At present, 82% of global energy is generated by fossil fuels which produce substantial emissions and have a significant impact on the environment. Heat transfer devices play a vital role in enhancing the efficiency of power generation systems and mitigating environmental impact. Among various heat transfer devices, natural circulation loops (NCLs) assume significance due to their simplicity and safety. In the present study, numerical investigations were conducted on three-dimensional rectangular circular cross-section supercritical CO2-based NCL across three distinct operating regimes. These regions include the average temperature of NCL maintained near the widom line (near pseudo-critical region), away from the widom line (higher buoyancy region) and very far away from the widom line (deeply supercritical region). The results indicate that in all regions, there is an increase in both the mass flow rate and heat transfer rate as pressure increases. At a pressure of 14 MPa, the maximum heat transfer rate across all regions is observed. Although the higher buoyancy region exhibits a superior heat transfer rate, the near pseudo-critical region demonstrates efficient heat transfer capabilities. For example, at 11 MPa, the temperature difference in the higher buoyancy region exceeds that in the near pseudo-critical region by 73%. However, the reduction in heat transfer rate in the near pseudo-critical region is only 37% compared to the higher buoyancy regions. For low-temperature applications, the near pseudo-critical region effectively transfers heat. However, in high-temperature applications, the sink temperature should be kept in the liquid-like region to maximize system buoyancy.