HC Group Research Articles

Background: Aβ1-42 and APOE concentrations, as well as Aβ42/40 ratio, may be considered as a link between hypertension (HTN) or diabetes mellitus (DM), brain amyloidosis, and dementia. HTN and DM are associated with cognitive impairment and may contribute to the development of Alzheimer’s disease (AD). This preliminary study aimed to evaluate the impact of vascular risk factors on the concentration of biochemical AD markers and cognitive state. As it is a cross-sectional study in nature, causal relationships cannot be established. Methods: The study was conducted in the south of Poland among a rural population over 65 years of age. A total of 58 patients qualified into the study were divided into groups according to the presence of HTN (n = 18) or HTN coexisting with DM (n = 40). A healthy control group was also formed (n = 20), resulting in 78 study participants. The study population was also divided based on M-ACE results, forming a normal cognition group (NC) and a deteriorated cognition group (DC). Biochemical tests, neurological scales assessments, and ultrasound examinations were conducted. Results: Patients who scored in the normal range on the M-ACE had higher Aβ1-42 (median 38.52 vs. 27.35 pg/mL, p = 0.02) and apoE concentrations (median 125.0 vs. 65.73 μg/mL, p = 0.002), and a higher Aβ42/40 ratio (median 0.39 vs. 0.29 p < 0.000) compared to the DC group. Considering the study groups, the highest Aβ42/40 ratio was found among the HC group (median 0.47). The median score for the M-ACE scale was 3 points lower when HTN and DM coexisted, compared to the sole diagnosis of HTN (25 points and 28 points, respectively). A higher number of years of education correlated with better M-ACE results. Lipid and uric acid concentrations were not related to M-ACE or MMSE scores. An inverse relationship connected Aβ1-40 and Aβ1-42 to BMI, the duration of HTN treatment, and glycated hemoglobin. Conclusions: Aβ1-42, APOE, and Aβ42/40 are not only correlated with cognition but also related to patient’s disease profile. The coexistence of DM and HTN was associated with the most significant decline in cognitive functioning. However, a higher number of years of education may protect against the development of dementia in old age. The roles of cholesterol and uric acid in cognitive decline are still inconclusive.

Although attention-deficit/hyperactivity disorder (ADHD) with familial risk for bipolar I disorder (BD) may represent a more severe illness conferring greater risk for developing BD, associated neurostructural substrates remain poorly understood. This study examined cerebellum structural alterations, which prior studies suggested may be associated with BD risk. We enrolled 151 youth (ages 10-18 years) in three groups: psychostimulant-free ADHD youth with a biological parent or sibling with BD (high-risk, n = 52, mean age 13.8 ± 2.6 years), psychostimulant-free ADHD youth without any first- or second-degree relative with mood or psychotic disorders (low-risk, n = 50, mean age 14.1 ± 2.5 years), and healthy controls (HC, n = 49, mean age 14.6 ± 2.4 years). ADHD youth were stimulant-naïve or had no psychostimulant exposure within 3 months prior to enrollment. Region-of-interest (ROI) analyses were conducted on the whole cerebellum and 28 lobules to quantify cerebellar volumes using the SUIT toolbox, and voxel-based morphometry (VBM) analyses were also performed. Exploratory analyses evaluated associations between regional cerebellar volumes and symptom measures. Significant group differences in volume were observed for the whole cerebellum, bilateral lobules VIIIa, right VIIb, and left X. Post hoc comparisons showed that the high-risk group exhibited volume deficits in the whole cerebellum, bilateral lobules VIIIa, and right VIIb, compared with HC and low-risk groups, whereas both high-risk and low-risk groups exhibited left X volume deficits compared to HC. Similar results were obtained using VBM. Among all ADHD youth, significant inverse correlations were observed between significant ROI volumes and Child Behavior Checklist (CBCL) total score and several subscales, including the dysregulation profile. Psychostimulant-free ADHD youth with BD familial risk exhibit whole and regional cerebellar volume deficits compared with those without such risk and healthy youth. Inverse associations between regional cerebellar volumes and CBCL total and subscale scores among ADHD youth suggest clinical relevance and may represent a potential BD risk biomarker.

EEG microstates as biomarkers of drug-naïve major depressive disorder in young adults with non-suicidal self-injury.

Quantitative perfusion assessment with arterial spin labeling magnetic resonance imaging for predicting cognitive decline in Alzheimer's disease: A systematic review and meta-analysis.

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and one of the leading causes of cancer-related deaths worldwide. Early diagnosis of HCC, as well as the identification of biomarkers that can help determine the effectiveness of applied treatments, is extremely important. In the present study, the effects of Theranekron (TCAE, Tarantula cubensis alcoholic extract) and Sorafenib (S) on plasma and liver tissue levels of alpha-fetoprotein (AFP), heat shock protein 90 alpha (HSP90α), and indoleamine 2,3-dioxygenase 1 (IDO1) were investigated in Wistar-Albino rats with experimentally induced HCC using diethylnitrosamine (DEN) and n-nitrosomorpholine (nMOR). The study included a total of 58 rats divided into 7 groups: Healthy Group (HG, n = 6), HG + TCAE (HGT, n = 6), HG + Sorafenib (HGS, n = 6), HCC Control (HC, n = 10), HCC + TCAE (HT, n = 10), HCC + Sorafenib (HS, n = 10), and HCC + TCAE + Sorafenib (HTS, n = 10). Plasma and liver AFP, HSP90α, and IDO1 levels were found to be significantly elevated in the HC group compared with the healthy control groups (p < 0.001). Administration of Theranekron and Sorafenib, either alone or in combination, resulted in significant reductions in AFP, HSP90α, and IDO1 levels, particularly in plasma (p < 0.001). Furthermore, histopathological evaluation revealed that Theranekron and Sorafenib treatments exhibited less tumorigenic morphology compared with the HC group. Taken together, these results demonstrate that Theranekron enhances the antitumor efficacy of Sorafenib. Moreover, HSP90α and IDO1 levels appear to provide higher specificity and sensitivity, suggesting their potential as more reliable biomarkers for monitoring tumor prognosis.

Auditory-verbal hallucinations (AVH)-the experience of hearing voices in the absence of auditory stimulation-are a cardinal psychotic feature of schizophrenia-spectrum disorders. It has long been suggested that some AVH may reflect the misperception of inner speech as external voices due to a failure of corollary-discharge-related mechanisms. We aimed to test this hypothesis with an electrophysiological marker of inner speech. Participants produced an inner syllable at a precisely specified time, when an audible syllable was concurrently presented. The inner syllable either matched or mismatched the content of the audible syllable. In the passive condition, participants did not produce an inner syllable. We compared the amplitude of the N1, P2, and P3-components of the auditory-evoked potential between: (1) schizophrenia-spectrum patients with current AVH (SZAVH+, n = 55), (2) schizophrenia-spectrum patients without current AVH (SZAVH-, n = 44), (3) healthy controls (HC, n = 43). The HC group showed reduced N1-amplitude in the Match condition (relative to Passive and Mismatch), replicating our previous results. In contrast, the SZAVH+ group showed the opposite effect: enhanced N1-amplitude in the Match condition (relative to Passive and Mismatch). The SZAVH- group showed reductions in the Mismatch condition (relative to Passive and Match). This study provides empirical support for the theory that AVH are related to abnormalities in the normative suppressive mechanisms associated with inner speech. This phenomenon of "inner speaking-induced suppression" may have utility as a biomarker for schizophrenia-spectrum disorders generally, and may index a tendency for AVH specifically at more extreme levels of abnormality.

BackgroundHeart failure (HF) pathology is complex and seriously life-threatening. SGLT2 inhibitors, as one of the new quadruple drugs for HF treatment, have a complex mechanism for improving HF. Energy metabolism is one of the important aspects of HF pathology, and the PPARα signaling pathway plays an important role in energy metabolism. Therefore, this study aims to observe changes in the PPARα signal transduction pathway in chronic HF by 18F-FDG MicroPET/CT imaging. Based on the myocardial metabolic imaging of 18F-FDG MicroPET/CT, this study aims to verify the mechanism of SGLT2 inhibitor treatment in rats with HF through the PPARα signal transduction pathway of energy metabolism and provide an imaging diagnostic basis.ResultsIn 18F-FDG PET/CT myocardial metabolic imaging, pretreatment myocardial glucose metabolism rate (MRGlu) levels in the HC group of HF rats were significantly higher than that in the other three groups. Post-treatment, MRGlu and glucose uptake decreased markedly in the empagliflozin (EMPG) group, while no significant changes were observed in the fenofibrate (FF) group. Compared with normal healthy rats, HF model rats showed a significant increase in MRGlu, and the expression of the lipid metabolism pathway proteins (PPARα, RXRα, CPT1α, and CD36) and the energy metabolism pathway proteins (AMPKα and sirt1) were significantly inhibited, while the expression of the glycolytic pathway protein (GLUT4) was enhanced. After 4 weeks of drug treatment in HF model rats, EMPG showed the same lipid metabolism pathway proteins (PPARα, RXRα, and CPT1α) and energy metabolism pathway proteins (AMPKα and sirt1) as FF, but only EMPG showed a significant decrease in MRGlu, inhibition of glycolytic pathway protein (GLUT 4) expression, and decreased cardiac fibrosis in HF rats.ConclusionThis study led to the following conclusions. 1) Rats with HF showed a significant increase in MRGlu compared with healthy rats. 2) Empagliflozin can improve the energy supply efficiency of the heart in rats with chronic HF by inhibiting glucose metabolism and promoting lipid metabolism, thereby ameliorating energy metabolism in chronic HF. 3) 18F-FDG MicroPET/CT can observe the energy metabolism changes of HF, and the MRGlu can provide quantitative data for the changes of HF energy metabolism.

While substantial research has focused on general anxiety in anorexia nervosa (AN), eating-related anxiety is insufficiently understood and less is known about its underlying neurobiological mechanisms. We integrated behavioral and magnetic resonance spectroscopy (MRS) methods to characterize anxiety-to-eat and to identify its neurometabolic correlates in females with AN (n = 16) and in healthy weight females without a lifetime history of an eating disorder (healthy controls; HC; n = 16). Anxiety-to-eat was assessed via a computer-based task in which participants rated their level of anxiety-to-eat on a visual analogue scale in response to images of a standard serving of higher (HED) and lower energy density (LED) foods. Levels of nine neurometabolites in the dorsal anterior cingulate cortex (dACC), a brain region putatively involved in modulating anxiety-related responses, were assessed using edited MRS. The AN group reported greater anxiety-to-eat in response to HED and LED foods relative to the HC group. Both groups reported greater anxiety-to-eat in response to HED relative to LED foods. The neurometabolite myo-inositol (myo-I), a carbocyclic sugar and precursor molecule to phosphatidyl-inositol species in second-messenger systems shown to be dysregulated in AN (e.g., adrenergic, serotonergic, glutamatergic), was lower in the dACC in AN relative to HC. Additionally, in the AN group only, myo-I levels negatively predicted anxiety-to-eat in response to HED but not LED foods independent of body mass index, duration of illness, and general anxiety. These findings raise the possibility that lower myo-I in the dACC and its relationship with anxiety-to-eat responsesin AN reflect a distinct biological and behavioral phenotype of AN pathology. To understand the clinical implications of these findings, future studies should investigate the effect of treatment on myo-I levels or directly manipulate myo-I levels in the diet and assess resulting changes in anxiety-to-eat.

ObjectiveThis study utilized resting-state functional magnetic resonance imaging (rs-fMRI) to investigate changes in the spontaneous activity of the default mode network (DMN) in patients with primary dysmenorrhea (PD) through amplitude of low-frequency fluctuation (ALFF) and functional connectivity (FC) analyses, aiming to explore their relationship with emotional regulation.MethodsA total of 14 PD patients (the PD group) and 24 healthy controls matched by age, education, and gender (the HC group) underwent rs-fMRI scans. First, changes in ALFF were calculated for the PD group in comparison to the HC group, and brain regions with ALFF differences were used as regions of interest (ROIs). Subsequently, rs-fMRI was employed to detect differences in FC intensity between the two groups. Nine PD patients completed neuropsychological scale assessments, and correlations between their ALFF and FC values were analyzed.ResultsCompared to the HC group, the PD group exhibited decreased ALFF in the middle temporal gyrus, temporal pole, and superior temporal gyrus on the left side. Using the temporal pole as the ROI, the PD group also showed decreased connectivity between the temporal pole and the superior frontal gyrus (SFG), dorsolateral supplementary motor area (SMA), and precentral gyrus on the right side. A trend suggesting a positive correlation between ALFF values and anxiety was observed.ConclusionPD patients exhibited multidimensional functional changes in the brain. ALFF and FC may serve as sensitive biomarkers for distinguishing PD patients from healthy individuals.

PurposeThis study aimed to explore factors affecting adherence to remote home-based pulmonary rehabilitation (PR) in patients with stable chronic obstructive pulmonary disease (COPD) and to develop a predictive model.Patients and MethodsThis multicenter, cross-sectional survey study included 86 patients who underwent 12 weeks of health education-integrated, home-based PR with remote monitoring. Patients were stratified into high-completion (HC, ≥ 70%) and low-completion (LC, < 70%) groups. Demographic data, clinical features, and psychological parameters were analyzed. Receiver operating characteristic curve and area under the curve (AUC) analyses evaluated the predictive performance of key indicators. Binary logistic regression identified four predictors: Pulmonary Rehabilitation Adapted Index of Self-Efficacy (PRAISE), Outcome Expectations for Exercise Scale (OEE), Montreal Cognitive Assessment (MoCA), and Visual Analog Scale (VAS). These components formed an optimized predictive model with corresponding formula and cutoff values.ResultsA cross-sectional survey of 71 patients, 44 in the HC group and 27 in the LC group, revealed significantly higher scores in the HC group in the following domains of the 36-Item Short Form Health Survey (SF-36), including physical functioning, role limitations due to physical health, role limitations due to emotional problems, energy/fatigue, mental health, and social functioning, as well as in the MoCA scores (all p-values < 0.05). Significant intergroup differences were also observed in PRAISE, OEE and VAS scores (all p < 0.001). PRAISE (AUC = 0.810), OEE (AUC = 0.784), MoCA (AUC = 0.719), and VAS (AUC = 0.801) demonstrated discriminatory power in assessing PR adherence. The combined predictive model achieved an AUC of 0.895 (95% confidence interval: 0.812–0.977, p < 0.05), with 77.8% sensitivity and 93.2% specificity.ConclusionSocial cognitive theory (SCT) originated from social learning theory. It explains human behavior through a triadic, dynamic, and reciprocal model. This model posits continuous interaction among an individual’s behavior, cognitive factors, and environmental context. The four-variable predictive model, based on SCT, effectively evaluates adherence to home-based PR under remote monitoring in patients with COPD. Among the indicators in the four-variable model, PRAISE shows potential as a target for intervention to enhance PR completion rates.

High-temperature environments significantly compromise the productivity of laying hens by damaging intestinal mucosal structure and impairing nutrient absorption. The effects of dietary canthaxanthin (CX) supplementation on egg production rate and intestinal health in Huaixiang chickens raised at high temperatures were assessed in this study. Six groups were randomly selected from among 216 hens: NC (basal diet, 25 ± 1°C), HC (basal diet, 32 ± 1°C for 8 h/day), and four HCX groups (basal diet supplemented with 4, 6, 8, or 10 mg/kg CX, 32 ± 1°C for 8 h/day), with six replicates of six birds each over 28 days. High temperature significantly decreased feed intake, egg production rate, and feed conversion ratio (FCR; p < 0.05), reduced serum total antioxidant capacity (T-AOC), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities (p < 0.05), while increasing malondialdehyde (MDA) and reactive oxygen species (ROS; p < 0.05). High temperature also decreased T-AOC activity in the duodenum, jejunum and ileum (p < 0.05), and increased MDA and ROS levels in these intestinal segments (p < 0.05). Relative to the HC group, dietary CX increased egg production rate and FCR, enhanced serum T-AOC, SOD and GSH-Px activities, while reducing MDA and ROS levels (p < 0.05). CX increased T-AOC activity in the small intestine and decreased MDA and ROS levels (p < 0.05). In addition, heat stress impaired intestinal morphology, lowering villus height (VH), villus surface area (VSA), and villus height to crypt depth ratio (V/C; p < 0.05) while increasing apoptosis rate (p < 0.05). This was accompanied by decreased jejunal fatty acid binding protein 1 (FABP1) expression and lowered serum concentrations of total protein (TP), total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C; p < 0.05). Relative to the HC group, dietary CX alleviated intestinal villus atrophy and rupture, effectively maintained normal small intestinal VH, VSA, and V/C ratios, and significantly reduced intestinal epithelial cell apoptosis rate. CX significantly increased serum TP, TG, TC, LDL-C, and HDL-C while maintaining normal expression levels of FABP1 mRNA in the jejunum. These results demonstrate that dietary supplementation with 8 mg/kg CX effectively mitigates high temperature-induced declines in egg production by improving intestinal nutrient absorption.

Background:The risk of second anterior cruciate ligament (ACL) injury remains high after ACL reconstruction (ACLR), indicating the need to improve rehabilitation and return-to-sport assessment. Because ACL injuries frequently occur in cognitively demanding situations, dual-task screening provides a promising opportunity to detect movement impairments by testing cognitive and motor skills simultaneously.Purpose/Hypothesis:The purpose was to evaluate cognitive-motor impairments that persist after ACLR. It was hypothesized that jump landing biomechanics would be impaired in athletes with previous ACLR versus controls and that these impairments would be exacerbated when the jump landings were performed with a cognitive challenge.Study Design:Controlled laboratory study.Methods:A total of 35 individuals who underwent primary ACLR (ACLR group) and 35 healthy controls (HC group), matched by sex, age, dominant limb, body mass index, sports activities, Tegner score, and Marx activity score, participated in this study. Participants performed jumping tasks under a variety of conditions, including with and without visual constraint, rapid decision-making, and visual-spatial challenges. Primary dependent variables included second ACL injury factors such as asymmetry of knee extensor moment at initial contact (KEM-Asym-IC). Second-level analysis focused on other variables associated with ACL loading and injury (eg, peak knee flexion angle [pKFA]). Mixed-effect models were tested for group and condition interactions as well as group and condition main effects.Results:A total of 35 individuals (25 women and 10 men) who underwent ACLR (ACLR group) (age, 19.9 ± 1.7 years; height, 1.7 ± 0.1 m; mass, 69.9 ± 13.1 kg; years after ACLR, 1.5 ± 0.6 years; Tegner score, 6.8 ± 1.8; and Marx score, 10.6 ± 3.8) were matched with 35 (25 women and 10 men) HC individuals (HC group) (age, 20.1 ± 1.9 years; hight, 1.7 ± 0.1 m; mass, 67.1 ± 8.4 kg; Tegner score, 6.6 ± 1.6; and Marx score, 11 ± 3.9). No significant group and condition interactions were detected. A group effect for KEM-Asym-IC (HC group, –0.005 ± 0.8 % bodyweight–height vs ACLR group, 0.43 ± 0.82 % bodyweight–height; P < .001) indicated relatively more knee extensor moment in the uninvolved limb at initial contact for the ACLR group, regardless of condition. In addition, a condition effect for pKFA indicated that both groups demonstrated decreased knee flexion in response to rapid decision-making challenges (anticipated conditions, 79°-80° vs rapid decision-making conditions, 76°-78°; P < .001).Conclusion:After return-to-sport clearance, the ACLR group showed increased presence of mechanics associated with second ACL injury compared with the HC group during jump landing movements, with rapid decision-making conditions also eliciting reduced pKFA during landing for both groups.Clinical Relevance:The extent to which these multivariable outcomes may compound injury risk after ACLR requires further research to more precisely understand opportunities for neurocognitive challenges to augment ACLR return-to-sport assessment.

ABSTRACTBackgroundAcne vulgaris (AV) is a common inflammatory skin disease during adolescence. Metformin (MET) has recently been found to have the effects of regulating lipid disorders, suggesting its potential benefits in the treatment of AV patients.MethodRecruited 18 patients with moderate to severe AV, and then received MET treatment (AVM group) for a continuous period of 12 weeks, while 20 healthy controls (HC group) served as the control group. The Global Acne Grading System (GAGS) score and VISIA‐CRTM imaging system were used to evaluate the severity of AV patients before and after treatment, and the serum lipid metabolomics differences were detected by liquid chromatograph mass spectrometer (LC–MS) before and after treatment. Multivariate statistical analysis of differentially expressed lipid metabolites was performed using partial least squares discriminant analysis (PLS‐DA) and orthogonal partial least squares discriminant analysis (OPLS‐DA). The Mann–Whitney U test was used to analyze the differences in lipid metabolites between groups. Spearman correlation analysis was conducted to examine the correlation between differentially expressed serum lipid metabolites and the acne severity index. The Kyoto Encyclopedia of Genes and Genomes (KEGG) database was used to predict the metabolic pathways involved in the differentially expressed lipid metabolites in the AVM group.ResultsCompared to before treatment, the GAGS score (p < 0.001), red zone (p < 0.001) and Porphyrin (p < 0.01) indices of AV patients significantly improved after oral administration of MET. The results of PLS‐DA and OPLS‐DA indicated a clear separation in the composition of lipid metabolites between AV patients and the HC group; however, after MET treatment, the composition of lipid metabolites in AV patients showed a trend towards resembling that of the HC group. The 25 lipid metabolites with the most significant differences between AV patients and the HC group were all restored to the levels of the HC group after MET treatment. The Spearman correlation results showed that the serum PC (16:1/22:6) concentration in AV patients before treatment was positively correlated with the porphyrin area index (r = 0.47, p = 0.049). The KEGG analysis revealed 6 metabolic pathways that showed significant downregulation after treatment with MET.ConclusionThe therapeutic effect of MET on patients with moderate to severe AV may be achieved through the positive regulation of lipid metabolism. Its molecular mechanism may be related to the downregulation of inflammatory mediators associated with choline metabolism and arachidonic acid metabolism.

Deciphering the enzymatic responses, composition, network complexity, and functional degraders of the marine sediment bacterial community in response to 2-methyl-4-isothiazoline-3-one exposure.

Characteristics and specific differential gene analysis of the TCR immune repertoire in secondary adult HLH lymphocytes.

Multimodal MRI biomarkers optimize differentiation between progressive supranuclear palsy and Parkinson's disease.

Patients with borderline personality disorder show initially reduced psychophysiological relaxation levels but intact relaxation response.

Stearoyl-CoA desaturase 1 (SCD1) and elongase 6 (ELOVL6) are key enzymes in the synthesis of monounsaturated fatty acids (MUFA). Gene expression for SCD1 and ELOVL6 is high in the white adipose tissue (WAT) and is regulated at the transcriptional level by various factors. This study aimed to assess the effect of (a) cholesterol-enriched diet and (b) atorvastatin in a hypercholesterolemic state, on the relative mRNA and protein levels and indices for SCD1 and ELOVL6 in rat retroperitoneal WAT (rWAT). The mRNA and protein levels of SCD1 and ELOVL6 were determined using the RT-qPCR and Western blot techniques, respectively. Gas chromatography was used to determine the FA composition, and the SCD1 and ELOVL6 indices were then calculated. In the HC group, the content of SAT decreased, as did the percentage of 14:0, 16:0, and 18:0. Conversely, PUFA content increased, as did the percentage of 18:2 n-6 and the indices for SCD18 and FA elongation compared to the CT group. In the AT group, the mRNA and protein levels of SCD1 increased, whereas the MUFA content and the percentage of 18:1 n-9 decreased compared to the HC group. The study showed that a cholesterol-enriched diet increased the SCD1 index, leading to a decrease in SAT as these were used for MUFA synthesis. In contrast, atorvastatin lowered MUFA content, suggesting a protective effect of this compound in the rWAT of hypercholesterolemic rats. Furthermore, atorvastatin increased the expression of SCD1 mRNA and protein but did not affect the SCD1 index.

Acute stress response dysfunction in problem gambling (PG) and relationships with features of addiction.

ObjectiveEpidemiological evidence links exposure to certain metals with decreased kidney function and kidney disease progression. This study investigates the metallome profiles in chronic kidney disease (CKD) patients and their relationship to disease onset and progression.MethodsA total of 341 CKD patients (CKD group) and 60 healthy controls (HC group) were recruited. Renal function markers, including urea, creatinine (Creat), uric acid (UA), cystatin C (CysC), and complement component 1q (C1q), along with the levels of 26 metal elements, were assessed to examine the relationship between metal element concentrations and renal function markers.ResultsCompared to the HC group, serum concentrations of Li, Mg, Al, Ca, V, Mn, Ni, Cu, Ga, Se, Rb, Mo, Sn, Cs, and Pb were elevated in CKD patients (all P<0.05), while Co, Hg, and U levels were reduced (all P<0.05). Serum concentrations of Li, Al, V, Mo, Sn, Cs, and Hg correlated with renal function markers (Urea |r|=0.146 to 0.545, Creat |r|=0.120 to 0.584, CysC |r|=0.132 to 0.641; all P<0.05). Logistic regression identified Al, V, Co, Ga, Cs, and Pb as independent predictors of CKD onset (all P<0.05), while Li, V, Mo, and Cs were linked to disease progression (all P<0.05). Strong positive correlations were observed between Al and V (r=0.821), Al and Ga (r=0.717), and V and Ga (r=0.646), while Co negatively correlated with Al (r=−0.449), V (r=−0.410), and Ga (r=−0.288).ConclusionCKD patients exhibit altered serum levels of various metals. Al, V, Co, Ga, Cs, and Pb are linked to CKD onset, while Li, V, Mo, and Cs relate to its progression. These findings suggest that monitoring specific metal elements like V, Pb and Mo could aid in early CKD detection and progression assessment.