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Human Gut Microbiota Research Articles

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Overview
3279 Articles

Published in last 50 years

Related Topics

  • Diversity Of Gut Microbiota
  • Diversity Of Gut Microbiota
  • Human Intestinal Microbiota
  • Human Intestinal Microbiota
  • Gut Microbiota Composition
  • Gut Microbiota Composition
  • Colonic Microbiota
  • Colonic Microbiota
  • Gut Microbiota
  • Gut Microbiota
  • Microbiota Composition
  • Microbiota Composition

Articles published on Human Gut Microbiota

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Investigating the bidirectional interactions between senotherapeutic agents and human gut microbiota.

Investigating the bidirectional interactions between senotherapeutic agents and human gut microbiota.

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  • Journal IconEuropean journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • Publication Date IconJun 1, 2025
  • Author Icon Nannapat Sangfuang + 7
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Modulatory effects of red seaweeds (Palmaria palmata, Porphyra umbilicalis and Chondrus crispus) on the human gut microbiota via an in vitro model.

Modulatory effects of red seaweeds (Palmaria palmata, Porphyra umbilicalis and Chondrus crispus) on the human gut microbiota via an in vitro model.

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  • Journal IconFood chemistry
  • Publication Date IconJun 1, 2025
  • Author Icon Aroa López-Santamarina + 4
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Shaping the human gut microbiota: The role of canine companionship, lifestyle choices, and Blastocystis sp.

Shaping the human gut microbiota: The role of canine companionship, lifestyle choices, and Blastocystis sp.

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  • Journal IconOne health (Amsterdam, Netherlands)
  • Publication Date IconJun 1, 2025
  • Author Icon Zuzana Pavlíčková + 9
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An efficient lysate-based approach for biosynthesis of the pyrrolobenzodiazepine natural product tilimycin.

An efficient lysate-based approach for biosynthesis of the pyrrolobenzodiazepine natural product tilimycin.

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  • Journal IconJournal of biotechnology
  • Publication Date IconJun 1, 2025
  • Author Icon Monica R Macdonald + 1
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Selective metabolism of tormentil rhizome constituents by human gut microbiota and its impact on biodiversity ex vivo.

Selective metabolism of tormentil rhizome constituents by human gut microbiota and its impact on biodiversity ex vivo.

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  • Journal IconFood chemistry
  • Publication Date IconJun 1, 2025
  • Author Icon Aleksandra Kruk + 5
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Lactobacillus plantarum-loaded pomelo pith matrix gel beads: Fabrication, characterization, and regulatory effects on human gut microbiota

Lactobacillus plantarum-loaded pomelo pith matrix gel beads: Fabrication, characterization, and regulatory effects on human gut microbiota

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  • Journal IconFood Hydrocolloids
  • Publication Date IconJun 1, 2025
  • Author Icon Yejun Zhong + 6
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Gut microbiota-derived short-chain fatty acids and their role in human health and disease.

Short-chain fatty acids (SCFAs) are a group of organic compounds produced by the fermentation of dietary fibre by the human gut microbiota. They play diverse roles in different physiological processes of the host with implications for human health and disease. This Review provides an overview of the complex microbial metabolism underlying SCFA formation, considering microbial interactions and modulating factors of the gut environment. We explore the multifaceted mechanistic interactions between SCFAs and the host, with a particular focus on the local actions of SCFAs in the gut and their complex interactions with the immune system. We also discuss how these actions influence intestinal and extraintestinal diseases and emerging therapeutic strategies using SCFAs.

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  • Journal IconNature reviews. Microbiology
  • Publication Date IconMay 13, 2025
  • Author Icon Indrani Mukhopadhya + 1
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Temporal response patterns of human gut microbiota to dietary fiber

AbstractThe gut microbiota is a highly dynamic and complex ecosystem. However, the processes by which its members respond to dietary fibers remain incompletely understood. Here, we performed daily sampling over a 14‐day observational period under the habitual diet, followed by a 14‐day dietary fiber intervention in overweight participants with and without type 2 diabetes mellitus. By combining daily sampling, guild‐level approach, and time‐series analysis, we revealed diverse temporal response patterns among various microbiota members that are often missed by conventional sampling. These patterns were closely linked to their genetic capacities for carbohydrate utilization and transport. Moreover, time‐delayed analysis of longitudinal multi‐omics data identified specific metabolites that potentially mediate the beneficial effects of gut microbiota on host metabolism. Overall, our findings demonstrate the necessity of high‐frequency sampling for capturing dynamic microbial responses and offer reliable targets for mechanistic investigations.

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  • Journal IconiMeta
  • Publication Date IconMay 10, 2025
  • Author Icon Xiaotong Lin + 5
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Exploring the Interactions between Gut Microbes and Human Tissue: Implications for Health and Disease

The human gut microbiota plays a crucial role in regulating a wide array of physiological processes, including digestion, immune function, and metabolism. Disruptions to the balance of this microbial community, known as dysbiosis, have been linked to various chronic diseases, such as inflammatory bowel disease (IBD), obesity, and diabetes. This study explores the interactions between gut microbiota and human tissue, focusing on how microbial imbalances contribute to disease development. Using a combination of microbiota analysis, metabolomics, immune response assessments, and tissue analysis, we investigate the effects of gut-derived metabolites, immune dysregulation, and tissue-level changes in patients with IBD, obesity, and diabetes. Our findings reveal distinct microbial signatures in these disease states, with IBD patients showing a 32% reduction in Firmicutes and a 25% increase in Proteobacteria compared to healthy controls. Additionally, we observed a 28% decrease in short-chain fatty acids (SCFAs) such as butyrate in IBD and diabetes patients. Immune response markers, including TNF-α and IL-6, were elevated by 35% and 42%, respectively, in IBD and obesity patients compared to controls. Tissue-level alterations, such as a 22% increase in gut permeability (measured by LPS levels) and a 15% rise in adipocyte size in obesity patients, were also noted. These results underscore the importance of gut microbiota in disease pathogenesis and highlight its potential as a target for therapeutic interventions, including probiotics, prebiotics, and fecal microbiota transplantation. The study further emphasizes the need for personalized medicine approaches that integrate microbiome data to manage and treat chronic diseases effectively.

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  • Journal IconSouth Asian Journal of Research in Microbiology
  • Publication Date IconMay 10, 2025
  • Author Icon Fagbemi Oluwaseyi Ajibola + 8
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Gut microbiota associated with equol production in school-age children

PurposeLittle is known about the relationship between the human gut microbiota composition and equol-producing ability. The aim of this study is to evaluate the relationship between equol production and the gut microbiota in school-age children, with consideration of sex, age, and exposure to soy isoflavones.MethodsParticipants were 1110 students aged 7–8, 10–11 and 13–14 years. The cumulative participation rate was 85.2%. Equol production, defined as a log-transformed equol/daidzein ratio of −1.75 or greater, was determined in urine collected after two days of soymilk supplementation. Urinary daidzein, genistein, and equol were measured by liquid chromatography–mass spectrometry. The microbiota in 223 fecal samples was determined by 16S rRNA gene sequencing analysis.ResultsThe observed operational taxonomic unit number, Chao 1, and Shannon index were significantly higher in equol producers than in non-producers after adjustments for survey time, sex, and age. Principal coordinate analysis plots based on weighted and unweighted UniFrac distances showed significant differences in the gut microbiota between equol producers and non-producers. Among the species with an average abundance of ≥0.1%, several species were more abundant in equol producers than in non-producers, with significant positive correlations between relative abundances and equol/daidzein ratios. Of species previously reported as equol-producing, Asaccharobacter celatus and Slackia isoflavoniconvertens were significantly associated with equol production.ConclusionEquol production was strongly associated with the diversity of the gut microbiota. The richness of a diverse microbiota and the interrelationships among microbes may be involved in equol production.

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  • Journal IconEuropean Journal of Nutrition
  • Publication Date IconMay 9, 2025
  • Author Icon Keiko Wada + 12
Open Access Icon Open Access
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Gut Microbiome-Derived Metabolism Screen System Reveals Dehydrogenation Metabolism of Isorhynchophylline.

Plant-derived natural products are commonly consumed orally and can be structurally modified by the gut microbiota, potentially altering their biological activity. However, high-throughput studies on their microbial metabolism remain limited. This study applied an in vitro screening system for microbiome-derived metabolism using liquid chromatography-mass spectrometry to analyze the metabolism of 200 natural products by human gut microbiota, and successfully annotated 118 natural products metabolized by gut microbiota. For the first time, metabolic reactions of isorhynchophylline and wilforgine in the intestine were documented. Notably, a substantial increase in the plasma concentration of isocorynoxeine was observed in human microbiota-colonized rats following isorhynchophylline administration compared to those without colonization, suggesting that the dehydrogenation of isorhynchophylline by gut microbiota observed in the in vitro screening system also occurs in vivo. 16S rRNA gene sequencing further revealed an increased abundance of Klebsiella and Escherichia-Shigella following isorhynchophylline administration, suggesting that these genera may influence its microbial transformation or pharmacological activity.

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  • Journal IconJournal of natural products
  • Publication Date IconMay 8, 2025
  • Author Icon Yang Lin + 10
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Biofabrication of microstructured bacterial ecosystems using chaotic bioprinting: advancing in vitro research for microbial engineering.

Mixed microbial communities are essential for various ecosystems, with bacteria often exhibiting unique behaviors in structured environments. However, replicating these interactions in vitro remains challenging, as traditional microbiology techniques based on well-mixed cultures fail to capture the spatial organization of natural communities.
Chaotic 3D printing offers a versatile, high-throughput method for fabricating hydrogel constructs with multilayered microstructure in which different bacterial strains can coexist, closely mimicking the partial segregation seen in natural microbial ecosystems. Using a Kenics static mixer (KSM) printing nozzle, we bioprinted a bacterial consortium consisting of Lactobacillus rhamnosus, Bifidobacterium bifidum, and Escherichia coli as a simplified model for human gut microbiota. Chaotic bioprinting enabled the creation of microstructured cocultures with distinct niches, allowing all bacterial strains to coexist (without being scrambled) and reach a population equilibrium.
We characterized the cocultures through fluorescence microscopy, colony counting, and quantitative polymerase chain reactions (qPCR). Our results demonstrate that the microarchitecture of the printed fibers significantly influences bacterial growth dynamics. Stratified arrangements enhanced coculture viability and balance over 72 hours compared to well-mixed and suspension conditions. Chaotic printing also allows the rational arrangement of strict anaerobic bacteria, such as B. bifidum, by positioning them in construct layers that are more susceptible to hypoxia.
Chaotic bioprinting presents a powerful tool for engineering microbial ecosystems with precise spatial control. This approach holds promise for advancing our understanding of microbial interactions and has potential biomedical applications in antibiotic testing, microbiota research, bioremediation, and synthetic biology.&#xD.

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  • Journal IconBiofabrication
  • Publication Date IconMay 7, 2025
  • Author Icon Ariel Cantoral Sánchez + 9
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The altitudinal patterns of global human gut microbial diversity

BackgroundThe human gut microbiota is closely associated with human health, influencing not only overall well-being but also the incidence and treatment outcomes of diseases. Altitudinal gradients are considered to impact gut microbial community characteristics through factors such as environmental temperature, humidity, and lifestyle. While previous studies have reported altitudinal variations in human gut microbiota in specific regions, a comprehensive exploration of these patterns at a global scale is still lacking. In this study, we analyzed 16S rRNA amplicon sequencing data from healthy human gut microbiota, spanning altitudes from 3 m to 3850 m, obtained from multiple open-access databases. The analysis focused on elucidating the altitudinal patterns of microbial diversity, community composition, and functional profiles.ResultsAfter screening, a total of 6702 sequences from 15 countries were obtained. The diversity of human gut microbiota decreased with increasing altitude (R = -0.047, P < 0.001), but no consistent results were acquired among continents. The relative abundances of the genera Faecalibacterium and Blautia decreased with rising altitude (R = -0.131 and R = -0.135, respectively, P < 0.001 for both), while the relative abundance of the genus Prevotella increased with altitude (R = 0.336, P < 0.001). However, taxa such as Bacilliota, Bacteroides, and Bifidobacterium exhibit no consistent trends across different continents. The abundance of genes associated with the metabolism of terpenoids and polyketides, lipid metabolism, neurodegenerative diseases, and aging increased with altitude (R = 0.146, 0.037, 0.366, and 0.317, respectively; lipid metabolism P = 0.003, others P < 0.001). Conversely, the abundance of genes related to the immune system and carbohydrate metabolism decreased with increasing altitude (R = -0.166 and R = -0.219, respectively; P < 0.001 for both).ConclusionAltitude significantly influences diversity, composition, and functional attributes of the human gut microbiota.

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  • Journal IconBMC Microbiology
  • Publication Date IconMay 5, 2025
  • Author Icon Lu-Lu Peng + 3
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Simulated Digestion and Fermentation of Polyphenols From Sargassum wightii Acts as Potential Modulator of Alzheimer's Disease.

The human gut microbiota regulates various aspects of Alzheimer's disease (AD) pathophysiology, influencing neuroinflammation and metabolic homeostasis. Dietary polyphenols, specifically phlorotannins from brown macroalgae, are known to mitigate AD's pathological effects due to their ability to pass through the blood-brain barrier. Marine polyphenols extracted from Sargassum wightii were processed through simulated gastrointestinal digestion and in vitro fermentation. Characterization was performed using ultraviolet (UV), Fourier transform infrared spectroscopy (FTIR), HPLC, and liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) both before and after biotransformation. We evaluated their metal chelation capacity (Cu2⁺ and Fe2⁺) and acetylcholinesterase (AChE) inhibitory activity using colorimetric assays. Additionally, the antioxidant capacity of the polyphenol extract was evaluated before and upon fermentation using 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS), and ferric reducing antioxidant potential (FRAP) assays. The extraction yield of polyphenols from S. wightii was 2.67 ± 0.27mg PGE/g of macroalgae. In vitro biotransformation of these polyphenols resulted in the formation of various low-molecular weight (LMW) compounds with enhanced metal chelation and AChE inhibition activities. Additionally, a substantial rise in antioxidant activity was observed postbiotransformation. S. wightii polyphenols become more effective after biotransformation, with enhanced bioactive properties and promising for use in diets to prevent and manage AD.

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  • Journal IconMolecular nutrition & food research
  • Publication Date IconMay 4, 2025
  • Author Icon Anushree Gade + 1
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In vitro fermentation of Auricularia auricula polysaccharides and their regulation of human gut microbiota and metabolism.

In vitro fermentation of Auricularia auricula polysaccharides and their regulation of human gut microbiota and metabolism.

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  • Journal IconInternational journal of biological macromolecules
  • Publication Date IconMay 1, 2025
  • Author Icon Nannan Liu + 6
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Physicochemical properties and biofunctional activities of polysaccharides from carob (ceratonia siliqua) pod by microwave-assisted deep eutectic solvent extraction and its effects on human gut microbiota

Physicochemical properties and biofunctional activities of polysaccharides from carob (ceratonia siliqua) pod by microwave-assisted deep eutectic solvent extraction and its effects on human gut microbiota

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  • Journal IconFood Hydrocolloids
  • Publication Date IconMay 1, 2025
  • Author Icon Maduni Paththuwe Arachchi + 9
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Rhamnosidase from Parabacteroides distasonis exhibit the catabolism of epimedin C in the human gut microbiota.

Rhamnosidase from Parabacteroides distasonis exhibit the catabolism of epimedin C in the human gut microbiota.

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  • Journal IconInternational journal of biological macromolecules
  • Publication Date IconMay 1, 2025
  • Author Icon Jiaojiao Ding + 8
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Bespoke plant glycoconjugates for gut microbiota-mediated drug targeting.

The gut microbiota of mammals possess unique metabolic pathways with untapped therapeutic potential. Using molecular insights into dietary fiber metabolism by the human gut microbiota, we designed a targeted drug delivery system based on bespoke glycoconjugates of a complex plant oligosaccharide called GlycoCaging. GlycoCaging of exemplar anti-inflammatory drugs enabled release of active molecules triggered by unique glycosidases of autochthonous gut bacteria. GlycoCaging ensured drug efficacy was potentiated, and off-target effects were eliminated in murine models of inflammatory bowel disease. Biochemical and metagenomic analyses of gut microbiota of individual humans confirmed the broad applicability of this strategy.

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  • Journal IconScience (New York, N.Y.)
  • Publication Date IconMay 1, 2025
  • Author Icon Wei Jen Ma + 22
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In vitro fermentation of a purified fraction of polysaccharides from the root of Brassica rapa L. by human gut microbiota and its interaction with Bacteroides ovatus.

In vitro fermentation of a purified fraction of polysaccharides from the root of Brassica rapa L. by human gut microbiota and its interaction with Bacteroides ovatus.

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  • Journal IconFood chemistry
  • Publication Date IconMay 1, 2025
  • Author Icon Wei Yi + 6
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Personalized and precise functional assessment of innovative flatbreads toward the colon microbiota of people with metabolic syndrome: Results from an in vitro simulation.

Personalized and precise functional assessment of innovative flatbreads toward the colon microbiota of people with metabolic syndrome: Results from an in vitro simulation.

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  • Journal IconFood research international (Ottawa, Ont.)
  • Publication Date IconMay 1, 2025
  • Author Icon Andrea Gianotti + 10
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