The process of hydro-desulfurization of various mineral oils, which play a big role in the modern oil refining technology, continues to improve intensively and its value increases. Despite the fact that nowadays, hydro treating is one of the largest catalytic processes in the modern oil refining industry, the power of hydro desulfurization in the world is estimated as 950 million tons a year. So, it can be concluded that the study of hydro treating catalysts, the chemistry of hydro-desulfurization processes are the high priority tasks leading to the technological solving of the problem of hydro treating process. Moreover, it is also necessary to study other major issues related to the hydro treating process: study of the interaction between active metals and carriers; reactions in the solid phase as swell as issues of oxide reduction or their conversion to sulfides. The determination of the surface state in equilibrium conditions, the amount of the coke deposits, the stoichiometry of the catalysts, its changes during activation and regeneration during catalytic process. This article outlines the development of the production of highly active aluminum-nickel-molybdenum catalysts for hydro treating distillate raw materials, improving its physical and chemical properties and activity by modification of the carrier and by studying of the influence of activation conditions. KEYWORDS: hydrogenation activity, sulfurization of Al-Ni-Mo catalyst, activity of the catalyst, thiophene hydrogenolysis.