Hollow Fiber Research Articles

Innovative hollow fiber membranes decorated with cobalt-doped Mn₃O₄: Sustainable solution for effective tetracycline removal from wastewater.

Innovative hollow fiber membranes decorated with cobalt-doped Mn₃O₄: Sustainable solution for effective tetracycline removal from wastewater.

Hollow carbon fiber supported MoS2 nanosheets composite for reliable sulfur electrochemistry

Hollow carbon fiber supported MoS2 nanosheets composite for reliable sulfur electrochemistry

Modeling of ceramic hollow fiber membrane self-heated with electrical current for oxygen separation from air

Modeling of ceramic hollow fiber membrane self-heated with electrical current for oxygen separation from air

Pressure-enhanced inner-selective Matrimid hollow fiber membranes for highly permselective CO2/N2 and CO2/CH4 separation

Pressure-enhanced inner-selective Matrimid hollow fiber membranes for highly permselective CO2/N2 and CO2/CH4 separation

Preparation of hollow fiber nanofiltration membranes with intensified charge density for Li+/Mg2+ separation from brines with high Mg2+/Li+ ratios

Preparation of hollow fiber nanofiltration membranes with intensified charge density for Li+/Mg2+ separation from brines with high Mg2+/Li+ ratios

Catalyst-assisted secondary polymerization for fabricating positively charged polysulfonamide hollow fiber nanofiltration membrane with robust acid resistance

Catalyst-assisted secondary polymerization for fabricating positively charged polysulfonamide hollow fiber nanofiltration membrane with robust acid resistance

Hydrogen recovery using hollow fiber membranes in the ammonia cracking process

Hydrogen recovery using hollow fiber membranes in the ammonia cracking process

Solvent-free green preparation of PVDF/ PPTA-pulp hollow fiber membrane and construction of the multi-porous structure

Solvent-free green preparation of PVDF/ PPTA-pulp hollow fiber membrane and construction of the multi-porous structure

Pebax composite hollow fiber membranes by modulating PDMS surface hydrophilicity and coatability for CO2 capture

Pebax composite hollow fiber membranes by modulating PDMS surface hydrophilicity and coatability for CO2 capture

The mystery of ‘air resistance’ in submerged hollow fiber membranes: A controllable ‘irreversible fouling’

The mystery of ‘air resistance’ in submerged hollow fiber membranes: A controllable ‘irreversible fouling’

Development of a magnetic stirrer assisted hollow fiber–liquid phase microextraction for the extraction of dexamethasone in raw cow milk samples before its determination with HPLC–DAD

Development of a magnetic stirrer assisted hollow fiber–liquid phase microextraction for the extraction of dexamethasone in raw cow milk samples before its determination with HPLC–DAD

Microstructure tailoring of the nickel hollow fiber membranes toward catalytic membrane reactors

Microstructure tailoring of the nickel hollow fiber membranes toward catalytic membrane reactors

Masked stereolithography and polymerization induced phase separation for 3D printing of membranes

Conventional polymeric membrane manufacturing faces significant limitations, including reliance on harsh chemicals, limited geometrical shapes (primarily flat sheets and hollow fibers), low resolution, and slow production speeds. This study introduces an innovative approach for 3D printing complex-shaped membranes with tailored properties, utilizing polymerization-induced phase separation (PIPS) and masked stereolithography (MSLA). The influence of processing parameters, including resin volume, irradiation duration, and temperature, on membrane characteristics—such as pore size, porosity, thickness, surface morphology, water permeability, and rejection rate— is systematically investigated. The findings indicate that this method can fabricate membranes with a wide range of pore sizes and porosities. The membrane architecture comprises interconnected nodules, the dimensions of which are contingent upon the processing conditions. Furthermore, the study demonstrates that PIPS facilitates the phase inversion of thermosets and the incorporation of environmentally friendly biobased solvents, thereby broadening the scope of membrane fabrication with novel polymers.

Establishment and validation of downsized hollow-fibre infection model and pharmacokinetics/pharmacodynamics analysis of VAN on Enterococcus faecium.

This study clarified the target values of VAN against Enterococcus faecium using pharmacokinetics/pharmacodynamics (PK/PD) analysis and compared a downsized hollow fibre infection model (HFIM) with a conventional HFIM. VAN was administered subcutaneously and blood concentrations were measured to calculate the PK parameters. PD studies were performed in an infected mouse model by administering VAN at doses ranging from 25 to 400 mg/kg based on PK parameters. PK/PD parameters correlated with antimicrobial efficacy were determined, and a target value of 2 log10 kills was calculated. The efficacy of VAN against E. faecium was evaluated by reproducing the VAN PK in the plasma at doses that achieved the target value using conventional and novel downsized HFIMs. PK/PD analysis showed that fAUC/minimum inhibitory concentration (MIC) demonstrated the most relevant index, with a target value of 249 to achieve a 2 log10 kill. Blood concentrations of 750 mg VAN every 12 h (equivalent to 260 fAUC/MIC) were simulated well with both HFIMs. Changes in E. faecium caused by continuous exposure to VAN resulted in a reduction in bacterial counts by ∼6.0 log10 kill 168 h after the start of treatment in both models. Downsizing reduced the extracapillary space volume, circulating medium, amount of drugs used and infectious waste. The total cost of the downsized cartridge system was approximately half that of the conventional model system. We established a downsized HFIM and demonstrated its viability as a cost-effective and environmentally sustainable in vitro PK/PD. The findings highlighted its potential as a future PK/PD analysis standard.

Robust Design of Fiber Bundle Reinforced PES Hollow Fiber Loose Nanofiltration Membranes With Long‐Term Operation Stability

ABSTRACTUsually, reinforcement is introduced into the membrane matrix to solve the problem of hollow fiber membranes with poor mechanical properties. Herein, the fiber bundle reinforced PES hollow fiber loose NF membranes with GO doping were fabricated by the skin‐core fiber spinning technology and concentric circle method in order to overcome the easily collapsible hollow fiber membrane at medium and high‐pressure operation. The reinforced structure and content of GO exhibited noticeable effects on the structure and properties of membranes. On the one hand, the fiber bundle constructed the excellent mechanical properties of the membrane (185 MPa) for enhancing the lateral pressure resistance, which was beneficial for long‐term stability. On the other hand, the high permeation flux and efficient dye desalination property were obtained due to the doping of GO. For example, the permeation flux of the obtained PPG‐3 membrane was up to 115.6 L m−2 h−1 with the rejection of Congo red (99.8%) and MgCl2 (only 4.0%). Consequently, the GO‐doping and fiber bundle reinforced way could be considered as a synergistic effect to prepare the high permeation flux and long‐term operation stability of the hollow fiber loose NF membranes, which will be suitable for dye desalination in textile wastewater treatment.

Synergistic combination of next-generation polymyxin MRX-8 and meropenem against carbapenem-resistant A. baumannii.

MRX-8 is a new next-generation polymyxin with potent antibacterial activity against carbapenem-resistant Acinetobacter baumannii (CRAB). This study evaluated the MRX-8 and meropenem combination and their dosing regimens against CRAB in clinics. Seven CRAB strains isolated from Huashan Hospital were tested. Two strains of AB21-3881 and AB21-3759 were selected for static time-kill and the Hollow Fiber Infection Model (HFIM). Adaptive resistance to MRX-8 was assessed via population analysis profiling (PAP) at 2 mg/L of MRX-8. Multilocus sequence typing identified all seven strains as ST2. Minimum inhibitory concentration values for MRX-8 ranged from 0.5 to 1 mg/L. Synergy was observed in six out of seven (85.7%) strains. The combination of 1 mg/L MRX-8 with 1 mg/L meropenem completely inhibited bacterial growth within 24 h for both selected strains. In HFIM, the combination of MRX-8 (0.75 mg/kg q8h continuous infusion) and meropenem (1 g q6h continuous infusion) achieved synergistic killing over 72 h for AB21-3759, while single treatment of MRX-8 (0.75 mg/kg q8h continuous infusion) achieved bactericidal effect (lower than the detect limitation) over 72 h. PAP analysis demonstrated that the combinational therapy could delay the emergence of adaptive resistance sub-populations by 12-24 h. The combination of MRX-8 and meropenem demonstrated synergistic bactericidal activity by checkerboard and static time-kill curves. Additionally, in HFIM, MRX-8 at 1 mg/kg q12h combined with meropenem at 2 g q12h, as well as MRX-8 at 0.75 mg/kg q8h continuous infusion combined with meropenem at 1 g q6h continuous infusion, achieved bacteriostatic killing at 72 h compared to the initial inoculum.

Mesenchymal stem cell-derived exosome subpopulations remained consistent for 28 culture days, displaying therapeutic effects in a silicosis mouse model

IntroductionThe clinical translation of mesenchymal stem cell-derived exosome faces critical challenges in scalable production, subpopulation stability, and therapeutic route optimization. This study systematically addresses these barriers to advance exosome-based therapies.MethodsWe established a 28-day biomanufacturing workflow using a Hollow Fiber 3D bioreactor integrated with the RoosterBio exosome-harvesting system. Exosomes were subsequently purified and rigorously characterized at multiple production stages, followed by isotopically labeled with 89Zr for biodistribution studies. Therapeutic efficacy was evaluated in a silica-induced mouse silicosis model comparing intravenous and respiratory administration routes.ResultsOur findings indicate that (1) the RoosterBio exosome harvesting system in the Hollow Fiber 3D bioreactor enables 28 days production of exosomes, with stable harvesting of the main subpopulations over a certain period; (2) systemic administration via intravenous injection in rats reveals distinct tissue tropism, with isotope-labeled exosomes exhibiting predominant hepatic accumulation; and (3) in the silica-induced mouse silicosis model, respiratory delivery of exosomes significantly improves disease progression, whereas intravenous infusion of exosomes does not yield notable therapeutic effects.DiscussionThis study proposes a holistic workflow for early-stage development of natural exosomes as therapeutics, offering guidance on industrial-scale production, purification, and characterization of exosomes with stable subpopulation distribution and functional consistency. It further addresses administration route selection in pulmonary disease animal models and heterogeneity assessment of natural exosomes. These advancements facilitate clinical translation of exosome-based therapies.

Enzyme-Enhanced CO₂ Capture in Carbonate Solution Using Hollow Fiber Membrane Contactors: A Novel Numerical Approach

<p>Due to the widespread use of fossil fuels, atmospheric levels of carbon dioxide (CO₂), a major contributor to climate change, have increased dramatically. Through the simulation of a two-dimensional (2D), bovine carbonic anhydrase (bCA)-mediated mechanism, this work presents a novel approach method for CO₂ capture using a membrane contactor; the technique uses aqueous carbonate solution as a chemical solvent. It is tested both with and without bCA. The influence of important parameters on the CO₂ capture performance, such as gas flow rate, liquid flow rate, and bCA concentration in both counter- and co-current flow, are investigated. The results show that the addition of 5 mg L⁻¹ bCA improves the removal efficiency by 24%; it is found that increasing the gas flow rate of CO₂ from 10 mL min⁻¹ to 30 mL min⁻¹ reduces the CO₂ removal from 60.47% to 23.94%, whereas with 5 mg L⁻¹ bCA, increasing the gas flow rate of CO₂ from 10 mL min⁻¹ to 30 mL min⁻¹ reduces the CO₂ removal from 84.09% to 46.85%. Increasing the liquid flow rate from 10 mL min-1 to 30 mL min-1 increases the CO2 removal from 60.47% to 87.06% without the addition of bCA; with 5 mg L-1 bCA, the CO2 removal increases from 84.06% to 95.04%. The counter-current is better than the co-current by a 4% improvement. The effect of the bCA enzyme on CO₂ capture is limited by the availability of CO₂ (the substrate) and the catalytic capacity of the enzyme. Maximum CO₂ removal efficiency, approaching almost total removal, is achieved at an enzyme concentration of approximately 30 mg L⁻¹ for the same CO₂ load.</p>

Investigations on The Effect of Selected Post-Treatment with Thermal and Oxidizing Agents on The Characteristics and Performance of Polysulfone Hemodialysis Hollow Fiber Membranes

Investigations on The Effect of Selected Post-Treatment with Thermal and Oxidizing Agents on The Characteristics and Performance of Polysulfone Hemodialysis Hollow Fiber Membranes

Membrane-Based SO2 Removal Using a Hollow Fiber Membrane Process for Flue Gas Treatment

Membrane-Based SO₂ Removal Using a Hollow Fiber Membrane Process for Flue Gas Treatment