Drawing on a sample of 438 working professionals from various organizations across the central United States, the authors investigated the relationship between Holland's (1959, 1997) RIASEC (Realistic, Investigative, Artistic, Social, Enterprising, Conventional) model and employee perceptions of work‐family conflict. Results revealed that the RIASEC model contributed unique variance in predicting work‐family conflict beyond demographic characteristics and the Big Five personality constructs. The RIASEC interests were found to be associated with different dimensions of work‐family conflict. These results signal that vocational interests may influence not only work‐related attitudes and behaviors (e.g., job satisfaction, performance), but also one's ability to balance work and family demands.