Titanium dioxide (TiO2) nanomaterial has numerous applications in the fields of cosmetics, medicines, coatings, inks, plastics, food, and textiles. Therefore, the problem of heat and mass transport on Bödewadt flow of TiO2/water nanofluid over a rotating disk subjected to wall suction is studied. The impact of chemical reaction with partial slip and temperature jump conditions are also considered. For the numerical solution to the problem, the similarity variables are added to transform the three-dimensional flow equations into a favorable set of ordinary differential equations. The impacts of shear stresses, rates of heat and mass transport, and cooling efficiency of nanofluid on the flow are investigated by employing a bvp4c routine in Matlab software. Additionally, the plots for two-dimensional streamlines are presented to visualize the impact of slip velocity and rotation. Through asymptotic analysis, it is found that the presence of similarity solutions for nanofluid over the disk can occur only if the disk is driven to a significant amount of suction. The skin friction factor grows by enhancing the nanoparticle volume fraction [Formula: see text] with a slight reduction in heat and mass transport rates. The fluid temperature is reduced by augmenting [Formula: see text] providing the cooling efficiency of TiO2. The fluid concentration falls significantly when a chemical reaction occurs at a faster rate.