Transdermal patches are the cutting-edge drug delivery approachthat may be utilized to bypass hepatic first-pass metabolism and to increaseabsorptionforeffective systemic effects. By using HPMC, Eudragit L-100, Plasticizer, and Permeation Enhancer in varying proportions, the Astaxanthin drug patch was prepared by SIT technique. For Astaxanthin patches, various physicochemical characteristics including, Moisture Content, Smoothness, Folding Endurance, Thickness, Weight Variation, Tensile Strength, Hardness, and Flexibility, were assessed. The formulation F3 showed high drug content (95.02%), Flexibility, uniform weight andThickness, Smoothness,and ow moisture level. The formulation was developed usingthe Korsmeyer-Peppas diffusion mechanism, and the in-vitro diffusion test was performed using a Franz diffusion cell with a pig ear skin serving as the membrane for diffusion. The formulation incorporates Eudragit L-100: HPMC in varied ratios, as polymers demonstrated a quicker rate of release. After being stored in various storage conditions, the stability analyses showed that all the Transdermalpatch formulations had excellent physico-chemical attributes and drug content. Studies on compatibility demonstrated no physiochemical interaction between pure drug and selected polymers. Therefore, the present study's objective was to develop a Transdermal patch of Astaxanthin utilizing various polymer compositions.