presence of 2-aminopyridine yielded 3-(4-carboxypropyl-1)indazole N-tosylate. Under similar conditions, 5-(benzimidazole-2-yl)- and 5-(indazol-3-yl)pentanoic acid isopropyl ester N-mesylates were formed from the oxohexane homologue ketoxime in a ratio of approximately 5 : 1.

Organic acid-enhanced production of hydroxyl radicals during H2O2-based chemical oxidation for the remediation of contaminated soil.

In this study, a domino multicomponent strategy was followed for the cyclo condensation reaction of aldehydes with β-ketoesters and hydroxylamine hydrochloride to produce a variety of 3,4- disubstituted isoxazol-5(4H)-ones using a novel Yttrium (III)-MMZ catalyst. Aprotic polar solvents and hard Lewis acid metal ions were found to greatly influence the reaction. In this study, the effect of the Y3+ in the MMZ framework and the nature of substrates and their positions in determining the yield of products were also described, along with a supporting mechanism. The structural morphology of Y3+-MMZ was characterized by the electron microscopic technique, and the loading level of Y3+ ions was determined by EDAX analysis. Most of the experiments did not require further purification by column chromatography. The present catalytic method offers several other advantages over the other reported methods, such as easy preparation, recyclization of the catalyst (up to 3 times), mild reaction conditions, shorter reaction time, and ease of work-up on recovering the products.

Cyclohexylamines are important and valuable key intermediates in the chemical industry, playing a crucial role in the synthesis of a variety of compounds. Developing a low-cost and efficient synthesis route for these chemicals is highly desirable but also presents significant challenges due to the complexity of the reactions involved. Herein, we designed three pathways for the production of 1,3-cyclohexanediamine (1,3-CHDA), including the one-pot reductive amination of resorcinol (RES) with ammonia and molecular hydrogen, the reductive amination of 1,3-cyclohexandione (1,3-CHD) with ammonia, and the oximation–hydrogenation of 1,3-CHD. Through systematical investigation, we finally developed a low-cost, simple operation and an efficient methodology for the synthesis of 1,3-CHDA as follows: RES was firstly hydrogenated in H2O over Raney Ni to obtain 1,3-CHD, and then the obtained liquid reaction mixture was used directly for the subsequent oximation with hydroxylamine hydrochloride without further purification to form the oxime intermediate, followed by the hydrogenation of the oxime in methanol over Raney Ni to achieve the target product 1,3-CHDA with a high yield.

Innovative immobilization of β-glucosidase on amidoximated acrylic fabric integrated with magnetite Fe3O4 nanoparticles.

Abstract The development of eco‐friendly, sustainable, and efficient catalytic systems has become a highly attractive area of research for promoting heterogeneous organic reactions. In this study, we report the use of cerium oxide nanoparticles (CeO₂ NPs) as a heterogeneous catalyst for the one‐pot synthesis of isoxazol‐5(4H)‐one derivatives. The CeO₂ NPs were synthesized via an environmentally benign method using an extract from Holy Basil (Ocimum sanctum), offering a green, sustainable, and cost‐effective approach. This green synthesis not only minimizes the use of hazardous chemicals but also enhances the physiochemical properties of the CeO₂ NPs, including their catalytic performance. The catalytic activity of the synthesized nanoparticles was evaluated through reactions involving a variety of aldehydes, hydroxylamine hydrochloride, and β‐dicarbonyl compounds. A wide range of isoxazol‐5(4H)‐one derivatives was obtained with excellent yields and high purity under mild conditions. Furthermore, the reusability of the CeO₂ NPs was thoroughly investigated, demonstrating minimal loss of activity over multiple reaction cycles. This study highlights a promising and sustainable method for synthesizing valuable heterocyclic compounds using green nanotechnology, thereby contributing significantly to the advancement of environmentally responsible practices in synthetic organic chemistry. Moreover, the antibacterial properties of the isoxazol‐5(4H)‐one derivatives further emphasize the significance of the green‐synthesized CeO₂ NPs.

Enhancing lipase enzymatic performance with dynamic covalent dextran-based hydrogels.

N-Benzylhydroxylamine hydrochloride serves as a critical intermediate in organic synthesis, yet traditional synthesis methods often face significant safety risks and high production costs. In this work, we developed a continuous synthesis process for N-benzylhydroxylamine hydrochloride, achieving an overall yield of 75% under mild and safe reaction conditions. Additionally, the implementation of solvent recovery and the recycling of hydroxylamine hydrochloride reduced the production cost to approximately $10 per kilogram. These advancements underscore the economic and practical viability of this method for large-scale industrial applications.