Hospital Anxiety And Depression Scale Research Articles

PurposeTo evaluate anxiety and depression levels in patients receiving intravitreal injections for diabetic macular edema (DME), age-related macular degeneration (AMD), and retinal vein occlusion (RVO), and their associations with visual acuity, disease type, and demographic factors.MethodsThe study included 90 patients (43 males and 47 females) mean age 73.9 ± 12.4 years; (range: 22-92 years). Anxiety levels were assessed using the state anxiety form of the State-Trait Anxiety Inventory (STAI-S), and depression symptoms were assessed using the Hospital Anxiety and Depression Scale (HADS). Best-corrected visual acuity (BCVA) was recorded, and patients were evaluated according to disease type, severity of visual impairment, and number of injections.ResultsThe mean STAI-S score was 36.2 ± 8.9, and that of HADS was 13.9 ± 12.6. There were no significant differences in STAI-S scores between the disease groups (p = 0.17). However, HADS scores were significantly lower in the RVO group than in the DME and AMD groups (p = 0.02, p = 0.04). A significant association was observed between severity of visual impairment and STAI-S scores (p = 0.016), with moderate visual impairment showing higher anxiety levels than mild and severe impairment (p = 0.07, p = 0.02). However, HADS scores were not significantly associated with visual acuity (p = 0.058). Women exhibited higher HADS scores (p = 0.036). Neither injection frequency nor waiting time significantly affected STAI-S or HADS scores (p > 0.05).ConclusionPatients receiving intravitreal injections have varying levels of anxiety and depression, considering disease type, sex, and severity of visual impairment affecting these psychological parameters. These findings provide invaluable insights into the importance of psychological support in ophthalmic care.

BackgroundThe Coronavirus (COVID-19) pandemic caused considerable panic and anxiety among health workers in all countries of the world, including Nigeria. This study aimed to identify the spatial clustering for prevalence and factors associated with anxiety and depression among frontline health workers (FHWs) during COVID-19 in the 36 states of Nigeria.MethodsThis was a cross-sectional study conducted in COVID-19 hospital treatment centres (one in each state) across 36 Nigerian states and Federal Capital Territory. A total of 3,353 FHWs were recruited using convenient sampling technique. The main outcomes were depression and anxiety symptoms examined using the Hospital Anxiety and Depression Scale (HADS) and categorised into binary. The sequential modelling approach in Multivariate logistic regression analysis was used to identify factors associated with anxiety and depression among FHWs. The spatial distribution of anxiety and depression across Nigerian states was examined, and prevalence and adjusted odds ratios (aORs) for mental health outcomes were visualized using ArcGIS Desktop 10.86, with graduated color symbols representing aORs adjusted for confounders.ResultsFHWs in the Southeastern States of Anambra, Enugu, Abia, and Imo, experienced higher odds of depression and anxiety compared with other states. For anxiety alone, higher odds were observed among FHWs in Benue, Cross River, Ebonyi, and Edo states. Logistic regression analyses revealed higher odds for anxiety and depression among Nurses, while FHWs who have practiced for 1–6 years had significantly higher odds for depression (adjusted odds ratios (AOR) = 3.21, 95%CI: 1.90, 5.43 for 5–6 years; and AOR = 2.33, 95%CI: 1.27, 4.26 for 1–4 years). The odds for anxiety and depression were significantly lower among FHWs with a prior history of psychological distress compared to those without such a history.ConclusionsThis study highlights significant spatial clustering of anxiety and depression among FHWs in Nigeria, with the highest burden in Southeastern states. Nurses and FHWs with fewer years of practice were particularly vulnerable, indicating the need for targeted mental health interventions. Those with a prior history of psychological distress had lower odds of experiencing anxiety and depression, suggesting potential resilience or coping mechanisms. These findings underscore the urgency for tailored mental health support and policy interventions to mitigate the psychological impact of future public health crises on healthcare workers.Supplementary InformationThe online version contains supplementary material available at 10.1186/s12889-025-24941-0.

Which polycystic ovary syndrome (PCOS)-related and general patient characteristics are associated with higher levels of anxiety and depressive symptoms, as well as with reduced body appreciation in women with PCOS? Anxiety was more common among participants with alopecia, obesity, younger age, and a history of anxiety or depression; depression was more common in participants with alopecia, unemployment, and a history of depression; and body appreciation scores were lower in participants with hirsutism, acne, alopecia, obesity, younger age, and a history of anxiety or depression. Women diagnosed with PCOS face over 30% likelihood of clinically relevant anxiety symptoms, over a 15% likelihood of clinically relevant depressive symptoms, and also experience reduced body appreciation. Evidence suggests that in women with PCOS, various factors may contribute to increased levels of anxiety and depression and reduced body appreciation. However, findings across studies are inconsistent, and the nature of these associations, as well as the potential influence of patient characteristics that have been less studied, are still not well understood. A cross-sectional online survey study was carried out from May 2021 to July 2023. Recruitment occurred through fertility clinics in the Netherlands, employing posters, leaflets with QR codes, and online platforms run by patient organizations. The participants were women with self-reported PCOS. They completed the Hospital Anxiety and Depression Scale (HADS) and the Body Appreciation Scale-2 (BAS-2). We assessed the association with mental health outcomes (symptoms of anxiety and depression, as well as body appreciation) with PCOS-related patient characteristics (hirsutism, acne, alopecia, obesity, and oligomenorrhea) and general characteristics (age, employment status, medical history, and medication use). Multivariable logistic and linear regression analyses were used, and adjusted odds ratios (aORs) or adjusted mean differences (aMDs) with 95% CI were calculated. We included 982 women, with 37.0% showing clinically relevant symptoms of anxiety (score ≥11) and 17.4% showing clinically relevant depressive symptoms (score ≥11). Risk factors associated with anxiety symptoms were alopecia (aOR: 1.79, 95% CI 1.35-2.38), obesity (aOR: 1.40, 95% CI 1.03-1.90), younger age (aOR per year older: 0.93, 95% CI: 0.91-0.96), and medical history of anxiety or depression (aOR: 2.63, 95% CI 1.82-3.79 and aOR: 1.60, 95% CI 1.13-2.28). Risk factors associated with symptoms of depression were alopecia (aOR: 1.74, 95% CI 1.21-2.50), unemployment (aOR: 2.59, 95% CI 1.56-4.31), and a medical history of depression (aOR: 1.89, 95% CI 1.25-2.85). Risk factors associated with reduced body appreciation were hirsutism (aMD: -2.29, 95% CI -3.41 to -1.16), acne (aMD: -1.14, 95% CI -2.11 to -0.17), alopecia (aMD: -1.93, 95% CI -2.89 to -0.97), obesity (aMD: -6.31, 95% CI -7.36 to -5.27), oligomenorrhea (aMD: -1.81, 95% CI -2.78 to -0.83), and younger age (aMD per year older: 0.13, 95% CI 0.04-0.23). A medical history of anxiety or depression disorder was also associated with reduced body appreciation (aMD: -1.80, 95% CI -3.10 to -0.50; aMD: -2.81, 95% CI -4.05 to -1.57, respectively). Results are based on self-reported PCOS diagnoses and may have been affected by sampling bias. It is crucial for healthcare providers to understand which characteristics in women with PCOS may influence the development of anxiety, depression, or reduced body appreciation. Such awareness helps them to be more alert and better recognize the different types of mental health concerns, enabling referrals and more targeted mental health support. This study was not funded by a specific grant. No conflicts of interest were reported in relation to the current research. Not applicable.

Mepolizumab treatment and reduced oral corticosteroid exposure improves symptoms of depression and anxiety in severe eosinophilic asthma: data from the Australian Mepolizumab Registry.

Preoperative anxiety (Pop-Anx) is highly prevalent among patients undergoing orthopaedic surgery. Pop-Anx can stem from fears related to the procedure, anaesthesia, or the recovery process. It has been linked to poorer postoperative outcomes, including greater pain, reduced function, and a lower quality of life. Despite its clinical significance, Pop-Anx is inconsistently assessed due to a lack of standardized tools and clear guidelines. The objective was to identify instruments used for measuring Pop-Anx in patients undergoing orthopaedic surgeries. A systematic search was conducted across five databases up to September 2024, following PRISMA guidelines. Data on anxiety assessment tools, timing, administration, and related outcomes were extracted. Meta-analyses were conducted on studies with a low risk of bias using random-effects models. Screening of the literature revealed that 42 studies assessed Pop-Anx, involving a total of 115,380 patients. Ten different tools were used to measure Pop-Anx, with the Hospital Anxiety and Depression Scale (HADS) being the most frequent. Significant variability was observed in assessment timing and methodology. A meta-analysis showed that Pop-Anx was positively correlated with postoperative anxiety (z = 0.60) and pain (z = 0.22) and negatively correlated with joint function (z = -0.25). Females reported higher Pop-Anx (g = 0.38). The timing of outcome assessment did not significantly moderate these relationships. Although Pop-Anx is associated with worse postoperative outcomes, it is assessed using heterogeneous and sometimes inadequate tools. Standardized, context-specific assessment methods are needed. Despite its clinical relevance, Pop-Anx remains underassessed in some common orthopaedic procedures.

Effects of kettlebell exercise training on functional capacity and metabolic costs of activities of daily living in patients with pulmonary arterial hypertension: A randomized controlled trial.

Background: Stroke represents a leading cause of disability worldwide and is frequently associated with cognitive impairment, anxiety, and post-stroke depression (PSD), all of which can hinder rehabilitation and reduce quality of life. This study aimed to evaluate the correlations between cognitive function, depression, and anxiety in stroke survivors. Methods: A total of 71 patients (41 female, 30 male; mean age 68.1 years, range 42–88) were assessed during rehabilitation using the Mini-Mental State Examination (MMSE), the Hospital Anxiety and Depression Scale (HADS), and the Patient Health Questionnaire-9 (PHQ-9). Stroke type and comorbidities, including hypertension, chronic ischemic heart disease, atrial fibrillation, and type II diabetes, were also recorded. Results: As expected, most patients experienced ischemic strokes (73.1%), while 16.9% had hemorrhagic strokes. Comorbidities were highly prevalent, particularly hypertension (63 patients) and chronic ischemic heart disease (60 patients). Cognitive impairment (MMSE < 24) was observed in 28.2% of participants. Emotional assessment showed a mean HADS score of 11.55, with 36.6% of patients classified as having moderate to severe depression (PHQ-9 ≥ 10). Hemorrhagic stroke patients reported slightly higher PHQ-9 scores (8.4 compared to 8.2), while ischemic patients had higher HADS scores (11.8 compared to 9.8). A strong correlation was found between PHQ-9 and HADS (r = 0.90), while MMSE scores showed weak associations with emotional outcomes. Conclusions: Cognitive and affective disturbances are common during stroke rehabilitation, with depression and anxiety strongly interrelated but only weakly linked to cognitive decline. These findings emphasize the need for integrated screening and mental health support in rehabilitation programs. Future studies may explore technology-assisted tools, including virtual reality, to enhance patient engagement and recovery.

BackgroundWhile triggering by physical activity is a criterion for the diagnosis of migraine, evaluations regarding fear of movement related to physical activity are lacking in the literature. This study aimed to investigate the validity and reliability of the Turkish version of the Tampa Scale of Kinesiophobia, adapted to headache (TSK-H), in patients with episodic migraine (EM) and chronic migraine (CM). This questionnaire is a newly developed version adapted for headache, based on but different from the original TSK used in low back pain, and has not been previously validated in Turkish for headache.MethodsPatients between the ages of 18–70 were included in the study. Demographic-clinical information was obtained after expert committee evaluation and cross-cultural adaptation of the questionnaire. Numerical Pain Rating Scale (NPRS), Migraine Disability Assessment (MIDAS), Headache Impact Test-6 (HIT-6), Hospital Anxiety and Depression Scale (HADS) and TSK-H were evaluated for structural validity. Exploratory Factor Analysis (EFA) and Confirmatory Factor Analysis (CFA) were performed. Intraclass Correlation Coefficient (ICC) and Cronbach’s α values ​​were analyzed for reliability.ResultsA total of 329 patients (n = 148 EM, n = 181 CM) with a mean age of 37.2 ± 10.6 years for EM and 39.8 ± 13.1 years for CM were included in the study. Headache intensity on NPRS was 6.89 ± 1.86 for EM and 7.56 ± 2.10 for CM. Item-total correlations ranged from − 0.030 to 0.758. Cronbach’s α was 0.925. TSK-H had good test-retest reliability (ICC = 0.866, n = 151) and high internal consistency (Cronbach’s α = 0.928). TSK-H was associated with NPRS, MIDAS, HIT-6 and HADS (p < 0.000 for each one). EFA identified a four-factor structure explaining 58.64% of the variance. CFA remained within acceptable limits.ConclusionThe Turkish version of the 23-item TSK-H is a valid and reliable tool for assessing kinesiophobia in patients with migraine and is significantly associated with physical, functional and psychosocial factors.Supplementary InformationThe online version contains supplementary material available at 10.1186/s12883-025-04471-3.

ObjectiveTo systematically evaluate the synergistic effects of virtual reality (VR) combined with traditional therapies in the treatment of chronic obstructive pulmonary disease (COPD).MethodsA systematic review was conducted to identify relevant randomized controlled trials (RCTs) evaluating the effects of VR combined with conventional therapy on lung function, exercise tolerance, quality of life, and mental health in patients with COPD. Two researchers independently screened the literature, extracted data, and assessed study quality. A meta-analysis was performed on the outcome measures.ResultsIncluded 15 RCTs (eight from China, three from Poland, one from Turkey, one from Indonesia, and two from Italy), involving a total of 809 COPD patients (published between 2014 and 2024). All studies demonstrated significant improvements in at least one aspect (lung function, mental health, or quality of life). The meta-analysis showed that VR-based therapy significantly improved the 6-min walk test (6MWT), forced expiratory volume in 1 s (FEV1/FVC), and the Hospital Anxiety and Depression Scale (HADS). High heterogeneity was observed for FEV1% predicted, COPD Assessment Test (CAT), and modified Medical Research Council Dyspnea Scale (mMRC); subgroup analyses suggested that intervention duration and single-session duration were potential contributing factors.ConclusionVR combined with traditional therapy has significant advantages over traditional therapy alone, with synergistic effects that can improve lung function and exercise endurance in COPD patients, alleviate psychological problems such as anxiety and depression, and enhance quality of life. Although the effects are significant, future research is needed to verify its clinical relevance (e.g., meeting the Minimal Clinically Important Difference (MCID) criteria for COPD patients) and to develop personalized plans based on individual differences to enhance its clinical application value.

According to preliminary sources, general anxiety and anxiety about getting fat (AGF) are associated with the occurrence of binge eating disorder (BED). Still, there is little research in this area. The aim of the present study was to investigate anxiety, AGF, and depression in BED. The research focused on BED from two separate perspectives: the number of BED symptoms and the recurrence rate of BED episodes. Women (n = 103) were surveyed using a self-developed questionnaire evaluating the presence of BED symptoms, the Hospital Anxiety and Depression Scale (HADS), and the Body Mass Anxiety Scale (BMAS-20). Participants who met the criteria for BED reported elevated levels of anxiety and AGF. Significant differences were observed in the level of anxiety and AGF between groups with a lower and higher number of BED symptoms. Also, groups with mild, moderate, and severe BED were found to differ significantly in the level of depression symptoms. AGF was associated with a greater number of BED symptoms, suggesting it may contribute to symptom escalation.

Background/AimsWe aim to investigate the effectiveness, safety, and predictors of treatment response to fecal microbiota transplantation (FMT) in Korean irritable bowel syndrome (IBS) patients.MethodsPatients with moderate to severe diarrhea-predominant IBS (IBS-D) or mixed-type IBS (IBS-M) received FMT from one healthy donor via esophagogastroduodenoscopy. IBS–symptom severity score (IBS-SSS), Bristol stool form scale (BSFS), IBS Quality of Life (IBS-QoL) questionnaires, Hospital Anxiety and Depression Scale (HADS), and gut microbiome profiles were assessed at baseline, 4 weeks and 12 weeks post-FMT.ResultsAmong the 46 enrolled IBS patients, 37 patients (IBS-D:IBS-M = 28:9) completed a 12-week follow-up. Significant improvements were observed in IBS-SSS, IBS-QoL, and BSFS after 12 weeks. FMT led to increased microbial diversity and a sustained increase in beneficial bacterial genera, including Holdemanella, Ruminococcus, and Faecalibacterium. In terms of β-diversity, the distance between the patient’s gut microbiome and that of the donor decreased after FMT; greater reduction in distance to donor microbiota was associated with greater symptom improvement (Unweighted UniFrac distance, P < 0.05). Responders (IBS-SSS reduction > 50 points) exhibited lower baseline relative abundances of Roseburia and Subdoligranulum, and more profound microbiome shifts toward the donor profile after FMT.ConclusionsFMT appears to be a potentially effective treatment for moderate to severe IBS, with significant symptom relief and gut microbiota changes. Lower baseline abundances of Roseburia and Subdoligranulum and greater shifts of gut microbiome profile toward donor microbiota after FMT may predict favorable FMT response. Long-term follow-up is on the way to assessing the durability of these effects.

Background Stroke is a leading global cause of disability and mortality in adults, and early rehabilitation is critical for improving patients’ functional recovery and quality of life; however, conventional rehabilitation models often focus solely on medical interventions and overlook the impact of the patient’s comprehensive ecological environment on recovery, making it necessary to explore more holistic intervention approaches. To investigate the efficacy of health ecology theory-based health education in early stroke rehabilitation and its impacts on neurological/motor/cognitive function, psychological status, and metabolic biomarkers. Methods A total of 150 stroke patients during June–October 2024 were randomized into control and intervention groups based on interventions. Outcomes assessed included National Institutes of Health Stroke Scale (NIHSS) for neurological deficit, Fugl-Meyer Assessment (FMA) for motor function, Modified Barthel Index (MBI) for activities of daily living, Montreal Cognitive Assessment (MoCA) for cognition, Hospital Anxiety and Depression Scale (HADS) for psychological status, and metabolic biomarkers glycated hemoglobin (HbA1c) and low-density lipoprotein cholesterol (LDL-C). Structural equation modeling (SEM) was employed to analyze path relationships among metabolic_indices, recovery_effect, and mental_status. Results The intervention group demonstrated significantly greater improvement in NIHSS, FMA, MoCA, HbA1c, and LDL-C. Multivariate linear regression models showed moderate-to-substantial explanatory power, particularly for LDL-C and HbA1c (adjusted R 2 ≈ 30%). Although models for HADS and MBI had lower explanatory power, the intervention effect remained statistically significant ( p &amp;lt; 0.05). SEM revealed a significant positive path from mental_status to metabolic_indices ( β = 0.42). The negative path from recovery_effect to metabolic_indices (β = −0.45) signified that better recovery correlated with better metabolic profiles. A significant indirect effect of the intervention on metabolic_indices via improved mental_status was identified ( β = 1.00 × 0.42). Conclusion Health ecology-based health education effectively improves neurological/motor/cognitive function and metabolic control during early stroke rehabilitation. The intervention establishes a “physiological-psychological-social” virtuous cycle through multidimensional effects, providing an innovative framework for collaborative stroke recovery management.

Sleep Management Combined with Rehabilitation Exercise to Alleviate Chronic Pain Following Total Knee Arthroplasty: A Randomized Controlled Trial.

Background The high incidence of negative emotions among lung cancer patients has become a significant challenge to global public health. Newly diagnosed patients may experience cancer information overload (CIO) when exposed to a large amount of uncertain cancer-related information within a short time. However, research on the relationship between CIO and negative emotions, and the roles of Fear of Progression (FoP) and social support, is still lacking. Objective To explore the mediating effect of FoP between CIO and negative emotion in newly diagnosed lung cancer patients, and the moderating role of social support among CIO, FoP and negative emotion. Method This study adopted a cross-sectional survey design. From October 2024 to February 2025, newly diagnosed lung cancer patients were recruited as research subjects from the oncology departments of three tertiary hospitals in Deyang City, China. Through the General Information Questionnaire, Cancer Information Overload Scale (CIOS), Fear of Progression Questionnaire-Short Form (FoP-Q-SF), Hospital Anxiety and Depression Scale (HADS) and the Social Support Rating Scale (SSRS) were used to investigate patients’ CIO, FoP, negative emotions and social support, and a total of 358 valid questionnaires were retrieved. All data were processed using SPSS 26.0, and the mediating effect and moderating effect were tested using the Process plugin. Results The incidence of anxiety was 56.1% (201/358), and the incidence of depression was 53.1% (190/358). CIO had a positive predictive effect on FoP (β=0.338, P &amp;lt; 0.001) and negative emotion (β=0.375, P &amp;lt; 0.001). FoP has a positive predictive effect on negative emotion (β=0.342, P &amp;lt; 0.001), and FoP plays a mediating role between CIO and negative emotion (β= 0.115, 95%CI=[0.072, 0.166]). Social support plays a negative moderating role between FoP and negative emotion, with a moderating index of -0.124 and 95%CI=[-0.214,-0.033]. Conclusion Patients with newly diagnosed lung cancer bear a heavy burden of anxiety and depression, which urgently needs attention. CIO plays a mediating role between FoP and negative emotion. Social support weakens the positive predictive effect of FoP on negative emotion. Our research results provide new insights and methods for supporting the improvement of negative emotions in lung cancer patients.

BackgroundGastroesophageal reflux disease (GERD) often coexists with anxiety, depression, and poor sleep quality, which worsen symptom perception and reduce quality of life. While each factor has been linked to GERD, their combined effects have rarely been examined, especially in sleep clinic populations. This study aimed to assess the individual and combined associations of anxiety, depression, and sleep quality with probable GERD in patients at a tertiary hospital sleep center.MethodsThis retrospective cross-sectional study examined patient data from the Sleep Center of National Cheng Kung University Hospital collected between July 2020 and July 2021. All included patients completed the Gastroesophageal Reflux Disease Questionnaire (GERDQ), Pittsburgh Sleep Quality Index (PSQI), and Hospital Anxiety and Depression Scale (HADS). Multivariable logistic regression was used to determine associations between elevated HADS-A (anxiety), HADS-D (depression), PSQI scores, and probable GERD (GERDQ score ≥ 9), adjusting for relevant confounders.ResultsAmong 877 patients, 93 (10.6%) had probable GERD. Elevated HADS-A (adjusted odds ratio [aOR]: 2.18, 95% confidence interval [CI]: 1.40–3.39, p < 0.001), HADS-D (aOR: 2.10, 95% CI: 1.34–3.29, p = 0.001), and PSQI (aOR: 3.32, 95% CI: 2.10–5.27, p < 0.001) scores were significantly associated with probable GERD. Patients with both high HADS-A and PSQI scores had a stronger association (aOR: 4.74, 95% CI: 2.62–8.60), and those with both high HADS-D and PSQI scores had the greatest odds (aOR: 5.09, 95% CI: 2.72–9.41).ConclusionResults reaffirm that anxiety, depression, and poor sleep quality are significantly associated with probable GERD. However, given the cross-sectional design, causal relationships cannot be established. The combined use of HADS and PSQI may enhance GERD risk identification, suggesting that individuals with psychological and/or sleep disturbances should consider gastroenterological evaluation.

Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by recurrent synovial inflammation, leading to joint damage, functional limitations, and reduced quality of life. High disease activity is often accompanied by psychological problems, particularly anxiety and depression. Objective: This study aims to evaluate the relationship between disease activity levels based on the Disease Activity Score 28–C-reactive protein (DAS28-CRP) and symptoms of anxiety and depression assessed using the Hospital Anxiety and Depression Scale (HADS) in RA patients at Royal Prima Hospital in Medan. Method: The study used an observational analytical design with a cross-sectional approach. A total of 58 RA patients were selected using simple random sampling. Data were collected through DAS28-CRP examinations and HADS questionnaires, then analyzed using Spearman's correlation test. Results: Of the 58 respondents, most were female (91.4%) with the highest disease activity distribution in the high category (41.4%). The majority of respondents showed normal anxiety levels (81.0%) and normal depression (82.8%). Statistical analysis showed a significant correlation between disease activity and anxiety (r = 0.304; p = 0.020), while no significant relationship was found with depression (r = 0.246; p = 0.062). Conclusion: Disease activity in AR affects patients' anxiety levels but is not proven to be associated with depression. These results emphasize the importance of considering psychological aspects in the comprehensive management of AR patients.

The purpose of scientific research there was a studying of distribution of frequencies of alleles of a polymorphic marker 4G(-675)5G of PAI-1 gene among patients with ischemic heart disease (IHD) and at patients with risk factors of IHD. In our scientific research included 63 patients with the diagnosis ischemic heart disease (IHD) especially with stable angina (48 men and the 15 woman) passing on hospitalization in I-cardiology department of Multidisciplinary clinic of Tashkent Medical Academy. Average age of patients was 56,8±6,40 years (42 up to 66 years). Average age of men were 56,4±6,60 years and women age were 58,0±5,52 years. The state of hypercoagulability was assessed by measures of polymorphism gene of PAI-1 and plasma level of PAI-1. Besides in our research work we assessed the main risk factor of IHD such as, obesity, smoking, anxiety-depressive syndrome (ADS). Obesity was calculated with Quetelet's formula. Smoking was estimated by Fagerstrem’s test. ADS was assesses by using Hospital Anxiety and Depression Scale (HADS). Assessment of occurrence of various genotypes of a polymorphic marker 4G(-675)5G of PAI-1 gene, established that differences between distribution 5G/5G,4G/5G,4G/4G of genotypes depending on FC of CVD weren't reliable as CHI – a square on persen turned out χ2=1,85 that corresponds (р0.05). On the basis of these results it is possible to assume that, existence of heterozygous and homozygous mutagen genotypes of a gene of PAI-1 doesn't influence disease severity in a particular on degree of FC of SA. Our investigation results show thatPAI-14G/5G polymorphism was significant associated with CAD risk in uzbek nationality. In the subgroup analysis according to FC of SA, the results suggested thatPAI-14G/5G polymorphism was associated with CAD risk and high level of PAI-1 in plasma.

Background/Objectives: Psychiatric morbidity is frequent in oncology, yet prevalence and correlates differ across tumour sites. Urogenital cancers, in particular, involve psychosocial stressors related to sexuality, fertility, continence, and body image, which may intensify anxiety and depression. This study aimed to estimate the proportion of psychiatric morbidity among psychiatry-assessed oncology inpatients in a real-world hospital setting to compare urogenital with non-urogenital malignancies and to examine clinical correlates and hospitalisation outcomes. Methods: We conducted a retrospective analysis of 174 oncology inpatients who were evaluated by liaison psychiatry and completed the Hospital Anxiety and Depression Scale (HADS) during admission to a tertiary hospital in Galați, Romania, between 2019 and 2022. All patients completed the Hospital Anxiety and Depression Scale (HADS) and underwent liaison psychiatry evaluation. Mixed anxiety–depressive disorder (ICD-10 F41.2) was the primary psychiatric outcome. Demographic, clinical, and functional data—including Eastern Cooperative Oncology Group (ECOG) performance status—were extracted from medical records. Comparative and multivariable analyses were performed to identify predictors of severe depressive symptoms (primary outcome, HADS-D ≥ 11) and to explore associations with length of stay and costs. Results: Overall, 59% of patients had elevated HADS-Anxiety and 62% elevated HADS-Depression, while 40% received a psychiatric diagnosis. Mixed anxiety–depressive disorder predominated, especially in cervical (95%), bladder (100%), and prostate (≈70–75%) cancers. Urogenital cancers showed significantly higher rates of anxiety/depression than non-urogenital cancers (85% vs. 46%, p &lt; 0.01). Poorer ECOG status independently predicted severe depressive symptoms (OR 3.6, 95% CI 2.1–6.2, p &lt; 0.001). Psychiatric morbidity was associated with a trend toward longer LOS (median 12 vs. 9 days, p ≈ 0.08) and ≈10% higher hospital costs. Conclusions: Anxiety and depression were highly frequent among psychiatry-assessed oncology inpatients, particularly in urogenital malignancies. Functional impairment strongly correlates with psychiatric morbidity. These findings underscore the need for systematic screening and risk-stratified psycho-oncologic interventions to improve patient outcomes and resource utilisation.

Objectives This study explored the potential impact of a structured yoga program over an 8-week period on aspects of psychological health and health-related quality of life (HRQoL) among individuals diagnosed with non-cystic fibrosis bronchiectasis. Methods A prospective, controlled clinical study was carried out from January 2023 to January 2024. Sixty-nine adults with clinically stable non-cystic fibrosis bronchiectasis were recruited and assigned randomly to either a yoga intervention group (n = 24) or a control group receiving standard care (n = 45). The yoga group engaged in supervised online sessions three times weekly, while the control group continued with routine clinical management without any added exercise regimen. HRQoL was measured using the Quality of Life-Bronchiectasis (QOL-B) questionnaire. Psychological variables were assessed through the Short Form-36 (SF-36), Hospital Anxiety and Depression Scale (HADS), and the Perceived Stress Scale-10 (PSS-10). Evaluations took place at baseline and after the 8-week period. Statistical analyses were applied based on data distribution, with significance determined at a threshold of P &amp;lt; 0.05. Results Participants undergoing yoga demonstrated notable improvements in select QOL-B domains, particularly in areas such as respiratory symptoms, emotional aspects, and vitality, when compared to the control group ( P &amp;lt; 0.05). SF-36 results suggested gains in both physical and mental summary scores in the yoga group; however, the control group showed no comparable changes. Psychological assessments indicated reduced anxiety and depression scores, as well as lower perceived stress levels, in those practicing yoga ( P &amp;lt; 0.01). Group comparisons suggested that the yoga intervention was more favorable than standard care in influencing the measured outcomes. However, the study was limited by its relatively small sample size, short intervention duration, and reliance on self-reported data, which may affect the generalizability and long-term sustainability of the observed benefits. Conclusion An 8-week structured yoga program may contribute to improvements in psychological well-being and quality of life among patients with non-cystic fibrosis bronchiectasis. Yoga might represent a complementary approach alongside conventional management, though its role requires additional exploration.

The impact of alcohol addiction on the quality of life, mental condition, clinical condition and nutritional status of patients with head and neck cancer.