High Specific Surface Area Research Articles

Synthesis of Jasminaldehyde (α-pentylcinnamaldehyde) using Cs-AlMCM-41 Nanoparticle as Heterogeneous Solid Base Catalyst

In this study, the ultra-small mesoporous Cs-AlMCM-41 nanoparticle materials were obtained with high specific BET surface areas in the range of 426 m2g-1 with 1.97 nm pore size. The pore volume was found to be 0.86 cm3. The material possesses a basic site due to caesium ions (Cs+) counterbalancing the negative rise by Al in the mesoporous framework. The basicity of the sample was found to be 115.48 mol g-1. The basicity was proven via the condensation reaction of heptanal and benzaldehyde using microwave irradiation with a microwave power of 800 W. The sample (Cs-MCM-41) gave a higher conversion of heptanal (73.8%) with (70.1%) selectivity to jasminaldehyde. The CsMCM-41 can be a promising base catalyst in aldol condensation reaction for the synthesis of jasminaldehyde under autogenous pressure. Hence, the solid catalyst is easily recycled up to five (5) times with minimal loss of activity due to washing.

Decolorization of RhB on three-dimensional porous CeO2/LaFeO3/SrTiO3 catalyst via photo-fenton-like catalysis.

The catalysts with three-dimensional porous (3DP) CeO2, LaFeO3 and SrTiO3 are synthesized by sol-gel method and chemical precipitation method. The resulting multi-component 3DP CeO2/LaFeO3/SrTiO3 composite material featured a high specific surface area (26.08 m2/g), which can provide more surface active sites to improve adsorption capacity and catalytic performance. The photocatalytic, Fenton-like, photo-Fenton-like performance of the catalyst are studied on decolorization of RhB under UV irradiation, respectively. 3DP CeO2/LaFeO3/SrTiO3 exhibits high catalytic performance. Compared with photocatalytic or Fenton-like performance, 3DP CeO2/LaFeO3/SrTiO3 catalyst exhibits higher photo-Fenton-like performance, facilitating efficient decolorization of the rhodamine B. Moreover, the initial reaction rate on decolorization of RhB with 3DP CeO2/LaFeO3/SrTiO3 is 10.55, 5.52, 3.67 and 1.51 times higher than that with SrTiO3, LaFeO3, 3DP CeO2 and 3DP CeO2/LaFeO3, respectively. Meanwhile, 3DP LaFeO3/CeO2/SrTiO3 has a wider pH usage range in the synergistic reaction. Finally, a catalytic mechanism for the decolorization of rhodamine B is proposed. The continuous cycling of Fe3+/Fe2+ and Ce4+/Ce3+ and the production of active substances are achieved under the photo-Fenton-like effect of the catalyst.

Porous carbon derived from center part of the corn cob for high-performance symmetrical supercapacitors

The central part of agricultural waste biomass corn cob was used as carbon precursor and KHCO3 as activating agent, and porous carbon materials were prepared by one-step carbonization method. The effect of KHCO3 on the structure and properties of porous carbon was studied. The results show that KHCO3 has an etching effect on porous carbon, and the greater the amount of KHCO3, the stronger the etching effect. The obtained biomass porous carbon material has abundant pores, reasonable pore size distribution and high specific surface area, which is conducive to ion transfer and charge storage. In addition, the heteroatom self-doping of porous carbon can improve surface hydrophilicity and generate additional pseudocapacitance, thereby improving its electrochemical properties. Electrochemical characterization shows that the porous carbon has a specific capacitor of up to 323 F g−1. The assembled symmetric supercapacitor (SSC) has an energy density of 20 Wh kg−1 at a power density of 350 W kg−1. This low-cost, high-performance electrode material has potential applications in high-power supercapacitors.

Electropsun non-woven luminescent two-dye pH sensors: Effect of morphology on the sensing performance

Electrospun (ES) non-woven matrices are regarded as promising platforms for the development of miniaturized sensing systems with improved detection capacity. Their high specific surface area and void-to-volume ratio are expected to promote higher and faster interaction of the sensing molecular probes with the target stimuli increasing sensor sensitivity and response time. However, the poor light transparency of ES non-woven mats appears as the main limiting effect regarding their use as optical sensor platforms being important to determine to what extent it affects the sensor prediction accuracy. This work addresses this question providing a comparative analysis of the performance of flat cast and ES non-woven cellulose acetate luminescent platforms loaded with a pH sensitive dye-pair, i.e. fluorescein isothiocyanate (FITC) and rhodamine 6 G (R6G). This study follows a comprehensive approach aiming at clarifying the effect of the platform morphology on the sensitivity of their spectral properties to pH and to understand about the advantages of using dual dye systems for pH detection. The presence of R6G improved remarkably the sensitivity of these ES matrices extending the analytical capacity of the probes to the alkaline range. The emission of ES matrices showed stronger sensitivity to pH. However, pH prediction accuracy was found to depend crucially on a synergistic effect from the platform morphology and the signal analysis methodology. ES non-woven matrices allows for accurate pH prediction, characterized by determination errors < 10 % for pH < 10, by exponential analysis of the dye-pair emission at λExc of 450 nm and λEm of 519 nm. Furthermore, it shows a strong reduction of the determination errors, at extremely acidic conditions, resulting in values comparable to that obtained by analysis of the emission signal from flat cast platforms with more complex Förster Resonance Energy Transfer (FRET) methodologies.

PH independent adsorption: Reusable zinc-ferrite nanospheres for the selective recovery of dyes from binary mixtures

Efficient separation of colorant pollutants is a formidable challenge, prompting research into innovative materials. We developed zinc-ferrite nanoparticles via the Microwave-Assisted Solvothermal Technique (MAST), exploiting judicious solvent compositions to enhance Lewis's acidity. Upscaling to gram batches yielded nanoparticles with a higher specific surface area (149 m2g−1). These nanoparticles demonstrated selective separation of dyes from binary mixtures, including Orange-G (OG), Fluorescein-Sodium (FSS), and Methyl-Orange (MO), with their high sorption rate fitting to the pseudo-second-order kinetic model. Langmuir isotherm for OG and MO were observed with respective adsorption capacity (qm) of 94.12 mg/g, 104.28 mg/g, whereas FSS more likely matched Sips isotherm with qm = 124.31 mg/g at natural pH in room temperature (27 °C). Desorption, reliant on solution pH and OH− ions, enabled efficient regeneration and multiple reuses without significant efficiency loss over five reuse cycles. Remarkably, selective separation was independent of surface charge and remained effective across a wide pH range and in the presence of common anions, namely I−, NO3−, C2H3O2− routinely encountered in dye effluents. This ecologically safe, scalable adsorbent offers a promising solution for expensive dye recovery.

Solvent-Free Synthesis of HKUST-1 with Abundant Defect Sites and Its Catalytic Performance in the Esterification Reaction of Oleic Acid.

HKUST-1 has received increasing attention because of its potential applications in many fields, such as heterogeneous catalysis, sensors, gas storage, and separation. Herein, we report that HKUST-1 can be facilely prepared by heating a ground mixture of copper nitrate trihydrate and 1,3,5-benzenetricarboxylic acid in an autoclave at 80 °C for 10 h. The data from nitrogen sorption show that the obtained material, named HKUST-1-free, possesses a high BET specific surface area of 1671 m2/g and a pore volume of 0.8 cm3/g. The results from acid-base titration indicate that the number of defect sites in HKUST-1-free is more than that in HKUST-1-solvent prepared by the solvothermal method. As a heterogeneous catalyst, HKUST-1-free gave a high yield (91%) of methyl oleate in the esterification reaction of oleic acid with methanol at room temperature compared to HKUST-1-solvent (70%). Additionally, it is proven that HKUST-1-free is a heterogeneous catalyst and can be reused.

β-Ketoenamine Porous Organic Polymers for High-Efficiency Carbon Dioxide Adsorption and Separation.

To mitigate the greenhouse effect, a number of porous organic polymers (POPs) has been developed for carbon capture. Considering the permanent quadrupole of symmetrical CO2 molecules, the integration of electron-rich groups into POPs is a feasible way to enhance the dipole-quadrupole interactions between host and guest. To comprehensively explore the effect of pore environment, including specific surface area, pore size, and number of heteroatoms, on carbon dioxide adsorption capacity, we synthesized a series of microporous POPs with different content of β-ketoenamine structures via Schiff-base condensation reactions. These materials exhibit high BET specific surface areas, high stability, and excellent CO2 adsorption capacity. It is worth mentioning that the CO2 adsorption capacity and CO2/N2 selectivity of TAPPy-TFP reaches 3.87 mmol g-1 and 27. This work demonstrates that the introduction of β-ketoenamine sites directly through condensation reaction is an effective strategy to improve the carbon dioxide adsorption performance of carbon dioxide.

Sucrose-based reticulated vitreous carbon modified with N-doped TiO2 as an adsorbent and photocatalyst: Enhanced removal of methyl orange from aqueous solutions

A novel and low-cost 3D reticulated vitreous carbon (RVC) was synthesized and modified with (N-TiO2) to obtain an RVC/N-TiO2 composite, which was employed to remove methyl orange in an aqueous solution. This material was synthesized using the sacrificial template method and impregnated with an environmentally friendly sucrose resin, followed by N-TiO2 impregnation by dip-coating technique. SEM-EDS characterization confirmed the uniform covering of the TiO2, and XRD, Raman, and XPS evinced the presence of anatase and rutile polymorphs in the film and the N-doping, respectively. N-TiO2 coating onto RVC provides a higher specific surface area and electrochemical active area, boosting the wettability and the adsorption capacity. Additionally, this film favoured the photoelectrochemical response of the composite and the generation of •OH radicals. The adsorption, desorption, and photocatalytic studies demonstrated that >95 % decolorization of MO was achieved in 30 min without light irradiation and that >95.5 % degradation was attained in 120 min under visible light. The foam demonstrated reusability for over five cycles of adsorption/desorption of MO, with a capacity to recover up to 99 % of the dye after the first cycle and up to 94.07 % after the fifth cycle. Meanwhile, the minimal desorption of the dye (2.5 %) after illumination confirmed the photocatalytic degradation. This indicates that the process was not merely adsorption but also photocatalytic degradation.

NiAl-LDHs-derived NiO/Al2O3 with high specific surface area for wide range hydrogen detection

The construction of heterojunctions is generally considered as one of the effective strategies to improve gas sensing performance. Herein, the NiO/Al2O3 (NAO) hybrid structure is constructed by calcining Ni–Al layered double hydroxides (NiAl-LDHs). The specific surface area and pore size of NAO are effectively regulated by changing the content of NaOH. The XPS and BET characterization results indicate that NAO-5 exhibits a high oxygen vacancy content, a large specific surface area (468.524 m2 g−1), and abundant pore size. The hydrogen (H2) sensitivity property of NAO was investigated, and NAO-5 exhibited outstanding gas sensing performance to 500 ppm H2 at 370 °C, including high response (10.524), fast response recovery speed (21 and 30 s), and wide detection range (0.1–5000 ppm). The improved gas property is mainly attributed to the increased oxygen vacancies and specific surface area. This study provides a feasible approach for NiAl-LDHs in H2 monitoring and early warning.

Hydrogen-bonded organic frameworks as stationary phase for open-tubular capillary electrochromatography

BackgroundCapillary electrochromatography (CEC) stationary phases have always been the focus of attention. The selection of excellent stationary phases are the key to realize separate of different compounds. Hydrogen-bonded organic frameworks (HOFs) are porous materials connected by hydrogen bonds between molecules, which have the advantages of renewable, high specific surface area and mild synthesis conditions. At present, HOFs are used in gas adsorption and storage, catalysis and drug delivery. Because of its unique advantages, HOFs have a bright future as CEC stationary phases. ResultsUsing melamine (MA) and 1,3,6,8-tetra (4-carboxylphenyl)pyrene (H4TBAPy) as reaction monomers, a HOFs named MA/PFC-1 was synthesized by solvent evaporation at room temperature. The inner wall of the capillary column was coated with MA/PFC-1 by chemical bonding. Sulfonamides were used as the target analytes. The effects of pH, phosphate buffer solution concentration, organic additive content and applied voltage on sulfonamides separation were investigated. The MA/PFC-1-coated capillary column had good resolution (>1.5) and reproducibility. The intra-day, inter-day, column-to-column, and inter-batch precision of the retention times were 0.03%–0.09%, 0.04%–0.09%, 0.03%–0.14% and 0.06%–0.09%, respectively. The intra-day, inter-day, column-to-column, and inter-batch precision of the peak areas were 0.11%–0.25%, 0.13%–0.20%, 0.12%–0.15% and 0.08%–0.15%, respectively. The MA/PFC-1-coated capillary column was run 150 consecutive times, and the results showed no noticeable change, which proved that this method had good stability. SignificanceThis work applied HOFs to CEC. The results show the that MA/PFC-1-coated capillary column has good separation performance. The MA/PFC-1-coated capillary column has been successfully applied to the determination of sulfamethoxazole in tablets, which has practical application value. To open up the application of HOFs in CEC and provide a new idea for developing new CEC stationary phases.

High specific surface area (2840.3 m2/g) in activated carbon/SnFe2O4 spinel nanocomposite: structural, optical, dielectric, and magnetic properties for Li-ion battery soft and porous electrode applications

High specific surface area (2840.3 m2/g) in activated carbon/SnFe2O4 spinel nanocomposite: structural, optical, dielectric, and magnetic properties for Li-ion battery soft and porous electrode applications

One-step E-Jet printing of loofah-like ZnO nanostructures by real-time laser zone irradiation

Loofah-like nanostructures have been applied in many fields because of their high specific surface area, high porosity, and low density. Developing additive manufacturing methods for loofah-like nanostructures remains a challenge. This paper proposed a novel E-Jet nanoprinting method with real-time laser zone irradiation, for one-step fabricating of loofah-like ZnO nanostructures. The combination of laser irradiation and electrohydrodynamic effect had been proved in detail by adding laser irradiation to the traditional E-Jet printing process. Printable ZnO inks were prepared. The numerical model of the jetting under the combination of flow field and electric field; and the model of the interaction between laser and printing structure were established respectively. The laser beam irradiated the printing structure in real-time to rapidly absorb energy, resulting in thermal expansion and thermal decomposition. The shock wave generated by laser irradiation induced the physical fragmentation and redistribution of particles in the printed structure. Printing at different laser powers was investigated; and the loofah-like ZnO nanostructures, down to the scale of ∼90 nm, have been directly printed without post-processing. The characteristic morphology and hydrophilic characteristics of the printed structure were studied. This study provided a new way for green and efficient additive fabrication of loofah-like nanostructures, which was of significance for the development of nanofabrication and nanodevices.

Catalytic development of boron and sulphur-doped g-C3N4 supported Cu-MOF composite for nitroarenes reduction reaction

Todays, the mesoporous heteroatom-doped materials were attracted the scientist interest due to their outstanding properties such as thermal/chemical stability, high specific surface area (SSA), facile synthetic protocol and also abundance precursor. So, in this study, the advanced and applicable Boron and Sulphur-doped g-C3N4 (g-BSCN) supported Cu-MOF (Cu@g-BSCN) was prepared via in situ growth of Cu-MOF on the surface of g-BSCN using H3BO3, thiourea, Cu(NO3)2. 3H2O, and Terephthalic acid. The synergistic effect of B and S as the heteroatoms was triggered the plenty activated sites owing to the structural defect on the surface of the mesoporous g-BSCN. Moreover, the catalytic efficiency of g-BSCN was improved by in situ formation of copper-based MOF. The synthesized Cu@g-BSCN composite was utilized as the competent heterogenous catalyst in nitroarenes reduction in green and mild reaction condition (green solvent, and ambient temperature). High catalytic performance and desired recoverability are some of the benefits of this catalytic system.

Enhancing the capacitance of carbonized wood by regulating the morphology and valence state of guest electrochemically active materials

Using bottom-top methodology to load metal oxides with high pseudocapacitive activity onto carbonized wood (CW) is an efficient strategy to fabricate electrodes with large capacitance, while the morphology and metal valence in metal oxides are as important as their content but have received little attention. Herein, a heating treatment integrating carbonization and activation processes is used on Cu2+ loaded natural wood to prepare CW/CuxOy electrodes in which CuxOy with pseudocapacitive activity and CW with a high specific surface area (SSA) of 832 m2/g and good electric conductivity of 1.25 S cm−1 are collaboratively achieving a capacitance of 430.5F/g at 150 mA g−1. Then, a constant potential method is utilized not only to regulate the valence state of Cu and Cu2+ in CuxOy to Cu+ with much higher pseudocapacitive activity, but also to convert the morphology of CuxOy from sphericity to urchin-like and cluster structure with more available active sites. Therefore, the optimized electrode achieves a greatly improved capacitance of 855F/g, and the fabricated supercapacitor delivers an energy density of 75.93 Wh kg−1 at 138 W kg−1. This work provides an approach to enhance the specific capacitance of metal oxides-based electrodes from a fresh perspective.

Ultrasound-assisted freezing for the preparation of aerogel-based intelligent packaging

Due to their highly porous and high specific surface area, aerogels are promising materials for intelligent food packaging. However, aerogel-based intelligent packaging prepared by traditional freeze-drying methods severely limits the preparation efficiency and the packaging performance of the aerogels due to the low freezing efficiency and the large and uncontrollable pore size caused by the uncontrolled growth of the crystals during freezing; this leads to the destruction of the aerogel structure. In this study, an aerogel-based food intelligent packaging was prepared using gelatin and gum Arabic (GG) as the substrate materials for real-time shrimp freshness detection. An ultrasound-assisted freeze-drying (UAFD) strategy was applied to improve the freezing efficiency of the cavitation-induced nucleation of aerogel. By affecting secondary nucleation, the UAFD-160 W strategy produced aerogels (GG-160) with smaller pore sizes (14.76 μm) and narrower pore size distributions than those using intelligent packaging prepared by the traditional freeze-drying method (GG-0, pore size = 254.14 μm). Due to the advantages of the above structure, the GG-160 aerogel has a significantly improved hardness (28956.5 ± 101.6 N), excellent water resistance and hydrophobicity (93.6 ± 0.99°), sensitive ammonia responsiveness, and stable properties under high humidity. Consequently, compared with that in the GG-0 treatment, the color of the shrimp in the GG-160 treatment was more sensitive to spoilage. The proposed UAFD strategy provides a new way to improve the properties of aerogels by structural modulation such that the prepared aerogels have better food packaging applications.

Scalable method for the preparation of CoxNi1-x/alumina nanocomposites and their magnetic heating properties

Magnetic nanocomposites with a high surface area matrix are attractive materials for novel catalyst supports. They can be remotely and selectively heated inside the reactor vessel when exposed to a high-frequency alternating magnetic field (AMF). These so-called "magnetic" or "cold" catalysts can revolutionize the chemical industry's electrification, particularly for renewable energy applications such as hydrogen storage and release. In this study, we developed a scalable method for synthesizing magnetic CoxNi1-x-Al2O3 nanocomposites. The synthesis is based on the co-precipitation of Co and Ni ions from an aqueous solution, coating the precipitated nanoparticles with a boehmite (AlOOH) shell via the in-situ hydrolysis of AlN powder and reduction at 850 °C in a flow of H2. A combination of X-ray diffractometry (XRD) and scanning transmission electron microscopy (STEM/EDXS) showed the formation of nanocomposites containing globular CoxNi1-x nanoparticles (∼ 14 nm in size), homogenously distributed within the matrix composed of thin γ-Al2O3 nanosheets (∼ 30 nm wide and up to 3 nm thick), providing a high specific surface area (∼ 140 m2 g−1). The reduction process was studied using high-temperature XRD, hydrogen-temperature programmed reduction (H2-TPR), and X-ray photoelectron spectroscopy (XPS). The magnetic properties were measured with a vibrating-sample magnetometer (VSM). The nanocomposites exhibited an excellent heating ability, exceeding 800 °C within a few minutes, even at relatively low AMF amplitudes (up to 58 mT) in a fixed-bed reactor. These results underscore the potential of CoxNi1-x-Al2O3 nanocomposites for high-temperature catalytic processes, marking an advancement in magnetic catalyst support synthesis.

Oriented growth of NiCo metal–organic framework nanosheets on electrode materials for ternary mixed metal oxide supercapacitors

Metal–organic frameworks (MOFs) are porous structures that possess high specific surface areas, making them promising cathode materials for energy storage devices. However, solving the problems of random growth and easy aggregation of MOF nanosheets remains a challenge. In this study, hydrothermal and calcination methods were used to successfully create nickel cobalt molybdenum metal oxide (NCMO) nanoflowers, followed by the directional growth of NiCo–MOF on its surface. The oriented growth of NiCo–MOF nanosheets on NCMO nanospheres effectively prevented agglomeration, forming NCMO@NiCo–MOF with enhanced electrochemical sensitivity and a large quantity of active sites. When used as an electrode, NCMO@NiCo–MOF forms a large contact area with the electrolyte, demonstrating a high specific capacitance of 1724 F g−1 at a current density of 1 A g−1. Furthermore, at a power density of 824.8 W kg−1, an asymmetric supercapacitor constructed from NCMO@NiCo–MOF and activated carbon exhibited a high energy density of 44.5 Wh kg−1. This study presents a facile method for the assembly of MOF nanosheets for three-dimensional supercapacitors.

Fabrication of high-crystallinity hydrazone‐linked fluorescent covalent organic framework and its sulfonated material for the design of sensing and adsorption dual-functional platforms

Hydrazone-linked fluorescent covalent organic frameworks (COFs) with high crystallinity exhibit remarkable stability under acid-base conditions and in various organic solvents, maintaining structural integrity for cyclic utilization in sensing and adsorption processes. Consequently, developing new high-crystallinity hydrazone-linked fluorescent COFs is of significant importance. Notably, post-modification can enhance the detection diversity, selectivity, and adsorption performance of these COFs. Herein, a new hydrazone-linked fluorescent COF (namely COF-YYL) with high crystallinity was synthesized using 2,5-bis(allyloxy)terephthalohydrazide (DHzDAll) and 4,4′,4″-(1,3,5-triazine-2,4,6-triyl)tribenzaldehyde (TTB) as precursors at room temperature. COF-YYL demonstrated superior characteristics including a high specific surface area (653.33 m2·g−1), good chemical and thermal stability, and dual-functionality in detecting methyl orange (MO) and Cu2+ with limits of detection (LODs) of 33 nM (2.1 ng·mL−1) and 1 ng·mL−1, respectively, and an MO adsorption capacity of 112.81 mg·g−1. To increase functional diversity, COF-YYL underwent post-modification via “click” chemistry between the double bonds on DHzDAll and −SH on 3-mercapto-1-propanesulfonic acid sodium salt (MPS), yielding COF-SO3Na. Compared with COF-YYL, COF-SO3Na exhibited a higher specific surface area (815.23 m2·g−1), better dispersion performance, and richer functional group properties. Leveraging these advantages, COF-SO3Na served as a dual-function platform for detecting and adsorbing four cationic dyes including brilliant green (BG), crystal violet (CV), malachite green (MG), and methylene blue (MB), with satisfactory LODs (170 ng·mL−1) and good adsorption capacities ranging from 98.94 to 162.87 mg·g−1. Further, COF-YYL and COF-SO3Na were used to analyze related analytes in tap water samples, achieving satisfactory recoveries. This study introduces a new high-crystallinity hydrazone-linked fluorescent COF, along with its sulfonated material, increasing the diversity of detection and adsorption platforms.

A Strategic Synthesis of Orange Waste-Derived Porous Carbon via a Freeze-Drying Method: Morphological Characterization and Cytocompatibility Evaluation.

Porous carbon materials from food waste have gained growing interest worldwide for multiple applications due to their natural abundance and the sustainability of the raw materials and the cost-effective synthetic processing. Herein, orange waste-derived porous carbon (OWPC) was developed through a freeze-drying method to prevent the demolition of the original biomass structure and then was pyrolyzed to create a large number of micro, meso and macro pores. The novelty of this work lies in the fact of using the macro-channels of the orange waste in order to create a macroporous network via the freeze-drying method which remains after the pyrolysis steps and creates space for the development of different types of porous in the micro and meso scale in a controlled way. The results showed the successful preparation of a porous carbon material with a high specific surface area of 644 m2 g-1 without any physical or chemical activation. The material's cytocompatibility was also investigated against a fibroblast cell line (NIH/3T3 cells). OWPC triggered a mild intracellular reactive oxygen species production without initiating apoptosis or severely affecting cell proliferation and survival. The combination of their physicochemical characteristics and high cytocompatibility renders them promising materials for further use in biomedical and pharmaceutical applications.

Exploratory Investigation of Zinc-Modified Borosilicate Bioactive Glass: A New Methodology for Its Biocompatibility, Immunoregulation, and Pro-Angiogenic Property Evaluation.

The assessment of biodegradable materials, such as bioactive glass, under the existing ISO 10993 standard test methods poses a significant challenge due to potential cell viability impairment caused by the accumulation of degraded products in a static environment. Therefore, innovative methodologies are urgently needed to tailor the unique biodegradation characteristics of these materials, providing more precise and scientific insights into biosafety and efficacy verification. Motivation by its bidirectional regulation of angiogenesis and immunity, zinc (Zn) was incorporated into sol-gel-derived borosilicate bioactive glasses (SBSGs) to fabricate Zn-incorporated borosilicate bioactive glasses (SBSG-Zn) to complement the tissue repair capabilities of bioactive glasses. Both SBSG and SBSG-Zn glasses consist of nanosized particles, slit mesoporous pores, high specific surface areas, and bioreactivity. In vitro comparative analysis, conducted according to ISO 10993 standards, demonstrates that only at suitable dilution rates─such as the 8-fold dilution employed in this study─do extracts of SBSG and SBSG-Zn glasses exhibit low cytotoxicity when cultured with human umbilical vein endothelial cells (HUVECs). Notably, SBSG-Zn glasses show optimal promotion of angiogenic gene expression in HUVECs. Furthermore, within an appropriate concentration range of released ions, SBSG-Zn glass extracts not only promote cell survival but also modulate the expression of anti-inflammatory genes while simultaneously inhibiting pro-inflammatory genes concurrently. After being implanted in rat subcutaneous defect models, both SBSG and SBSG-Zn glasses demonstrated the local immunoregulation and angiogenic effects. SBSG-Zn stands out by demonstrating superior modulation of M1/M2 polarization in macrophages as validated by altered secretion of key factors in macrophages and expression of relevant growth factors in HUVECs. These findings underscore the potential for convenient manipulation of localized angiogenic and immunoregulation through the incorporation of zinc into bioactive glass, emphasizing the importance of ensuring the appropriate ion doses are applied for achieving optimal therapeutic efficiency.