A novel Weyl–Heisenberg algebra in Clifford spaces is constructed that is based on a matrix-valued extension of Planck's constant. As a result of this modified Weyl–Heisenberg algebra one will no longer be able to measure, simultaneously, the pairs of variables (x, px), (x, py), (x, pz), (y, px), ... with absolute precision. New Klein–Gordon and Dirac wave equations and dispersion relations in Clifford spaces are presented. The latter Dirac equation is a generalization of the Dirac–Lanczos–Barut–Hestenes equation. We display the explicit isomorphism between Yang's noncommutative spacetime algebra and the area-coordinates algebra associated with Clifford spaces. The former Yang's algebra involves noncommuting coordinates and momenta with a minimum Planck scale λ (ultraviolet cutoff) and a minimum momentum p = /R (maximal length R, infrared cutoff). The double-scaling limit of Yang's algebra λ → 0, R → ∞, in conjunction with the large n → ∞ limit, leads naturally to the area quantization condition λR = L2 = nλ2 (in Planck area units) given in terms of the discrete angular-momentum eigenvalues n. It is shown how modified Newtonian dynamics is also a consequence of Yang's algebra resulting from the modified Poisson brackets. Finally, another noncommutative algebra which differs from Yang's algebra and related to the minimal length uncertainty relations is presented. We conclude with a discussion of the implications of noncommutative QM and QFT's in Clifford spaces.