Cetyl Research Articles

(266) Miconazole Vaginal Cream-Induced Acquired Neuroproliferative Vestibulodynia

Abstract Introduction The endodermal vestibule lies between the ectodermal vulva and the mesodermal vagina. Unlike the vulvar skin, the vestibular epithelium is thin, non-keratinized, and its submucosal immune cells are more susceptible to activation. Topical pharmaceutical agents that are applied to the genitals for various medical indications are likely to contact the vestibular epithelium. For example, miconazole vaginal cream (MVC) is approved for treatment of vaginal yeast infections and the irritation associated with the yeast infection. Active and inactive ingredients in MVC include miconazole nitrate, benzoic acid, cetyl alcohol, isopropyl myristate, polysorbate 60, potassium hydroxide, propylene glycol, purified water and stearyl alcohol. We have observed cases where individuals, previously without vestibular pain, have applied MVC to their genitals and immediately experienced excruciating burning that resulted in persistent unrelenting severe pain throughout the vestibule, which is a symptom of acquired neuroproliferative vestibulodynia (ANPV). Objective Our objective is to report cases of patients who used MVC and were diagnosed with ANPV in order to provide awareness of this condition. Methods We performed a retrospective chart review of persons with vulvas presenting to a single sexual medicine clinic between 6/2019-6/2023 who were clinically suspected to have ANPV after experiencing an allergic reaction following use of MVC. Patients were included who failed conservative treatments for provoked vestibular pain, underwent vestibulectomy and were histopathlogically diagnosed with ANPV (>8 CD117 stained immunopositive cells per high-power field (HPF), consistent with mast cells, and excess PGP117 stained immunopositive cells, consistent with nerves). Demographic data, prior diagnoses and treatments, and results from validated questionnaires were collected. Results Our patient cohort included 7 individuals who met the criteria for MVC-induced ANPV. Mean age at time of MVC-induced vestibular pain was 23 (range 18-29) years. Mean age of presentation to our sexual medicine facility was 28 (range 22-33) years. Mean years of delay in diagnosis of MVC-induced ANPV was 5 (range 1-12) years. 71% and 29% were previously diagnosed and unsuccessfully managed as hormone-mediated vestibulodynia and interstitial cystitis, respectively. The mean pain score and overall score for the Female Sexual Function Index (FSFI) was 1.2/6 (range 0-3.2/6) and 11.7/36 (range 4.2-18.1/36), respectively. All total FSFI scores were <26 and indicative of sexual dysfunction. The mean Female Sexual Distress Scale-Revised score was 32.2/52 (21-39/52), consistent with significant distress. Conclusions Our cohort of patients with MVC-induced ANPV experienced several years of misdiagnoses, unsuccessful treatments, and significant pain and distress. It is hypothesized that MVC induces ANPV in genetically susceptible individuals possibly due to activation of the innate submucosal immune cells from an allergic reaction to active or inactive ingredients in the MVC. This allergic reaction results in accumulation of mast cells in the subepithelial stroma that release cytokines and growth factors leading to proliferation of nerves with subsequent symptoms of allodynia and hyperalgesia. Avoidance of topical medications and use of systemic antifungal strategies in individuals with yeast infections may be advisable. Disclosure No.

EFEKTIFITAS SEDIAAN REPELLENT STICK EKSTRAK BUAH WALAY (Meistera chinensis) TERHADAP NYAMUK Aedes sp

Repellent is a preparation used to avoid bites from insects, including the Aedes sp mosquito. Repellent sticks are applied without direct contact with the hands, unevaporate easily and can last relatively longer on the skin. One of the plants from Southeast Sulawesi, namely Walay fruit (Meistera chinensis), contains triterpenoid and flavonoid compounds which have the potential as an active substance in anti-mosquito repellant. This study aims to formulate repellent sticks of Meistera chinensis fruit extract which effective against Aedes sp. Three formula consists of 1%, 3% and 5% extracts with additional ingredients carnouba wax, cetyl alcohol, Vaseline alba, SLS, propylene glycol, span 80, tween 80, Na benzoate, BHT, eucalyptus and aquadest. The results of the physical evaluation showed the repellent had brown in color, an eucalyptus aroma, solid, homogeneous, pH of 6.8-6.9, melting temperature 60°C-62°C, applied 1x, and was not irritating. After 14 days of storage at room temperature the repellent was stable. The repellent effectiveness against Aedes sp showed that formula C with 5% extract had the highest protection power, namely 90%. The results of the ANOVA statistical analysis obtained a value of sig.0.009 (p<0.05) which shows that there are significant differences in effectiveness between treatment groups.

PENGARUH VARIASI KONSENTRASI SETIL ALKOHOL SEBAGAI EMULSIFYING AGENT PADA SEDIAAN LOTION EKSTRAK LIDAH BUAYA (Aloe vera (L.) Burm. f)

Lotion is a liquid emulsion consisting of an aqueous phase and an oil phase that is stabilized by an emulsifying agent and contains one or more active ingredients. The use of cetyl alcohol as an emulsifying agent was selected because of its properties as a softener, emulsifier, and absorbing water. Cetyl alcohol can increase the stability of the consistency and improve the texture. This study aims to determine the effect of concentration variations in cetyl alcohol on the physical properties of aloe vera extract lotion. The research design used in this study is a pre-experimental preparation formula lotion that was divided into 3 sample groups with different concentrations of cetyl alcohol, namely (2%), (3%), and (4%). Then the sample will be tested for physical properties including organoleptic tests (color, texture, flavor), pH test, spreadability test, and viscosity test, homogeneity test. The research results showed that variations in cetyl alcohol concentrations affected the physical properties of the preparations organoleptic texture, and viscosity. Lotion preparations do not affect organoleptic color, flavor, pH, and homogeneity. Formulation with concentration variation of 3% cetyl alcohol had good physical properties and met the criteria including organoleptic testing with a milky white color, slightly viscous texture, strong jasmine flower flavor, pH value of 7.16 ± 0.34, spreadability value 6.99cm ± 0.18, viscosity value 31.6 dPas ± 2.88, and homogeneous. 
 
 Keywords: lotion, cetyl alcohol, Aloe vera

Formulasi Dan Stabilitas Fisik Krim Ekstrak Daun Kelor (Moringa Oleifera Lamk) Dengan Perbedaan Humektan

One of the medicinal plants used as traditional medicine is kelor (Moringa oleifera Lamk). Moringa leaves are rich in vitamin C and antioxidants which can increase collagen production to prevent and slow down premature aging. The effect of humectants on cream preparations is to obtain creams that have good physical characteristics during storage. This study aims to determine the formulation and physical stability of moringa leaf extract cream preparations (Moringa oliefera Lamk) that meet the requirements. The variations of humectants used in this study include propylenglycol-glycerin (FI), glycerin (FII) and propylenglycol (FIII). Stearic acid, cetyl alcohol (oil phase) were melted on a water bath, TEA, methylparaben, propylparaben, glycerol and distilled water (water phase) were heated. The two phases gradually and grind to form a creamy mass and add the extract. Test the physical quality of the cream for 1 week, namely organoleptic test, homogeneity test, pH test, spreadability test and viscosity test. The results of the cream spreadability test of Moringa leaf extract (Moringa oleifera Lamk) in formula I did not meet the requirements, formula II produced cream preparations that met the requirements with a spreadability range of 5-6 cm, formula III did not meet the requirements. The results of the viscosity test on the formula I, II, III are in the range of 22000-30000 cPs. Based on the results of research on formula II with the addition of the humectant glycerin, it produces a good cream preparation.

Cetyl alcohol surface functionalization: a strategy for modulating electronic characteristics of boron nitride nanosheets

Hexagonal boron nitride (h-BN) is a two-dimensional material with a unique layered structure akin to Graphene. Cetyl alcohol (CH₃(CH₂)₁₅OH) denoted as CA, a fatty alcohol derived from natural sources like palm oil and coconut oil, holds a significant place in various industries due to its versatile properties. Cetyl alcohol's has a potential in forming stable nanostructures and its interactions with other compounds, shedding light on its utility in nanotechnology and materials science. In this work exfoliation of BNNS and subsequent functionalization using Cetyl alcohol is investigated. The functionalization of boron nitride nanosheets (BNNS) using CA is investigated in this study. The modification process aims to enhance the properties and applications of BNNS. OH groups are functionalized and bring about beneficial changes to its properties, enabling enhanced interactions with other compounds. This modification can lead to improved solubility, emulsification, and lubrication capabilities, expanding its utility in various applications such as cosmetics, pharmaceuticals, and industrial processes. Characterization techniques, including Thermogravimetric analysis(TG/DTA), UV-Visible spectroscopy, Photoluminescence, X- ray diffraction (XRD), Raman spectroscopy, Fourier transform infrared spectroscopy (FTIR) are employed to analyze the efficacy of the functionalization process. Thermogravimetric-differential thermal analysis (TG-DTA) was utilized to investigate the thermal characteristics of the functionalized samples.

Reversible thermochromic properties of bisphenol A aromatic phenolic resin's composite natural rubber film

Based on open system and solution copolycondensation method, 2,6-monosubstituted bisphenol A aromatic phenolic resin with M‾n of 1.133 × 103 g·mol−1 and PDI of 1.005, was prepared by microwave, using bisphenol A (BPA), terephthalaldehyde (TPD) and isophthalaldehyde (IPD) as monomers. The number of BPA and phthalaldehyde (TPD or IPD) monomers participating in alternating copolymerization were 3 and 3, respectively. TPD and IPD had similar and low activities, therefore their competitive polymerization reactivity ratio was consistent with raw materials' practical molar ratio. The resin's structure was confirmed by 1H NMR, 13C NMR and FTIR. Reversible thermochromic composite natural rubber film was prepared by resin as chromogenic agent. When mass ratio of crystal violet lactone, resin, mixed alcohols (cetyl alcohol and octadecanol) and natural rubber is 1:3.0:30:20, i.e. 0.0075:0.023:0.23 (0.14:0.09):0.15 (g), the composite film was obtained by salivation method. The composite film's total color difference (ΔE) is about 85, and its absorption-scattering color depth difference (ΔKS) values are averagely 15 and 40 at visible light zone of 480–600 nm and 600–660 nm at 20–35 °C respectively. Composite film has good thermal stability and recyclability stability.

Formulation and Evaluation of Multipurpose Cosmetic Cream

Cosmetic Creams are the preparation used to enhance the human appearance. The main Aim of our work was to develop a Cosmetic cream which can give multipurpose effect like moisturizer, Anti-aging, and Antioxidants, herbal ingredients in our preparations is Green Tea. All the products were found to be stable with no sign of phase separation and no change in color. The cream was prepared by using the cream base that is Bees wax, Propylene Glycol, Cetyl Alcohol, Stearic Acid, Methyl paraben, Vitamin-E, With Oils like Argon oil, Jojoba oil, Almond oil, Olive oil, Grape Seed oil. We have developed three batches of our herbal cream, namely F1, F2, and F3. All three batches were evaluated for different parameters like appearance, pH, viscosity, washability, spreadability, Rancidity, Extrudability, All the three formulations F1, F2 and F3 showed good appearance, pH, viscosity, washability, spreadability and Rancidity, Extrudability was observed. All the three formulations were stable at room temperature. Green tea (Camellia sinensis) It is used in cosmetic preparation can protect the skin from UV damage and aging of the skin. Catechin compounds contained in green tea are polyphenol substances. The polyphenols are secondary metabolite of plants and are generally involved in defense against UV radiations, also in protecting skin.

Formulation and Evaluation of Hair Removal Cream by Using an Herbal Base

The cosmetic and hygiene industry and the hair removal market are growing in importance. Teenage girls and women often worry about unwanted hair. This study highlights the importance of choosing herbal hair removers over herbal depilatories due to their high efficacy, safety and lack of side effects. Hair removal herbs and their composition in herbal creams, as well as other hair removal methods, are being studied. Hair removers are cosmetic products designed to remove hair from the skin. Chemical hair removers mostly contain salts of thioglycolic acids as active components. The following ingredients are needed to make the hair cream: thioglycolic acid, cetyl alcohol, turmeric powder, neem and Tulsi extract, ginger and papaya powder, liquid paraffin and the required amount of orange oil. The pH, viscosity, spreadability and homogeneity of the depilatory cream composition were evaluated. The results showed the composition and excellent properties of F3.

Influence of monomer purity on molecular weight of racemic polylactic acid

Aiming at the low molecular weight of polylactic acid due to the presence of water molecules in the ring-opening polymerization of racemic lactide, this paper selected racemic lactide as the main raw material, stannous caprylate as the catalyst, and cetyl alcohol as the initiator, and studied the effects of recrystallization process conditions such as the number of recrystallization and drying time on the purity of monomer. The influence of initiator dosage on the properties of racemic polylactic acid was also studied. The purity, water content and free acid content of racemic lactide were determined by infrared spectrometer, differential scanning calorimeter, Gel Permeation Chromatography and tensile testing machine. The molecular weight and mechanical properties of racemic polylactic acid were characterized. The results show that the purity of racemic lactide after recrystallization can reach 99.3%, the water content is as low as 0.008% and the free acid content is less than 0.1%. When the amount of initiator is 0.13%, the molecular weight of the prepared racemic polylactic acid is 14.06 KDa and the tensile strength is 37 MPa.

Cetyl alcohol, stearyl alcohol and colloidal oatmeal-based gentle skin cleanser in management of dry and sensitive skin: a cross-sectional study

Background: Effective skin cleansing is vital for maintaining skin health and appearance. An ideal skin cleaner retains moisture, removes oils, sweat, and dirt without causing irritation or dehydration. This study was designed to evaluate the efficacy, safety, tolerability and usage trends of a gentle skin cleanser containing cetyl alcohol, stearyl alcohol and colloidal oatmeal for individuals having dry and sensitive skin. Methods: We conducted a retrospective review at 102 centres, focusing on individuals aged 18 to 65 years with atopic dermatitis and dry skin conditions who required the use of gentle skin cleanser. Total 568 cases were taken; 488 cases of dry and sensitive skin were further analysed over a 2-week study period. Results: Gentle skin cleanser exhibited significant reduction (p<0.0001) in skin dryness, itchiness and irritation by 4.42±1.92 (63.38%), 4.03±2.71 (49.38%) and 4.44±2.07 (65.58%) respectively in participants with dry skin and by 4.25±1.48 (58.49%), 3.26±3.22 (18.02%) and 4.42±1.56 (63.23%) in participants with sensitive skin after its regular usage. Participants provided positive feedback and expressed overall satisfaction with the study product. Conclusions: Skin cleanser was efficacious and well-tolerable in participants in providing moisturizing, soothing, exfoliating, and antioxidant effects making it a preferred primary choice for managing dry and sensitive skin. The cleanser effectively cleansed excess oil, dirt, dead cells, microorganisms, and sweat providing a gentle and mild experience, in daily skin care.

MXene nanosheets coated conjugated microporous polymers hollow microspheres incorporating with phase change material for continuous desalination

The inevitable intermittency of solar illumination during the interfacial evaporation process can cause a reduction in the evaporation performance of solar evaporators. Here, we report the fabrication of a new solar-driven interfacial evaporator using MXene nanosheets as the photothermal layer, modifying them with conjugated microporous polymer hollow microspheres, and then compounding them with the phase change material, in this case, cetyl alcohol, to form a composite evaporator (CE) that can perform all-weather solar interfacial evaporation. By combining interfacial evaporation photothermal conversion with energy storage, the evaporator achieves an evaporation rate of 1.57 kg⋅m−2⋅h−1 at a light intensity of 1 kW⋅m−2 and 2.79 kg⋅m−2⋅h−1 at a light intensity of 2 kW⋅m−2. In addition, the evaporator attains an excellent solar evaporation efficiency of over 91% in both cases and even in salt water. In addition, interestingly, our CE exhibits excellent continuous evaporation ability, e.g., the mass of evaporated water was increased by 0.36 kg⋅m−2 at a light intensity of 2 kW⋅m−2 compared to the cavity evaporator without the phase change material (PCM) when solar light was turned off. These results could be attributed to the fact that the energy released by the incorporated phase change material allows the evaporator to maintain stable evaporation under conditions of insufficient or intermittent solar irradiation, potentially providing a new opportunity for addressing the intermittent problem of evaporation at the solar interface due to unstable light intensity, thus showing great potential for practical continuous desalination.

Cannabidiol-Loaded Lipid-Stabilized Nanoparticles Alleviate Psoriasis Severity in Mice: A New Approach for Improved Topical Drug Delivery.

Cannabidiol (CBD) is a promising natural agent for treating psoriasis. CBD activity is attributed to inhibition of NF-kB, IL-1β, IL-6, and IL-17A. The present study evaluated the anti-psoriatic effect of cannabidiol in lipid-stabilized nanoparticles (LSNs) using an imiquimod (IMQ)-induced psoriasis model in mice. CBD-loaded LSNs were stabilized with three types of lipids, Cetyl alcohol (CA), Lauric acid (LA), and stearic-lauric acids (SALA), and were examined in-vitro using rat skin and in-vivo using the IMQ-model. LSNs loaded with coumarin-6 showed a localized penetration depth of about 100 µm into rat skin. The LSNs were assessed by the IMQ model accompanied by visual (psoriasis area severity index; PASI), histological, and pro-psoriatic IL-17A evaluations. Groups treated with CBD-loaded LSNs were compared to groups treated with CBD-containing emulsion, unloaded LSNs, and clobetasol propionate, and to an untreated group. CBD-loaded LSNs significantly reduced PASI scoring compared to the CBD emulsion, the unloaded LSNs, and the untreated group (negative controls). In addition, SALA- and CA-containing nanoparticles significantly inhibited IL-17A release, showing a differential response: SALA > CA > LA. The data confirms the effectiveness of CBD in psoriasis therapy and underscores LSNs as a promising platform for delivering CBD to the skin.

Synthesis and surface properties of branched-chain tertiary fatty alcohol sulfate surfactants

Abstract In this paper, anionic branched-chain tertiary fatty alcohol sulfate surfactants were synthesized from n-hexene and n-octene using selective olefin dimerization, hydration reaction (hydroxylation), and sulfur trioxide sulfation. The direct hydration reaction of the α-olefin dimer 2-butyl-1-octene with water as a model reaction was explored for the synthesis of branched-chain tertiary fatty alcohols. Two branched-chain tertiary fatty alcohol sulfate surfactants, namely C12-SBTAS and C16-SBTAS, with different carbon chain lengths, were synthesized by the sulfur trioxide sulfation method. Their structures were confirmed by various analytical techniques, including HPLC, FT-IR, HR-MS, and 1H NMR. Equilibrium and dynamic surface tension, foaming, wetting, and emulsifying properties were compared with those of Guerbet cetyl alcohol sulfate (C16-SGAS). C12-SBTAS and C16-SBTAS exhibited good surface activity with equilibrium surface tension (γ CMC) values of 27.41 mN m−1 and 26.69 mN m−1, respectively. They also had low foaming and rapid defoaming abilities, as well as good wetting and emulsifying properties, which match the application characteristics of typical branched-chain surfactants.

The synthesis and characterization of phase change material microcapsules with titanium oxide nanotubes for thermal energy regulation

In this work, highly efficient phase change materials have been used to enhance the temperature regulation of epoxy resin composites, with the aim of reducing building energy consumption. To overcome the leakage and poor thermal conductivity of organic phase change materials, we have designed to dope the titanium dioxide nanotubes into the shell of phase change material microcapsules. Firstly, titanium dioxide nanotubes were prepared via an emulsion-templated interfacial polycondensation reaction. Then, the resultant titanium dioxide nanotubes were doped into novel microcapsules based on a cetyl alcohol core and a polymethyl methacrylate shell through in-situ polymerization. The thermogravimetric analysis proved that the phase change material microcapsules with titanium dioxide nanotubes had enhanced thermal stability, manifested as an increase of 6.1 % in residual mass. Differential scanning calorimetry showed that the latent heat and initial melting temperature of the phase change material microcapsules with titanium dioxide nanotubes were 165.8 J/g and 45.7 °C. The results of cone calorimeter tests indicated that the peak heat release rate and total heat release rate of epoxy resin containing microcapsules with titanium dioxide nanotubes were 501.72 KW/m2 and 62.02 MJ/m2, which decreased by 31.65 % and 16.46 % compared to that containing the microcapsules. Using a mini-room model to evaluate the temperature regulation, the results proved that the phase change material microcapsules with titanium dioxide nanotubes made the peak indoor temperature decrease from 30.09 °C to 28.52 °C. This study provides an effective method for improving the temperature regulation and fire safety of epoxy resin composites.

Chemical Characterization of Spathodea campanulata for natural dye

Spathodea campanulata a perennial tree identified the potential source of natural dye obtained from the flower at forest college and research institute, mettupalayam during 2016-2017. Spathodea campanulata produces a flower dye that has a wide variety of uses like antimicrobial, anti-fungal, antitumor, etc. So the natural dye extracted from African tulip flowers is found to be environmentally friendly and medical value in nature. To identify various components, the dye is analyzed through Gas chromatography and Mass spectroscopy (GC-MS) using the extract prepared from Soxhlet apparatus using methanol. The following compounds were identified in GCMS analysis, Pectinose Beta-GALACTOSIDASE (yellow), 1-Hexadecanol(Cetyl alcohol), Dodecane (substitute for kerosene fuel), Methyl stearate (ester). The spectrum of the unknown component was compared with the spectrum of the known components stored in the inbuilt library. The extraction of dye from Spathodea campanulata can be done easily and a wide spectrum color range is also available which will be helpful to replace the synthetic dyes. This study may give information on the possible production of natural dyestuff components on a large scale as a source of natural dye.

Melatonin delivered in solid lipid nanoparticles ameliorated its neuroprotective effects in cerebral ischemia

The current study explores the potential of melatonin (MLT)-loaded solid lipid nanoparticles (MLT-SLNs) for better neuroprotective effects in ischemic stroke. MLT-SLNs were prepared using lipid matrix of palmityl alcohol with a mixture of surfactants (Tween 40, Span 40, Myrj 52) for stabilizing the lipid matrix. MLT-SLNs were tested for physical and chemical properties, thermal and polymorphic changes, in vitro drug release and in vivo neuroprotective studies in rats using permanent middle cerebral artery occlusion (p-MCAO) model. The optimized MLT-SLNs showed particle size of ∼159 nm, zeta potential of −29.6 mV and high entrapment efficiency ∼92%. Thermal and polymorphic studies showed conversion of crystalline MLT to amorphous form after its entrapment in lipid matrix. MLT-SLNs displayed a sustained release pattern compared to MLT dispersion. MLT-SLNs significantly enhanced the neuroprotective profile of MLT ascertained by reduced brain infarction, recovered behavioral responses, low expression of inflammatory markers and improved oxidation protection in rats. MLT-SLNs also showed reduced hepatotoxicity compared to p-MCAO. From these outcomes, it is evidenced that MLT-SLNs have improved neuroprotection as compared to MLT dispersion and thereby present a promising approach to deliver MLT to the brain for better therapeutic outcomes in ischemic stroke.

Preparation of composite supported phase change materials from inorganic-based microcapsules of cetyl alcohol and investigation of their phase change material (PCM) behaviors

Preparation of composite supported phase change materials from inorganic-based microcapsules of cetyl alcohol and investigation of their phase change material (PCM) behaviors

Injectable systems of chitosan in situ forming composite gel incorporating linezolid-loaded biodegradable nanoparticles for long-term treatment of bone infections

The objective of the current study was to create an efficient, minimally invasive combined system comprising in situ forming hydrogel loaded with both spray-dried polymeric nanoparticles encapsulating linezolid and nanohydroxyapatite for local injection to bones or their close vicinity. The developed system was designed for a dual function namely releasing the drug in a sustained manner for long-term treatment of bone infections and supporting bone proliferation and new tissues generation. To achieve these objectives, two release sustainment systems for linezolid were optimized namely a composite in situ forming chitosan hydrogel and spray-dried PLGA/PLA solid nanoparticles. The composite, in situ forming hydrogel of chitosan was prepared using two different gelling agents namely glycerophosphate (GP) and sodium bicarbonate (NaHCO3) at 3 different concentrations each. The spray-dried linezolid-loaded PLGA/PLA nanoparticles were developed using a water-soluble carrier (PVP K30) and a lipid soluble one (cetyl alcohol) along with 3 types of dl-lactide and/or dl-lactide-co-glycolide copolymer using nano-spray-drying technique. Finally, the optimized spray-dried linezolid nanoparticles were incorporated into the optimized composite hydrogel containing nanohydroxy apatite (nHA). The combined hydrogel/nanoparticle systems displayed reasonable injectability with excellent gelation time at 37 °C. The optimum formulae sustained the release of linezolid for 7–10 days, which reveals its ability to reduce the frequency of injection during the course of treatment of bones infections and increase the patients’ compliance. They succeeded to alleviate the bone infections and the associated clinical, biochemical, radiological, and histopathological changes within 2–4 weeks of injection. As to the state of art in this study and to the best of our knowledge, no such complete and systematic study on this type of combined in situ forming hydrogel loaded with spray-dried nanoparticles of linezolid is available yet in literatures.Graphical

Effect of Chain Length on Fatty Alcohol Sulfation using SO3-DMF

The fatty alcohols C8, C10, C16 and C18 were used as raw materials for the sulfation reaction using the SO3-DMF complex to study the ratio of carbon chains. The first step is to prepare the SO3-DMF complex, by reacting SO3 gas into DMF at a temperature of 0-4 0C with a reaction time of 3 hours, then sulfation is carried out at 100 0C for 5 hours on C8, C10, C16 and C18. Tests were carried out on the results of sulfation with an FT-IR Spectrophotometer. Surface tension, foam stability and yield calculations. From the sulfation results, the yield results were respectively 83%, 81%, 68% and 61% then the results from the surface tension analysis were 35.3, dyne/cm, 30.3 dyne/cm, 29.4 dyne/cm and 33.6 dyne/cm and foam stability analysis of 0.2 cm, 0.8 cm, 0.7 cm and 1 cm. Based on the surface tension reduction value, palmityl alcohol is the best raw material for making surfactants.

Synthesis, Characterization, and Antifungal Activity Test of Nanosilver in Body Lotion Preparation

Nanosilver is a nanoparticle known for its good antifungal ability. This study aims to determine the synthesis process and characterization of nanosilver produced and the antifungal activity of nanosilver in body lotion preparations. Body lotion in this study was made using a body lotion base which includes stearic acid, cetyl alcohol, TEA, glycerin, olive oil and distilled water. F1, F2, and F3 have nanosilver content of 10%, 15% and 20%, respectively. F4, as the positive control, contained methylparaben and F5 as a negative control. The body lotion produced in this study has a colour, aroma and texture that panellists prefer. The body lotion produced does not irritate the skin, is homogeneous, has good spreadability and has a pH value of 7. Nanosilver in this study was synthesized using a chemical reduction method with sodium citrate as a reducer and stabilizer. The synthesized nanosilver was characterized using a Transmission electron Microscope (TEM) and UV-Vis spectrophotometer to determine the nanosilver’s shape, size and stability. The nanosilver produced has a round shape with an average particle diameter of 34.793 nm and has good stability because it has a wavelength absorption peak that is not large. Namely, at week-0, nanosilver has an absorption peak at a wavelength of 415.20 nm, and week-8 has an absorption peak at a wavelength of 423 nm. The antifungal activity test using the direct microscope count (DMC) method was conducted for eight weeks. Until week 8, it showed that each formulation experienced an increase in fungal hyphae, reaching 34.4% for F1, 21.2% for F2, 19.8% for F3, 16.8% for F4 and 46% for F5. From the results of this study, it can be seen that nanosilver can suppress fungal activity in body lotion preparations.