When a fast parton propagates in nuclear medium it may suffer multiple scattering with other partons, which leads to two effects: transverse momentum broadening and jet quenching. In this article, we review the theoretical development of the transverse momentum broadening in the nuclear medium based on the pQCD factorization of higher twist processes, and discuss the implementation of the parton energy loss within higher twist expansion framework in the calculation of the leading hadron productions in relativistic heavy ion collisions at the RHIC and the LHC. We introduce the techniques of next-to-leading order (NLO) calculation for twist-4 process, and verify, for the first time, the universality of nuclear medium property, and we also identify the QCD evolution equation for the nuclear medium. We apply the high twist factorization formalism to calculate the hadron production at backward rapidity in proton-nucleus collisions at RHIC and the LHC, and find that the nuclear enhancement phenomena observed in experiments can be explained as incoherent double scattering. We further investigate parton energy loss effect in the framework of higher twist expansion on the leading hadron production in heavy ion collisions up to the accuracy of NLO pQCD, and calculate the yields and the nuclear modification factors of $\pi^0$, $\eta$, $\rho^0$, $\phi$, $K^0_{\rm~S}$ and $\omega$, and discuss the ratios of the identified hadron yields. By comparing our theoretical results with the latest experimental data on the leading hardon spectra in heavy ion collisions, we also extrapolate the jet transport coefficient. It is found the identified hadron yields in A+A collisions depend on three factors: the initial hard jet spectrum and the energy loss mechanism as well as parton fragmentation functions to the hadron in vacuum.
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