High Tone Research Articles

The role of the cardiac vagus in maintaining cardiac function during exercise

There is a strong association between parasympathetic nervous system activity (vagal tone) and physical fitness. High vagal tone is associated with increased capacity to exercise and overall cardiovascular health. Evidence for vagal withdrawal during exercise comes from historic studies examining heart rate control and the use of cholinergic blockers. However, more recent studies have challenged this assumption. We hypothesized that cardiac vagal activity increases during exercise and maintains cardiac function via neurotransmitters other than acetylcholine. The left cardiac vagal branch was identified in anesthetized open-chested sheep. Cardiac innervation of the left cardiac vagal branch was confirmed with lipophilic tracer dyes (DiO). Custom-built coil electrodes were placed around the left cardiac vagal branch. 3-10 days after surgery, conscious, direct recordings of cardiac vagal nerve activity (CVNA), cardiac output, coronary artery blood flow and heart rate were recorded in adult female sheep during whole-body treadmill exercise. Sheep were exercised with pharmacological blockers of acetylcholine (atropine, 250 mg), vasoactive intestinal peptide (VIP) ([4Cl−D-Phe6,Leu17]-VIP 25 μg), or saline control, randomized on different days. In a subset of sheep, the left cardiac vagal branch was denervated. Neural innervation from the cardiac vagal branch is seen at major cardiac ganglionic plexi, and within the fat pads associated with the coronary arteries. Directly recorded CVNA increased during exercise. CVNA increases during the lowest exercise intensity and plateaus as exercise intensity increases. Left cardiac vagal branch, denervation attenuated the maximum changes in coronary artery blood flow (maximum exercise, control: 63.5 ± 5.9 ml/min, n = 8, cardiac vagal denervated: 32.7 ± 5.6 ml/min, n = 6, mean ± SEM. P = 2.5x10−7. Two-way ANOVA-interaction), cardiac output and heart rate during exercise. Atropine did not affect any cardiac parameters during exercise, but VIP antagonism significantly reduced coronary artery blood flow during exercise to a similar level to vagal denervation (maximum exercise, paired: control: 68.2 ± 6.0 ml/min, VIP antagonism: 44.9 ± 3.9 ml/min, n = 6, mean ± SEM. P = 4.8x10−3. Two-way ANOVA-interaction). Our study challenges the conventional view and demonstrates that cardiac vagal nerve activity increases and is crucial for maintaining cardiac function during exercise. Furthermore, our findings show that the dynamic modulation of coronary artery blood flow during exercise is mediated by VIP and that acetylcholine has no role in modulating cardiac function during exercise. This work is supported by the Health Research Council of New Zealand 23/119 (Fellowship. JS) and the New Zealand Heart Foundation (JS, RR). This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

Cardiovascular Autonomic Control During Hibernation in American Black Bears

The dramatic early decrease in HR upon entry into torpor in small hibernators has recently been shown to be associated with a marked increase in cardiac parasympathetic activity as indicated by increased short term beat to beat heart rate variability (RMSSD) normalized to average R-R interval (RMDSSD/RR, Zanetti et al 2023). At steady state torpor, as their body temperature drop to ~2°C, small hibernators benefit from the Q10 effect on cardiac pacemaker cells in maintaining a low HR with a reduced parasympathetic activity. Black bears in hibernation maintain body temperatures between 30-35°C while suppressing metabolism by 75% and with a marked decrease in HR from non-hibernating 55 bpm to hibernating 6-12 bpm including extreme respiratory sinus arrhythmia (Tøien et al 2011). As hibernating bears would not significantly benefit from the Q10 effect on cardiac pacemaker cells to sustain a low HR, we hypothesized that an elevated cardiac parasympathetic tone is needed to suppress HR. Continuous electrocardiogram (ECG) and blood pressure (BP) were recorded with implantable telemetry transmitters (DSI D70-CCP/EET and Konigsberg T28F-14B) in American black bears. A Pan-Tomkins algorithm modified for R-wave detection with long R-R intervals followed by visual inspection was used for the analysis. RMDSSD/RR for a 2 hour period in mid hibernation with no activity was 3 times higher than that during the resting phase in non-hibernation (0.68 vs. 0.23, n=10 and 7 respectively, p<0.001), confirming the presence of a high parasympathetic tone during hibernation. HR decreased from 68.3 ± 5.8 bpm to 12.9 ± 0.9 bpm (±SE, p<0.0001). RMSSD/RR during a 10 min period recovering from anesthesia (Telazol with supplemental Ketamin) during hibernation in mid March was only 0.019 ± 0.008 vs 0.58 ± 0.14 during a 10 min period before disturbance to induce anesthesia and HR 87.0 ± 8.7 b/min vs. 16.3 ± 1.4 b/min, demonstrating a parasympatholytic effect (n=6, p< 0.0006). The longest R-R intervals during extreme sinus arrhythmia detected in mid hibernation ranged from 11.8 to 33.0 s (Mean 19.0 ± 2.7, n=21). BP typically increased to above 200 mmHg during periods of rapid heart beats, and decayed slowly to 50-60 mmHg at the end of the longest R-R intervals. Analysis of data from a single bear from 2 hour periods at 2 week intervals throughout hibernation and recovery indicates that a high parasympathetic activity is maintained throughout hibernation and strongly correlated to the maximum observed R-R interval. We conclude that opposed to small hibernators, hibernating bears sustain low HR in hibernation with high parasympathetic activity controlling the extreme sinus arrhythmia. We suggest that BP is maintained during long R-R intervals by peripheral vasoconstriction. Supported by NIH COBRE grant number [P20GM130443]. This is the full abstract presented at the American Physiology Summit 2024 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.

Uso de auriculares y la audición en estudiantes de medicina de una universidad pública de Lima, Perú

Introduction: Hearing loss affects millions globally, especially young people who frequently use headphones. Objectives: To establish the relationship between headphone use and hearing among medical students in Lima, Peru. Methods: An observational, analytical, and cross-sectional study was conducted at the Universidad Nacional Federico Villarreal. Participants included 98 medical students (18-32 years) who regularly used headphones. Those with previous hearing pathologies were excluded. Data collection included surveys on headphone use and audiometries performed in a silent booth. Results were analyzed using descriptive and inferential statistics, employing the Spearman's Rho correlation coefficient to assess the relationship between variables. Results: 59.2% of the students were women. 39.2% had mild hearing loss at high tones, while 36.2% had normal hearing. 71.4% reported decreased hearing capacity, and 56.1% experienced ear pain. Headphone use showed a positive and significant correlation with hearing (Rho = 0.298, p = 0.003). Exposure time was also significant (Rho = 0.260, p = 0.010), but sound intensity was not (Rho = 0.193, p = 0.057). Conclusion: There is a positive relationship between headphone use and hearing loss in medical students. It is recommended to implement awareness programs on safe headphone use and conduct regular hearing evaluations to prevent auditory deterioration.

Preschool mother-child emotional preparation program leads to significant improvement in autonomic regulation: a randomized controlled trial

IntroductionMany studies have documented the profound impact that the mother-child relationship has on child sociality and behavior. However, the biological mechanisms that govern the relationship are poorly understood. We developed a mother-child emotional preparation program (MCEP), based on a novel autonomic nervous system learning mechanism. MCEP is hypothesized to condition the child's autonomic nervous system to better meet the preschool socioemotional classroom challenges.MethodsWe conducted a randomized controlled trial of MCEP, comparing a group of children receiving standard curriculum with children receiving standard curriculum plus MCEP. Previously, we reported that the MCEP mother-child dyads (vs controls) were more emotionally connected at six months post intervention and MCEP children (vs controls) displayed better socioemotional behavior at home and in the classroom. At six months post intervention, mothers and children underwent a stressful interaction-interruption paradigm, during which we acquired child ECG. We analyzed heart rate and several measures of child heart rate variability obtained during the 10-minute post-stress recovery period.ResultsWe found that MCEP children showed better autonomic regulation following the stressor, as measured by lower heart rate (p = 0.017) and increased high frequency respiratory sinus arrhythmia (RSA) or vagal tone (p = 0.043). Surprisingly, despite a sample size limited by COVID (n = 12 and 12), the effect sizes were large (g's ranging from 0.89 to 1.09). In addition, we found significant correlations with large effect sizes between autonomic measures and scores on the Welch Emotional Connection Screen (WECS).DiscussionThese findings support the conclusion that MCEP had a significant positive impact on child autonomic regulation in response to stress, which correlates with behavioral assessments of emotional connection. We discuss theoretical considerations and the implications of our findings for preschool education programs in general. This trial was retrospectively registered (clinicaltrial.gov registry NCT02970565) three months after the start of the first recruitment on April 9, 2019.

Carboxylate Bridged Binuclear Cobalt(II) Complexes Catalyze the Hydrolysis of Thiolates to Alcohols

AbstractA binuclear Co(II) complex, [Co2(PhBIMP)(μ‐O2CPh)(MeCN)]2+ (1) (PhBIMP is the anion of 2,6‐bis[(bis((N‐1‐methyl‐4,5‐diphenylimidazoylmethyl) amino)methyl]‐4‐methylphenol) catalyzes the hydrolysis of thiolates to the corresponding alcohols/phenols at room temperature. Hydrolysis of 11 different thiolates has been investigated with a catalyst loading of 4–6.7 mol% and with the highest TON values reaching 22. Furthermore, the effects of electron donating and electron withdrawing groups on the bridging benzoate of 1 have been investigated. The intermediates, products, and fate of the catalyst have been identified by mass spectrometric, gas chromatographic and gravimetric methods, and based on that, a mechanism for the catalytic cycle has been proposed.

Trade War Actions, Reporting Strategies, and Stock Market Reactions

Investors’ perceptions of uncertainty have increased since Donald Trump’s inauguration, primarily as a result of trade frictions. In the context of China-US trade frictions, this study investigates the joint effects of the actions of the parties and media tone on the Chinese stock market. The trade friction reports are classified into 12 groups based on two dimensions, that is, the actions of the parties and the tone of the state-controlled media. The result shows that the role played by the state-controlled media depends on the actions taken by both the parties, as well as the type of firms. Specifically, when the US took action, either launched attacks or made concessions, adopting a high tone played some role in boosting returns and curbing fluctuations; adjusting reporting strategies also played some role in elevating the liquidity of both types of firms and influencing domestic southbound investments. Market reactions were more influenced by the actions than the official attitudes when China made concessions or when both sides took action (attacks or concessions).

Microwave-Assisted Transfer Hydrogenation of Carbonyl and ­Nitro Compounds Using Bimetallic Ru(II) Cymene Complexes

AbstractWe report an investigation of the microwave-assisted catalytic transfer hydrogenation (TH) of carbonyl and nitro compounds by employing Ru(II) complexes: bimetallic [(p-cymene)2(RuCl)2L1]2X (X = BF4 (Cat2); X = PF6 (Cat3)) and mononuclear [(p-cymene)(RuCl)L2]BF4 (Cat4) (where L1 = N,N′-(3,3′,5,5′-tetraisopropyl-[1,1′-biphenyl]-4,4′-diyl)bis(1-(pyridin-2-yl)methanimine) and L2 = N-(2,6-diisopropylphenyl)-1-(pyridin-2-yl)methanimine). At a low catalyst loading of 0.01 mol% (Cat2/Cat3), a broad range of substrates, comprising aromatic as well as aliphatic ketones and aldehydes, undergo the TH reaction in a short reaction time of just 10 minutes. Additionally, chemoselective hydrogenation of nitroaromatic compounds is achieved under microwave irradiation in the presence of Cat2 within 5 minutes. Control experiments demonstrate that microwave heating conditions outperform conventional heating in terms of improved catalytic activity and reaction efficiency. The bimetallic catalyst Cat2 is used at a very low loading of 0.001 mol% to achieve high TONs and TOFs of 7.7 × 104 and 2.3 × 105 h–1, respectively, for the TH reaction. Spectrometry experiments involving trapping of intermediates are used to propose a mechanism for the TH of the carbonyl compounds.

Does environmental and social performance affect pricing efficiency? Evidence from earnings conference call tones

This paper examines how environmental and social (ES) performance, proxied by related incidents, affect the managerial and analyst tones in quarterly earnings conference calls and its incremental effect on post-earnings call returns. We document that firms experiencing poor ES performance in the quarter prior to the earnings call exhibit more negative management tone after controlling for quarterly financial performance metrics. Tone difference in conference calls between managers and analysts predicts negative abnormal returns in the three-day window around the call. In the 60-day post-call period, we show that firms with poor ES performance exhibit returns negatively related to the tone difference on the conference call – low tone difference leads to return continuation and high tone difference predicts reversals for firms with positive earnings surprises. These results are consistent with an increase in information asymmetry and lower transparency for firms following poor ES performance.

How word stress is realized in Thai: evidence from the ordering of coordinate compounds

Abstract This study challenges the widespread belief that Thai lacks word stress, demonstrating its pivotal role in morphophonology. Through a Maximum Entropy analysis, we investigated how specific segmental properties statistically influence speakers’ choices of word order in coordinate compounds. Results indicate a significant effect of phonological weight on the ordering patterns. Specifically, the dispreference for stop codas in final positions and the preference for long or low vowels word-finally converge to differentially distribute phonological weight, ensuring that final syllables are heavier in accordance with the Stress-to-Weight Principle. Additionally, a marginal affinity is observed between the final syllable and the (historical) high-register tone, aligning with the well-documented tone-stress interaction where high tones gravitate towards stressed syllables. These findings provide compelling evidence for the existence of word stress in Thai: compound stress necessarily coincides with word stress, as dictated by the Continuous Column Constraint. Thus, this work suggests that relying solely on phonetic cues is insufficient for identifying stress; instead, a comprehensive analysis incorporating “phonological exponents” is essential to capture the greater phonological contrasts licensed in stressed syllables. This study also contributes to a deeper understanding of metrical and prosodic prominence, revealing that word stress can sometimes be masked by higher-level prominence.

Efficient electrocatalytic alkyne Semi-Hydrogenation and deuteration using Pd/PANI catalysts supported on nickel foam

In this study, we synthesized Pd/PANI catalysts anchored on nickel foam (NF) via a single-step CV electrodeposition process. The resulting Pd0.3/PANI-NF materials exhibited outstanding selectivity and activity for electrocatalytic alkyne semi-hydrogenation and deuteration under ambient conditions. Characterization of Pd/PANI and control experiment revealed that the combination of PANI and Pd had a synergistic effect on the catalytic performance of Pd/PANI-NF for alkyne semi-hydrogenation. Optimized conditions in H-cells allowed efficient conversion of various terminal and internal alkynes into their corresponding alkenes with remarkable yields up to 92 % and a Faradaic efficiency of 88 %, even at low Pd loading (0.4 mol%). The Pd0.3/PANI-NF showed sustained catalytic activity for gram-scale alkene synthesis through five usage cycles under continuous flow conditions, marked by a high TOF (up to 230 h−1) and combined TONs of 2151, establishing its practical viability for electrocatalytic hydrogenation.

Vagal tone, pain sensitivity and exercise-induced hypoalgesia: The effect of physical activity level.

Vagal activity has analgesic effects that are attributed to exercise-induced hypoalgesia (EIH). High vagal tone and low pain sensitivity are reported in individuals who routinely exercise yet, their association is unclear. Furthermore, it is unknown if the heightened vagal tone following high physical activity predicts and intensifies EIH. Fifty-one healthy participants (27 low-moderately physically active; 27 females) underwent a resting-state electrocardiogram followed by heart rate variability analysis. Pain measurements, including pressure (PPT) and heat (HPT) pain thresholds, ratings of tonic heat pain (THP) and conditioned pain modulation (CPM) paradigm, were conducted pre- and post-exercise on a cycle ergometer. The highly active group demonstrated higher vagal tone compared to the low-moderately active (root mean square of successive differences between R-R intervals: 63.96.92 vs. 34.78 ms, p = 0.018; percentage of successive R-R intervals that exceed 50 ms: 24.41 vs. 11.52%, p = 0.012). Based on repeated-measure ANOVA, the highly active group showed higher PPT at pre-exercise, compared to the low-moderately active group (382 kPa vs. 327 kPa; p = 0.007). Post-exercise, both groups demonstrated EIH, increased HPT (p = 0.013) and decreased THP ratings (p < 0.001). Linear regression revealed that only in the low-moderately active group, higher vagal tone was associated with more efficient pre-exercise CPM and a greater reduction in THP ratings post-exercise (p ≤ 0.01). Highly active individuals demonstrate greater vagal tone and lower pain sensitivity but no greater EIH. Vagal tone moderates pain inhibition efficiency and EIH only in low-moderately active individuals. These findings suggest that physical activity level moderates the vagal-pain association via the endogenous analgesia system. Highly physically active individuals exhibit greater vagal tone and reduced sensitivity to experimental pain, yet they do not benefit more from exercise-induced hypoalgesia (EIH) compared to low-moderately active individuals. Moreover, low-moderately active individuals with greater vagal tone exhibited more efficient endogenous pain inhibition and greater EIH, suggestive of the moderation effect of physical activity level on vagal-pain associations.

The connection between religiosity and psychological stability among Muslims in Russian megacities

The article presents the results of an analysis of the relationship between external and internal religiosity, religious practice and psychological stability among Muslims living in Russian megacities. The study involved 87 respondents: 12 men and 75 women aged from 16 to 70 years. To determine the level of external and internal religiosity, the Mussarat Jaben Khan scale of Muslim religiosity was used (Khan, 2014). To measure psychological stability, the method of diagnosing “The dominant state” of L.V. Kulikov was used. Kulikov in a shortened version (DS-6) (Kulikov, 2003), the respondents’ attitude towards religious practice was assessed by the author’s questionnaire. Analysis of the study results confirmed our hypothesis that the level of religiosity, both external and internal, is associated with various aspects of psychological stability. The study revealed a significant positive relationship between internal religiosity and such scales of the dominant psychological state as “stability of emotional tone”, “calmness”, “high tone”, and a negative relationship with the scale “active attitude to life situation”. And also the results of the study showed that the connection between external religiosity and the scales of the dominant psychological state is not significant in any of the cases, except for the negative connection with the “stability of emotional tone” scale. This generally indicates that for Muslims living in Russian megacities and who took part in the study, internal religiosity is a significant factor in increasing psychological stability.

Language-Specific Prosody in Statements of Palenquero/Spanish Bilinguals

This study explores the extent to which Palenquero/Spanish bilinguals, a population that is said to have a residual high tone of African origin, keep their two languages temporally and intonationally distinct across statements. While creole languages that emerged from the contact of African and European languages, such as Palenquero, may develop hybrid prosodic systems with tones from substrate languages, and stress from the majority language, language-specific prosody might be expected to converge or simplify over the course of time. As prosodic convergence seems to be inescapable under Palenquero’s circumstances, which factors could support language-specific prosody in this population, if there are any? Two-hundred and thirty-four five-syllable statements were elicited through a discourse completion task, with the participation of ten Palenquero/Spanish bilinguals, in two unilingual sessions. Both phrase-final lengthening and F0 contours were assessed using linear mixed-effects models testing their association with final stress, language, and generation. F0 contours were dimensionally reduced using functional principal component analysis. Despite the strong similarities between the two languages, results indicate that both groups keep their two languages intonationally distinct using plateau-shaped contours in Palenquero initial rises followed by steeper declinations in Spanish. However, elderly bilinguals implement penultimate lengthening language-specifically, being more pronounced in Palenquero. Adults, in contrast, do not show this distinction. In addition to this, elderly speakers show hyperarticulation in Spanish intonation, increasing the difference between their languages. This leads us to believe that adults exhibit a more simplified prosodic system between their languages, relative to elderly bilinguals. In spite of such differences, both generations seem to have the same underlying process (perhaps a substrate effect) driving plateau-shaped intonation in Palenquero, which enhances language differentiation.

Free Cognitive Capacity Assessed by the P300 Method During Manual Docking Training in Space.

INTRODUCTION: The classical P300 brain potential method was used to assess the cognitive capacity during training of manual docking in space. The aim of the study was to enhance the safety of this operation during a mission.METHODS: To examine this, N = 8 cosmonauts had to perform the manually controlled docking task simultaneously with an acoustic monitoring task. The P300 component was evoked by the acoustic stimuli of the secondary task. The docking task had to be executed at three difficulty levels: low (station not turning); medium (station turning around one axis); and difficult (station turning around three axes). In the secondary task, subjects had to discriminate between a low and a high tone, which occurred with a probability of 90% and 10%, respectively. Subjects had to count the high tones. After the 10th high tone, they had to inspect the power supply by giving an oral command.RESULTS: A methodology for event-related potentials was successfully demonstrated under space conditions. The P300 amplitude was largest and the latency shortest during the medium difficult task.DISCUSSION: The results suggest that P300 can be recorded during the complex manual docking task in space and could be used to assess individual available cognitive capacity of cosmonauts during a space mission.Bubeev JA, Johannes B, Kotrovska TI, Schastlivtseva D, Bronnikov S, Hoermann H-J, Gaillard AWK. Free cognitive capacity assessed by the P300 method during manual docking training in space. Aerosp Med Hum Perform. 2024; 95(4):187-193.

“pandemic pelvis”: identifying high tone pelvic floor disorder and associated pelvic floor symptoms during the COVID-19 pandemic

“pandemic pelvis”: identifying high tone pelvic floor disorder and associated pelvic floor symptoms during the COVID-19 pandemic

Вариативност при реализацията на българска интонация

The study presents the intonational phonology of Contemporary Standard Bulgarian (CSB) and the BG_ToBI annotation system. CSB uses the following pitch accents: L*, L*+H, L+H*, H*, H+!H*; phrase accents: L-, H-, and !H-; and boundary tones: %H, L%, H%, !H%. In the realization of the pitch accents, there is often variable alignment between the tonal target and the boundaries of the lexically stressed syllable. This variability is due to both speaker-specific speech strategies and the position of the stressed syllable within the utterance. For example, when the H* pitch accent is near the beginning of the utterance, the high target is usually reached towards the end of the stressed syllable. When it is near the end of the utterance, the high target is reached towards the beginning of the stressed syllable. In rising accents (L*+H and L+H*), the high tone can be delayed up to three syllables after its original target. In signaling the information structure of the utterance, there is no one-to-one correspondence between the type of focus and the choice of pitch accent: the same type of focus can be ex-pressed with different accent types, and the same accent can signal different types of focus. For example, H* can signal broad focus, narrow focus, and contrastive focus; L+H* can signal narrow focus and contrastive focus. Thematic material is not necessarily deaccented. From a pragmatic and functional perspective, four different tunes associated with the various vocative types in Bulgarian are presented: neutral vocative (L+H* L-%), insistent vocative (L+&lt;H* L-% [+long]), challenging chant (L* H-L% [+long]), and vocative chant (L+H* !H-% [+long]). When the final syllable is lengthened, the vowel in it is not fully reduced, which contradicts the phonological pattern of vowel reduction in CSB.

An acoustic study of Jonglish Communiy: Javanese-accented speech

People who speak English with a Javanese accent are referred to as Jonglish (Jowo-English) speakers. They end their sentences in a high tone, therefore, the aims of this study were to compare the intensity and pitch of Javanese accent speakers (specifically from Pekalongan, Semarang, and Pati) with native speakers. The focus was on investigating whether the high tone at the end of sentences affects the engaging nature of the conversation. It employed descriptive qualitative design and included data collection, acoustic analysis, perception analysis, linguistic analysis, and interpretation. The data were collected by audio recording in the form of sentences. Praat, a voice analysis, was utilized to analyze the data. The findings demonstrated that Pekalongan and Semarang speakers had higher pitch than native speaker (232.25 Hz and 206.27 Hz). Meanwhile, the pitch score for Pati was lower than native; 192.04 Hz. On the other hand, the intensity from those regions were lower than native speaker; 69.58 dB, 61.51 dB, and 68.203 dB, while the of native speaker was 71.306 dB. The fact that the Jonglish includes a tendency to end sentences with a high tone suggests a particular intonation pattern. Despite these variations, effective communication often relies on contextual cues and the listeners ability to adapt to different speech patterns. The study has the potential to make meaningful contributions to English pronunciation instruction, cultural awareness, and effective cross-cultural communication. The outcomes of the research can inform pedagogical practices and support the broader goal of promoting linguistic diversity in English language education.

Sandhi-based predictability of pitch accent facilitates word recognition in Kansai Japanese speakers.

This study investigates the predictability effects of pitch accent on word recognition using the sandhi rule in Kansai Japanese (KJ). Native KJ speakers and native Tokyo Japanese (TJ) speakers (control group) saw images of four objects while hearing modifier + noun phrases and selected the corresponding image as quickly as possible. The word-initial tone of the noun's initial mora was predictable or unpredictable based on the tone of the preceding modifier's final mora in KJ but not in TJ. Experiment 1 found faster reaction times in the predictable conditions compared with the unpredictable conditions in KJ speakers but only when the modifier had an all-low tone sequence. This finding suggests that a modifier-ending that changes following the sandhi rule can function as a reliable cue to constrain an upcoming tone, whereas a modifier-ending tone that remains the same as in the citation form cannot (although the next tone is predictable). Unexpectedly, we found the same effect, albeit weaker, in TJ speakers. Experiment 2 replicated this effect and additionally showed that the facilitation effect was not due to TJ speakers having sufficient exposure to KJ to be familiar with the KJ sandhi rule. We speculate that the effect in TJ speakers is related to a language universal constraint against a sequence of low tones without a high tone within a phonological word, which may urge listeners to listen for a high tone in the upcoming input.

Comparison of vestibular evoked myogenic potentials between low and high tone idiopathic sudden sensorineural hearing loss

Objectives: Vestibular evoked myogenic potentials (VEMP) have been reported to be useful in evaluating not only vestibular function but also the prognosis of idiopathic sudden sensorineural hearing loss (ISSNHL) patients. Even though low frequency, high frequency, and all frequency-involved ISSNHL groups tend to show varied clinical characteristics, there is a lack of data using VEMP results to analyze these subgroups. We investigated if the VEMP test is a valuable tool to predict recovery from hearing loss in association with different frequencies. Methods: A total of 26 ISSNHL patients were divided into three different groups impaired with low tone (ascending type), high tone (descending type), and all tones (flat type) based on the initial audiograms. Each group included five, 10, and 11 patents, respectively, and their VEMP results were compared between the three subgroups. Results: Abnormal VEMP results were found in five of the total 26 ISSNHL patients (19.2%). Two (40.0%), one (10.0%), and two (18.1%) patients of low tone, high tone, and all tone hearing loss groups, respectively, showed abnormal VEMP results. However, there was no statistically significant difference between the three groups. Conclusions: Even though VEMP is known as a valuable tool for predicting the prognosis of ISSNHL patients, it does not seem to reflect frequency-sensitive aspects of ISSNHL.

Pelvic Pain of Myofascial Origin in Women: Correlation with Lower Urinary Tract Symptoms.

Women with lower urinary tract symptoms (LUTS) and high-tone pelvic floor often experience pain and have positive trigger points upon pelvic floor examination. However, the correlation of these findings has not yet been systematically examined and sufficiently understood. The aim of this cross-sectional study is to examine the correlation of pelvic myofascial pain with LUTS and pelvic floor tone. All participants filled a standardized pelvic floor questionnaire to assess LUTS, which consists of a total of 43 questions regarding bladder, bowel, and sexual function as well as prolapse symptoms. Myofascial trigger points in different muscle groups including pubococcygeus, iliococcygeus, and obturator as well as pelvic floor muscle tone were assessed using a standardized digital examination technique. 110 women were included in the study. There was a significant correlation between pain in various muscle groups and LUTS as well as high-tone pelvic floor muscle. A significant correlation could also be found between high pelvic floor muscle tone and the overall questionnaire score (p < 0.001) as well as the bladder function score (p < 0.001) and various pain scores of the different groups. Individuals with high-tone pelvic floor were more likely to have more LUTS and higher pain scores. The existence of myofascial pelvic floor trigger points and high pelvic floor muscle tone seem to be reflective of pelvic floor symptoms, as assessed with a standardized pelvic floor questionnaire.