High Sociability Research Articles

Genes showing altered expression in the medial preoptic area in the highly social maternal phenotype are related to autism and other disorders with social deficits

BackgroundThe mother-child relationship is the most fundamental social bond in mammals, and previous studies indicate that the medial preoptic area (MPOA) contributes to this increase in sociability. It is possible that the same genes that lead to elevated sociability in one condition (the maternal state) might also be dysregulated in some disorders with social deficits (e.g. autism). In this study, we examined whether there was enrichment (greater than chance overlap) for social deficit disorder related genes in MPOA microarray results between virgin and postpartum female mice. We utilized microarrays to assess large scale gene expression changes in the MPOA of virgin and postpartum mice. The Modular Single Set Enrichment Test (MSET) was used to determine if mental health disorder related genes were enriched in significant microarray results. Additional resources, such as ToppCluster, NIH DAVID, and weighted co-expression network analysis (WGCNA) were used to analyze enrichment for specific gene clusters or indirect relationships between significant genes of interest. Finally, a subset of microarray results was validated using quantitative PCR.ResultsSignificant postpartum MPOA microarray results were enriched for multiple disorders that include social deficits, including autism, bipolar disorder, depression, and schizophrenia. Together, 98 autism-related genes were identified from the significant microarray results. Further, ToppCluser and NIH DAVID identified a large number of postpartum genes related to ion channel activity and CNS development, and also suggested a role for microRNAs in regulating maternal gene expression. WGCNA identified a module of genes associated with the postpartum phenotype, and identified indirect links between transcription factors and other genes of interest.ConclusionThe transition to the maternal state involves great CNS plasticity and increased sociability. We identified multiple novel genes that overlap between the postpartum MPOA (high sociability) and mental health disorders with low sociability. Thus, the activity or interactions of the same genes may be altering social behaviors in different directions in different conditions. Maternity also involves elevated risks for disorders, including depression, psychosis, and BPD, so identification of maternal genes common to these disorders may provide insights into the elevated vulnerability of the maternal brain.

Neuroimaging Evidence of Major Morpho-Anatomical and Functional Abnormalities in the BTBR T+TF/J Mouse Model of Autism

BTBR T+tf/J (BTBR) mice display prominent behavioural deficits analogous to the defining symptoms of autism, a feature that has prompted a widespread use of the model in preclinical autism research. Because neuro-behavioural traits are described with respect to reference populations, multiple investigators have examined and described the behaviour of BTBR mice against that exhibited by C57BL/6J (B6), a mouse line characterised by high sociability and low self-grooming. In an attempt to probe the translational relevance of this comparison for autism research, we used Magnetic Resonance Imaging (MRI) to map in both strain multiple morpho-anatomical and functional neuroimaging readouts that have been extensively used in patient populations. Diffusion tensor tractography confirmed previous reports of callosal agenesis and lack of hippocampal commissure in BTBR mice, and revealed a concomitant rostro-caudal reorganisation of major cortical white matter bundles. Intact inter-hemispheric tracts were found in the anterior commissure, ventro-medial thalamus, and in a strain-specific white matter formation located above the third ventricle. BTBR also exhibited decreased fronto-cortical, occipital and thalamic gray matter volume and widespread reductions in cortical thickness with respect to control B6 mice. Foci of increased gray matter volume and thickness were observed in the medial prefrontal and insular cortex. Mapping of resting-state brain activity using cerebral blood volume weighted fMRI revealed reduced cortico-thalamic function together with foci of increased activity in the hypothalamus and dorsal hippocampus of BTBR mice. Collectively, our results show pronounced functional and structural abnormalities in the brain of BTBR mice with respect to control B6 mice. The large and widespread white and gray matter abnormalities observed do not appear to be representative of the neuroanatomical alterations typically observed in autistic patients. The presence of reduced fronto-cortical metabolism is of potential translational relevance, as this feature recapitulates previously-reported clinical observations.

Activative fathering predicts later children's behaviour dysregulation and sociability

This study examined activative fathering observed during father–child interactions in the family home, focusing on the relation between activative fathering at children aged four and children's behaviour dysregulation and sociability at children aged five. One hundred twenty-seven families participated in the study. Activative fathering was associated with later lower child dysregulation during a problem solving task, higher dysregulation during a wait task, and higher sociability in the home. Contrary to expectations, paternal control did not moderate these relations. Results are discussed in relation to father–child activation relationship theory.

Neuroanatomical analysis of the BTBR mouse model of autism using magnetic resonance imaging and diffusion tensor imaging

Autism is a neurodevelopmental disorder characterized by abnormal reciprocal social interactions, communication deficits, and repetitive behaviors with restricted interests. Autism-relevant phenotypes in the inbred mouse strain BTBR T+tf/J (BTBR) offer translational tools to discover biological mechanisms underlying unusual mouse behaviors analogous to symptoms of autism. Two of the most consistent findings with BTBR are lack of sociability as measured by the three-chamber social approach task and increased amount of time engaged in self-grooming in an empty cage. Here we evaluated BTBR as compared to two typical inbred strains with high sociability and low self-grooming, C57BL/6J (B6) and FVB/AntJ (FVB), on both the automated three-chambered social approach task and repetitive self-grooming assays. Brains from the behaviorally tested mice were analyzed using magnetic resonance imaging and diffusion tensor imaging to investigate potential neuroanatomical abnormalities throughout the brain; specifically, to discover neuroanatomical mechanisms which could explain the autism-relevant behavioral abnormalities. Significant differences in volume and white matter microstructure were detected in multiple anatomical regions throughout the brain of BTBR compared to B6 and FVB. Further, significant correlations were found between behavioral measures and areas of the brain known to be associated with those behaviors. For example, striatal volume was strongly correlated to time spent in self-grooming across strains. Our findings suggest that neuropathology exists in BTBR beyond the previously reported white matter abnormalities in the corpus callosum and hippocampal commissure and that these brain differences may be related to the behavioral abnormalities seen in BTBR.

Do you have a question for me? How children with Williams syndrome respond to ambiguous referential communication during a joint activity

Research on language in individuals with Williams syndrome (WS) has been fueled by persistent theoretical controversies for two decades. These shifted from initial focus on dissociations between language and cognition functions, to examining the paradox of socio-communicative impairments despite high sociability and relatively proficient expressive language. We investigated possible sources of communicative difficulties in WS in a collaborative referential communication game. Five- to thirteen-year-old children with WS were compared to verbal mental age- and to chronological age-matched typically developing children in their ability to consider different types of information to select a speaker's intended referent from an array of items. Significant group differences in attention deployment to object locations, and in the number and types of clarification requests, indicated the use of less efficient and less mature strategies for reference resolution in WS than expected based on mental age, despite learning effects similar to those of the comparison groups, shown as the game progressed.

Do more sociable dogs gaze longer to the human face than less sociable ones?

Domestic dogs (Canis familiaris) are especially skillful in communicating with humans, and they rely on special abilities to do that. One of these skills involves gazing at human faces in cases of uncertainty or when seeking for something out of reach. In this study, we evaluated the relationship between dogs' sociability level and the ability to learn to gaze in a situation with food in sight but out of their reach. Thirty-nine adult dogs were tested in two procedures: (1) a sociability test that involved interacting with an unknown person, and (2) a learning task that consisted of training trials in which gazing at the experimenter's face was food reinforced, followed by extinction trials in which gazing was not followed by food. A significant positive correlation was found between the duration of physical contact with the unknown person in the sociability test and gaze duration during extinction. Moreover, high sociability dogs gazed significantly longer at humans during extinction trials. We discuss the possibility that, more sociable animals, such as those who pay more attention to the person in our sociability test, may be more persistent in their communicative attempts because the presence of the human is intrinsically reinforcing to them. Finally, we comment on the importance of these findings for training purposes.

Low sociability in BTBR T + tf/J mice is independent of partner strain

Inbred mouse strains differ greatly in social behaviors, making them a valuable resource to study genetic and non-genetic mechanisms underlying social deficits relevant to autism spectrum disorders. A hallmark symptom of autism is a lack of ability to understand other people's thoughts and intentions, which leads to impairments in adjusting behaviors in response to ever-changing social situations in daily life. We compared the ability of BTBR T+tf/J (BTBR), a strain with low sociability, and C57BL/6J (B6), a strain with high sociability, for their abilities to modulate responses to social cues from different partners in the reciprocal social interaction test. Results indicate that BTBR exhibited low sociability toward different partners and displayed minimal ability to modify behaviors toward different partners. In contrast, B6 showed high sociability toward different partners and was able to modify social behaviors toward different partners. Consistent results were found in two independent cohorts of different ages, and in both sexes. In the three-chambered test, high sociability in B6 and low sociability in BTBR were independent of strain of the novel mouse. Since social deficits in BTBR could potentially be caused by physical disabilities in detecting social olfactory cues, or in cognitive abilities, we tested BTBR and B6 mice on measures of olfaction and cognition. BTBR mice displayed more sniffing of social odors emitted by soiled bedding than of an odorless novel object, but failed to show a preference for a live novel mouse over a novel object. On olfactory habituation/dishabituation to a sequence of odors, BTBR displayed discrimination abilities across three non-social and two social odors. However, as compared to B6, BTBR displayed less sniff time for both non-social and social odors, and no significant dishabituation between cage odors from two different novel mouse strains, findings that will be important to investigate further. BTBR was generally normal in spatial acquisition on the Morris water maze test, but showed deficits in reversal learning. Time spent freezing on contextual and cued fear conditioning was lower in BTBR than in B6. Our findings suggest that BTBR has poor abilities to modulate its responses to different social partners, which may be analogous to social cognition deficits in autism, adding to the value of this strain as a mouse model of autism.

Effect of Emotions and Sociability on Human Decisions

In the recent trends of research in cognitive science, psychology, neurology etc., emotions and sociability attracted the scientifically attention from decision researchers who are working in interdisciplinary areas. Decision making was viewed as a cognitive processa matter of estimating which of various alternative actions would yield the most positive consequences. Humans or decision makers are assumed to evaluate the potential consequences of their decisions dispassionately and to choose actions that maximized the utility of those consequences. The last several years, however, have witnessed a burst of interest in the role of emotions in decision making. Research conducted within the last decade has shown that even incidental affect that is unrelated to the decisions at hand can have a significant impact on judgment and choice (Bagozzi, Dholakia, & Basuroy, 2003; Barnes, & Thagard, 1996). Emotional deficits, whether innate or experimentally induced can degrade the quality of decision making (Damasio, 1994). Incorporating affect in models of decision making can greatly increase their explanatory power. Thus, contemporary decision research is characterized by an intense focus on emotions in behavioral and cognitive perspectives.In a similar line, we have several supported views of inculcating the minds of researchers in the role of sociability in decision making process. Sociability is an interpersonal skill or potential element to promote the thought process and insights and new emotion-related developments in order to make effective decisions. Thus the researchers concentrate to explore the influence of sociability on decision making in cognitive and behavioral dimensions. Human performance in the domain of decision taking has been the subject of active research from several perspectives. From a psychological perspective, it is necessary to examine individual decisions in the context of a set of needs, preferences and values they seek. From a cognitive perspective, the decision making process must be regarded as a continuous process integrated in the interaction of human with environment. From a normative perspective, the analysis of individual decisions is concerned with the logic of decision making and rationality along with the invariant choice it leads to.Yet, at another level, it might be regarded as a problem solving activity which is terminated when a satisfactory solution is reached. Therefore, decision making is a reasoning or emotional process which can be rational or irrational, based on explicit assumptions or tacit assumptions. As sociability influences the human decisions, People with low sociability due to lack of required interpersonal communication and social skills cannot make decisions on the frontline. These people may work better in situations that limit social interaction. People with high sociability work well with direct contact and communication skills for making effective decisions. In this dimension, the emotions and sociability plays vital role in psychological perspectives with emotional stability in making effective decisions.The variety of emotions and sociability in different perspectives, have major role in designing the network of decisions. Behind every decision in cognitive and behavioral aspects the brain circuitry allows the emotions in two pathways namely direct and indirect ways.Recent research suggests that emotions are just as influential as cognitive processes when it comes to decision making. This is interesting because emotions are often considered irrational occurrences that may distort reasoning (Barnes & Thagard, 1996). Research done by Isen and Patrick (1983) put forth the theory of mood maintenance which states that happy decision-makers are reluctant to gamble. In other words happy people decide against gambling, since they would not want to undermine the happy feeling. Raghunathan and Pham (1999) studied that emotions cannot simply be classified as positive or negative as we need to consider the consequences of the emotions in ultimate decision-making. …

Sociability and brain development in BALB/cJ and C57BL/6J mice

Sociability—the tendency to seek social interaction—propels the development of social cognition and social skills, but is disrupted in autism spectrum disorders (ASD). BALB/cJ and C57BL/6J inbred mouse strains are useful models of low and high levels of juvenile sociability, respectively, but the neurobiological and developmental factors that account for the strains’ contrasting sociability levels are largely unknown. We hypothesized that BALB/cJ mice would show increasing sociability with age but that C57BL/6J mice would show high sociability throughout development. We also hypothesized that littermates would resemble one another in sociability more than non-littermates. Finally, we hypothesized that low sociability would be associated with low corpus callosum size and increased brain size in BALB/cJ mice. Separate cohorts of C57BL/6J and BALB/cJ mice were tested for sociability at 19-, 23-, 31-, 42-, or 70-days-of-age, and brain weights and mid-sagittal corpus callosum area were measured. BALB/cJ sociability increased with age, and a strain by age interaction in sociability between 31 and 42 days of age suggested strong effects of puberty on sociability development. Sociability scores clustered according to litter membership in both strains, and perinatal litter size and sex ratio were identified as factors that contributed to this clustering in C57BL/6J, but not BALB/cJ, litters. There was no association between corpus callosum size and sociability, but smaller brains were associated with lower sociability in BALB/cJ mice. The associations reported here will provide directions for future mechanistic studies of sociability development.

Interações sociais e proficiência motora em escolares do ensino fundamental

Este estudo discute características de crianças que ingressam no ensino fundamental. Mais especificamente, o objetivo do estudo foi analisar a proficiência motora dessas crianças em relação com o nível socioeconômico e as interações sociais. O trabalho foi realizado com 30 crianças, as quais foram analisadas a partir do cruzamento de dados provenientes de teste de proficiência motora, questionário socioeconômico, observação direta e sociograma. Os resultados apontam que existe significância entre índices maiores de renda e sociabilidade com proficiência motora. Entretanto, o estudo também aponta para os desvios em relação à tendência encontrada, refletindo sobre a necessidade em se analisar os fatores macroscópicos do desenvolvimento sem recorrer a determinismos.

Using novel control groups to dissect the amygdala's role in Williams syndrome

Williams syndrome is a neurodevelopmental disorder with an intriguing behavioral phenotype—hypersociability combined with significant non-social fears. Previous studies have demonstrated abnormalities in amygdala function in individuals with Williams syndrome compared to typically developing controls. However, it remains unclear whether the findings are related to the atypical neurodevelopment in Williams syndrome, or are also associated with behavioral traits at the extreme end of a normal continuum. We used functional magnetic resonance imaging (fMRI) to compare amygdala blood-oxygenation-level-dependent (BOLD) responses to non-social and social images in individuals with Williams syndrome compared to either individuals with inhibited temperament (high non-social fear) or individuals with uninhibited temperament (high sociability). Individuals with Williams syndrome had larger amygdala BOLD responses when viewing the non-social fear images than the inhibited temperament control group. In contrast, when viewing both fear and neutral social images, individuals with Williams syndrome did not show smaller amygdala BOLD responses relative to the uninhibited temperament control group, but instead had amygdala responses proportionate to their sociability. These results suggest heightened amygdala response to non-social fear images is characteristic of WS, whereas variability in amygdala response to social fear images is proportionate to, and might be explained by, levels of trait sociability.

Social peers rescue autism‐relevant sociability deficits in adolescent mice

Behavioral therapies are currently the most effective interventions for treating the diagnostic symptoms of autism. We employed a mouse model of autism to evaluate components of behavioral interventions that improve sociability in mice. BTBR T+tf/J (BTBR) is an inbred mouse strain that exhibits prominent behavioral phenotypes with face validity to all three diagnostic symptom categories of autism, including robust and well-replicated deficits in social approach and reciprocal social interactions. To investigate the role of peer interactions in the development of sociability, BTBR juvenile mice were reared in the same home cage with juvenile mice of a highly social inbred strain, C57BL/6J (B6). Subject mice were tested as young adults for sociability and repetitive behaviors. B6 controls reared with B6 showed their strain-typical high sociability. BTBR controls reared with BTBR showed their strain-typical lack of sociability. In contrast, BTBR reared with B6 as juveniles showed significant sociability as young adults. A 20-day intervention was as effective as a 40-day intervention for improving social approach behavior. High levels of repetitive self-grooming in BTBR were not rescued by peer-rearing with B6, indicating specificity of the intervention to the social domain. These results from a robust mouse model of autism support the interpretation that social enrichment with juvenile peers is a beneficial intervention for improving adult outcome in the social domain. This novel paradigm may prove useful for discovering factors that are essential for effective behavioral treatments, and biological mechanisms underlying effective behavioral interventions.

Low stress reactivity and neuroendocrine factors in the BTBR T +tf/J mouse model of autism

Autism is a neurodevelopmental disorder characterized by abnormal reciprocal social interactions, communication deficits, and repetitive behaviors with restricted interests. BTBR T+tf/J (BTBR) is an inbred mouse strain that displays robust behavioral phenotypes with analogies to all three of the diagnostic symptoms of autism, including low social interactions, reduced vocalizations in social settings, and high levels of repetitive self-grooming. Autism-relevant phenotypes in BTBR offer translational tools to discover neurochemical mechanisms underlying unusual mouse behaviors relevant to symptoms of autism. Because repetitive self-grooming in mice may be a displacement behavior elevated by stressors, we investigated neuroendocrine markers of stress and behavioral reactivity to stressors in BTBR mice, as compared to C57BL/6J (B6), a standard inbred strain with high sociability. Radioimmunoassays replicated previous findings that circulating corticosterone is higher in BTBR than in B6. Higher basal glucocorticoid receptor mRNA and higher oxytocin peptide levels were detected in the brains of BTBR as compared to B6. No significant differences were detected in corticotrophin releasing factor (CRF) peptide or CRF mRNA. In response to behavioral stressors, BTBR and B6 were generally similar on behavioral tasks including stress-induced hyperthermia, elevated plus-maze, light ↔ dark exploration, tail flick, acoustic startle and prepulse inhibition. BTBR displayed less reactivity than B6 to a noxious thermal stimulus in the hot plate, and less immobility than B6 in both the forced swim and tail suspension depression-related tasks. BTBR, therefore, exhibited lower depression-like scores than B6 on two standard tests sensitive to antidepressants, did not differ from B6 on two well-validated anxiety-like behaviors, and did not exhibit unusual stress reactivity to sensory stimuli. Our findings support the interpretation that autism-relevant social deficits, vocalizations, and repetitive behaviors are not the result of abnormal stress reactivity in the BTBR mouse model of autism.

How do young people identify with online and offline peer groups? A comparison between UK, Spain and Japan

Peer groups such as neighbourhoods and hobby circles are important sources of social identity for young people, but their viability is challenged by processes of urbanisation and labour mobility. In recent years, traditional peer groups have been joined by easily accessible computer-mediated groups, which have become an everyday part of life in many countries. In this article, we examine how young people identify with various online and offline peer groups. We compare online and offline identification experiences from the perspective of how socio-demographic position and individual sociability characteristics influence them, and examine how these identification processes differ between national contexts. Empirical analyses are conducted based on a survey of online community users from the UK, Spain and Japan (N=4299). It is found that participants identify as strongly with their online communities as they do with their own families, and stronger than with offline hobby groups. In the mature online societies of the UK and Japan, the online group provides a more socio-demographically inclusive source of identification than traditional leisure-time formations. As friends and family move online, affinity towards online groups is more likely to be a reflection of high sociability than a lack of it. Games, social networking sites and other online environments should be seen as crucial contexts for today's youth's socialisation and identification experiences.

Reduced scent marking and ultrasonic vocalizations in the BTBR T+tf/J mouse model of autism.

Qualitative impairments in communication, such as delayed language and poor interactive communication skills, are fundamental to the diagnosis of autism. Investigations into social communication in adult BTBR T+tf/J (BTBR) mice are needed to determine whether this inbred strain incorporates phenotypes relevant to the second diagnostic symptom of autism, communication deficits, along with its strong behavioral phenotypes relevant to the first and third diagnostic symptoms, impairments in social interactions and high levels of repetitive behavior. The aim of the present study was to simultaneously measure female urine-elicited scent marking and ultrasonic vocalizations in adult male BTBR mice, in comparison with a standard control strain with high sociability, C57BL/6J (B6), for the assessment of a potential communication deficit in BTBR. Adult male BTBR mice displayed lower scent marking and minimal ultrasonic vocalization responses to female urine obtained from both B6 and BTBR females. Lower scent marking and ultrasonic vocalizations in a social setting by BTBR, as compared with B6, are consistent with the well-replicated social deficits in this inbred mouse strain. Our findings support the interpretation that BTBR incorporate communication deficits, and suggest that scent marking and ultrasonic vocalizations offer promising measures of interest in social cues that may be widely applicable to investigations of mouse models of autism.

Enhanced prefrontal serotonin 5-HT(1A) currents in a mouse model of Williams-Beuren syndrome with low innate anxiety.

Williams-Beuren syndrome (WBS) is a neurodevelopmental disorder caused by the hemizygous deletion of 28 genes on chromosome 7, including the general transcription factor GTF2IRD1. Mice either hemizygously (Gtf2ird1 +/−) or homozygously (Gtf2ird1 −/−) deleted for this transcription factor exhibit low innate anxiety, low aggression and increased social interaction, a phenotype that shares similarities to the high sociability and disinhibition seen in individuals with WBS. Here, we investigated the inhibitory effects of serotonin (5-HT) on the major output neurons of the prefrontal cortex in Gtf2ird1 −/− mice and their wildtype (WT) siblings. Prefrontal 5-HT receptors are known to modulate anxiety-like behaviors, and the Gtf2ird1 −/− mice have altered 5-HT metabolism in prefrontal cortex. Using whole cell recording from layer V neurons in acute brain slices of prefrontal cortex, we found that 5-HT elicited significantly larger inhibitory, outward currents in Gtf2ird1 −/− mice than in WT controls. In both genotypes, these currents were resistant to action potential blockade with TTX and were suppressed by the selective 5-HT1A receptor antagonist WAY-100635, suggesting that they are mediated directly by 5-HT1A receptors on the recorded neurons. Control experiments suggest a degree of layer and receptor specificity in this enhancement since 5-HT1A receptor-mediated responses in layer II/III pyramidal neurons were unchanged as were responses mediated by two other inhibitory receptors in layer V pyramidal neurons. Furthermore, we demonstrate GTF2IRD1 protein expression by neurons in layer V of the prefrontal cortex. Our finding that 5-HT1A-mediated responses are selectively enhanced in layer V pyramidal neurons of Gtf2ird1 −/− mice gives insight into the cellular mechanisms that underlie reduced innate anxiety and increased sociability in these mice, and may be relevant to the low social anxiety and disinhibition in patients with WBS and their sensitivity to serotonergic medicines.Electronic supplementary materialThe online version of this article (doi:10.1007/s11689-010-9044-5) contains supplementary material, which is available to authorized users.

Repetitive Self-Grooming Behavior in the BTBR Mouse Model of Autism is Blocked by the mGluR5 Antagonist MPEP

Autism is a neurodevelopmental disorder characterized by abnormal reciprocal social interactions, communication deficits, and repetitive behaviors with restricted interests. BTBR T+tf/J (BTBR) is an inbred mouse strain that shows robust behavioral phenotypes with analogies to all three of the diagnostic symptoms of autism, including well-replicated deficits in reciprocal social interactions and social approach, unusual patterns of ultrasonic vocalization, and high levels of repetitive self-grooming. These phenotypes offer straightforward behavioral assays for translational investigations of pharmacological compounds. Two suggested treatments for autism were evaluated in the BTBR mouse model. Methyl-6-phenylethynyl-pyridine (MPEP), an antagonist of the mGluR5 metabotropic glutamate receptor, blocks aberrant phenotypes in the Fmr1 mouse model of Fragile X, a comorbid neurodevelopmental disorder with autistic features. Risperidone has been approved by the United States Food and Drug Administration for the treatment of irritability, tantrums, and self-injurious behavior in autistic individuals. We evaluated the actions of MPEP and risperidone on two BTBR phenotypes, low sociability and high repetitive self-grooming. Open field activity served as an independent control for non-social exploratory activity and motor functions. C57BL/6J (B6), an inbred strain with high sociability and low self-grooming, served as the strain control. MPEP significantly reduced repetitive self-grooming in BTBR, at doses that had no sedating effects on open field activity. Risperidone reduced repetitive self-grooming in BTBR, but only at doses that induced sedation in both strains. No overall improvements in sociability were detected in BTBR after treatment with either MPEP or risperidone. Our findings suggest that antagonists of mGluR5 receptors may have selective therapeutic efficacy in treating repetitive behaviors in autism.

Personality traits affect individual interests in day service activities

To assess the association of user interest in various activities with personality traits for the provision of activity programs at adult day centers. A self-reported questionnaire survey of service users was conducted at 25 day centers in Tokyo; 133 men and 344 women, with a mean age of 81.6 +/- 7.9 years, responded. The questionnaire examined their demographics, lifestyles, requested activities, purpose of activity participation, attitudes toward participation, and personality traits by using the BASIC-3 Personality Inventory (PI)-short version. The participants with higher sociability and novelty-seeking scores on the BASIC-3 PI-short version requested significantly more activities than those with lower scores. Music appreciation and singing were significantly associated with both sociability and novelty-seeking facets. The sociability facets were significantly associated with activities, such as walking and interaction with children, while the novelty-seeking facets were significantly associated with contact with animals and the Internet. There was no significant relationship between the neuroticism facets and any specific activity. Flower arrangement, handicrafts, fashion or make up, cooking, and singing were significantly more frequently requested by the women than by the men, while shogi or mahjong was requested significantly more frequently by the men than by the women. Sociability and novelty-seeking facets, sex, and age were significantly associated with an interest in particular activities. We recommend that adult day centers create a system under which nurses and formal caregivers fully assess the elderly in order to provide activity programs based on user needs.

Amygdala response to faces parallels social behavior in Williams syndrome.

Individuals with Williams syndrome (WS), a genetically determined disorder, show relatively strong face-processing abilities despite poor visuospatial skills and depressed intellectual function. Interestingly, beginning early in childhood they also show an unusually high level of interest in face-to-face social interaction. We employed functional magnetic resonance imaging (fMRI) to investigate physiological responses in face-sensitive brain regions, including ventral occipito-temporal cortex and the amygdala, in this unique genetic disorder. Participants included 17 individuals with WS, 17 age- and gender-matched healthy adults (chronological age-matched controls, CA) and 17 typically developing 8- to 9-year-old children (developmental age controls, DA). While engaged in a face discrimination task, WS participants failed to recruit the amygdala, unlike both CA and DA controls. WS fMRI responses in ventral occipito-temporal cortex, however, were comparable to those of DA controls. Given the integral role of the amygdala in social behavior, the failure of WS participants to recruit this region during face processing may be a neural correlate of the abnormally high sociability that characterizes this disorder.

Admissions of Cats to Animal Welfare Shelters in Melbourne, Australia

Although the number of companion animal (pet) cats (Felis catus) in Australia is decreasing, there has not been a corresponding reduction in feline admissions to nonhuman animal welfare shelters. This study tracked 15,206 cat admissions to 1 large Melbourne shelter over a 12-month period. Data collected included factors believed indicative of the cats' source subpopulation, including body condition, injuries, and sociability. The majority (81.6%) of admissions were strays. Overall desexing levels were low (4%), even among caregiver (owner)-relinquished cats (12.8%). The high sociability of many stray cats and kittens suggests that many may be “semiowned” animals. Colony cats were typically thinner and in poorer health than other admissions. The pattern of kitten admissions suggests that many queens are producing 2 litters per season. The majority of cats admitted were euthanized, indicating that there is an oversupply of cats in Melbourne, Australia, and that strategies to reduce the euthanasia rate need to target the subpopulations of cats who contribute to the current oversupply.