With the rapid aging of the population, disability and dementia have become major public health challenges affecting the health and quality of life of the elderly in the community. The multidisciplinary collaborative intervention model for the risk of disability and dementia in the elderly, covering key areas such as clinical medicine, public health and social support systems, has become a current research focus. This expert consensus concentrates on eight core functional dimensions-mobility, cognition, emotion, vision, hearing, excretion, swallowing, and comorbidity management-and the corresponding modifiable risk factors. It systematically reviews the clinical evidence and latest advances in relevant interventions in China and abroad. By integrating opinions from multidisciplinary experts through the Delphi method, the consensus ultimately formulates 15 intervention strategies and recommendations across these eight dimensions for the elderly in the community, with the aim of establishing effective approaches to delay the progression of disability and dementia, providing evidence-based support for primary health-care services, and promoting healthy ageing in China.

This study introduces the 3E framework of volunteering, including time exposure (e.g., volunteering hours), role engagement, and task essence (e.g., types of activities) and investigates how these dimensions and their interactions impact healthy aging outcomes in older adults. A mixed-methods cross-sectional study using purposive sampling was conducted in social care units with 457 participants aged 60 and older who volunteered at least one hour in the past year in Hong Kong (2024-2025), in addition to seven focus groups involving 46 older adults. Role engagement in volunteering was assessed using the adapted Chinese version of the Utrecht Work Engagement Scale. Role engagement (β = 0.92, p < .001), emotional support tasks (β = 1.35, p = .022), and creative activities (β = 1.09, p = .018) were positively associated with subjective well-being (SWB). Creative activities were linked to better self-rated health, while time exposure was associated with improved cognition. Role engagement amplified the health benefits of both time exposure and task nature. A three-way interaction among role engagement, time exposure, and creative tasks was significantly associated with better SWB (β = 0.66, p = .026) and lower depressive symptoms (β = -0.39, p = .027). Qualitative findings revealed that role engagement in late-life volunteering unfolds through four themes: role internalization, mental resilience, cognitive investment, and meaning-making. This study validates the 3E framework, demonstrating that role engagement optimizes the health benefits of late-life volunteering hours and volunteering types. Policymakers should transition from focusing solely on volunteering quantity to adopting a holistic approach that optimizes healthy-aging benefits of late-life volunteering.

Food insecurity and multidimensional healthy aging across 31 countries: pooled longitudinal evidence from four cohorts.

Transferrin receptor (TfR)-targeting of biologics has emerged as a promising strategy to improve drug delivery across the blood-brain barrier (BBB). However, most preclinical studies evaluating TfR-enabled drugs have been conducted in young adult animals. It remains unclear whether age and aging-related diseases impact TfR protein levels and/or BBB transport capacity. Here, we utilized a previously described TfR-targeting antibody transport vehicle (ATVTfR) to investigate how healthy aging and disease progression in the 5xFAD mouse model of Alzheimer's disease (AD) impact TfR protein and TfR-mediated brain delivery. ATVTfR transport capacity remained stable across 3- to 24-month-old healthy mice and 5xFAD progression did not impair ATVTfR brain transport up to 10.5 months, despite significant amyloid burden. Interestingly, neonates exhibited significantly elevated levels of vascular TfR protein and ATVTfR brain exposure compared to adult mice. Furthermore, vascular TfR in AD patient brains was similar to age-matched controls, suggesting conserved TfR transport is also likely in human AD. Overall, our data demonstrates broad functional utility for TfR-based brain delivery in both healthy aging and in an AD mouse model. Additionally, elevated TfR-mediated brain delivery during early mouse development highlights the potential of added efficacy in utilizing such platforms in disease treatment of infants and children.

Comparison of anti-aging effect of PQQ (Pyrroloquinoline quinone) and NMN/NR (Nicotinamide mononucleotide /Nicotinamide riboside) - possible combination use.

A systematic review of multivariate studies in cognitive aging: Introducing the concept of cognitive organization.

Temperature and cholesterol regulate the association of native bovine lens alpha-crystallin with in vitro reconstituted membranes made of synthetically prepared lipids and cholesterol.

Oral health and healthy aging: A multiregional review

Environmental determinants of health influence the experience of ageing, yet the contribution of informal public spaces, known as third places, remains underexplored, preventing adequate policy and planning action. Third places, such as cafes, libraries and parks, provide opportunities for older adults to build social connections and engage in physical activity, both of which are crucial for maintaining health and wellbeing. This study explored how third places influence the health of older people living in Springfield, a rapidly growing, master-planned community in South-East Queensland, Australia. A qualitative, cross-sectional design was applied, using semi-structured interviews with 15 older residents (aged 60 years and over). Interviews explored the experiences of using third places, including the perceived benefits and challenges for physical activity and social connections. Social connections were considered through the lens of four types of social ties: stranger, absent, weak, and strong ties. Data were thematically analysed to identify key environmental and social determinants relevant to healthy ageing. Third places were perceived as essential for forming social connections, particularly through the accumulation of weak, absent and stranger ties, which provided a sense of belonging and safety. However, access was limited by transport, walkability and the design of spaces that did not always encourage prolonged interaction. Physical activity opportunities were valued but were secondary to the perceived social benefits of third places. Findings highlight the importance of third places as accessible, socially inclusive environments for older adults that play a key role in forming and strengthening four types of social ties, from encounters with strangers to enduring friendships. SO WHAT?: The importance of stranger ties-alongside absent, weak, and strong ties-and the dynamic role that third places play in fostering these connections, especially for older people, has not been fully recognised. Insights from this research can inform urban planning and health policy to strengthen community design that supports healthy ageing.

Intrinsic capacity deficits across the lifespan in a nationally representative community cohort: findings from the Queenstown study.

Effectiveness of a Community-Based eHealth Program on Self-Care, Cognition, and Health Outcomes of Older Adults With Chronic Diseases: A Multi-Site Cluster-Controlled Trial.

Key factors of depression in middle-aged and older adults based on social-ecological systems theory: an interpretable machine learning approach.

Measuring biological age: Insights from omics studies.

Oxytocin and the pace of life history strategies: From evolutionary trade-offs to translational pathways.

Characterizing patterns in causes, risk factors, and life expectancy among the oldest old (aged 95+ years).

Introduction: The elderly population (aged ≥60 years) is vulnerable to malnutrition due to age-related physiological and socioeconomic factors. In urban India, challenges such as limited dietary diversity, economic dependence, and inadequate nutrient intake further elevate the risk of poor nutritional outcomes. Aim: To assess the nutritional status, dietary intake, and food diversity among elderly individuals residing in the urban area of Belagavi, Karnataka, India. Materials and Methods: A community-based cross-sectional study was conducted from March 2023 to April 2024 in the urban field practice area of Jawaharlal Nehru Medical College, Belagavi. A total of 188 elderly participants were selected using purposive sampling. Data were collected using a pre-tested, semi-structured questionnaire that included sociodemographic details, anthropometric measurements, a 24-hour dietary recall on three non-consecutive days, and a Food Frequency Table (FFT) for dietary diversity. Nutrient intake was compared with ICMR recommendations. Descriptive statistics and chi-square tests were applied to assess associations between food diversity and sociodemographic variables. A p-value &lt;0.05 was considered statistically significant. Results: In the present study, the mean age of participants was 69.5±7.1 years, and of 188 subjects, 53.2% were male. The average energy intake was 1050.75±233.09 kcal/day and protein intake was 22.43±9.30 g/day, both significantly below ICMR guidelines. Poor food diversity (1-3 food groups/week) was observed in 89.9% of participants. Most had normal BMI, but central obesity was common according to Waist-to-Hip Ratio (WHR). Statistically significant associations were observed between food diversity and gender (χ2 =6.03, p=0.043), educational status (χ2 =8.94, p=0.006), and income status (χ2 =5.36, p=0.018). Conclusion: This study highlights the widespread prevalence of low dietary diversity and inadequate nutrient intake among the urban elderly in Belagavi. Interventions should focus on nutrition education, improved dietary access, and social support to promote healthy aging in this population.

Air pollution and accelerated epigenetic aging: Evidence from multiple epigenetic clocks in the Taiwan Biobank.

Association between social determinants of health and intrinsic capacity trajectories: A population-based longitudinal study.

Strength but not power training increases soluble alpha klotho levels in pre-frail older adults.

The past, present, and future of adipose tissue browning and aging: A review combined with bibliometrics and bioinformatics of 2527 documents published over the past four decades.