Metal organic framework based synergistic improvement of hypoxia for optimizing diabetic wounds healing.

Mesenchymal stromal cells and their derivatives: A regenerative frontier in burn wound healing.

Perianal abscess is a common anorectal emergency, and simple incision and drainage (I&D) remains the standard initial treatment. However, failure to address an underlying fistulous tract at the primary surgery may result in high rates of abscess recurrence and subsequent fistula formation. The role of drainage with concurrent initial fistula management remains debated due to concerns regarding anal continence. To compare outcomes of simple incision and drainage versus drainage with initial fistula management in patients with acute perianal abscess, with special reference to abscess recurrence. This Prospective observation studies was conducted in the Department of General Surgery at SRM Medical College Hospital and Research Centre from march 2025 to December 2025. A total of 142 patients with acute perianal abscess were randomized into two groups: Group A underwent simple I&D (n = 71) and Group B underwent I&D with primary fistula management (n = 71). Patients were followed for 10months. Primary outcomes included abscess recurrence and fistula formation. Secondary outcomes included anal incontinence assessed using the Fecal Incontinence Severity Index (FISI), postoperative pain, wound healing time, and hospital stay. Statistical analysis was performed using SPSS v25.0 with p < 0.05 considered significant. Abscess recurrence was significantly higher in the simple drainage group (23.9%) compared to the drainage with fistula management group (4.2%) (p = 0.001). Fistula formation occurred exclusively in the simple drainage group (25.4%) (p < 0.001). Mean FISI scores were higher following simple drainage (5.10 ± 3.15) than drainage with fistula management (3.30 ± 2.13) (p < 0.001). Hospital stay was significantly shorter in the combined procedure group (p < 0.001), while postoperative pain scores were comparable. Drainage with initial fistula management significantly reduces abscess recurrence and fistula formation without increasing postoperative pain, and is associated with better continence outcomes and shorter hospital stay compared to simple drainage alone.

The optimal management of AO/OTA 33-C3 distal femoral fractures combined with symptomatic medial compartment knee osteoarthritis remains uncertain. This preliminary feasibility series explored whether metaphyseal comminution could be used as a "natural osteotomy" window to permit intentional valgus alignment correction during dual-plate fixation, while maintaining anatomical articular reconstruction and fracture stability. This retrospective preliminary feasibility series included 17 patients with AO/OTA 33-C3 distal femoral fractures complicated by Kellgren-Lawrence grade 3 or 4 medial compartment knee osteoarthritis. All patients underwent anatomical reconstruction of the articular surface, intentional mild valgus alignment correction using the metaphyseal comminuted zone as a "natural osteotomy," and medial-lateral dual-plate fixation. The primary feasibility outcomes included successful articular reconstruction, achievement and maintenance of planned valgus alignment, fracture union, and absence of early mechanical failure or reoperation. Operative time, intraoperative blood loss, articular step-off and gap, healing time, complications, mLDFA, and HKA angle were assessed. Pain, range of motion, Knee Society Score, and ambulatory status were evaluated as exploratory clinical outcomes. Mean operative time was 148.18 ± 10.01min and blood loss 351.18 ± 30.18mL. Anatomical articular reduction (step-off ≤ 2mm) was achieved in all patients, with mean step-off 0.97 ± 0.20mm and gap 0.98 ± 0.16mm. All fractures united (mean healing time 29.76 ± 3.42weeks), with no nonunion, implant failure, or reoperation within years. mLDFA changed from contralateral baseline 93.09° ± 0.65°to postoperative 85.03° ± 0.50°(P < 0.001); HKA changed from varus -9.12° ± 1.41°to valgus 2.47° ± 0.80°(P < 0.001). At final follow‑up, VAS pain score decreased from 7.47 ± 0.87 to 1.18 ± 0.39 (P < 0.001). KSS knee score increased from 34.12 ± 3.64 to 89.76 ± 3.21 (P < 0.001), and KSS function score from 43.82 ± 4.85 to 81.65 ± 2.80 (P < 0.001). Mean maximum knee flexion was 99.29° ± 4.22°at final follow‑up. Independent ambulation was achieved in 16 patients (94.1%). In this small single-center preliminary feasibility series, intentional valgus alignment correction using the metaphyseal comminuted zone as a "natural osteotomy" during dual-plate fixation was technically feasible in selected patients with AO/OTA 33-C3 distal femoral fractures and medial compartment knee osteoarthritis. This approach achieved fracture union, maintained coronal alignment, and showed favorable exploratory pain and functional outcomes at mid-term follow-up. These preliminary findings support this joint-preserving concept and warrant further validation in prospective comparative studies with longer follow-up.

Introduction. Gunshot soft tissue injuries remain a significant challenge in modern surgery under conditions of martial law, being associated with a high level of microbial contamination and a substantial risk of infectious complications. This study analyzes the effectiveness of combined photobiomodulation (blue and red light spectra) together with probiotic therapy based on Bacillus spp. in the treatment of gunshot wounds. Aim. To evaluate the effectiveness of photobiomodulation (blue and red light spectra) in combination with probiotic therapy using Bacillus spp. in the treatment of gunshot wounds. Materials and methods. The study included 40 patients with soft tissue injuries of the extremities, who were divided into two groups: the main group and the comparison group. Results and discussion. It was established that the proposed approach ensured a more rapid reduction of microbial load to a subcritical level (&lt;10³ CFU/ml) already by days 3–5 (7.2±2.5×10² CFU/ml vs 1.2±0.3×10⁵ CFU/ml; p&lt;0.05), which enabled earlier wound closure (days 6–7 vs days 9–10). A significantly faster reduction in wound area (22.4±3.8 cm² vs 26.8±4.2 cm²; p&lt;0.05) and volume (61.2±7.5 cm³ vs 75.1±8.3 cm³; p&lt;0.05) was observed, as well as a decrease in healing time to 6.8±1.3 days compared to 9.7±1.9 days (p&lt;0.05). Conclusions. The obtained results indicate that the combined use of photobiomodulation and probiotics is an effective method for the treatment of gunshot wounds, allowing acceleration of the wound healing process, reduction of microbial load, and optimization of surgical outcomes.

To investigate the effectiveness of minimally invasive hemi-cortical longitudinal bone transport technique for concurrent treatment of bone and soft tissue defects in patients with tibial osteomyelitis. A retrospective analysis was conducted on 14 patients with tibial osteomyelitis accompanied by bone and skin soft tissue defects, who were admitted between January 2022 and August 2023. There were 10 males and 4 females, with an average age of 51.2 years (range, 35-75 years). Traumatic osteomyelitis was diagnosed in 11 cases, and hematogenous osteomyelitis in 3 cases. The duration of infection ranged from 0.2 to 1.9 months (mean, 1.1 months). All bone defects were rated as Orthopaedic Trauma Association (OTA) type Ⅰ. The length of bone defects ranged from 3.4 to 6.2 cm (mean, 4.8 cm); the width of defects corresponded to 1/4-1/2 of the tibial circumference. The extent of soft tissue defects ranged from 6.5 cm×2.0 cm to 7.0 cm×3.0 cm. Upon admission, primary debridement and antibiotic calcium sulfate bead filling of the medullary cavity were performed, followed by antibiotic-coated bone cement coverage for soft tissue defects. After infection control, secondary minimally invasive tibial osteotomy was performed, followed by Orthofix unilateral external fixator for upper limb use to facilitate bone tissue transport. The time required for external fixation and bone transport was recorded, and wound healing status, bone healing progress, and adjacent joint function were observed. Scoring was performed according to the Paley healing criteria. All patients completed two phases of treatment. The external fixation duration ranged from 2.1 to 6.5 months (mean, 4.5 months); bone transport duration ranged from 1.1 to 2.3 months (mean, 1.5 months); external fixation index ranged from 0.6 to 1.3 months/cm (mean, 0.98 months/cm). During bone transport, only 1 patient developed a pin tunnel reaction, with no other complications occurring. All patients were followed up 23-27 months (mean, 25.1 months). All wounds healed, with healing time ranging from 1.1 to 2.6 months (mean, 1.5 months); no infection recurrence was observed during follow-up. Imaging re-examination confirmed complete fracture healing, with healing time ranging from 2.6 to 3.5 months (mean, 3.2 months). At 3 months after discontinuation of bone transport, according to the Paley healing criteria, the bone healing in 14 patients achieved excellent; the joint function was rated as excellent in 11 patients and good in 3 patients. The minimally invasive hemi-cortical longitudinal bone transport technique demonstrates satisfactory effectiveness in the concurrent treatment of bone and soft tissue defects following tibial osteomyelitis.

Anemia is a common complication of long-term hematochezia in patients with mixed hemorrhoids. This study aimed to evaluate the effect of preoperative anemia on the prognosis of mixed hemorrhoids after Milligan-Morgan hemorrhoidectomy. A total of 127 patients with mixed hemorrhoids who underwent Milligan-Morgan hemorrhoidectomy at the Affiliated Hospital of Southwest Medical University from January 2021 to August 2022 participated in this study, comprising 48 patients in the preoperative anemia group and 79 patients in the preoperative non-anemia group. Postoperative complications such as postoperative pain, delayed bleeding, wound infection, wound edema, urinary retention, insomnia severity index (ISI) within 7 days, wound healing time, and recurrence rates (prolapse or bleeding) within 12 months were retrospectively analyzed in the two groups. There were no significant differences in the demographic and baseline clinical characteristics between the two groups (P > 0.05). The visual analog scale pain scores at 12h (P = 0.018), 1day (P = 0.010), 3 days (P = 0.034), and 7 days (P = 0.001) after surgery and total analgesic consumption within 7 days (P = 0.036) in the preoperative anemia group were higher than those in the preoperative non-anemia group. The ISI within 7 days in the preoperative anemia group was higher than that in the preoperative non-anemia group (P = 0.046). There were no significant differences in delayed bleeding, wound infection, wound edema (P = 0.740), urinary retention (P = 0.648), anal stenosis, or wound healing time (P = 1.101) between the two groups. There were no significant differences in recurrence (prolapse or bleeding) rates within 12 months between the two groups (P = 0.513). In this retrospective observational study, preoperative anemia was associated with higher postoperative pain scores and poorer sleep quality within 7 days after Milligan-Morgan hemorrhoidectomy. However, no significant associations were observed between preoperative anemia and other postoperative complications, wound healing time, or 12-month recurrence rates. Given the observational design and the exploratory nature of the analysis, these findings should be interpreted with caution and require confirmation in larger, adequately powered studies with multivariable adjustment.

This cohort study compared split-thickness skin graft transplantation and dispersed implantation of autologous strip skin (ASS) grafts combined with small autologous columnar skin (SCS) grafts for the treatment of small-area deep burn wounds. The experimental group was treated with dispersed implantation of ASS grafts combined with SCS grafts, whereas the control group underwent split-thickness skin graft (STSG) transplantation. The graft survival rate was significantly greater in the experimental group (p < 0.0001). The time to complete epithelialization was similar for both groups (p = 0.6626). The ratio of the donor site area to the wound area was lower (p = 0.0002), and the healing time for the donor site was shorter in the experimental group (p < 0.0001). Additionally, the Vancouver Scar Scale (VSS) scores for both the donor and recipient sites were significantly lower in the experimental group (p < 0.0001, p = 0.0075). The combined implantation of ASS and SCS grafts effectively promoted the healing of small-area third-degree burn wounds, with good preservation of hair follicles and sebaceous glands. This method reduces wound contraction and damage to the donor site, with no significant lamellate scar hyperplasia observed during long-term follow-up, making it a viable alternative to split-thickness skin graft transplantation.

To resolve the "strengthening-self-healing" contradiction and antifouling requirements of self-healing polysiloxane materials, this study prepared a hydrogen-rich polysiloxane resin (SDC) containing dynamic imine bonds. By compositing low-content silane-homologous modified graphene oxide (s-GO) and a silver metal-organic framework (Ag-MOF), the composite's tensile strength was improved by 39.0%. Low-content fillers act as hard domains to provide local cross-linking sites without impeding the long-range motion of molecular chains, thus achieving mechanical reinforcement without compromising the self-healing performance. The self-healing efficiency reached 100% at 25 °C in 60 min, and the healing time could be shortened at 37 °C or via the photothermal effect of s-GO. The released Ag+ can kill bacteria and Chlorella, completely avoiding microbial adhesion. This synergistic design achieves a trinity of functions of mechanical reinforcement, efficient self-healing and antifouling, providing a new idea for intelligent antifouling polysiloxane materials.

To evaluate clinical outcomes and postoperative complications associated with fusion podoplasty in dogs with chronic interdigital follicular cysts (CIFCs) unresponsive to multimodal medical management. In this retrospective observational study, medical records from 2 referral hospitals were reviewed to identify dogs that underwent fusion podoplasty from 2005 through 2025. Included dogs were diagnosed with CIFCs presumed secondary to mechanical friction or trauma and refractory to medical management. Dogs with other causes of interdigital dermatitis were excluded. Data included signalment, clinical history, dermatologic findings, surgical procedures, and postoperative management. Partial fusion podoplasty (PFP) or total fusion podoplasty (TFP) was performed. Outcomes included time to wound healing, postoperative outcome classification, and complications categorized as minor or major. Eleven dogs met the inclusion criteria, with a median follow-up of 16 months. Total fusion podoplasty was performed on 9 paws and PFP on 7. All paws healed, with a median healing time of 28 days. Twenty complications occurred in 9 dogs, 18 minor and 2 major; partial incisional dehiscence was the most common (7 of 20). No wound complications occurred in the 5 TFP procedures in which a Penrose drain was placed. Long-term outcomes were excellent in 8 dogs, acceptable in 1, and poor in 2. Fusion podoplasty resulted in satisfactory long-term outcomes in most dogs with medically refractory CIFCs, with TFP associated with fewer postoperative complications than PFP. Fusion podoplasty represents a valuable salvage option for dogs with refractory CIFCs and may be particularly beneficial when TFP is combined with passive drainage.

Antimicrobial resistance (AMR) in common bacterial pathogens, including methicillin-resistant Staphylococcus aureus (MRSA), is an increasingly dire public health threat, with MRSA accounting for up to 90% of S. aureus infections. To expand the treatment arsenal against MRSA infections, we developed a class of tunable three-dimensional tricyclic 2-pyridones, termed TriPcides, that can kill MRSA resistant to last-resort antibiotics and eliminate MRSA persister cells. No preexisting resistance was detected across hundreds of clinical isolates, and continuous exposure of MRSA to TriPcides did not elicit detectable resistance. Treatment with TriPcides causes a rapid decrease in membrane integrity and increased levels of reactive oxygen species. Last, TriPcides effectively reduce secretion of important virulence factors and result in reduced ulcer size and healing time in S. aureus murine skin and soft tissue infections but do not reduce bacterial burden.

Postoperative pancreatic fistula (POPF) is a serious complication following pancreaticoduodenectomy (PD). While numerous studies have investigated POPF incidence and risk factors, few have focused on POPF healing time (POPF-HT). Skeletal muscle mass has been increasingly recognized as an endocrine organ involved in interorgan communication. The aim of this study was to evaluate how skeletal muscle mass influenced the healing time of POPF after PD. This investigation included patients who developed POPF of grade B-C after PD with pancreaticojejunostomy during the study period. POPF-HT was defined as the duration from the date of PD to the removal of all drains placed for POPF treatment. Skeletal muscle mass was assessed based on preoperative computed tomography images. Clinical factors associated with POPF-HT were analyzed, including skeletal muscle index (SMI). The mean POPF-HT was 40 ± 15 days (median: 37 days; range: 21-105 days). Compared to those with high SMI, patients with low SMI had a significantly longer POPF-HT (46 ± 18 days vs. 37 ± 11 days, p = 0.0101). In univariate analysis, low SMI was significantly associated with prolonged POPF-HT (hazard ratio: 0.5655, 95% confidence interval: 0.3687-0.8673, p = 0.0090). Kaplan-Meier curves confirmed that patients with low SMI exhibited significantly delayed cumulative POPF healing (p = 0.0065). Decreased skeletal muscle mass is significantly associated with prolonged POPF-HT after PD. Therefore, preoperative SMI may serve as a potentially modifiable factor associated with POPF-HT.

Wound healing depends on a suitable microenvironment and infection control. However, existing dressings fail to meet the needs of moisture balance and antibacterial properties at the same time. In this study, we synthesized a moisture-balancing antibacterial dressing, polyurethane@polydopamine@silver(PU@PDA@Ag), by soaking dopamine-coated polyurethane (PU@PDA) in a silver nitrate solution. The performance of the dressing was then evaluated in vitro and in vivo. In vitro experiments revealed that compared with nonwoven fabrics and hydrogels, PU@PDA@Ag2.5 prepared with 2.5 mg/mL silver nitrate had excellent moisture absorption-water retention performance (a swelling rate of 1000% for 1 h and a water retention rate of 481.69% for 6 h). SEM, EDS, and FTIR confirmed that the silver nanoparticles were loaded uniformly by PDA, the porous structure of PU was not destroyed, the water contact angle decreased to 60.6°, and the hydrophilicity improved. This dressing had no significant cytotoxicity or systemic toxicity and had good biocompatibility. The inhibition zone areas against S. aureus and E. coli reached 113.8 and 94.7 mm2, respectively, and they were able to kill bacteria by destroying bacterial cell membranes. In a full-thickness infection mouse model, PU@PDA@Ag2.5 reduced the average healing time from 16-17 days (PU group or Vaseline group) to 12 days, accelerated re-epithelialisation, promoted granulation tissue formation and collagen deposition. Transcriptome sequencing showed that PU@PDA@Ag2.5 may regulate the Wnt pathway (which promotes regeneration) through up-regulation and NOD-like receptors and the RAS/PI3K/Akt/mTOR pathway (which causes inflammation) through down-regulation. Immunohistochemistry and ELISA validation showed that PU@PDA@Ag2.5 promoted the proliferation of proliferating cells (PCNA positive) and neovascularisation (CD31 positive) and reduced the expression levels of pro-inflammatory cytokines such as IL-1β, IL-6, TNF-α), which were consistent with the sequencing results. This study has verified that PU@PDA@Ag2.5 can regulate the humidity balance and antibacterial properties simultaneously, providing a dressing option for infected wounds repair.

To explore the clinical effect of cannulated screw fixation for coracoid process fractures of the scapula assisted by robot navigation combined with O-arm imaging. A retrospective analysis was conducted of the clinical data from 19 patients with scapular coracoid process fractures who underwent surgical treatment at our center from January 2022 to July 2023. All the patients had their coracoid process fractures fixed with screws assisted by the robot navigation system combined with the O-arm imaging navigation system by experienced orthopedic surgeons. Three patients were excluded due to insufficient follow-up, and finally 16 patients were included in the study. The patients' surgical conditions (operation time, intraoperative blood loss) and fracture healing time were recorded. During the outpatient follow-up 12months after the operation, the Constant score was used to evaluate the function of the patients' shoulder joints, and the Visual Analogue Scale (VAS) pain score was applied to assess the residual pain of the patients' shoulder joints. All patients were followed for at least 12months, with an average of 14.2months (ranging 12 to 19months). The average operation time of the 16 patients was 75.8min (ranging from 52 to 98min), and the average intraoperative blood loss was 47.3ml (ranging from 28 to 75ml). All 16 fractures healed without nonunion or loss of reduction, and the average healing time was 10.2weeks (range, 8 to 14weeks). One year after the operation, the shoulder joint functions of all 16 patients were good. The average Constant score was 90.5 points (ranging from 82 to 97 points), and the average VAS score of the shoulder joints was 1.0 points (ranging from 0 to 4 points). No cases of blood vessel or nerve injury related to surgical operation were found in all patients during the perioperative period and follow-up period. In this retrospective case series, robot-assisted cannulated screw fixation with O-arm navigation for coracoid process fractures resulted in satisfactory fracture healing and shoulder function, with minimal blood loss and low perioperative complication rates. The proceduralized workflow may facilitate surgical standardization. Given the study's exploratory nature and low level of evidence, further controlled studies are needed to confirm comparative advantages.

Intramedullary nailing is the preferred treatment for lower limb long bone fractures, but stability is reduced in extra-isthmic fractures due to nail-metaphysis mismatch. Poller screws may help, but their use is controversial. This study evaluates whether Poller screws are associated with improved prognosis in intramedullary nailing for lower limb extra-isthmic fractures and explores their mechanical mechanisms. PubMed, EMBASE, Cochrane Library, and Web of Science were searched up to December 2025 using keywords like 'Fracture,' 'Intramedullary nail,' 'Poller screw,' and 'Blocking screw.' Studies were screened, and data were collected for meta-analysis. A 3D tibial model was created, and finite element analysis assessed Poller screws' effect on distal tibial fractures under axial load. Out of 1134 studies, 5 trials with 413 participants were included. The Poller screw group showed increased union rates (OR = 2.48; 95% CI, 1.13-5.46; p = 0.020). Surgery duration increased, but secondary surgical procedures decreased. No differences were found in malalignment, time to union, or infection. Poller screws reduced fracture site displacement by 54.88%. The use of Poller screws in intramedullary nailing for lower limb extra-isthmic fractures is associated with higher union rates without affecting alignment or healing time. While surgery duration increases, infection remains unchanged, and secondary surgery decreases. The improved healing outcomes may contribute to Poller screws enhancing construct stiffness and reducing micro-motion.

Burn injuries trigger complex inflammatory and metabolic cascades that impair wound healing and increase morbidity. Fibroblast growth factor 2 (FGF2), a potent mediator of cellular proliferation, angiogenesis, and extracellular matrix remodeling, has emerged as a promising therapeutic agent in burn care. This systematic review evaluated the biological mechanisms, delivery strategies, and clinical outcomes associated with FGF2 in burn wound healing to clarify its therapeutic value and translational potential. Following PRISMA 2020 standards, a structured literature search was conducted across PubMed, EMBASE, Web of Science, Cochrane, and Google Scholar to identify studies investigating FGF2 in thermal injuries. Eligible records included clinical trials, in vivo models, and in vitro experiments. Methodological quality and risk of bias were assessed using the Newcastle-Ottawa Scale, the SYRCLE tool, and the Oxford Levels of Evidence. Thirty-three studies (1992-2025) met inclusion criteria, encompassing randomized controlled trials, animal models, and mechanistic analyses. Fibroblast growth factor 2 accelerated repair by stimulating fibroblast proliferation, keratinocyte migration, angiogenesis, and matrix organization. Topical FGF2 formulations shortened healing time and improved scar quality in partial-thickness burns. Innovative carriers, including hydrogels, liposomes, and gene-activated matrices, enhanced bioavailability and sustained local effects. In diabetic and complex burn models, FGF2 mitigated inflammation, preserved barrier integrity, and promoted re-epithelialization. Efficacy depended on dosage and wound characteristics. Studies reported favorable safety profiles with minimal and mild adverse events. Fibroblast growth factor 2 demonstrates regenerative and immunomodulatory potential in burn management. Broader adoption requires harmonized regulatory evaluation, optimized delivery systems, and multicenter validation to define its role in precision-guided burn care.

Phenome-wide association studies (PheWAS) can reveal novel associations between variants in drug-target genes and disease and, as such, can be used to predict new drug-indication pairs for repurposing drugs with a known mechanism of action. A platelet-derived growth factor receptor beta (PDGFRβ) PheWAS demonstrated that patients with a single nucleotide variant that reduces PDGFRβ expression exhibit a higher prevalence of chronic skin ulcers, skin grafts, and reconstructive surgeries. Recombinant human platelet derived growth factor BB (rhPDGF) is a therapeutic that binds to and activates PDGFRβ and has received FDA approval for multiple indications, including improving healing of lower extremity diabetic neuropathic ulcers, augmenting periodontal bone and soft tissue reconstruction, and stimulating orthopedic bone regeneration. Leveraging a drug-repurposing methodology informed by PheWAS, we hypothesize that rhPDGF will provide therapeutic benefit in the treatment of other complex wounds, like full-thickness surgical wounds of the head or neck that cannot heal by primary intention following skin cancer excision. This prospective, double-blinded, single-site study aims to enroll 40 participants, randomized at a ratio of 1:1, comparing the efficacy of an advanced wound matrix saturated with rhPDGF or saline. Comparisons will be stratified by anatomical location (scalp/forehead versus face/neck) and maximum surgical defect dimensions ( < 3cm versus > 3cm). The primary outcome of this study will evaluate the time in days to 81-100% granulation of the wound bed by expert clinical assessment of daily photographs. Secondary outcomes will assess the superiority of the rhPDGF-enhanced wound matrix relative to control with respect to wound granulation rate, epithelialization, complete wound healing, and patient reported outcomes (PROMs). Although reconstructive techniques are available for healing complex head and neck wounds following skin cancer excision, these procedures are invasive, and older, frail patients are often suboptimal candidates. There remains a need for less invasive therapeutic approaches that reduce the healing time and mitigate the morbidity associated with chronic wounds. A PheWAS analysis identified complex wounds requiring reconstructive surgery as a novel drug-indication pair for repurposing rhPDGF. This protocol is designed to evaluate the efficacy of an rhPDGF-enhanced advanced wound matrix for healing complex head and neck wounds post skin cancer excision that cannot heal by primary intention. This trial is registered at ClinicalTrials.gov ( NCT06634030 ).

To investigate the clinical efficacy of moist wound healing technique in the repair of facial traumatic wounds, and to evaluate its impact on the wound healing process, incidence of complications, as well as long-term scar formation and pigmentation, so as to provide clinical evidence for standardized wound care of facial traumatic injuries. A total of 60 patients with facial trauma admitted to our hospital from January 2024 to March 2025 were retrospectively enrolled as study subjects. They were divided into the observation group (moist wound healing group, n=30) and the control group (conventional dry wound healing group, n=30) according to the wound management protocol. The control group received conventional wound care with povidone-iodine disinfection combined with dry dressing, while the observation group was treated with a standardized wound care regimen based on the concept of moist wound healing. The wound healing time, epithelial migration rate, incidence of complications, as well as the occurrence of scar hyperplasia, pigmentation, and wound hyperemia after surgery were compared between the 2 groups. The wound healing time of the observation group was significantly shorter than that of the control group, and the epithelial migration rate of the wound at 3 days after surgery was significantly faster than that of the control group, with statistically significant differences (P<0.001). The total incidence of complications, including wound infection, delayed healing, subscab pus accumulation, and wound dehiscence after suture removal, was 10.00% in the observation group, which was significantly lower than 33.33% in the control group (P<0.05). During the postoperative follow-up of 6 to 12 months (mean: 10mo), the Vancouver Scar Scale (VSS) scores of the observation group were significantly lower than those of the control group, and the incidence rates of hyperpigmentation and wound hyperemia were lower than those of the control group. The application of moist wound healing technique in facial trauma repair can effectively accelerate the re-epithelialization process of wounds, reduce the risk of wound complications, significantly diminish long-term scar hyperplasia, and reduce the incidence of postoperative hyperpigmentation and wound hyperemia, thus improving the facial aesthetic prognosis of patients. It is a safe, effective, and cost-effective regimen for facial trauma repair, which is worthy of widespread clinical promotion.

ObjectiveThis study investigated the clinical value of antibiotic-loaded bone cement (ALBC) in managing infected diabetic foot ulcers (DFUs), aiming to address the limitations of conventional therapies such as slow healing and high recurrence rates.MethodsA retrospective analysis was conducted on 43 eligible DFU patients (21 males, 22 females) with infected ulcers who underwent debridement combined with ALBC implantation. Clinical data on infection control, wound healing, adverse events, and functional assessments were collected.ResultsThe results demonstrated effective local infection control: 90.7% of patients achieved normalized white blood cell counts and C-reactive protein levels within 1-2 weeks, with no observable pus secretion after 3 weeks. Wound healing outcomes were favorable, with an overall healing rate of 95.3% (41/43). The median healing time was 42 days (range: 30-63 days), and the average wound area reduction rate reached 85% at 4 weeks post-treatment. Only two cases experienced delayed healing due to poor glycemic control, with no reports of severe adverse reactions. Furthermore, all patients maintained basic ambulation without significant gait impairment during follow-up, as the ALBC was customized to minimize interference with foot function.ConclusionsALBC combined with debridement effectively controls infection, promotes wound healing, and exhibits a good safety profile in treating infected DFUs, without adversely affecting daily ambulation. This regimen represents a novel and cost-effective therapeutic option. Future prospective randomized controlled trials are warranted to validate these findings and optimize protocols for patients with poor baseline conditions.Trial registry statementNot applicable.

Wound healing in cosmetological and aesthetic surgery extends beyond tissue closure to achieving rapid regeneration, minimal scarring, and restoration of functional skin architecture. However, conventional wound care strategies inadequately regulate the complex wound microenvironment required for optimal cosmetic outcomes, leading to prolonged healing times and suboptimal aesthetic results, which can negatively impact patient satisfaction and increase the risk of complications. Phytochemicals exhibit multifunctional bioactivities, such as antioxidant, anti-inflammatory, antimicrobial, and pro-regenerative effects, but their clinical translation faces obstacles due to poor solubility, stability, and bioavailability. Nanotechnology-based delivery systems have emerged as a critical enabling strategy to overcome these limitations. This narrative review provides an updated, mechanistically integrated synthesis of phytochemical-loaded nanotherapeutics, including polymeric nanoparticles, nanohydrogels, nanofibers, and lipid- and vesicle-based systems, with a specific focus on their roles in modulating key wound-healing pathways, such as inflammation resolution, angiogenesis, collagen remodelling, and re-epithelialization. Evidence from preclinical studies consistently demonstrates that nano-enabled phytochemicals enhance therapeutic efficacy, improve skin penetration, and contribute to superior cosmetic outcomes, particularly by reducing fibrosis and scar formation. However, critical gaps remain, including limited high-quality clinical evidence, a lack of standardized formulation design, variability in reported outcomes, and unresolved concerns regarding long-term safety and regulatory translation. Taken together, the key insight of this review is that phytochemical-loaded nanotherapeutics represent a promising but still transitional strategy, biologically compelling at the preclinical level yet clinically under-validated. Bridging this gap requires rigorously designed clinical trials, quantitative outcome reporting, and balanced regulatory frameworks. Advancing these areas will be essential to translate nano-enabled phytochemicals from experimental systems into reliable, evidence-based solutions for cosmetological wound management.