In this work we study the interactions of the multiquark state $Z_{cs} (3985)^-$ with light mesons in a hot hadron gas. Using an Effective Lagrangian framework, we estimate the vacuum cross sections as well as the thermal cross sections of the production processes $ \bar{D}_{s}^{(*)} D_{s}^{(*)} \rightarrow Z_{cs}^- X \, (X=\pi , K, \eta) $ and the corresponding inverse reactions. The results indicate that the considered processes have sizeable cross sections. Most importantly, the thermal cross sections for $Z_{cs}$ annihilation are much larger than those for production. This feature might produce relevant effects on some observables, such as the final $Z_{cs}$ multiplicity, measured in heavy ion collisions.