Vortex-induced vibration (VIV) of a bluff body is well known as a canonical phenomenon in complex fluid–structure interactions (FSI). However, our understanding and physical theories of this phenomenon are still restricted to a lower Reynolds number (Re) range owing to the limitations of experimental fluid mechanics. Herein, we describe a virtual physical framework (VPF) capable of editing and controlling the physical parameters of an actual physical system with high fidelity by combining numerical disciplinary and mechanical actuators. We demonstrated the effectiveness of applying a VPF to address the experimental fluid mechanical challenges of vortex-induced vibration (VIV) for a bluff body at a high Re by virtualizing a large, flexibly mounted rigid cylindrical system. We observed the VIV evolution of the bluff body at different Re values. Notably, the VIV appears in its “soar” stages with unexpected amplitudes of 2.4 D, nearly 200% higher than the traditionally acknowledged value at approximately Re = 2.0E5, while suddenly entering into its “death” stages with no vibrations over the critical Re region. The dissynchrony changes in the energy dissipation and input with Re caused by drag and excitation forces in the fluid system were further found to result in these VIV phenomena. This discovery upsets previous perceptions of VIVs and raises profound questions regarding related engineering projects. The VPF also opens a promising paradigm in experimental research for accelerating scientific discovery and investigating unaddressed classical physical phenomena.