High Incidence Of Disease Research Articles

Myocardial Perfusion Scintigraphy in Diagnosic of Coronary Heart Disease

<i>Introduction: </i>Atherosclerosis plays a key role in the etiopathogenesis of cardiovascular diseases. Atherosclerosis is a generalized chronic inflammatory disease of the vascular wall, which results in anatomical and histological changes that, together with functional changes, lead to endothelial dysfunction, narrowing of the arterial lumen, and insufficient blood supply to the tissues. The shift in the incidence of cardiovascular diseases to younger age groups is alarming. The presence of microvascular changes in the myocardium is significant. The high incidence of cardiovascular diseases, especially ischemic heart disease, requires early diagnosis and modern treatment. <i>Aim: </i>The aim of the paper is to analyse and point out early diagnosis of coronary heart disease using nuclear medicine methods. <i>Set of examined patients and methodology: </i>Using nuclear medicine methods, we try to detect these changes in time and thus prevent the occurrence of acute coronary events. In nuclear cardiology, instead of a large-area scintillation detector, a new type of cardio-gamma camera "Discovery CZT 530c" based on the principle of semiconductor detectors began to be used. The abbreviation CZT stands for semiconductor composition (Cadmium-Zinc-Tellur). The set of respondents consisted of 4270 people examined in the years 2014-2016 by myocardial perfusion scintigraphy. There were 950 diabetic patients in the analysed group of the 4270 examined. <i>Results:</i> In the analysed group of 4270 respondents, 61% had negative findings and 39% had positive findings in terms of the presence of ischemic heart disease. In the group of diabetic patients, there was a negative finding in 28% of respondents and a positive finding in 72% of the respondents in the sense of positive ischemic heart disease. Using myocardial perfusion scintigraphy in the diagnosis of functional changes, we confirmed a great benefit in detecting early changes in coronary heart disease, including in the diagnosis of microvascular angina. <i>Conclusion:</i> Nuclear medicine methods are of great benefit for the diagnosis of small vessel disease, diabetic cardiomyopathy and cardiac autonomic neuropathy in patients with diabetes mellitus. The new type of cardio gamma camera "Discovery CZT 530c" allows more accurate assessment of myocardial perfusion abnormalities and at the same time the reduction of the radiopharmaceutical dose reduces the patient's radiation load by 50%.

Pseudoperonospora cubensis Causing Downy Mildew on Luffa aegyptiaca in Korea

In November 2021, sponge gourd (<i>Luffa aegyptiaca</i>) plants with typical downy mildew symptom were observed in Korea. Based on morphological characteristics of sporangiophores and sporangia, combined with molecular phylogenetic analysis of the internal transcribed spacer rDNA and <i>cox</i>2 mtDNA regions, the causal pathogen was identified as <i>Pseudoperonospora cubensis</i> (Oomycota). This is the first report of downy mildew caused by <i>P. cubensis</i> on <i>L. aegyptiaca</i> in Korea. Given that <i>P. cubensis</i> exhibits high disease incidence and severity on many Cucurbitaceae crops, it could pose a significant threat to sponge gourd cultivation.

Evaluation of Reduced Fungicide Applications for Disease Management in Cold-Climate Wine Grapes in Wisconsin.

Cold-climate wine grapes are produced on 8,000 ha in the North Central region of the United States. Wisconsin has experienced considerable growth, with a 26% increase in acreage since 2017. Chemical management of fungal diseases in cold-climate, interspecific hybrid grapes mirrors that of traditional Vitis vinifera cultivars despite significant differences in disease susceptibility. Most cold-climate cultivars display disease tolerance or resistance to key pathogens such as Plasmopara viticola (downy mildew), Erysiphe necator (powdery mildew), and Phyllosticta ampelicida (black rot). Current fungicide programs in Wisconsin's cold-climate grape industry underutilize genetic resistance, resulting in overreliance on at-risk fungicides and an increased threat of fungicide resistance development. In vineyard trials, the impacts of a reduced fungicide application number compared to current grower "Standard" programs was assessed for disease incidence and severity for five diseases: anthracnose, black rot, downy mildew, Phomopsis cane and leaf spot and powdery mildew. In 2022, with moderate disease pressure at both vineyard sites, there were no significant differences observed when fewer fungicides (six or five applications vs. four applications) were applied. In 2023, higher disease incidence was observed in the "Standard" spray program at one study location which received a greater number of fungicide applications. In both years, grape cultivar was a significant factor with the 'LaCrosse' displaying greater average disease severity than the 'St. Pepin' in both the "Standard" and "Reduced" Programs. These findings present a promising opportunity for cold-climate grape growers to reduce the number of fungicide applications while maintaining disease control and marketable yield.

Environmental impacts of cement production in Ewekoro, Ogun State, southwestern Nigeria from 2005 to 2006 on surface water quality, vegetation, and workers' health

ABSTRACT The present study investigated the environmental impacts of cement production on surface water quality and vegetation in the vicinity of the industry. A 2-year study was conducted, covering both wet and dry seasons. Water samples were collected from the Akinbo River, where the cement industry discharges its liquid waste and effluents, and analysed for physical and chemical parameters using standard procedures. The vegetation around the factory was analysed for chlorophyll, plant density, basal areas, and heights of woody species. The study also assessed the health impacts of cement production on the factory employees and the residents living in the vicinity of the factory. The health assessment was based on hospital information obtained from two clinics in the villages near the factory. The water quality results revealed elevated concentrations of Ca and Fe. All the trees sampled around the study area had small basal areas and short heights. There was also a significant reduction in the chlorophyll contents of the vegetation. The health study showed a high incidence of upper-respiratory tract infections, cardiovascular diseases, arthritis, and dermatitis among factory workers. This study suggests a review of the existing dust-suppressing system put in place by the industry, to protect public health.

Leaf-whorl inoculation with Sporisorium reilianum may overcome field resistance of maize.

Maize yield is threatened by increasing incidences of head smut disease caused by Sporisorium reilianum. To help breeders identify S. reilianum-resistant maize lines, the availability of efficient screening systems would be an advantage. Here we assessed maize lines with distinct levels of field resistance against head smut disease in greenhouse experiments using two different inoculation techniques. Addition of mixtures of mating-compatible sporidia to the soil at seedling stage of the plant did not lead to plant disease, and we could detect only marginal amounts of fungal DNA in apical meristems at eighteen days after sowing. Inoculation of the maize lines by leaf-whorl inoculation led to both high disease incidence and prominent levels of fungal DNA in apical meristems in all tested maize lines regardless of their field resistance levels. Thus, S. reilianum entering the plant via the leaf whorl can escape existing resistance mechanisms of currently known field-resistant maize lines. Since field-resistant lines are also resistant to inoculation via teliospore-contaminated soil, we propose teliospore addition to seeds at the time of sowing (rather than leaf-whorl inoculation of seedlings) combined with quantitative detection of fungal DNA in apical meristems, as an efficient screening procedure to discover field-resistant lines. However, screening maize plants for resistance against the leaf-whorl inoculation method might be promising for the discovery of novel resistance mechanisms needed to develop durably resistant maize lines.

Barriers to the Uptake of Tickborne Disease Prevention Measures: Connecticut, Maryland 2016-2017.

Public health programs promote numerous tickborne disease (TBD) prevention measures. However, measures are not frequently or consistently performed. Describe barriers to consistent use of 4 commonly promoted TBD prevention measures. We conducted an online survey (n=1883) evaluating behaviors regarding TBD prevention measures including conducting tick checks, applying insect repellents, showering/bathing, and applying chemical or natural pesticides to residential yards. Respondents could select reasons for never, rarely, or sometimes performing these measures. Descriptive analysis and logistic regression modeling evaluated associations between the 3 most cited barriers for each measure and select demographic variables. The survey was administered to residents in high Lyme disease incidence counties of Connecticut and Maryland, 2016-2017. For tick checks (n=800), the most cited barriers were forgetting (63%), not spending time in tick habitat (28%), and too much trouble (11%). For applying insect repellents (n=1303), the most cited barriers were forgetting (38%), personal safety concerns (24%), and too much trouble (19%). For showering/bathing 2 hours after outdoor activity in tick habitat (n=1080), the most cited barriers were being unaware of the prevention measure (51%), too much trouble (18%), and forgetting (18%). For applying chemical pesticides to yards (n=1320), the most cited barriers were having environmental (45%), pet safety (31%), and personal safety concerns (28%). Lastly, for applying natural pesticides to yards (n=1357), the most cited barriers were being unaware of natural pesticides (31%), having cost concerns (23%), and not being concerned about ticks on property (16%). Forgetting, too much trouble, unawareness, and safety concerns were primary barriers to using several TBD prevention measures. Education regarding effectiveness, safety, and timing may increase uptake of certain measures. These challenges can be difficult to address, highlighting the need for passive TBD prevention measures, such as a Lyme disease vaccine.

Etiopathogenetic features of bone metabolism in patients with diabetes mellitus and Charcot foot

Diabetic neuropathy is one of the most common diabetes mellitus complications associated with mediocalcinosis of the lower extremities, a significant decrease in feet bone mineral density, and a high incidence of cardiovascular disease. In most cases, calcium-phosphorus metabolism changes occur in patients with diabetic neuroarthropathy, or Charcot foot, when we can observe feet local osteoporosis, which in 90% of cases associated with a vessel's calcification of the lower extremities in the majority of diabetes population. A large number of studies presented literature have demonstrated that patients with Charcot foot can have accelerated bone metabolism and increased bone resorption. Patients with Charcot foot often have crucial abnormalities in the calcium-phosphorus parameters, bone metabolism, and levels of vitamin D and its metabolites. In addition, the duration of diabetes mellitus, the degree of its compensation widely affects the development of its micro- and macrovascular complications, which could also accelerate the development of mineral and bone disorders in these types of patients. Multifactorial pathogenesis of these disorders complicates the management of patients with a long and complicated course of diabetes mellitus. This review discusses the peculiarities of vitamin D metabolism, the importance of timely diagnosis in phosphorus-calcium disorders, and the specifics of therapy in these patients. Special attention is paid to the timely diagnosis of the Charcot's foots acute stage based on the bone marrow edema by MRI evaluation and the possibility of reducing the immobilization period.

Epidemiology of Canine Wei Syndrome and Its Hemorheology Characteristics.

Canine paraplegia is a common condition in small animal medicine, referred to as Wei Syndrome (WS) in Traditional Chinese Veterinary Medicine (TCVM). Common clinical manifestations encompass hind limb paralysis, motor dysfunction, muscle atrophy, and the absence of pain perception. WS is considered a difficult-to-treat disease in small animal practice. The objective of this study was to investigate the epidemiology of canine WS and the characteristics of hemorheology. A total of 53 dogs with WS and 53 healthy dogs were included in this study. A retrospective case-controlled study design was employed. Data regarding the gender, season of WS occurrence, breed, and age of dogs with WS, as well as hemorheology from dogs with WS and healthy dogs, were collected and analyzed using SPSS 27.0. The study findings revealed that male dogs were more susceptible to WS (77.36%, 41/53). WS cases occurred more frequently in Winter (33.96%, 18/53), and were commonly found in Poodle breeds (43.40%, 23/53). The most affected age of WS was between 3 and 6 years old (54.72%, 29/53). Except for plasma viscosity and fibrinogen, the hemorheology indices of canine WS were significantly higher than those of healthy dogs (p < 0.05), especially in male dogs, Poodles and Bulldogs, those between 3 to 10 years, and in Autumn and Winter. This study provides evidence that male Poodles and Bulldogs aged 3 to 6 years are more prone to developing WS, with Winter being the season of high disease incidence. Abnormal hemorheology is a characteristic feature in dogs with WS, which should be considered during the treatment of WS.

Community Health Needs Assessment of Primary Healthcare in Saudi Arabia: A Cross-Sectional Study.

Continuous assessment of community health needs is essential to predict, recognize, and act on healthcare issues. Conducting community health needs assessments (CHNAs) in Saudi Arabia has become a priority to overcome the current healthcare challenges and keep pace with the Saudi Arabia 2030 vision. Studies reporting community health needs in Saudi Arabia regions are limited despite the high incidence of chronic diseases. This study aims to understand the community's health problems and the range of healthy behaviors and determine the priority health problems. We conducted a cross-sectional study based on the adults in Primary Health Care Centers in Hail, Northern Saudi Arabia, by using the CHNA standard questionnaire. In addition to the demographic information, the questionnaire collects data on personal health status, the health status of adults and children, health facilities access information, receiving of healthcare procedures, traveling for healthcare, source of medical information, safety measures and behaviors, health problems, childcare (special needs), and perceived community problems. In all, 336 individuals were approached to participate in this study; 303 agreed to participate (response rate: 90%). The analysis comprised 276 individuals after eliminating 27 who did not fulfill the age inclusion criteria or had missing gender data. Of these, 107 (38.8%) were men and 169 (61.2%) were women. Our data revealed that almost half of the participants, 135 (52.9%) constantly or 107 (42%) occasionally, were able to visit the doctors when needed. Our findings reported positive health behaviors and good accessibility to healthcare services when needed. However, the study findings also revealed healthcare challenges that required urgent action from Hail healthcare leaders. Developing healthcare strategies, screening/prevention programs, and changing healthcare policies in the Hail region are needed to control and prevent health problems and improve the population's health.

FUT6 Suppresses the Proliferation, Migration, Invasion, and Epithelial-Mesenchymal Transition of Esophageal Carcinoma Cells via the Epidermal Growth Factor Receptor/Extracellular Signal-Regulated Kinase Signaling Pathway.

Esophageal cancer (ESCA) is a high-incidence disease worldwide, of which the 5-year survival rate remains dismal since the cellular basis of ESCA remains largely unclear. Herein, we attempted to examine the manifestation of fucosyltransferase-6 (FUT6) in ESCA and the associated mechanisms. The GSE161533 dataset was used to analyze a crucial gene in ESCA. The expression of FUT6 was investigated in normal esophageal epithelial cells and ESCA cell lines. Following FUT6 knockdown or overexpression, cell proliferation, migration, invasion, and levels of epithelial–mesenchymal transition (EMT)-related and epidermal growth factor receptor (EGFR)/extracellular signal-regulated kinase (ERK) signaling pathway-related proteins were evaluated using CCK-8, Transwell, and Western blotting with antibodies against EGFR, p-EGFR, E-cadherin, Vimentin, N-cadherin, ERK1/2, and p-ERK1/2), respectively. EGF was administered to stimulate the EGFR/ERK signaling pathway, followed by the assessment of cellular activity. Database analysis revealed that FUT6 was downregulated in the ESCA cells. Our study indicated that FUT6 is suppressed in various ESCA cell lines. Moreover, cell proliferation, invasion, migration, and EMT-related protein levels were conspicuously enhanced or restrained by FUT6 disruption or overexpression. FUT6 overexpression suppressed the malignant activities of the cells when stimulated by EGF, including inhibition of cell growth, movement, invasion, and EMT advancement, as well the reduction the levels of EGFR/ERK pathway proteins. In conclusion, FUT6 can suppress the EGFR/ERK signaling pathway activated by EGF, leading to the potential attenuation of ESCA cell proliferation, invasion, migration, and EMT.

Evaluation of hot pepper (Capsicum annuum L.) genotypes for their reaction to wilt complex disease and yield performance in Jabi Tehena district, northwestern Ethiopia

Hot pepper (Capsicum annuum L.) production and productivity is highly hampered by biotic and abiotic factors in Ethiopia. Among biotic factors, wilt complex disease is the major production constraint both in the study area in particular and wherever hot pepper is grown in general. Field experiments were carried out during the 2020 and the 2021 main-rainy growing seasons to evaluate the reaction of 14 hot pepper genotypes to the wilt complex disease and their agronomic performance. Analysis of variance revealed differences among genotypes in disease reaction, growth and yield performance. The local check had the highest disease incidence (58.04%), severity (56.33%), area under the disease progression curve (1471.67% days), and faster disease progression rate (0.0157 units per day) as compared to the rest of the genotypes. The results categorize eight hot pepper genotypes as susceptible (Bako Local, local check, Marko Fana, Melka Awaze, Melka Dear, Melka Oli, Melka Shote and Melka Zala) and six hot pepper varieties as moderately susceptible (Chala, Deme, Dinisire, Kume, Oda Haro and Revival). There were no hot pepper genotypes categorized under the resistant reaction class to the wilt complex disease. Melka Zala produced the highest number of fruits per plant (133.80), marketable dry fruit yield (2.13 t ha−1) and total dry fruit yield (2.30 t ha−1). Out of the evaluated genotypes, the varieties Melka Zala, Melka Dera and Melka Oli were superior in their yield performance. Providing those high-yielding hot pepper varieties in the study area may serve as a short-term solution for sustainable production and productivity of the crop.

THE PREVALENCE OF INFLAMMATORY BOWEL DISEASES IN THE REGION OF GOSTIVAR DURING THE PERIOD OF 2018-2022

Lifestyle, especially nutrition, has changed over the centuries, tending to the consumption of fast foods, unhealthy lifestyles that increase the risk of many different diseases. This is expressed by the high incidence and prevalence of many chronic and acute diseases, which in different populations around the world are of different degrees. Nowadays, cardiovascular diseases and diabetes are the first diseases that have a high mortality rate, while inflammatory diseases of the gastrointestinal tract cannot be overlooked, which occupy the third place in terms of mortality rate. The aim of this paper consists in describing the pathology of inflammatory bowel diseases, presenting statistical data for cases with inflammatory bowel diseases in the region of Gostivar, in the 5-year period from 2018 to 2022. The main objectives of this paper is the identification of cases with two main inflammatory bowel diseases: ulcerative colitis and Crohn's disease, pathological description, determination of prevalence, etiology, clinical diagnosis and drug treatment of these disorders, incidence of these disorders by gender and age groups affected by ulcerative colitis and Crohn's disease. From the total number of 376 examined patients, for the period of 5 years, from 2018 to 2022, sick with inflammatory bowel diseases were of age 15-82. In the population included in the research, we can conclude from the data analysis in the 5-year period, according to gender, men have a higher prevalence of inflammatory bowel disease (one of the factors may be smoking), while it belongs to age. group is the age group from 31 to 50 years old. Regarding the form of inflammatory bowel disease, in the population included in the research, 44% of patients were diagnosed with ulcerative colitis, compared to 23% of patients with Crohn's disease.

Aspirations Dashed: Conventional Synovial Fluid Analysis Is Superior to Synovial Fluid and Blood Neutrophil-to-Lymphocyte Ratios in Diagnosing Pediatric Septic Arthritis of the Hip and Knee.

Recent research suggests that synovial fluid neutrophil-to-lymphocyte ratio (SF-NLR) is a superior diagnostic for pyogenic septic arthritis (SA) in adults compared with synovial fluid white blood cell count (SF-WBC) ≥50,000 cells/μL or ≥90% polymorphonuclear leukocytes (SF-%PMN). Other research also indicates that the neutrophil-to-lymphocyte ratio in the blood (B-NLR) may be of diagnostic significance. However, it is not known whether these findings extend to the pediatric population. Medical records at a large urban tertiary-care children's hospital were queried for emergency department visits between 2012 and 2023, where synovial fluid (SF) analysis was performed to evaluate for SA of the hip or knee. Patients 18 years old and above were excluded. The "conventional composite test" (CCT) for SA was considered positive if SF analysis showed any of the following: (1) SF-WBC ≥50,000 cells/μL, (2) ≥90% PMNs, or (3) organisms reported on gram stain. Patients with aspirate and/or operating room (OR) cultures (or supplemental testing, ie, nucleic acid identification) revealing an offending organism were considered to have culture-positive septic arthritis (CPSA). The remaining patients were considered culture-negative (CN). Serum and SF test data were analyzed to assess their diagnostic utility in identifying CPSA. Receiver operating characteristic (ROC) curves were examined to compare the predictive value of SF-NLR and B-NLR versus conventional indicators of SA. A total of 394 patients met the inclusion criteria. In all, 58.6% (n=231) were male, 67.5% (n=266) involved the knee, and 20.1% (n=79) had CPSA. Those with CPSA had higher ESR and CRP compared with CN patients ( P <0.01). Bivariate testing did not show a difference in SF-NLR or B-NLR between those with CPSA and CN patients ( P =0.93 and 0.37, respectively). The CCT showed 91% sensitivity and 35% specificity using conventional thresholds. ROC analysis showed that SF-WBC was superior to SF-NLR and B-NLR in the diagnosis of CPSA (AUC=0.71 vs. 0.50 and 0.53, respectively; both P <0.01). Among CCT (+) patients who ended up culture negative, Lyme testing was positive in 48.8% (100/205). In contrast to adults, SF-NLR and B-NLR were not found to be strong diagnostic indicators of SA of the hip or knee in pediatric patients. This may be because competing diagnoses in children come with systemic inflammatory responses similar to that seen in pyogenic SA, while noninfectious conditions that might represent the major alternate diagnoses in adults do not increase systemic inflammatory markers as significantly. Given the high incidence of Lyme disease seen among patients in this study, this topic should be further studied at pediatric centers outside Lyme-endemic areas to better understand the generalizability of these findings. Despite excitement regarding SF-NLR and B-NLR as diagnostics for adult SA, these criteria appear less useful in the diagnosis of pyogenic SA in pediatric patients in Lyme-endemic areas.

КЛИНИКО-ЭПИДЕМИОЛОГИЧЕСКИЕ ОСОБЕННОСТИ БОЛЕЗНИ ЛАЙМА В НОВГОРОДСКОЙ ОБЛАСТИ

Lyme disease is the most common vector-borne disease of the forest zone of the Northern hemisphere of the planet, which is characterized by polymorphism of clinical forms of the infectious process. The polysystemic nature of lesions, the complexity of specific diagnosis and the lack of information to the public and primary care physicians make it difficult to verify the diagnosis and often lead to late diagnosis and the development of irreversible functional disorders. The aim of the study is to study the clinical and epidemiological features of Lyme disease in the Novgorod region. Materials and methods. A retrospective analysis of the epidemic situation in the morbidity of the population of the Novgorod region and a retrospective analysis of the medical histories of hospitalized patients diagnosed with Lyme disease in the Novgorod Regional Infectious Diseases Hospital for the period 2013-2023 were carried out. The results obtained. The high incidence of Lyme disease in the Novgorod region determines a special wariness towards this disease. The number of ticks in nature increases annually (the average number of ticks in nature in 2023 was 1,9 ex/km, and in 2013 – 1,2 ex/km), which is directly related to an increase in the average climatic temperature. Lyme disease is a seasonal disease, and people of retirement age are most often infected. In 90% of cases, patients do not know about the danger of this disease, the possibility of its transition to a chronic form and do not go to medical institutions for specific emergency prevention. The most vulnerable places of tick suction are the abdomen and the inner surface of the shoulder. According to the clinical picture, the erythemic form of the disease prevailed (70,7%), the febrile form (20,3%) and the meningeal form (8,98%) were less common. The majority of patients are admitted to the hospital with early manifestations of the disease by the type of localized erythema. In 94,5% of cases, the diagnosis was confirmed by ELISA, in 8,98% by PCR. In 100% of cases, patients received antibacterial therapy. No complications were detected.

Forestry- and agriculture-derived materials as potential bacterial supplements in immunomodulatory urban greening

Decreased exposure to environmental microbes among urbanites is generally thought to contribute to the high incidence of several immune-mediated diseases. Urban landscaping materials that provide microbiological diversity and contain health-associated microbes, such as proteobacterial and mycobacterial taxa, could modulate the risk of the immune-mediated diseases. The aim of the current study was to develop soils that contain health-associated microbiota and are suitable for urban landscaping. Therefore, the potential of forestry- and agriculture-derived supplements in urban greening was investigated. Commercially available, peat-based lawn soil (standard substrate) was enriched with boreal forestry side streams (conifer needles, cones, pine bark, alnus leaves, moss debris, reed and manure), moss or side-stream based products (biochar, composted agricultural waste). The microbial communities of the standard and enriched substrates were followed in two year-long studies in which sod and grass were grown outdoors and indoors. Moss, conifer needles and reed retainded and increased the relative abundance of the phylum Proteobacteria and its classes, while Alnus litter and conifer needles supported the relative abundance of Mycobacterium. Temporal shifts in the relative abundance and richness of previously health-associated bacteria were evident. The method of enriching lawn soil with side streams appears to elicit desired shifts in health-associated microbial taxa. The results indicate that several agricultural and forestry side streams are suitable for shaping health-associated microbiota in commercially available soil. Further studies to explore the potential of side streams in immunomodulatory urban greening are recommended.

An assessment of musculoskeletal disorders and physical activity levels in dentists: Across-sectional study.

Dentistry is a physically and mentally demanding profession that involves long periods of muscle imbalance and asymmetrical postures when performing delicate procedures. This can lead to a high incidence of work-related diseases. However, physical activity may prevent or minimize the incidence of musculoskeletal discomfort and pain. The present study aimed to determine the association between musculoskeletal disorders and physical activity levels in dentists practicing in Turkey. This cross-sectional study was conducted between March and June 2023 with dentists from Turkey actively practicing dentistry. The short form of the International Physical Activity Questionnaire was used to determine dentists' physical activity levels, and the Extended Nordic Musculoskeletal Questionnaire was used to assess musculoskeletal disorders. IBM SPSS 20 software was used for statistical analysis. Data were presented as mean, standard deviation, median, minimum, maximum, percentage, and number. Chi-square, Mann-Whitney U, One-Sample Chi-Square tests, and an ordinal logistic regression test were used. The statistical significance level was taken as p < 0.05. A total of 116 dentists (63 females 53 males) between the ages of 24 and 60 (36.37±7.32) were included in the study. Forty-eight participants had a low level of physical activity, 56 had a moderate level of physical activity (MLPA), and 12 had a high level of physical activity (HLPA). There was no significant difference between the gender (p = 0.224) and age (p = 0.469) of the participants and levels of physical activity. Musculoskeletal discomfort was reported by 93.1% (n = 108) of the participants in one or more body parts (p < 0.001) and 55.6% (n = 60) of them were female. The number of dentists with neck (p < 0.001) and shoulder (p = 0.05) problems was significantly higher. There was no significant effect of gender (p > 0.05) on musculoskeletal conditions. However, the relationship between musculoskeletal conditions and physical activity levels was inconsistent. The HLPA group reported the lowest discomfort for all body parts, except the elbows and knees (p < 0.05). The MLPA group reported higher discomfort in the neck, shoulder, upper back, wrists/hands, lower back, and knees. The group with the lowest physical activity exhibited the highest discomfort in the elbow and ankle/feet regions. This study found that the prevalence of musculoskeletal disorders was high among dentists, many of whom reported either low or moderate physical activity levels. The results of this study may enhance dentists' understanding of work-related musculoskeletal diseases and promote their participation in physical activities.

Estimating the potential number of cases prevented by infant/ toddler immunisation with a MenACWY vaccine

Introduction: Meningococcal disease control in the UK relies on various vaccines, with the discontinuation of the Hib/MenC combination vaccine Menitorix® in 2018 necessitating reassessment of the immunisation strategy. The quadrivalent MenACWY vaccine emerges as a promising long-term solution, already integrated into the teenage immunisation regimen. While indirect control of group W and C cases is anticipated through existing programs, the high incidence of meningococcal disease in infancy underscores the potential benefits of infant/toddler vaccination.Methods: Utilizing data from two UK studies, we recalibrated age-specific carriage prevalence curves and estimated the proportion of meningococcal carriage attributed to ACWY and non-ACWY strains. Employing a dynamic transmission model, we evaluated the combined indirect effects of the teenage MenACWY vaccination initiative and the direct impact of administering MenACWY vaccine at either 3 or 12 months, alongside ongoing 4CMenB vaccination efforts. Given the pandemic-induced decline in cases and alterations in social contact patterns reported in prior research, we also simulated the transmission model to reflect periods of COVID-19 lockdown.Results: Our projections indicate effective control of carriage and disease associated with groups A, C, W, and Y through the teenage vaccination campaign. Assuming sustained high uptake of teenage vaccines amid pandemic scenario, we forecast MenACWY carriage prevalence to be below 1% by 2025. Across all scenarios, the impact of an infant/toddler MenACWY program on case reduction remains modest. Notably, administering the MenACWY dose at 3 months yields a greater number of prevented cases compared to administration at 12 months. With sustained uptake of teenage vaccination, our estimates suggest that between 3 and 22 cases could be averted in a 2025 birth cohort through a 3-month MenACWY dose.Conclusions: Provided teenage uptake remains high and the infant 4CMenB programme is maintained, we suggest that few cases will be prevented from an infant/ toddler MenACWY dose.

Ethical Challenges in Information Disclosure and Decision-making in Prenatal Testing: A Focus Group Study of Chinese Health Professionals in Maternal and Child Health Services.

The international community has proposed a comprehensive strategy to prevent congenital abnormalities. And China, with a high incidence of congenital diseases, has implemented measures including prenatal screening and diagnosis to reduce the morbidity of congenital abnormalities. However, ethical challenges arise in the practice of prenatal screening and diagnosis among healthcare professionals. Five focus group discussions were conducted with twenty-four health professionals working in maternal and child health services in Hunan Province, China, to explore the ethical challenges they encountered in prenatal testing decision-making and information disclosure practices, as well as their views on these challenges. Participants were selected through purposive sampling, ensuring maximum demographic diversity. Three main themes were identified: 1) balancing between information disclosure and privacy protection; 2) patient-oriented decision-making and tensions within family-oriented decision-making; 3) the disparity between the limited help clinical ethics committees (CECs) can provide and professionals' need for CECs. Ethical norms for information disclosure and autonomous decision-making within prenatal screening and diagnostic institutions must be established. Utilizing CECs is crucial to guide professionals in delivering prenatal testing services while simultaneously focusing on targeted improvement of communication skills among these professionals.

Mechanisms and Treatment Strategies of Coronary Microvascular Disease

Heart disease remains one of the primary causes of death and disability, particularly with a high incidence of ischemic heart disease, severely impacting people s health and lives. Among the causes of ischemic heart disease, angina and breathlessness are common, yet many patients clinically lack severe obstructive coronary artery disease, often presenting with coronary microvascular disease(CMD). This condition has multifaceted causes, complex mechanisms, high diagnostic challenges, and substantial treatment difficulties. It is elusive and requires careful determination of effective treatment strategies. Therefore, in-depth research into the mechanisms and treatment strategies of coronary microvascular disease is essential for advancing medical standards and positively impacting patient health and recovery.

Effects and neural mechanisms of different physical activity on major depressive disorder based on cerebral multimodality monitoring: a narrative review.

Major depressive disorder (MDD) is currently the most common psychiatric disorder in the world. It characterized by a high incidence of disease with the symptoms like depressed mood, slowed thinking, and reduced cognitive function. Without timely intervention, there is a 20-30% risk of conversion to treatment-resistant depression (TRD) and a high burden for the patient, family and society. Numerous studies have shown that physical activity (PA) is a non-pharmacological treatment that can significantly improve the mental status of patients with MDD and has positive effects on cognitive function, sleep status, and brain plasticity. However, the physiological and psychological effects of different types of PA on individuals vary, and the dosage profile of PA in improving symptoms in patients with MDD has not been elucidated. In most current studies of MDD, PA can be categorized as continuous endurance training (ECT), explosive interval training (EIT), resistance strength training (RST), and mind-body training (MBT), and the effects on patients' depressive symptoms, cognitive function, and sleep varied. Therefore, the present study was based on a narrative review and included a large number of existing studies to investigate the characteristics and differences in the effects of different PA interventions on MDD. The study also investigated the characteristics and differences of different PA interventions in MDD, and explained the neural mechanisms through the results of multimodal brain function monitoring, including the intracranial environment and brain structure. It aims to provide exercise prescription and theoretical reference for future research in neuroscience and clinical intervention in MDD.